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The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (... See more...
Aliases for LGALS3BP Gene
Aliases for LGALS3BP Gene
External Ids for LGALS3BP Gene
- HGNC: 6564
- Entrez Gene: 3959
- Ensembl: ENSG00000108679
- OMIM: 600626
- UniProtKB: Q08380
Previous GeneCards Identifiers for LGALS3BP Gene
- GC17P076798
- GC17P080282
- GC17M077428
- GC17M077564
- GC17M074478
- GC17M076970
- GC17M072389
Summaries for LGALS3BP Gene
-
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for LGALS3BP Gene
LGALS3BP (Galectin 3 Binding Protein) is a Protein Coding gene. Diseases associated with LGALS3BP include Gnathomiasis and Henoch-Schoenlein Purpura. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is DMBT1.
UniProtKB/Swiss-Prot Summary for LGALS3BP Gene
-
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Additional gene information for LGALS3BP Gene
- HGNC(6564)
- Entrez Gene(3959)
- Ensembl(ENSG00000108679)
- OMIM(600626)
- UniProtKB(Q08380)
- Open Targets Platform(ENSG00000108679)
- Search for LGALS3BP at DataMed
- Search for LGALS3BP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS3BP Gene
Genomics for LGALS3BP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LGALS3BP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LGALS3BP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LGALS3BP
- Top Transcription factor binding sites by QIAGEN in the LGALS3BP gene promoter:
-
- FOXF2
- HNF-3beta
- MRF-2
- NF-kappaB
- NF-kappaB1
- Pax-5
- PPAR-gamma2
- RelA
- RP58
- ZIC2
Genomic Locations for LGALS3BP Gene
Genomic Locations for LGALS3BP Gene
- chr17:78,971,238-78,979,947
- (GRCh38/hg38)
- Size:
- 8,710 bases
- Orientation:
- Minus strand
- chr17:76,967,320-76,976,191
- (GRCh37/hg19)
- Size:
- 8,872 bases
- Orientation:
- Minus strand
Genomic View for LGALS3BP Gene
Genes around LGALS3BP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
LGALS3BP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LGALS3BP Gene
Proteins for LGALS3BP Gene
-
Protein details for LGALS3BP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08380-LG3BP_HUMAN
- Recommended name:
- Galectin-3-binding protein
- Protein Accession:
- Q08380
- Q7M4S0
- Q9UCH8
- Q9UCH9
- Q9UCI0
Protein attributes for LGALS3BP Gene
- Size:
- 585 amino acids
- Molecular mass:
- 65331 Da
- Quaternary structure:
-
- Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID. Interacts with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:29162697). The unglycosylated form interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction may connect a pericentrosomal complex, made of AKAP9, CDK5RAP2, EB1/MAPRE1 and PDE4DIP, to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:29162697).
Protein Expression for LGALS3BP Gene
Post-translational modifications for LGALS3BP Gene
Other Protein References for LGALS3BP Gene
Antibody Products
- LifeSpan BioSciences MAC-2-BP / LGALS3BP Monoclonal Antibody (LS-B9815) and MAC-2-BP / LGALS3BP Monoclonal Antibody (LS-B15508)
- G Biosciences Immunotag™ LGALS3BP Antibody
- NSJ Bioreagents LGALS3BP Antibody / Galectin-3-binding protein
- Novus Biologicals Antibodies for LGALS3BP
-
Abcam antibodies for LGALS3BP
- Invitrogen Antibodies for LGALS3BP (AFLGC-LGALS3BP)
-
Custom Antibody ServicesProSci Antibodies for LGALS3BP
-
Santa Cruz Biotechnology (SCBT) Antibodies for LGALS3BP
- Sino Biological Antibodies for LGALS3BP
Protein Products
-
OriGene Purified Proteins for LGALS3BP
- Search Origene for MassSpec and Protein Over-expression Lysates for LGALS3BP
- Origene Custom Protein Services for LGALS3BP
- antibodies-online: Show 7 available LGALS3BP Proteins ranked by validation data
- Compare Top LGALS3BP Proteins
-
Quality Products:
-
Abcam proteins for LGALS3BP
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for LGALS3BP
- Novus Biologicals ELISA Kits for LGALS3BP
- antibodies-online: Show 40 available LGALS3BP Elisa Kits ranked by validation data
- Compare Top LGALS3BP Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for LGALS3BP
-
Abcam assays for LGALS3BP
No data available for DME Specific Peptides for LGALS3BP Gene
Domains & Families for LGALS3BP Gene
Gene Families for LGALS3BP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for LGALS3BP Gene
- InterPro:
- Blocks:
-
- BTB/POZ domain
- ProtoNet:
Suggested Antigen Peptide Sequences for LGALS3BP Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ53509, highly similar to Galectin-3-binding protein (B4DI70_HUMAN)
- cDNA FLJ53478, highly similar to Galectin-3-binding protein (B4DVE1_HUMAN)
