This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010] See more...

Aliases for LGALS12 Gene

Aliases for LGALS12 Gene

  • Galectin 12 2 3 5
  • Galectin-Related Inhibitor Of Proliferation 3 4
  • Lectin, Galactoside-Binding, Soluble, 12 2 3
  • Galectin-12 3 4
  • GRIP1 3 4
  • Testicular Secretory Protein Li 26 3
  • Gal-12 4
  • GAL12 3

External Ids for LGALS12 Gene

Previous GeneCards Identifiers for LGALS12 Gene

  • GC11P065785
  • GC11P064849
  • GC11P063524
  • GC11P063048
  • GC11P063031
  • GC11P063273
  • GC11P059603

Summaries for LGALS12 Gene

Entrez Gene Summary for LGALS12 Gene

  • This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

GeneCards Summary for LGALS12 Gene

LGALS12 (Galectin 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and lactose binding. An important paralog of this gene is LGALS9B.

UniProtKB/Swiss-Prot Summary for LGALS12 Gene

Additional gene information for LGALS12 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS12 Gene

Genomics for LGALS12 Gene

GeneHancer (GH) Regulatory Elements for LGALS12 Gene

Promoters and enhancers for LGALS12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063504 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 763.1 +0.5 476 2.5 MYC L3MBTL2 RAD21 MAX ZNF148 SP1 SP7 SMARCA4 IKZF1 RXRA LGALS12 PLAAT4 ENSG00000203520 PLAAT3 ENSG00000256789 ATL3 piR-57460-095
GH11J063505 Enhancer 0.3 ENCODE dbSUPER 750.6 -1.4 -1373 0.2 LGALS12 PLAAT4 PLAAT3 ENSG00000203520 ENSG00000256789 ATL3 piR-30876-024
GH11J063506 Enhancer 0.3 ENCODE 750.6 -1.8 -1788 0.2 IKZF1 LGALS12 PLAAT4 PLAAT3 ENSG00000203520 ENSG00000256789 ATL3 piR-30876-024
GH11J063608 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 25.3 +103.7 103739 3.2 CTCF FOXA1 RAD21 ELF3 SP1 SP7 PPARG EGR1 GLIS2 ZIC2 LGALS12 PLAAT3 PLAAT5 ENSG00000203520 lnc-PLA2G16-1 LOC105369335
GH11J063509 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.9 +4.9 4894 2.1 HLF SP1 RXRA POLR2A YY1 RAD21 TFAP4 HNF4A MAX HNF4G piR-57460-095 LGALS12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LGALS12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LGALS12 gene promoter:
  • C/EBPalpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for LGALS12 Gene

Genomic Locations for LGALS12 Gene
chr11:63,506,052-63,516,774
(GRCh38/hg38)
Size:
10,723 bases
Orientation:
Plus strand
chr11:63,273,524-63,284,246
(GRCh37/hg19)
Size:
10,723 bases
Orientation:
Plus strand

Genomic View for LGALS12 Gene

Genes around LGALS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS12 Gene

Proteins for LGALS12 Gene

  • Protein details for LGALS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DT0-LEG12_HUMAN
    Recommended name:
    Galectin-12
    Protein Accession:
    Q96DT0
    Secondary Accessions:
    • B2R9N2
    • G5E970
    • Q96DS9
    • Q96PR9
    • Q9H258
    • Q9H259
    • Q9NZ02

    Protein attributes for LGALS12 Gene

    Size:
    336 amino acids
    Molecular mass:
    37542 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LGALS12 Gene

neXtProt entry for LGALS12 Gene

Post-translational modifications for LGALS12 Gene

  • Ubiquitination at Lys237
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LGALS12 Gene

Domains & Families for LGALS12 Gene

Gene Families for LGALS12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LGALS12 Gene

Suggested Antigen Peptide Sequences for LGALS12 Gene

GenScript: Design optimal peptide antigens:
  • Galectin-related inhibitor of proliferation (LEG12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96DT0

UniProtKB/Swiss-Prot:

LEG12_HUMAN :
  • Contains two homologous but distinct carbohydrate-binding domains.
Domain:
  • Contains two homologous but distinct carbohydrate-binding domains.
genes like me logo Genes that share domains with LGALS12: view

Function for LGALS12 Gene

Molecular function for LGALS12 Gene

UniProtKB/Swiss-Prot Function:
Binds lactose. May participate in the apoptosis of adipocytes.

