The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposi... See more...

Aliases for LGALS7B Gene

Aliases for LGALS7B Gene

  • Galectin 7B 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 7B 2 3
  • P53-Induced Gene 1 Protein 3 4
  • Galectin-7 3 4
  • HKL-14 3 4
  • Gal-7 3 4
  • GAL7 2 3
  • PI7 3 4
  • Lectin Galactoside-Binding Soluble 7 3
  • Keratinocyte Lectin 14 3
  • P53-Induced Protein 1 3
  • LGALS7B 5
  • LGALS7 3
  • PIG1 4

External Ids for LGALS7B Gene

Previous GeneCards Identifiers for LGALS7B Gene

  • GC19M043955
  • GC19P043975
  • GC19P039279
  • GC19M035709

Summaries for LGALS7B Gene

Entrez Gene Summary for LGALS7B Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS7B Gene

LGALS7B (Galectin 7B) is a Protein Coding gene. Diseases associated with LGALS7B include Galactosemia I and Swine Influenza. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS7.

UniProtKB/Swiss-Prot Summary for LGALS7B Gene

  • Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.

Additional gene information for LGALS7B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS7B Gene

Genomics for LGALS7B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LGALS7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J038789 Promoter/Enhancer 0.8 EPDnew dbSUPER 600.7 0.0 -17 0.1 ZFHX2 ZNF335 KLF1 EGR2 LGALS7B HSALNG0125941 CAPN12 hsa-miR-5095-278 LGALS7
GH19J038790 Promoter/Enhancer 0.5 Ensembl dbSUPER 600.7 +0.5 501 0.2 LGALS7B HSALNG0125941 LGALS7 LGALS4
GH19J038647 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -129.4 -129408 25.6 ZNF221 SP1 HNRNPL CREB1 GATAD2A ZBTB33 ATF7 TEAD4 PRDM10 REST ACTN4 HNRNPL ZFP30 ZNF607 ZNF781 ZNF573 SUPT5H ENSG00000267152 PAK4 RN7SL566P
GH19J038761 Enhancer 0.9 Ensembl ENCODE 23.7 -26.1 -26100 3.9 GATAD2A TFE3 RBFOX2 SP1 CEBPA RBAK RAD51 ZNF316 YY1 JUND KR153194-090 LGALS7 CAPN12 LGALS7B FBXO17 piR-37567-080 ACTN4
GH19J038806 Enhancer 1 Ensembl ENCODE dbSUPER 18.3 +18.8 18786 2.4 ARHGAP35 ZNF512 IKZF1 MTA2 MTA1 ZNF24 YBX3 U2AF2 MEF2D ZBTB5 LGALS7 LGALS7B HNRNPL PAF1 ZFP36 RPS16 ECH1 lnc-ECH1-3 LGALS4 RF00017-2971
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LGALS7B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LGALS7B

Top Transcription factor binding sites by QIAGEN in the LGALS7B gene promoter:
  • Arnt
  • CREB
  • deltaCREB
  • HSF1 (long)
  • HSF2
  • NF-1
  • p53

Genomic Locations for LGALS7B Gene

Genomic Locations for LGALS7B Gene
chr19:38,789,200-38,791,754
(GRCh38/hg38)
Size:
2,555 bases
Orientation:
Plus strand
chr19:39,279,850-39,282,394
(GRCh37/hg19)
Size:
2,545 bases
Orientation:
Plus strand

Genomic View for LGALS7B Gene

Genes around LGALS7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS7B Gene

Proteins for LGALS7B Gene

  • Protein details for LGALS7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47929-LEG7_HUMAN
    Recommended name:
    Galectin-7
    Protein Accession:
    P47929
    Secondary Accessions:
    • Q6IB87

    Protein attributes for LGALS7B Gene

    Size:
    136 amino acids
    Molecular mass:
    15075 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LGALS7B Gene

neXtProt entry for LGALS7B Gene

Post-translational modifications for LGALS7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS7B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LGALS7B Gene

Domains & Families for LGALS7B Gene

Gene Families for LGALS7B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LGALS7B Gene

InterPro:
Blocks:
  • Galectin, galactose-binding lectin
ProtoNet:

Suggested Antigen Peptide Sequences for LGALS7B Gene

GenScript: Design optimal peptide antigens:
  • p53-induced gene 1 protein (LEG7_HUMAN)
genes like me logo Genes that share domains with LGALS7B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LGALS7B Gene

Function for LGALS7B Gene

Molecular function for LGALS7B Gene

UniProtKB/Swiss-Prot Function:
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Phenotypes From GWAS Catalog for LGALS7B Gene

Gene Ontology (GO) - Molecular Function for LGALS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016936 galactoside binding IBA 21873635
GO:0030246 carbohydrate binding TAS,IEA --
genes like me logo Genes that share ontologies with LGALS7B: view
genes like me logo Genes that share phenotypes with LGALS7B: view

Animal Models for LGALS7B Gene

MGI Knock Outs for LGALS7B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS7B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS7B Gene

Localization for LGALS7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS7B Gene