- Tumor-associated antigen 90K (LG3BP_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LGALS3BP Gene
Function for LGALS3BP Gene
Molecular function for LGALS3BP Gene
- UniProtKB/Swiss-Prot Function:
- Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
- GENATLAS Biochemistry:
- galectin 3,beta-galactoside specific lectin,associated with cancer and HIV infection,overexpressed in colorectal cancer in progression with poor prognosis and liver metastasis
Phenotypes From GWAS Catalog for LGALS3BP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005044 | scavenger receptor activity | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 29162697 |
Phenotypes for LGALS3BP Gene
- MGI mutant phenotypes for LGALS3BP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LGALS3BP:
Animal Models for LGALS3BP Gene
- MGI Knock Outs for LGALS3BP:
-
- Lgals3bp Lgals3bp<tm1Megt>
Animal Model Products
-
Taconic Biosciences Mouse Models for LGALS3BP
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LGALS3BP - Select products 50% OFF >
- * LGALS3BP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LGALS3BP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LGALS3BP
-
Santa Cruz Biotechnology (SCBT) CRISPR for LGALS3BP
miRNA for LGALS3BP Gene
- miRTarBase miRNAs that target LGALS3BP
-
- hsa-miR-596 (MIRT007309)
- hsa-miR-1-3p (MIRT024048)
- hsa-miR-7-5p (MIRT025918)
- hsa-miR-296-3p (MIRT038443)
- hsa-miR-26b-3p (MIRT038953)
- hsa-miR-671-5p (MIRT039290)
- hsa-miR-222-3p (MIRT046598)
- hsa-miR-1260b (MIRT052728)
- hsa-miR-3158-5p (MIRT451300)
- hsa-miR-3678-3p (MIRT451301)
- hsa-miR-1273h-3p (MIRT451302)
- hsa-miR-616-3p (MIRT451303)
- hsa-miR-939-5p (MIRT451304)
- hsa-miR-1343-5p (MIRT451305)
- hsa-miR-6827-5p (MIRT451306)
- hsa-miR-4533 (MIRT451307)
- hsa-miR-6499-3p (MIRT451308)
- hsa-miR-2467-3p (MIRT451309)
- hsa-miR-493-3p (MIRT451310)
- hsa-miR-1252-5p (MIRT451311)
- hsa-miR-17-3p (MIRT451312)
- hsa-miR-151b (MIRT451313)
- hsa-miR-151a-5p (MIRT451314)
- hsa-miR-4317 (MIRT451315)
- hsa-miR-4779 (MIRT451316)
- hsa-miR-6876-5p (MIRT451317)
- hsa-miR-4476 (MIRT451318)
- hsa-miR-6859-5p (MIRT451319)
- hsa-miR-3916 (MIRT451320)
- hsa-miR-3125 (MIRT451321)
- hsa-miR-6856-5p (MIRT451322)
- hsa-miR-6758-5p (MIRT451323)
- hsa-miR-3974 (MIRT451324)
- hsa-miR-198 (MIRT738718)
- hsa-miR-204-3p (MIRT738825)
- hsa-miR-3614-3p (MIRT741651)
- hsa-miR-3689d (MIRT742470)
- hsa-miR-3907 (MIRT742819)
- hsa-miR-4297 (MIRT743806)
- hsa-miR-4646-5p (MIRT746434)
- hsa-miR-4685-5p (MIRT746963)
- hsa-miR-5581-5p (MIRT750940)
- hsa-miR-6716-5p (MIRT753721)
- hsa-miR-6837-5p (MIRT757245)
- hsa-miR-6851-5p (MIRT757593)
- hsa-miR-7113-5p (MIRT759111)
- hsa-miR-765 (MIRT759568)
- hsa-miR-125a-3p (MIRT761670)
- hsa-miR-1273a (MIRT761793)
- hsa-miR-3141 (MIRT764985)
- hsa-miR-3683 (MIRT766768)
- hsa-miR-3934-3p (MIRT767831)
- hsa-miR-3934-5p (MIRT767836)
- hsa-miR-4299 (MIRT768481)
- hsa-miR-4456 (MIRT769201)
- hsa-miR-4743-5p (MIRT771897)
- hsa-miR-548q (MIRT774478)
- hsa-miR-6126 (MIRT775796)
- hsa-miR-6864-5p (MIRT780644)
- hsa-miR-6869-5p (MIRT780680)
- hsa-miR-764 (MIRT781813)
- hsa-miR-7978 (MIRT782288)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LGALS3BP
- Browse OriGene Inhibitory RNA Products For LGALS3BP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS3BP
Clone Products
- Applied Biological Materials (abm): Clones for LGALS3BP - Select products 50% OFF >
- * LGALS3BP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LGALS3BP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LGALS3BP
Cell Line Products
-
Horizon Cell Lines for LGALS3BP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGALS3BP Gene
Localization for LGALS3BP Gene
Subcellular locations from UniProtKB/Swiss-Prot for LGALS3BP Gene
- Secreted. Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005615 | extracellular space | TAS,IDA | 25645918 |
| GO:0016020 | membrane | IEA | -- |
| GO:0031089 | platelet dense granule lumen | TAS | -- |
| GO:0062023 | colocalizes_with collagen-containing extracellular matrix | HDA | 20551380 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LGALS3BP Gene
Pathways & Interactions for LGALS3BP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for LGALS3BP Gene
4 Reactome pathways for LGALS3BP Gene
Interacting Proteins for LGALS3BP Gene
Selected Interacting proteins:
Q08380-LG3BP_HUMAN
ENSP00000262776
for LGALS3BP Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LGALS3BP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0006897 | endocytosis | IEA | -- |
