Free for academic non-profit institutions. Other users need a Commercial license
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
LGALS7B (Galectin 7B) is a Protein Coding gene. Diseases associated with LGALS7B include Galactosemia I and Swine Influenza. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016936 | galactoside binding | IBA | 21873635 |
GO:0030246 | carbohydrate binding | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | TAS | 7534301 |
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IEA | -- |
GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | TAS,IEA | -- |
GO:0010628 | positive regulation of gene expression | IBA | 21873635 |
GO:0010629 | negative regulation of gene expression | IBA | 21873635 |
GO:0032689 | negative regulation of interferon-gamma production | IBA | 21873635 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LGALS7B 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LGALS7B 30 |
|
||
LGALS7 31 |
|
ManyToMany | |||
Mouse (Mus musculus) |
Mammalia | Lgals7 30 17 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | LGALS7 30 |
|
||
-- 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Lgals7 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | GRIFIN 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-95h12.2 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG11374 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | lec-12 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
CSA.123 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv29n47 | OTHER | inversion | 21111241 |
dgv3527n100 | CNV | gain | 25217958 |
esv1006530 | OTHER | inversion | 20482838 |
nsv1058132 | CNV | loss | 25217958 |
nsv1063592 | CNV | gain | 25217958 |
nsv175 | OTHER | inversion | 15895083 |
nsv510475 | OTHER | sequence alteration | 20534489 |
nsv7307 | OTHER | inversion | 18451855 |
nsv963045 | CNV | duplication | 23825009 |
nsv9720 | CNV | gain | 18304495 |
nsv9721 | CNV | loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
galactosemia i |
|
|
swine influenza |
|
|
tracheitis |
|
|
bladder squamous cell carcinoma |
|
|
avian influenza |
|
|