The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (... See more...

Aliases for LGALS3BP Gene

Aliases for LGALS3BP Gene

  • Galectin 3 Binding Protein 2 3 5
  • Mac-2-Binding Protein 2 3 4
  • M2BP 2 3 4
  • Lectin Galactoside-Binding Soluble 3-Binding Protein 3 4
  • Basement Membrane Autoantigen P105 3 4
  • Tumor-Associated Antigen 90K 3 4
  • Galectin-3-Binding Protein 3 4
  • Serum Protein 90K 2 3
  • L3 Antigen 2 3
  • MAC-2-BP 2 3
  • TANGO10B 2 3
  • Mac-2 BP 3 4
  • BTBD17B 2 3
  • MAC2BP 3 4
  • CyCAP 2 3
  • Gp90 2 3
  • 90K 2 3
  • Transport And Golgi Organization 10 Homolog B (Drosophila) 2
  • Lectin, Galactoside-Binding, Soluble, 3 Binding Protein 2
  • Transport And Golgi Organization 10 Homolog B 3
  • LGALS3BP 5

External Ids for LGALS3BP Gene

Previous GeneCards Identifiers for LGALS3BP Gene

  • GC17P076798
  • GC17P080282
  • GC17M077428
  • GC17M077564
  • GC17M074478
  • GC17M076970
  • GC17M072389

Summaries for LGALS3BP Gene

Entrez Gene Summary for LGALS3BP Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS3BP Gene

LGALS3BP (Galectin 3 Binding Protein) is a Protein Coding gene. Diseases associated with LGALS3BP include Gnathomiasis and Henoch-Schoenlein Purpura. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is DMBT1.

UniProtKB/Swiss-Prot Summary for LGALS3BP Gene

  • Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.

Gene Wiki entry for LGALS3BP Gene

Additional gene information for LGALS3BP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS3BP Gene

Genomics for LGALS3BP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LGALS3BP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LGALS3BP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LGALS3BP

Top Transcription factor binding sites by QIAGEN in the LGALS3BP gene promoter:
  • FOXF2
  • HNF-3beta
  • MRF-2
  • NF-kappaB
  • NF-kappaB1
  • Pax-5
  • PPAR-gamma2
  • RelA
  • RP58
  • ZIC2

Genomic Locations for LGALS3BP Gene

Genomic Locations for LGALS3BP Gene
chr17:78,971,238-78,979,947
(GRCh38/hg38)
Size:
8,710 bases
Orientation:
Minus strand
chr17:76,967,320-76,976,191
(GRCh37/hg19)
Size:
8,872 bases
Orientation:
Minus strand

Genomic View for LGALS3BP Gene

Genes around LGALS3BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS3BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS3BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS3BP Gene

Proteins for LGALS3BP Gene

  • Protein details for LGALS3BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08380-LG3BP_HUMAN
    Recommended name:
    Galectin-3-binding protein
    Protein Accession:
    Q08380
    Secondary Accessions:
    • Q7M4S0
    • Q9UCH8
    • Q9UCH9
    • Q9UCI0

    Protein attributes for LGALS3BP Gene

    Size:
    585 amino acids
    Molecular mass:
    65331 Da
    Quaternary structure:
    • Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID. Interacts with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:29162697). The unglycosylated form interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction may connect a pericentrosomal complex, made of AKAP9, CDK5RAP2, EB1/MAPRE1 and PDE4DIP, to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:29162697).