| GO:0006968 | cellular defense response | TAS | 8034587 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8390986 |
Transcripts for LGALS3BP Gene
mRNA/cDNA for LGALS3BP Gene
- 1 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262776 2202 nts (view in UCSC)
- ENST00000585407 936 nts (view in UCSC)
- ENST00000586300 442 nts (view in UCSC)
- ENST00000586720 1736 nts (view in UCSC)
- ENST00000587251 2091 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LGALS3BP - Select products 50% OFF >
- * LGALS3BP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LGALS3BP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LGALS3BP
-
Santa Cruz Biotechnology (SCBT) CRISPR for LGALS3BP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LGALS3BP
- Browse OriGene Inhibitory RNA Products For LGALS3BP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS3BP
Clone Products
- Applied Biological Materials (abm): Clones for LGALS3BP - Select products 50% OFF >
- * LGALS3BP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LGALS3BP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LGALS3BP
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP15: | - | - |
| ExUns: | 9d | · | 9e | · | 9f | ^ | 10a | · | 10b | · | 10c | · | 10d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | - | - | |||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | - | - | - | ||||||||||
| SP8: | |||||||||||||
| SP9: | - | - | |||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: | |||||||||||||
| SP14: | - | - | |||||||||||
| SP15: |
Relevant External Links for LGALS3BP Gene
- GeneLoc Exon Structure for
- LGALS3BP
Expression for LGALS3BP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Gut Tube (Gastrointestinal Tract)
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Liver (Hepatobiliary System)
- Ovary (Reproductive System)
- Germ Cells (Reproductive System)
- Gonad
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Amniocyte (19.2) and Urine (17.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LGALS3BP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LGALS3BP
SOURCE GeneReport for Unigene cluster for LGALS3BP Gene:
Hs.514535mRNA Expression by UniProt/SwissProt for LGALS3BP Gene:
Q08380-LG3BP_HUMAN
Tissue specificity:
Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
Evidence on tissue expression from TISSUES for LGALS3BP Gene
- Intestine(4.9)
- Lung(4.9)
- Nervous system(4.7)
- Liver(4.7)
- Skin(4.6)
- Bone marrow(4.5)
- Saliva(4.3)
- Pancreas(4.2)
- Heart(3.8)
- Stomach(3.6)
- Kidney(3.4)
- Muscle(3.1)
- Eye(3.1)
- Blood(2.8)
- Spleen(2.8)
- Lymph node(2.7)
- Thyroid gland(2.6)
- Adrenal gland(2.6)
- Gall bladder(2.6)
- Bone(2.3)
Primer Products
-
OriGene qPCR primer pairs for LGALS3BP
-
OriGene qPCR primer pairs and template standards for LGALS3BP
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS3BP Gene
Orthologs for LGALS3BP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LGALS3BP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CANT1 30 |
|
||
| LGALS3BP 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | LGALS3BP 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lgals3bp 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Lgals3bp 30 17 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | lgals3bpa 30 31 |
|
OneToMany | |
| LGALS3BP (3 of 3) 31 |
|
OneToMany | |||
| lgals3bpb 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8783 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tango10 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | W07A12.4 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for LGALS3BP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for LGALS3BP Gene
- ENSEMBL:
- Gene Tree for LGALS3BP (if available)
- TreeFam:
- Gene Tree for LGALS3BP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LGALS3BP: view image
Paralogs for LGALS3BP Gene
Paralogs for LGALS3BP Gene
(10) SIMAP similar genes for LGALS3BP Gene using alignment to 13 proteins:
- LG3BP_HUMAN
- K7EJD3_HUMAN
- K7EJY8_HUMAN
- K7EKQ5_HUMAN
- K7ELA1_HUMAN
- K7EM15_HUMAN
- K7EN99_HUMAN
- K7EP36_HUMAN
- K7EQT9_HUMAN
- K7ER67_HUMAN
- K7ERZ6_HUMAN
- K7ES75_HUMAN
- K7ESM3_HUMAN
Variants for LGALS3BP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LGALS3BP Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711190 | Benign: not provided | 78,971,723(-) | G/A | SYNONYMOUS_VARIANT | |
| 711212 | Benign: not provided | 78,972,227(-) | G/A | SYNONYMOUS_VARIANT | |
| 711213 | Benign: not provided | 78,972,335(-) | A/G | SYNONYMOUS_VARIANT | |