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS7B gene
Compartment Confidence
extracellular 4
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LGALS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 7534301
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with LGALS7B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LGALS7B Gene

Pathways & Interactions for LGALS7B Gene

PathCards logo

SuperPathways for LGALS7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS,IEA --
GO:0010628 positive regulation of gene expression IBA 21873635
GO:0010629 negative regulation of gene expression IBA 21873635
GO:0032689 negative regulation of interferon-gamma production IBA 21873635
genes like me logo Genes that share ontologies with LGALS7B: view

No data available for Pathways by source and SIGNOR curated interactions for LGALS7B Gene

Drugs & Compounds for LGALS7B Gene

No Compound Related Data Available

Transcripts for LGALS7B Gene

mRNA/cDNA for LGALS7B Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS7B

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS7B Gene

No ASD Table

Relevant External Links for LGALS7B Gene

GeneLoc Exon Structure for
LGALS7B

Expression for LGALS7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LGALS7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS7B Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x22.7), Skin - Sun Exposed (Lower leg) (x19.0), and Esophagus - Mucosa (x5.4).

Protein differential expression in normal tissues from HIPED for LGALS7B Gene

This gene is overexpressed in Hair follicle (14.9), Saliva (11.1), Urinary Bladder (8.4), Esophagus (8.4), Skin (6.8), and Urine (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LGALS7B Gene



Protein tissue co-expression partners for LGALS7B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LGALS7B

SOURCE GeneReport for Unigene cluster for LGALS7B Gene:

Hs.558355

mRNA Expression by UniProt/SwissProt for LGALS7B Gene:

P47929-LEG7_HUMAN
Tissue specificity: Mainly expressed in stratified squamous epithelium.

Evidence on tissue expression from TISSUES for LGALS7B Gene

  • Skin(4.4)
  • Nervous system(4.4)
  • Blood(2.8)
  • Kidney(2.2)
  • Intestine(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with LGALS7B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS7B Gene

Orthologs for LGALS7B Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS7B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LGALS7B 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LGALS7B 30
  • 80.99 (n)
LGALS7 31
  • 53 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Lgals7 30 17 31
  • 79.41 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia LGALS7 30
  • 79.35 (n)
-- 31
  • 71 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Lgals7 30
  • 77.21 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 62 (a)
OneToMany
Chicken
(Gallus gallus)
Aves GRIFIN 31
  • 30 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 24 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-95h12.2 31
  • 27 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG11374 31
  • 8 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea lec-12 31
  • 14 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
ManyToMany
-- 31
  • 15 (a)
ManyToMany
CSA.123 31
  • 15 (a)
ManyToMany
-- 31
  • 12 (a)
ManyToMany
Species where no ortholog for LGALS7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for LGALS7B Gene

ENSEMBL:
Gene Tree for LGALS7B (if available)
TreeFam:
Gene Tree for LGALS7B (if available)

Paralogs for LGALS7B Gene

(13) SIMAP similar genes for LGALS7B Gene using alignment to 1 proteins:

  • LEG7_HUMAN
genes like me logo Genes that share paralogs with LGALS7B: view

Variants for LGALS7B Gene

Additional dbSNP identifiers (rs#s) for LGALS7B Gene

Structural Variations from Database of Genomic Variants (DGV) for LGALS7B Gene

Variant ID Type Subtype PubMed ID
dgv29n47 OTHER inversion 21111241
dgv3527n100 CNV gain 25217958
esv1006530 OTHER inversion 20482838
nsv1058132 CNV loss 25217958
nsv1063592 CNV gain 25217958
nsv175 OTHER inversion 15895083
nsv510475 OTHER sequence alteration 20534489
nsv7307 OTHER inversion 18451855
nsv963045 CNV duplication 23825009
nsv9720 CNV gain 18304495
nsv9721 CNV loss 18304495

Variation tolerance for LGALS7B Gene

Gene Damage Index Score: 0.22; 4.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALS7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LGALS7B Gene

Disorders for LGALS7B Gene

MalaCards: The human disease database

(5) MalaCards diseases for LGALS7B Gene - From: DISEASES

Disorder Aliases PubMed IDs
galactosemia i
  • galk deficiency
swine influenza
  • influenza due to influenza a virus subtype h1n1
tracheitis
  • acute tracheitis
bladder squamous cell carcinoma
  • epidermoid carcinoma of the urinary bladder
avian influenza
  • avian flu
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with LGALS7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS7B Gene

Publications for LGALS7B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. (PMID: 11706006) Kuwabara I … Liu FT (The Journal of biological chemistry 2002) 3 4
  3. Structural basis for the recognition of carbohydrates by human galectin-7. (PMID: 9760227) Leonidas DD … Acharya KR (Biochemistry 1998) 3 4
  4. Cloning, expression, and chromosome mapping of human galectin-7. (PMID: 7534301) Madsen P … Celis JE (The Journal of biological chemistry 1995) 3 4
  5. Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. (PMID: 7729568) Magnaldo T … Darmon M (Developmental biology 1995) 3 4

Products for LGALS7B Gene

  • Signalway ELISA kits for LGALS7B

Sources for LGALS7B Gene