    Three dimensional structures from OCA and Proteopedia for LGALS3BP Gene

neXtProt entry for LGALS3BP Gene

Post-translational modifications for LGALS3BP Gene

  • Glycosylation at Asn69, Asn125, Asn192, Asn362, Asn398, Ser444, Asn551, and Asn580
  • Ubiquitination at Lys441 and Lys474
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • LG3BP_HUMAN (1256)

No data available for DME Specific Peptides for LGALS3BP Gene

Domains & Families for LGALS3BP Gene

Gene Families for LGALS3BP Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for LGALS3BP Gene

InterPro:
Blocks:
  • BTB/POZ domain
ProtoNet:

Suggested Antigen Peptide Sequences for LGALS3BP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53509, highly similar to Galectin-3-binding protein (B4DI70_HUMAN)
  • cDNA FLJ53478, highly similar to Galectin-3-binding protein (B4DVE1_HUMAN)
  • Tumor-associated antigen 90K (LG3BP_HUMAN)
genes like me logo Genes that share domains with LGALS3BP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LGALS3BP Gene

Function for LGALS3BP Gene

Molecular function for LGALS3BP Gene

UniProtKB/Swiss-Prot Function:
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
GENATLAS Biochemistry:
galectin 3,beta-galactoside specific lectin,associated with cancer and HIV infection,overexpressed in colorectal cancer in progression with poor prognosis and liver metastasis

Phenotypes From GWAS Catalog for LGALS3BP Gene

Gene Ontology (GO) - Molecular Function for LGALS3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IEA,IPI 29162697
genes like me logo Genes that share ontologies with LGALS3BP: view
genes like me logo Genes that share phenotypes with LGALS3BP: view

Animal Models for LGALS3BP Gene

MGI Knock Outs for LGALS3BP:

Animal Model Products

  • Taconic Biosciences Mouse Models for LGALS3BP

CRISPR Products

miRNA for LGALS3BP Gene

miRTarBase miRNAs that target LGALS3BP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS3BP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGALS3BP Gene

Localization for LGALS3BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS3BP Gene

Secreted. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS3BP gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LGALS3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005615 extracellular space TAS,IDA 25645918
GO:0016020 membrane IEA --
GO:0031089 platelet dense granule lumen TAS --
GO:0062023 colocalizes_with collagen-containing extracellular matrix HDA 20551380
genes like me logo Genes that share ontologies with LGALS3BP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LGALS3BP Gene

Pathways & Interactions for LGALS3BP Gene

genes like me logo Genes that share pathways with LGALS3BP: view

SIGNOR curated interactions for LGALS3BP Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for LGALS3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006897 endocytosis IEA --
GO:0006968 cellular defense response TAS 8034587
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 8390986
genes like me logo Genes that share ontologies with LGALS3BP: view

Drugs & Compounds for LGALS3BP Gene

(2) Drugs for LGALS3BP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LGALS3BP: view

Transcripts for LGALS3BP Gene

mRNA/cDNA for LGALS3BP Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS3BP

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS3BP Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ·
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - - - - - - -
SP13: - -
SP14: - - - - - - - - - - - - - - - - -
SP15: - -

ExUns: 9d · 9e · 9f ^ 10a · 10b · 10c · 10d
SP1: - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: - - -
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:

Relevant External Links for LGALS3BP Gene

GeneLoc Exon Structure for
LGALS3BP

Expression for LGALS3BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LGALS3BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LGALS3BP Gene

This gene is overexpressed in Amniocyte (19.2) and Urine (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LGALS3BP Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LGALS3BP

SOURCE GeneReport for Unigene cluster for LGALS3BP Gene:

Hs.514535

mRNA Expression by UniProt/SwissProt for LGALS3BP Gene:

Q08380-LG3BP_HUMAN
Tissue specificity: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.

Evidence on tissue expression from TISSUES for LGALS3BP Gene

  • Intestine(4.9)
  • Lung(4.9)
  • Nervous system(4.7)
  • Liver(4.7)
  • Skin(4.6)
  • Bone marrow(4.5)
  • Saliva(4.3)
  • Pancreas(4.2)
  • Heart(3.8)
  • Stomach(3.6)
  • Kidney(3.4)
  • Muscle(3.1)
  • Eye(3.1)
  • Blood(2.8)
  • Spleen(2.8)
  • Lymph node(2.7)
  • Thyroid gland(2.6)
  • Adrenal gland(2.6)
  • Gall bladder(2.6)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with LGALS3BP: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS3BP Gene