| 726894 | Benign: not provided | 78,974,782(-) | C/T | SYNONYMOUS_VARIANT | |
| 737487 | Likely Benign: not provided | 78,972,156(-) | C/T | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.58;
30.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LGALS3BP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LGALS3BP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS3BP Gene
Disorders for LGALS3BP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gnathomiasis |
|
|
| henoch-schoenlein purpura |
|
|
| strongyloidiasis |
|
|
| ostertagiasis |
|
|
| trichostrongyloidiasis |
|
|
Search LGALS3BP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LGALS3BP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS3BP Gene
Publications for LGALS3BP Gene
- The secreted tumor-associated antigen 90K is a potent immune stimulator. (PMID: 8034587) Ullrich A … Natoli C (The Journal of biological chemistry 1994) 2 3 4 23
- Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. (PMID: 8390986) Koths K … Wang A (The Journal of biological chemistry 1993) 2 3 4 23
- Functional studies on recombinant domains of Mac-2-binding protein. (PMID: 11867635) Hellstern S … Engel J (The Journal of biological chemistry 2002) 3 4 23
- Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PMID: 11146440) Tinari N … Liu FT (International journal of cancer 2001) 3 4 23
- Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. (PMID: 9501082) Sasaki T … Timpl R (The EMBO journal 1998) 3 4 23
ExternalLinks
Products for LGALS3BP Gene
- View all 8 R&D Systems LGALS3BP (Galectin-3BP/MAC-2BP) Products
- View all R&D Systems LGALS3BP (Galectin-3BP/MAC-2BP) Proteins and Enzymes
- View all R&D Systems LGALS3BP (Galectin-3BP/MAC-2BP) Primary Antibodies
- View all 3 R&D Systems LGALS3BP (Galectin-3BP/MAC-2BP) ELISAs
- View all R&D Systems LGALS3BP (Galectin-3BP/MAC-2BP) Luminex Assays
- View all 2 R&D Systems LGALS3BP (Galectin-3BP/MAC-2BP) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom LGALS3BP antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for LGALS3BP
- Custom Assay ServicesOriGene ELISA Kits for LGALS3BP
- OriGene Purified Proteins for LGALS3BP
- Search Origene for MassSpec and Protein Over-expression Lysates for LGALS3BP
- Origene Custom Protein Services for LGALS3BP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LGALS3BP
- Browse OriGene Inhibitory RNA Products For LGALS3BP
- OriGene qPCR primer pairs for LGALS3BP
- OriGene qPCR primer pairs and template standards for LGALS3BP
- OriGene CRISPR knockouts for LGALS3BP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LGALS3BP
- Sino Biological Human cDNA Clone for LGALS3BP
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for LGALS3BP
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LGALS3BP
- Novus Biologicals proteins and lysates for LGALS3BP
- Novus Biologicals ELISA Kits for LGALS3BP
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for LGALS3BP
- Abcam proteins for LGALS3BP
- Abcam assays for LGALS3BP
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- Browse Primary Antibodies
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- Taconic Biosciences Mouse Models for LGALS3BP
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for LGALS3BP (AFLGC-LGALS3BP)
- VectorBuilder Custom and pre-made DNA vectors for LGALS3BP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for LGALS3BP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for LGALS3BP (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for LGALS3BP CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LGALS3BP
- antibodies-online: Show 28 available LGALS3BP Antibodies ranked by validation data
- Compare Top LGALS3BP Antibodies
- antibodies-online: Show 40 available LGALS3BP Elisa Kits ranked by validation data
- Compare Top LGALS3BP Elisa Kits
- Quality Products:
- antibodies-online: Show 7 available LGALS3BP Proteins ranked by validation data
- Compare Top LGALS3BP Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for LGALS3BP
- Search Santa Cruz Biotechnology (SCBT) for LGALS3BP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LGALS3BP
- Custom Antibody ServicesProSci Antibodies for LGALS3BP
- Search for LGALS3BP Proteins at ProSci
- Horizon Cell Lines for LGALS3BP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LGALS3BP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LGALS3BP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LGALS3BP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS3BP
Sources for LGALS3BP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB