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This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010] See more...
Aliases for LGALS12 Gene
Aliases for LGALS12 Gene
External Ids for LGALS12 Gene
- HGNC: 15788
- Entrez Gene: 85329
- Ensembl: ENSG00000133317
- OMIM: 606096
- UniProtKB: Q96DT0
Previous GeneCards Identifiers for LGALS12 Gene
- GC11P065785
- GC11P064849
- GC11P063524
- GC11P063048
- GC11P063031
- GC11P063273
- GC11P059603
Summaries for LGALS12 Gene
-
This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
GeneCards Summary for LGALS12 Gene
LGALS12 (Galectin 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and lactose binding. An important paralog of this gene is LGALS9B.
UniProtKB/Swiss-Prot Summary for LGALS12 Gene
-
Binds lactose. May participate in the apoptosis of adipocytes.
Additional gene information for LGALS12 Gene
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS12 Gene
Genomics for LGALS12 Gene
GeneHancer (GH) Regulatory Elements for LGALS12 Gene
Promoters and enhancers for LGALS12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LGALS12 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LGALS12 gene promoter:
-
- C/EBPalpha
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for LGALS12 Gene
Genomic Locations for LGALS12 Gene
- chr11:63,506,052-63,516,774
- (GRCh38/hg38)
- Size:
- 10,723 bases
- Orientation:
- Plus strand
- chr11:63,273,524-63,284,246
- (GRCh37/hg19)
- Size:
- 10,723 bases
- Orientation:
- Plus strand
Genomic View for LGALS12 Gene
Genes around LGALS12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by HGNC
- 11q12.3 by Entrez Gene
- 11q12.3 by Ensembl
LGALS12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LGALS12 Gene
Proteins for LGALS12 Gene
-
Protein details for LGALS12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96DT0-LEG12_HUMAN
- Recommended name:
- Galectin-12
- Protein Accession:
- Q96DT0
- B2R9N2
- G5E970
- Q96DS9
- Q96PR9
- Q9H258
- Q9H259
- Q9NZ02
Protein attributes for LGALS12 Gene
- Size:
- 336 amino acids
- Molecular mass:
- 37542 Da
- Quaternary structure:
- No Data Available
Protein Expression for LGALS12 Gene
Post-translational modifications for LGALS12 Gene
Other Protein References for LGALS12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-LGALS12 monoclonal antibody and Anti-LGALS12 (full length) polyclonal antibody
- Novus Biologicals Antibodies for LGALS12
-
Biorbyt antibodies for LGALS12
Protein Products
- Creative Biomart Recombinant Human LGALS12 293 Cell Lysate and Recombinant Human LGALS12 Protein, His-tagged
-
OriGene Purified Proteins for LGALS12
- Search Origene for MassSpec and Protein Over-expression Lysates for LGALS12
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- Novus Biologicals lysates for LGALS12
- antibodies-online: Show 9 available LGALS12 Proteins ranked by validation data
- Compare Top LGALS12 Proteins
-
Quality Products:
-
Abcam proteins for LGALS12
Assay Products
- Aviva Systems Biology LGALS12 ELISA Kit (Human) (OKCD00741)
- Novus Biologicals ELISA Kits for LGALS12
No data available for DME Specific Peptides for LGALS12 Gene
Domains & Families for LGALS12 Gene
Gene Families for LGALS12 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for LGALS12 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for LGALS12 Gene
- GenScript: Design optimal peptide antigens:
-
- Galectin-related inhibitor of proliferation (LEG12_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96DT0UniProtKB/Swiss-Prot:
LEG12_HUMAN :- Contains two homologous but distinct carbohydrate-binding domains.
- Domain:
-
- Contains two homologous but distinct carbohydrate-binding domains.
Function for LGALS12 Gene
Molecular function for LGALS12 Gene
- UniProtKB/Swiss-Prot Function:
- Binds lactose. May participate in the apoptosis of adipocytes.