Orthologs for LGALS3BP Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS3BP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LGALS3BP 30 31
  • 99.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CANT1 30
  • 81.99 (n)
LGALS3BP 31
  • 75 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LGALS3BP 30 31
  • 79.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lgals3bp 30
  • 76.33 (n)
Mouse
(Mus musculus)
Mammalia Lgals3bp 30 17 31
  • 75.98 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii lgals3bpa 30 31
  • 49.39 (n)
OneToMany
LGALS3BP (3 of 3) 31
  • 35 (a)
OneToMany
lgals3bpb 31
  • 32 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8783 30
Fruit Fly
(Drosophila melanogaster)
Insecta Tango10 31
  • 16 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea W07A12.4 31
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
OneToMany
Species where no ortholog for LGALS3BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for LGALS3BP Gene

ENSEMBL:
Gene Tree for LGALS3BP (if available)
TreeFam:
Gene Tree for LGALS3BP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LGALS3BP: view image

Paralogs for LGALS3BP Gene

Paralogs for LGALS3BP Gene

(10) SIMAP similar genes for LGALS3BP Gene using alignment to 13 proteins:

  • LG3BP_HUMAN
  • K7EJD3_HUMAN
  • K7EJY8_HUMAN
  • K7EKQ5_HUMAN
  • K7ELA1_HUMAN
  • K7EM15_HUMAN
  • K7EN99_HUMAN
  • K7EP36_HUMAN
  • K7EQT9_HUMAN
  • K7ER67_HUMAN
  • K7ERZ6_HUMAN
  • K7ES75_HUMAN
  • K7ESM3_HUMAN
genes like me logo Genes that share paralogs with LGALS3BP: view

Variants for LGALS3BP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LGALS3BP Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
711190 Benign: not provided 78,971,723(-) G/A SYNONYMOUS_VARIANT
711212 Benign: not provided 78,972,227(-) G/A SYNONYMOUS_VARIANT
711213 Benign: not provided 78,972,335(-) A/G SYNONYMOUS_VARIANT
726894 Benign: not provided 78,974,782(-) C/T SYNONYMOUS_VARIANT
737487 Likely Benign: not provided 78,972,156(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for LGALS3BP Gene

Structural Variations from Database of Genomic Variants (DGV) for LGALS3BP Gene

Variant ID Type Subtype PubMed ID
nsv1057193 CNV gain 25217958
nsv2155 CNV insertion 18451855
nsv457917 CNV gain 19166990
nsv470610 CNV loss 18288195
nsv523650 CNV loss 19592680
nsv576101 CNV gain 21841781
nsv952377 CNV deletion 24416366

Variation tolerance for LGALS3BP Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALS3BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS3BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS3BP Gene

Disorders for LGALS3BP Gene

MalaCards: The human disease database

(14) MalaCards diseases for LGALS3BP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gnathomiasis
  • gnathostomiasis
henoch-schoenlein purpura
  • allergic purpura
strongyloidiasis
  • disseminated strongyloidiasis
ostertagiasis
trichostrongyloidiasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LGALS3BP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LGALS3BP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS3BP Gene

Publications for LGALS3BP Gene

  1. The secreted tumor-associated antigen 90K is a potent immune stimulator. (PMID: 8034587) Ullrich A … Natoli C (The Journal of biological chemistry 1994) 2 3 4 23
  2. Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. (PMID: 8390986) Koths K … Wang A (The Journal of biological chemistry 1993) 2 3 4 23
  3. Functional studies on recombinant domains of Mac-2-binding protein. (PMID: 11867635) Hellstern S … Engel J (The Journal of biological chemistry 2002) 3 4 23
  4. Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PMID: 11146440) Tinari N … Liu FT (International journal of cancer 2001) 3 4 23
  5. Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. (PMID: 9501082) Sasaki T … Timpl R (The EMBO journal 1998) 3 4 23

Products for LGALS3BP Gene

Sources for LGALS3BP Gene