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Aliases for LGALS9B Gene

Aliases for LGALS9B Gene

  • Galectin 9B 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 9B 2 3
  • Galectin-9-Like Protein A 3 4
  • Gal-9B 3 4
  • Galectin-9 Pseudogene 3
  • Galectin-9 Like 3
  • Galectin-9B 3

External Ids for LGALS9B Gene

Previous GeneCards Identifiers for LGALS9B Gene

  • GC17M020295
  • GC17M020352

Summaries for LGALS9B Gene

Entrez Gene Summary for LGALS9B Gene

  • This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more centromeric gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS9B Gene

LGALS9B (Galectin 9B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS9C.

UniProtKB/Swiss-Prot for LGALS9B Gene

  • Binds galactosides.

Additional gene information for LGALS9B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS9B Gene

Genomics for LGALS9B Gene

GeneHancer (GH) Regulatory Elements for LGALS9B Gene

Promoters and enhancers for LGALS9B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I020466 Promoter/Enhancer 1 EPDnew Ensembl 550.8 +0.2 239 1.4 SMARCA5 IKZF1 DPF2 ZIC2 LGALS9B KRT16P3 GC17M020454
GH17I020008 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 16.5 +457.3 457265 3.5 HDGF PKNOX1 ARNT SIN3A ZNF2 ZNF207 ZNF143 KLF13 SP3 ZHX2 ENSG00000261033 SPECC1 AKAP10 MEIS3P2 MAPK7 LGALS9B UPF3AP2 ENSG00000262202 ENSG00000264932 ULK2
GH17I020154 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 16.1 +311.5 311476 2.8 HDGF PKNOX1 SIN3A FEZF1 IRF4 GLIS2 ZNF207 ZNF143 RUNX3 KLF13 PIR42533 SPECC1 ENSG00000261033 LGALS9B RNU6-258P AKAP10 GC17M020165 GC17M020166
GH17I020320 Promoter/Enhancer 1.3 Ensembl ENCODE 15.6 +146.3 146339 1.2 PKNOX1 ATF1 NFIB RB1 SIN3A ZNF2 RAD21 RFX5 ZNF121 ARID2 CCDC144CP ENSG00000266839 RNU6-467P PIR36833 LGALS9B KRT17P6 ENSG00000263494
GH17I020184 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.1 +282.5 282513 1.5 HDAC1 PKNOX1 TCF12 CEBPB ZEB2 SMARCA4 IKZF1 MYNN KDM1A MEIS2 ENSG00000263494 AKAP10 LGALS9B NOS2P3 GC17M020166 GC17M020165 SPECC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LGALS9B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LGALS9B gene promoter:

Genomic Locations for LGALS9B Gene

Genomic Locations for LGALS9B Gene
18,145 bases
Minus strand

Genomic View for LGALS9B Gene

Genes around LGALS9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS9B Gene

Proteins for LGALS9B Gene

  • Protein details for LGALS9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NLF8
    • A8K2J8

    Protein attributes for LGALS9B Gene

    356 amino acids
    Molecular mass:
    39660 Da
    Quaternary structure:
    No Data Available
    • The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.

    Alternative splice isoforms for LGALS9B Gene


neXtProt entry for LGALS9B Gene

Post-translational modifications for LGALS9B Gene

No Post-translational modifications

Other Protein References for LGALS9B Gene

No data available for DME Specific Peptides for LGALS9B Gene

Domains & Families for LGALS9B Gene

Gene Families for LGALS9B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LGALS9B Gene

Suggested Antigen Peptide Sequences for LGALS9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LGALS9B: view

No data available for UniProtKB/Swiss-Prot for LGALS9B Gene

Function for LGALS9B Gene

Molecular function for LGALS9B Gene

UniProtKB/Swiss-Prot Function:
Binds galactosides.

Phenotypes From GWAS Catalog for LGALS9B Gene

Gene Ontology (GO) - Molecular Function for LGALS9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LGALS9B: view
genes like me logo Genes that share phenotypes with LGALS9B: view

Animal Models for LGALS9B Gene

MGI Knock Outs for LGALS9B:

miRNA for LGALS9B Gene

miRTarBase miRNAs that target LGALS9B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGALS9B Gene

Localization for LGALS9B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS9B gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LGALS9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with LGALS9B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LGALS9B Gene

Pathways & Interactions for LGALS9B Gene

SuperPathways for LGALS9B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS9B Gene


No data available for Pathways by source and SIGNOR curated interactions for LGALS9B Gene

Drugs & Compounds for LGALS9B Gene

No Compound Related Data Available

Transcripts for LGALS9B Gene

mRNA/cDNA for LGALS9B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LGALS9B Gene