Phenotypes From GWAS Catalog for LGALS12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0030395 | lactose binding | IDA,IBA | 11435439 |
Phenotypes for LGALS12 Gene
- MGI mutant phenotypes for LGALS12:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LGALS12:
Animal Models for LGALS12 Gene
- MGI Knock Outs for LGALS12:
-
- Lgals12 Lgals12<tm1Ftl>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for LGALS12
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- genomics-online: gRNA clones - Search for available LGALS12 gRNA products
- Overview of 147 available LGALS12 gene related products
- Applied Biological Materials (abm): CRISPR Clones for LGALS12 - Select products 50% OFF >
- * LGALS12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
Santa Cruz Biotechnology (SCBT) CRISPR for LGALS12
miRNA Products
Inhibitory RNA Products
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- Overview of 147 available LGALS12 gene related products
Clone Products
-
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- RC226979
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- RR211557
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- RR211557L2V
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- RR211557L3V
- RR211557L4
- RR211557L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LGALS12
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- * LGALS12 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for LGALS12
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS12 Gene
Localization for LGALS12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LGALS12 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 3 |
| cytosol | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005739 | mitochondrion | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LGALS12 Gene
Pathways & Interactions for LGALS12 Gene
Interacting Proteins for LGALS12 Gene
GPS-Prot Interaction Network for LGALS12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0045598 | regulation of fat cell differentiation | IEA | -- |
| GO:0050994 | regulation of lipid catabolic process | IEA | -- |
| GO:0097193 | intrinsic apoptotic signaling pathway | IDA | 11435439 |
No data available for Pathways by source and SIGNOR curated interactions for LGALS12 Gene
Drugs & Compounds for LGALS12 Gene
No Compound Related Data Available
Drug Products
- Creative Biomart Recombinant Human LGALS12 293 Cell Lysate and Recombinant Human LGALS12 Protein, His-tagged
Transcripts for LGALS12 Gene
mRNA/cDNA for LGALS12 Gene
- (5) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000255684 1667 bps (ENST00000255684.9)
- ENST00000394618 1618 bps (ENST00000394618.7)
- ENST00000340246 1425 bps (ENST00000340246.9)
- ENST00000415491 1816 bps (ENST00000415491.6)
- ENST00000425950 1789 bps (ENST00000425950.2)
CRISPR Products
-
OriGene CRISPR knockouts for LGALS12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LGALS12
- genomics-online: gRNA clones - Search for available LGALS12 gRNA products
- Overview of 147 available LGALS12 gene related products
- Applied Biological Materials (abm): CRISPR Clones for LGALS12 - Select products 50% OFF >
- * LGALS12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * LGALS12 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for LGALS12
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LGALS12
- Browse OriGene Inhibitory RNA Products For LGALS12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS12
- genomics-online: shRNA clones - Search for available LGALS12 shRNA products
- Overview of 147 available LGALS12 gene related products
Clone Products
-
- MG204480
- MR204480
- MR204480L3
- MR204480L3V
- MR204480L4
- MR204480L4V
- RC206967
- RC206967L3
- RC206967L3V
- RC206967L4
- RC206967L4V
- RC226967
- RC226967L3
- RC226967L3V
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- RC226967L4V
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- RC226974L3
- RC226974L3V
- RC226974L4
- RC226974L4V
- RC226979
- RC226979L3
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- RC226986
- RC226986L3
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- RC226986L4
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- RG206967
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- RG226979
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- RR211557
- RR211557L1
- RR211557L1V
- RR211557L2
- RR211557L2V
- RR211557L3
- RR211557L3V
- RR211557L4
- RR211557L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LGALS12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LGALS12
- Applied Biological Materials (abm): Clones for LGALS12 - Select products 50% OFF >
- * LGALS12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * LGALS12 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: |
Expression for LGALS12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for LGALS12 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x17.9), Adipose - Subcutaneous (x13.0), Breast - Mammary Tissue (x8.1), and Whole Blood (x4.7).
