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The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008] See more...
Aliases for LGALS1 Gene
Aliases for LGALS1 Gene
External Ids for LGALS1 Gene
- HGNC: 6561
- Entrez Gene: 3956
- Ensembl: ENSG00000100097
- OMIM: 150570
- UniProtKB: P09382
Previous GeneCards Identifiers for LGALS1 Gene
- GC22P034686
- GC22P036314
- GC22P036396
- GC22P038071
- GC22P021039
Summaries for LGALS1 Gene
-
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for LGALS1 Gene
LGALS1 (Galectin 1) is a Protein Coding gene. Diseases associated with LGALS1 include Trophoblastic Neoplasm and Fucosidosis. Among its related pathways are Validated targets of C-MYC transcriptional repression and MAP Kinase Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is LGALS2.
UniProtKB/Swiss-Prot Summary for LGALS1 Gene
-
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Additional gene information for LGALS1 Gene
- HGNC(6561)
- Entrez Gene(3956)
- Ensembl(ENSG00000100097)
- OMIM(150570)
- UniProtKB(P09382)
- Open Targets Platform(ENSG00000100097)
- Monarch Initiative
- Search for LGALS1 at DataMed
- Search for LGALS1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS1 Gene
Genomics for LGALS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LGALS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LGALS1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LGALS1
- Top Transcription factor binding sites by QIAGEN in the LGALS1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- E2F
- E2F-1
- HEN1
- MyoD
- p53
- YY1
Genomic Locations for LGALS1 Gene
Genomic Locations for LGALS1 Gene
- chr22:37,675,636-37,679,802
- (GRCh38/hg38)
- Size:
- 4,167 bases
- Orientation:
- Plus strand
- chr22:38,071,613-38,075,813
- (GRCh37/hg19)
- Size:
- 4,201 bases
- Orientation:
- Plus strand
Genomic View for LGALS1 Gene
Genes around LGALS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by HGNC
- 22q13.1 by Entrez Gene
- 22q13.1 by Ensembl
LGALS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LGALS1 Gene
Proteins for LGALS1 Gene
-
Protein details for LGALS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09382-LEG1_HUMAN
- Recommended name:
- Galectin-1
- Protein Accession:
- P09382
- B2R5E8
- Q9UDK5
Protein attributes for LGALS1 Gene
- Size:
- 135 amino acids
- Molecular mass:
- 14716 Da
- Quaternary structure:
-
- Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.
Protein Expression for LGALS1 Gene
Post-translational modifications for LGALS1 Gene
Other Protein References for LGALS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences LGALS1 / Galectin 1 Monoclonal Antibody (LS-B6776) and LGALS1 / Galectin 1 Monoclonal Antibody (LS-B7608)
- G Biosciences Immunotag™ LGALS1 Antibody and Immunotag™ LEG1 Antibody
- NSJ Bioreagents Galectin 1 Antibody (Mouse Monoclonal)
- Creative Diagnostics Rabbit Anti-Human Lgals1 monoclonal antibody, clone TQ358
-
Creative Biolabs
- Recombinant Anti-human LGALS1 Antibody
- Recombinant Anti-human LGALS1 Antibody Fab Fragment
- Anti-Human LGALS1 Therapeutic Antibody (8B5, 8F4, 8G3)
- Anti-Human LGALS1 Therapeutic Antibody scFv Fragment (8B5, 8F4, 8G3)
- Rabbit Anti-LGALS1 (C-terminus) Recombinant Antibody (CBFYH-3287)
- Mouse Anti-LGALS1 Recombinant Antibody (CBYJL-1501)
- Mouse Anti-LGALS1 Recombinant Antibody (6C8.4-1)
-
Custom Antibody ServicesOriGene Antibodies for LGALS1
- Novus Biologicals Antibodies for LGALS1
-
Abcam antibodies for LGALS1
- Invitrogen Antibodies for LGALS1 (AFLGC-LGALS1)
- antibodies-online: Show 69 available LGALS1 Antibodies ranked by validation data
- Compare Top LGALS1 Antibodies
-
Recommended
- 171 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 83 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 98 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (fro) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for LGALS1
- Sino Biological Antibodies for LGALS1
Protein Products
- G Biosciences Human Galectin-1/LGALS1, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for LGALS1
- Origene Custom Protein Services for LGALS1
- Sino Biological Recombinant Proteins for LGALS1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for LGALS1
-
ProSci Proteins for LGALS1
-
Abcam proteins for LGALS1
Assay Products
- G Biosciences Immunotag™ Human LGALS1 (Galectin-1) ELISA and Immunotag™ Galectin-1 ELISA Kit
- RayBiotech Human Galectin-1 ELISA
- Creative Diagnostics Human LGALS1 ELISA Matched Antibody Pair and Mouse Galectin-1 ELISA Kit
- Novus Biologicals ELISA Kits for LGALS1
- antibodies-online: Show 8 available LGALS1 Elisa Kits ranked by validation data
- Compare Top LGALS1 Elisa Kits
-
Quality Products:
-
Abcam assays for LGALS1
- Sino Biological Assays for LGALS1
No data available for DME Specific Peptides for LGALS1 Gene
Domains & Families for LGALS1 Gene
Gene Families for LGALS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for LGALS1 Gene
- InterPro:
- Blocks:
-
- Galectin, galactose-binding lectin
- ProtoNet:
