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The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
LGALS3BP (Galectin 3 Binding Protein) is a Protein Coding gene. Diseases associated with LGALS3BP include Gnathomiasis and Henoch-Schoenlein Purpura. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is DMBT1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005044 | scavenger receptor activity | IEA | -- |
GO:0005515 | protein binding | IEA,IPI | 29162697 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005615 | extracellular space | TAS,IDA | 25645918 |
GO:0016020 | membrane | IEA | -- |
GO:0031089 | platelet dense granule lumen | TAS | -- |
GO:0062023 | colocalizes_with collagen-containing extracellular matrix | HDA | 20551380 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002576 | platelet degranulation | TAS | -- |
GO:0006897 | endocytosis | IEA | -- |
GO:0006968 | cellular defense response | TAS | 8034587 |
GO:0007155 | cell adhesion | IEA | -- |
GO:0007165 | signal transduction | TAS | 8390986 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP15: | - | - |
ExUns: | 9d | · | 9e | · | 9f | ^ | 10a | · | 10b | · | 10c | · | 10d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | |||||||||||||
SP3: | |||||||||||||
SP4: | - | - | |||||||||||
SP5: | |||||||||||||
SP6: | |||||||||||||
SP7: | - | - | - | ||||||||||
SP8: | |||||||||||||
SP9: | - | - | |||||||||||
SP10: | |||||||||||||
SP11: | |||||||||||||
SP12: | |||||||||||||
SP13: | |||||||||||||
SP14: | - | - | |||||||||||
SP15: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LGALS3BP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CANT1 30 |
|
||
LGALS3BP 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | LGALS3BP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lgals3bp 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lgals3bp 30 17 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | lgals3bpa 30 31 |
|
OneToMany | |
LGALS3BP (3 of 3) 31 |
|
OneToMany | |||
lgals3bpb 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8783 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Tango10 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | W07A12.4 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711190 | Benign: not provided | 78,971,723(-) | G/A | SYNONYMOUS_VARIANT | |
711212 | Benign: not provided | 78,972,227(-) | G/A | SYNONYMOUS_VARIANT | |
711213 | Benign: not provided | 78,972,335(-) | A/G | SYNONYMOUS_VARIANT | |
726894 | Benign: not provided | 78,974,782(-) | C/T | SYNONYMOUS_VARIANT | |
737487 | Likely Benign: not provided | 78,972,156(-) | C/T | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
gnathomiasis |
|
|
henoch-schoenlein purpura |
|
|
strongyloidiasis |
|
|
ostertagiasis |
|
|
trichostrongyloidiasis |
|
|