The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008] See more...

Aliases for LGALS2 Gene

Aliases for LGALS2 Gene

  • Galectin 2 2 3 5
  • HL14 2 3 4
  • Lectin, Galactoside-Binding, Soluble, 2 2 3
  • Beta-Galactoside-Binding Lectin L-14-II 3 4
  • Lactose-Binding Lectin 2 3 4
  • S-Lac Lectin 2 3 4
  • Galectin-2 3 4
  • Gal-2 3 4
  • LGALS2 5

External Ids for LGALS2 Gene

Previous GeneCards Identifiers for LGALS2 Gene

  • GC22M034580
  • GC22M036209
  • GC22M036290
  • GC22M037966
  • GC22M020933

Summaries for LGALS2 Gene

Entrez Gene Summary for LGALS2 Gene

  • The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS2 Gene

LGALS2 (Galectin 2) is a Protein Coding gene. Diseases associated with LGALS2 include Myocardial Infarction and Blackwater Fever. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and galactoside binding. An important paralog of this gene is LGALS1.

UniProtKB/Swiss-Prot Summary for LGALS2 Gene

  • This protein binds beta-galactoside. Its physiological function is not yet known.

Gene Wiki entry for LGALS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS2 Gene

Genomics for LGALS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LGALS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LGALS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LGALS2

Top Transcription factor binding sites by QIAGEN in the LGALS2 gene promoter:
  • AP-1
  • ATF-2
  • ATF6
  • c-Jun

Genomic Locations for LGALS2 Gene

Genomic Locations for LGALS2 Gene
chr22:37,570,248-37,582,616
(GRCh38/hg38)
Size:
12,369 bases
Orientation:
Minus strand
chr22:37,966,253-37,978,623
(GRCh37/hg19)
Size:
12,371 bases
Orientation:
Minus strand

Genomic View for LGALS2 Gene

Genes around LGALS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS2 Gene

Proteins for LGALS2 Gene

  • Protein details for LGALS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05162-LEG2_HUMAN
    Recommended name:
    Galectin-2
    Protein Accession:
    P05162
    Secondary Accessions:
    • Q6FGY4

    Protein attributes for LGALS2 Gene

    Size:
    132 amino acids
    Molecular mass:
    14644 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for LGALS2 Gene

neXtProt entry for LGALS2 Gene

Post-translational modifications for LGALS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

  • Boster Bio ELISA Kits for LGALS2

No data available for DME Specific Peptides for LGALS2 Gene

Domains & Families for LGALS2 Gene

Gene Families for LGALS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LGALS2 Gene

InterPro:
Blocks:
  • Galectin, galactose-binding lectin
ProtoNet:

Suggested Antigen Peptide Sequences for LGALS2 Gene

GenScript: Design optimal peptide antigens:
  • S-Lac lectin 2 (LEG2_HUMAN)
  • HL14 protein (Q15954_HUMAN)
  • LGALS2 protein (Q6PIT8_HUMAN)
genes like me logo Genes that share domains with LGALS2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LGALS2 Gene

Function for LGALS2 Gene

Molecular function for LGALS2 Gene

UniProtKB/Swiss-Prot Function:
This protein binds beta-galactoside. Its physiological function is not yet known.
GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 2 (L14-II)

Phenotypes From GWAS Catalog for LGALS2 Gene

Gene Ontology (GO) - Molecular Function for LGALS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016936 galactoside binding IEA,IBA 21873635
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LGALS2: view
genes like me logo Genes that share phenotypes with LGALS2: view

Animal Models for LGALS2 Gene

MGI Knock Outs for LGALS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LGALS2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS2 Gene

Localization for LGALS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS2 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LGALS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with LGALS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LGALS2 Gene

Pathways & Interactions for LGALS2 Gene

PathCards logo

SuperPathways for LGALS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LGALS2 Gene

Drugs & Compounds for LGALS2 Gene

(1) Drugs for LGALS2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-D-Glucose Experimental Pharma Target 0
genes like me logo Genes that share compounds with LGALS2: view

Transcripts for LGALS2 Gene

mRNA/cDNA for LGALS2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS2

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS2 Gene

No ASD Table

Relevant External Links for LGALS2 Gene

GeneLoc Exon Structure for
LGALS2

Expression for LGALS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LGALS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS2 Gene

This gene is overexpressed in Kidney - Cortex (x16.4), Pancreas (x15.7), Small Intestine - Terminal Ileum (x8.0), and Colon - Transverse (x4.4).

