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This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
LGALS12 (Galectin 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and lactose binding. An important paralog of this gene is LGALS9C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005178 | integrin binding | IBA | 21873635 |
GO:0030246 | carbohydrate binding | IBA | 21873635 |
GO:0030395 | lactose binding | IBA,IDA | 11435439 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005739 | mitochondrion | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IEA | -- |
GO:0045598 | regulation of fat cell differentiation | IEA | -- |
GO:0050994 | regulation of lipid catabolic process | IEA | -- |
GO:0097193 | intrinsic apoptotic signaling pathway | IDA | 11435439 |
GO:1904977 | lymphatic endothelial cell migration | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||
SP2: | |||||||||||||||||||
SP3: | |||||||||||||||||||
SP4: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LGALS12 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LGALS12 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LGALS12 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lgals12 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lgals12 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | LGALS12 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LGALS12 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lgals12 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-199l3.2 31 |
|
ManyToMany | |
CABZ01042972.1 31 |
|
ManyToMany |
No disorders were found for LGALS12 Gene.