Lectin, galactoside-binding, soluble, 9B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS9B Gene

No ASD Table

Relevant External Links for LGALS9B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LGALS9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS9B Gene

This gene is overexpressed in Esophagus - Mucosa (x11.7), Stomach (x11.3), Colon - Transverse (x10.4), and Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for LGALS9B Gene

This gene is overexpressed in Nasal epithelium (61.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGALS9B Gene

Protein tissue co-expression partners for LGALS9B Gene

NURSA nuclear receptor signaling pathways regulating expression of LGALS9B Gene:


SOURCE GeneReport for Unigene cluster for LGALS9B Gene:


Evidence on tissue expression from TISSUES for LGALS9B Gene

  • Stomach(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with LGALS9B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS9B Gene

Orthologs for LGALS9B Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS9B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
(Rattus norvegicus)
Mammalia Lgals9 33
  • 79.4 (n)
(Mus musculus)
Mammalia Lgals9 33 16 34
  • 78 (n)
(Canis familiaris)
Mammalia LGALS9 34
  • 74 (a)
(Bos Taurus)
Mammalia LGALS9 34
  • 73 (a)
-- 34
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
-- 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals9c 33
  • 53.12 (n)
(Danio rerio)
Actinopterygii zgc:92326 34
  • 47 (a)
lgals9l1 34
  • 45 (a)
zgc:171951 34
  • 43 (a)
si:ch211-209m20.9 34
  • 42 (a)
zgc:136924 34
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GALE1 33
  • 44.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta galectin 33
  • 41 (n)
CG11374 34
  • 17 (a)
(Caenorhabditis elegans)
Secernentea lec-12 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
CSA.123 34
  • 29 (a)
Species where no ortholog for LGALS9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LGALS9B Gene

Gene Tree for LGALS9B (if available)
Gene Tree for LGALS9B (if available)

Paralogs for LGALS9B Gene

(15) SIMAP similar genes for LGALS9B Gene using alignment to 3 proteins: Pseudogenes for LGALS9B Gene

genes like me logo Genes that share paralogs with LGALS9B: view

Variants for LGALS9B Gene

Sequence variations from dbSNP and Humsavar for LGALS9B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs4985834 benign, not specified 20,467,454(-) G/C coding_sequence_variant, missense_variant
rs1000263259 -- 20,457,741(-) A/G intron_variant
rs1000809862 -- 20,461,184(-) C/T intron_variant
rs1000862656 -- 20,460,795(-) C/T intron_variant
rs1000963466 -- 20,469,488(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS9B Gene

Variant ID Type Subtype PubMed ID
nsv978389 CNV duplication 23825009
nsv953847 CNV deletion 24416366
nsv9507 CNV gain+loss 18304495
nsv833399 CNV loss 17160897
nsv833398 CNV loss 17160897
nsv833397 CNV loss 17160897
nsv821555 CNV deletion 20802225
nsv574591 CNV gain 21841781
nsv574589 CNV loss 21841781
nsv574581 CNV loss 21841781
nsv521025 CNV gain 19592680
nsv520772 CNV loss 19592680
nsv511599 CNV loss 21212237
nsv471495 CNV gain 19718026
nsv471392 CNV gain 19718026
nsv469852 CNV gain 16826518
nsv428338 CNV gain 18775914
nsv1150865 CNV duplication 26484159
nsv1112702 CNV deletion 24896259
nsv1072725 CNV deletion 25765185
nsv1071377 CNV deletion 25765185
nsv1066679 CNV gain 25217958
nsv1066226 CNV gain 25217958
nsv1059504 CNV gain 25217958
nsv1055600 CNV loss 25217958
esv3640202 CNV loss 21293372
esv3445794 CNV duplication 20981092
esv3419011 CNV duplication 20981092
esv3390945 CNV duplication 20981092
esv3380673 CNV duplication 20981092
esv3349827 CNV duplication 20981092
esv2758680 CNV gain 17122850
esv23447 CNV gain+loss 19812545
dgv5501n54 CNV loss 21841781
dgv5500n54 CNV gain 21841781
dgv5499n54 CNV gain 21841781
dgv3121n100 CNV loss 25217958
dgv1711e59 CNV duplication 20981092

Variation tolerance for LGALS9B Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.90; 79.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALS9B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS9B Gene

Disorders for LGALS9B Gene

Additional Disease Information for LGALS9B

No disorders were found for LGALS9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LGALS9B Gene

Publications for LGALS9B Gene

  1. Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs. (PMID: 11997339) Park SS … Lupski JR (Genome research 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for LGALS9B Gene

Sources for LGALS9B Gene

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