Protein differential expression in normal tissues from HIPED for LGALS2 Gene

This gene is overexpressed in Fetal gut (22.4), Islet of Langerhans (22.3), Pancreas (13.4), and Kidney (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LGALS2 Gene



Protein tissue co-expression partners for LGALS2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LGALS2

SOURCE GeneReport for Unigene cluster for LGALS2 Gene:

Hs.531776

Evidence on tissue expression from TISSUES for LGALS2 Gene

  • Intestine(4.4)
  • Gall bladder(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with LGALS2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS2 Gene

Orthologs for LGALS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LGALS2 30 31
  • 99.24 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LGALS2 30 31
  • 84.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LGALS2 30
  • 81.54 (n)
LGALS3 31
  • 78 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lgals2 30
  • 74.62 (n)
Mouse
(Mus musculus)
Mammalia Lgals2 30 17 31
  • 74.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LGALS2 31
  • 58 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LGALS2 31
  • 44 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LGALS2 30 31
  • 61.83 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lgals2 30
  • 57.76 (n)
Species where no ortholog for LGALS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LGALS2 Gene

ENSEMBL:
Gene Tree for LGALS2 (if available)
TreeFam:
Gene Tree for LGALS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LGALS2: view image

Paralogs for LGALS2 Gene

(10) SIMAP similar genes for LGALS2 Gene using alignment to 3 proteins:

  • LEG2_HUMAN
  • B0QYC9_HUMAN
  • Q6PIT8_HUMAN
genes like me logo Genes that share paralogs with LGALS2: view

Variants for LGALS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LGALS2 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
14472 Risk Factor: Myocardial infarction 37,576,621(-) G/A INTRON_VARIANT
718695 Benign: not provided 37,570,402(-) G/A MISSENSE_VARIANT
rs1434020843 A breast cancer sample p.Glu132Gln
rs2235339 - p.Val119Ile

Additional dbSNP identifiers (rs#s) for LGALS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LGALS2 Gene

Variant ID Type Subtype PubMed ID
nsv1057617 CNV gain 25217958
nsv1059320 CNV loss 25217958
nsv829203 CNV loss 20364138
nsv834191 CNV loss 17160897

Variation tolerance for LGALS2 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALS2 Gene

Human Gene Mutation Database (HGMD)
LGALS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS2 Gene

Disorders for LGALS2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LGALS2 Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, susceptibility to
blackwater fever
  • black water fever
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LGALS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LGALS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS2 Gene

Publications for LGALS2 Gene

  1. Lack of association between lymphotoxin-alpha, galectin-2 polymorphisms and coronary artery disease: a meta-analysis. (PMID: 19726041) Li W … Hui R (Atherosclerosis 2010) 3 23 41
  2. Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis. (PMID: 19330599) Panoulas VF … Kitas GD (Clinical and experimental hypertension (New York, N.Y. : 1993) 2009) 3 23 41
  3. Galectin-2 3279TT variant protects against the lymphotoxin-alpha 252GG genotype associated ischaemic stroke. (PMID: 19013708) Szolnoki Z … Melegh B (Clinical neurology and neurosurgery 2009) 3 23 41
  4. Lymphotoxin 252A>G polymorphism is common and associates with myocardial infarction in patients with rheumatoid arthritis. (PMID: 18230628) Panoulas VF … Kitas GD (Annals of the rheumatic diseases 2008) 3 23 41
  5. Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease. (PMID: 17040205) Asselbergs FW … Rimm EB (Clinical science (London, England : 1979) 2007) 3 23 41

Products for LGALS2 Gene

  • Boster Bio Antibodies for LGALS2
  • Boster Bio ELISA Kits for LGALS2

Sources for LGALS2 Gene