This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] See more...

Aliases for LGALS14 Gene

Aliases for LGALS14 Gene

  • Galectin 14 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 14 2 3
  • Charcot-Leyden Crystal Protein 2 3 4
  • Placental Protein 13-Like 3 4
  • Gal-14 3 4
  • PPL13 3 4
  • CLC2 3 4
  • Placental Protein 13-Like Protein 3
  • Galectin-14 4

External Ids for LGALS14 Gene

Previous GeneCards Identifiers for LGALS14 Gene

  • GC19P044887
  • GC19P044878
  • GC19P040194
  • GC19P036641

Summaries for LGALS14 Gene

Entrez Gene Summary for LGALS14 Gene

  • This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS14 Gene

LGALS14 (Galectin 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS13.

UniProtKB/Swiss-Prot Summary for LGALS14 Gene

  • Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.

Additional gene information for LGALS14 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS14 Gene

Genomics for LGALS14 Gene

GeneHancer (GH) Regulatory Elements for LGALS14 Gene

Promoters and enhancers for LGALS14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039676 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 500.3 -25.7 -25721 3.6 SIN3A SP1 KDM6A ZBTB10 MEF2C POLR2A TEAD1 FOXA2 TCF12 MAFF LGALS17A LGALS14 ENSG00000268088 HNRNPL LEUTX FBL CLC EID2B ZNF780A piR-41525-343
GH19J039703 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 500.7 +1.2 1237 3.5 ZBTB40 ZNF300 TRIM22 BCL11A NFIC ZBTB17 GABPA ARNT NBN NR2C1 LGALS14 ZNF780B HNRNPL LGALS17A NUMBL CLC AKT2 PAK4 EID2B piR-40110-341
GH19J039708 Enhancer 0.8 ENCODE dbSUPER 0.7 +4.6 4589 1.7 FOS NBN PKNOX1 IKZF1 TBX21 SPI1 MTA2 IKZF2 CREB1 EED LGALS17A LGALS14 piR-40110-341
GH19J039700 Enhancer 0.7 dbSUPER 0.7 -2.7 -2685 2.8 TRIM22 MEF2B NBN SMARCA5 POU2F2 EBF1 IKZF1 NFATC3 ZNF146 ATF2 CLC EID2B LGALS17A ZNF780B LGALS14 RPS29P27
GH19J039699 Enhancer 0.2 dbSUPER 0.7 -4.7 -4706 0.9 RPS29P27 CLC EID2B LGALS14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LGALS14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LGALS14

Genomic Locations for LGALS14 Gene

Genomic Locations for LGALS14 Gene
chr19:39,704,306-39,709,448
(GRCh38/hg38)
Size:
5,143 bases
Orientation:
Plus strand
chr19:40,194,946-40,200,088
(GRCh37/hg19)
Size:
5,143 bases
Orientation:
Plus strand

Genomic View for LGALS14 Gene

Genes around LGALS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS14 Gene

Proteins for LGALS14 Gene

  • Protein details for LGALS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCE9-PPL13_HUMAN
    Recommended name:
    Placental protein 13-like
    Protein Accession:
    Q8TCE9
    Secondary Accessions:
    • A8MPV8
    • B2R530
    • C5HZ19
    • Q7Z4X8
    • Q96KD4
    • Q96KD5
    • Q96KD6
    • Q9NR03

    Protein attributes for LGALS14 Gene

    Size:
    139 amino acids
    Molecular mass:
    16094 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LGALS14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LGALS14 Gene

Post-translational modifications for LGALS14 Gene

No Post-translational modifications

Other Protein References for LGALS14 Gene

No data available for DME Specific Peptides for LGALS14 Gene

Domains & Families for LGALS14 Gene

Gene Families for LGALS14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LGALS14 Gene

Blocks:
  • Galectin, galactose-binding lectin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LGALS14 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92317, Homo sapiens placental protein 13-like protein (PPL13), mRNA (B2R530_HUMAN)
  • Lectin, galactoside-binding, soluble, 14, isoform CRA_b (C5HZ19_HUMAN)
  • Galectin-14 (PPL13_HUMAN)
genes like me logo Genes that share domains with LGALS14: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LGALS14 Gene

Function for LGALS14 Gene

Molecular function for LGALS14 Gene

UniProtKB/Swiss-Prot Function:
Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.

Phenotypes From GWAS Catalog for LGALS14 Gene

Gene Ontology (GO) - Molecular Function for LGALS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LGALS14: view
genes like me logo Genes that share phenotypes with LGALS14: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS14 Gene

Localization for LGALS14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS14 gene
Compartment Confidence
nucleus 4
extracellular 2
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LGALS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with LGALS14: view

Pathways & Interactions for LGALS14 Gene

PathCards logo

SuperPathways for LGALS14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0070234 positive regulation of T cell apoptotic process IEA --
genes like me logo Genes that share ontologies with LGALS14: view

No data available for Pathways by source and SIGNOR curated interactions for LGALS14 Gene

Drugs & Compounds for LGALS14 Gene

No Compound Related Data Available

Transcripts for LGALS14 Gene

mRNA/cDNA for LGALS14 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for LGALS14 Gene

GeneLoc Exon Structure for
LGALS14

Expression for LGALS14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LGALS14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LGALS14

SOURCE GeneReport for Unigene cluster for LGALS14 Gene:

Hs.24236

mRNA Expression by UniProt/SwissProt for LGALS14 Gene:

Q8TCE9-PPL13_HUMAN
Tissue specificity: Highly expressed in placenta.

Evidence on tissue expression from TISSUES for LGALS14 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with LGALS14: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS14 Gene

Orthologs for LGALS14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LGALS14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100299023 30
  • 58.14 (n)
-- 31
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 37 (a)
OneToMany
Species where no ortholog for LGALS14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LGALS14 Gene

ENSEMBL:
Gene Tree for LGALS14 (if available)
TreeFam:
Gene Tree for LGALS14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LGALS14: view image

Paralogs for LGALS14 Gene

(11) SIMAP similar genes for LGALS14 Gene using alignment to 2 proteins:

  • PPL13_HUMAN
  • M0R163_HUMAN
genes like me logo Genes that share paralogs with LGALS14: view

Variants for LGALS14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LGALS14 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10755 - p.Phe127Leu
rs4830 - p.Cys67Arg

Additional dbSNP identifiers (rs#s) for LGALS14 Gene

Structural Variations from Database of Genomic Variants (DGV) for LGALS14 Gene

Variant ID Type Subtype PubMed ID
dgv3529n100 CNV loss 25217958
nsv579511 CNV loss 21841781

Variation tolerance for LGALS14 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALS14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS14 Gene

Disorders for LGALS14 Gene

Additional Disease Information for LGALS14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LGALS14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LGALS14 Gene

Publications for LGALS14 Gene

  1. Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1). (PMID: 11997112) Yang QS … Mao YM (Biochimica et biophysica acta 2002) 2 3 4 23 54
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41 54
  3. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. (PMID: 19497882) Than NG … Wildman DE (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 54
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 41 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for LGALS14 Gene

Sources for LGALS14 Gene