Phenotypes From GWAS Catalog for LGALS12 Gene

Gene Ontology (GO) - Molecular Function for LGALS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0030395 lactose binding IDA,IBA 11435439
genes like me logo Genes that share ontologies with LGALS12: view
genes like me logo Genes that share phenotypes with LGALS12: view

Animal Models for LGALS12 Gene

MGI Knock Outs for LGALS12:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS12 Gene

Localization for LGALS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS12 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for LGALS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with LGALS12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LGALS12 Gene

Pathways & Interactions for LGALS12 Gene

PathCards logo

SuperPathways for LGALS12 Gene

No Data Available

Interacting Proteins for LGALS12 Gene

Gene Ontology (GO) - Biological Process for LGALS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0045598 regulation of fat cell differentiation IEA --
GO:0050994 regulation of lipid catabolic process IEA --
GO:0097193 intrinsic apoptotic signaling pathway IDA 11435439
genes like me logo Genes that share ontologies with LGALS12: view

No data available for Pathways by source and SIGNOR curated interactions for LGALS12 Gene

Drugs & Compounds for LGALS12 Gene

No Compound Related Data Available

Transcripts for LGALS12 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2:
SP3:
SP4:

Relevant External Links for LGALS12 Gene

GeneLoc Exon Structure for
LGALS12
ECgene alternative splicing isoforms for
LGALS12

Expression for LGALS12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS12 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x17.9), Adipose - Subcutaneous (x13.0), Breast - Mammary Tissue (x8.1), and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for LGALS12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (60.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LGALS12 Gene



Protein tissue co-expression partners for LGALS12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LGALS12 Gene:

LGALS12

SOURCE GeneReport for Unigene cluster for LGALS12 Gene:

Hs.502774

mRNA Expression by UniProt/SwissProt for LGALS12 Gene:

Q96DT0-LEG12_HUMAN
Tissue specificity: Not widely expressed. Predominantly expressed in adipose tissue.

Evidence on tissue expression from TISSUES for LGALS12 Gene

  • Intestine(4.2)
  • Blood(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with LGALS12: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS12 Gene

Orthologs for LGALS12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LGALS12 33 32
  • 99.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LGALS12 33 32
  • 86.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LGALS12 33 32
  • 85.94 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lgals12 17 33 32
  • 85.3 (n)
rat
(Rattus norvegicus)
Mammalia Lgals12 32
  • 85.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LGALS12 33
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LGALS12 33
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals12 32
  • 53.42 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-199l3.2 33
  • 35 (a)
ManyToMany
CABZ01042972.1 33
  • 27 (a)
ManyToMany
Species where no ortholog for LGALS12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGALS12 Gene

ENSEMBL:
Gene Tree for LGALS12 (if available)
TreeFam:
Gene Tree for LGALS12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LGALS12: view image

Paralogs for LGALS12 Gene

(4) SIMAP similar genes for LGALS12 Gene using alignment to 2 proteins:

  • LEG12_HUMAN
  • G5E970_HUMAN
genes like me logo Genes that share paralogs with LGALS12: view

Variants for LGALS12 Gene

Sequence variations from dbSNP and Humsavar for LGALS12 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000589746 -- 63,510,906(+) C/T intron_variant
rs1000778653 -- 63,507,359(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000840899 -- 63,506,094(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000851004 -- 63,516,687(+) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001299946 -- 63,506,035(+) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS12 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV loss 19166990
nsv509417 CNV insertion 20534489
nsv555179 CNV loss 21841781

Variation tolerance for LGALS12 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALS12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS12 Gene

Disorders for LGALS12 Gene

Additional Disease Information for LGALS12

No disorders were found for LGALS12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LGALS12 Gene

Publications for LGALS12 Gene

  1. Cell cycle regulation by galectin-12, a new member of the galectin superfamily. (PMID: 11283015) Yang RY … Liu FT (The Journal of biological chemistry 2001) 2 3 4 23 56
  2. Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity. (PMID: 11435439) Hotta K … Matsuzawa Y (The Journal of biological chemistry 2001) 2 3 4 23 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Analyzing epigenetic control of galectin expression indicates silencing of galectin-12 by promoter methylation in colorectal cancer. (PMID: 29098769) Katzenmaier EM … Kopitz J (IUBMB life 2017) 3 56

Products for LGALS12 Gene

Sources for LGALS12 Gene