Aliases for LGALS3BP Gene
External Ids for LGALS3BP Gene
Previous GeneCards Identifiers for LGALS3BP Gene
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for LGALS3BP Gene
LGALS3BP (Galectin 3 Binding Protein) is a Protein Coding gene. Diseases associated with LGALS3BP include Gnathomiasis and Henoch-Schoenlein Purpura. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is DMBT1.
UniProtKB/Swiss-Prot Summary for LGALS3BP Gene
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.