This gene is overexpressed in Peripheral blood mononuclear cells (60.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LGALS12 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of LGALS12 Gene:
LGALS12SOURCE GeneReport for Unigene cluster for LGALS12 Gene:
Hs.502774mRNA Expression by UniProt/SwissProt for LGALS12 Gene:
Q96DT0-LEG12_HUMAN
Tissue specificity:
Not widely expressed. Predominantly expressed in adipose tissue.
Evidence on tissue expression from TISSUES for LGALS12 Gene
- Intestine(4.2)
- Blood(4.1)
- Eye(4)
Primer Products
-
OriGene qPCR primer pairs for LGALS12
-
OriGene qPCR primer pairs and template standards for LGALS12
- genomics-online: primer clones - Search for available LGALS12 Primer products
- Overview of 147 available LGALS12 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS12 Gene
Orthologs for LGALS12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LGALS12 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LGALS12 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LGALS12 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Lgals12 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Lgals12 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LGALS12 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LGALS12 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 33 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lgals12 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-199l3.2 33 |
|
ManyToMany | |
| CABZ01042972.1 33 |
|
ManyToMany |
- Species where no ortholog for LGALS12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for LGALS12 Gene
- ENSEMBL:
- Gene Tree for LGALS12 (if available)
- TreeFam:
- Gene Tree for LGALS12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LGALS12: view image
Paralogs for LGALS12 Gene
Paralogs for LGALS12 Gene
(4) SIMAP similar genes for LGALS12 Gene using alignment to 2 proteins:
- LEG12_HUMAN
- G5E970_HUMAN
Variants for LGALS12 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000589746 | -- | 63,510,906(+) | C/T | intron_variant | |
| rs1000778653 | -- | 63,507,359(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000840899 | -- | 63,506,094(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs1000851004 | -- | 63,516,687(+) | C/A | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1001299946 | -- | 63,506,035(+) | C/G/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.70;
57.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LGALS12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LGALS12
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS12 Gene
Disorders for LGALS12 Gene
Additional Disease Information for LGALS12
No disorders were found for LGALS12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LGALS12 Gene
Publications for LGALS12 Gene
- Cell cycle regulation by galectin-12, a new member of the galectin superfamily. (PMID: 11283015) Yang RY … Liu FT (The Journal of biological chemistry 2001) 2 3 4 23 56
- Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity. (PMID: 11435439) Hotta K … Matsuzawa Y (The Journal of biological chemistry 2001) 2 3 4 23 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
- Analyzing epigenetic control of galectin expression indicates silencing of galectin-12 by promoter methylation in colorectal cancer. (PMID: 29098769) Katzenmaier EM … Kopitz J (IUBMB life 2017) 3 56
ExternalLinks
Products for LGALS12 Gene
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- OriGene qPCR primer pairs for LGALS12
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- OriGene CRISPR knockouts for LGALS12
- MG204480
- MR204480
- MR204480L3
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- RC206967
- RC206967L3
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- RG206967
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- RR211557
- RR211557L1
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- RR211557L2
- RR211557L2V
- RR211557L3
- RR211557L3V
- RR211557L4
- RR211557L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LGALS12
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- Novus Biologicals Antibodies for LGALS12
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- antibodies-online: Show 7 available LGALS12 Antibodies ranked by validation data
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- antibodies-online: Show 9 available LGALS12 Proteins ranked by validation data
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- Quality Products:
- Horizon Cell Lines for LGALS12
- genomics-online: cdna clones - Search for available LGALS12 CDNA products
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- genomics-online: gRNA clones - Search for available LGALS12 gRNA products
- Overview of 147 available LGALS12 gene related products
- genomics-online: primer clones - Search for available LGALS12 Primer products
- Overview of 147 available LGALS12 gene related products
- genomics-online: shRNA clones - Search for available LGALS12 shRNA products
- Overview of 147 available LGALS12 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LGALS12
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- Biorbyt antibodies for LGALS12
Sources for LGALS12 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
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