Suggested Antigen Peptide Sequences for LGALS1 Gene
- GenScript: Design optimal peptide antigens:
-
- S-Lac lectin 1 (LEG1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LGALS1 Gene
Function for LGALS1 Gene
Molecular function for LGALS1 Gene
- UniProtKB/Swiss-Prot Function:
- Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
- GENATLAS Biochemistry:
- lectin,galactoside-beta binding,soluble 1,autocrine negative growth factor (L14-I)
Phenotypes From GWAS Catalog for LGALS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 10369126 |
| GO:0030246 | carbohydrate binding | IBA | 21873635 |
| GO:0030395 | lactose binding | IEA | -- |
| GO:0042802 | identical protein binding | IEA | -- |
Phenotypes for LGALS1 Gene
- MGI mutant phenotypes for LGALS1:
-
inferred from 1 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- reproductive system phenotype
- integument phenotype
- craniofacial phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for LGALS1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased viability in pancreas lineage
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for LGALS1 Gene
- MGI Knock Outs for LGALS1:
-
- Lgals1 Lgals1<tm1Rob>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LGALS1 - Select products 50% OFF >
- * LGALS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LGALS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for LGALS1
miRNA for LGALS1 Gene
- miRTarBase miRNAs that target LGALS1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LGALS1
- Browse OriGene Inhibitory RNA Products For LGALS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS1
Clone Products
- Applied Biological Materials (abm): Clones for LGALS1 - Select products 50% OFF >
- * LGALS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LGALS1
- Addgene plasmids for LGALS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LGALS1
Cell Line Products
-
Horizon Cell Lines for LGALS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGALS1 Gene
Localization for LGALS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LGALS1 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 4 |
| endoplasmic reticulum | 4 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA | 27068509 |
| GO:0005615 | extracellular space | IEA,IBA | 21873635 |
| GO:0005622 | intracellular | IDA | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for LGALS1 Gene
Pathways by source for LGALS1 Gene
1 BioSystems pathway for LGALS1 Gene
3 Cell Signaling Technology pathways for LGALS1 Gene
Interacting Proteins for LGALS1 Gene
Selected Interacting proteins:
P09382-LEG1_HUMAN
ENSP00000215909
for LGALS1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LGALS1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002317 | plasma cell differentiation | IEA | -- |
| GO:0006915 | apoptotic process | TAS,IEA | -- |
| GO:0010812 | negative regulation of cell-substrate adhesion | IEA | -- |
| GO:0010977 | negative regulation of neuron projection development | IEA | -- |
| GO:0031295 | T cell costimulation | IEA | -- |
Drugs & Compounds for LGALS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Thiodigalactoside | Experimental | Pharma | Target | 0 | ||
| 1,4-Dithiothreitol | Experimental | Pharma | Target | 0 | ||
| Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 115 | ||
| Mercaptoethanol | Experimental | Pharma | Target | 0 | ||
| mannose | Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for LGALS1 Gene
mRNA/cDNA for LGALS1 Gene
- 1 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000215909 528 nts (view in UCSC)
- ENST00000425542 637 nts (view in UCSC)
- ENST00000454173 331 nts (view in UCSC)
- ENST00000464120 303 nts (view in UCSC)
- ENST00000472321 546 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LGALS1 - Select products 50% OFF >
- * LGALS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LGALS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for LGALS1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LGALS1
- Browse OriGene Inhibitory RNA Products For LGALS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS1
Clone Products
- Applied Biological Materials (abm): Clones for LGALS1 - Select products 50% OFF >
- * LGALS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LGALS1
- Addgene plasmids for LGALS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LGALS1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||
| SP6: |
Relevant External Links for LGALS1 Gene
- GeneLoc Exon Structure for
- LGALS1
Expression for LGALS1 Gene
This gene is overexpressed in Amniocyte (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LGALS1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LGALS1
SOURCE GeneReport for Unigene cluster for LGALS1 Gene:
Hs.445351mRNA Expression by UniProt/SwissProt for LGALS1 Gene:
P09382-LEG1_HUMAN
Tissue specificity:
Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
Evidence on tissue expression from TISSUES for LGALS1 Gene
- Nervous system(5)
- Skin(4.9)
- Lung(4.9)
- Blood(4.7)
- Liver(4.7)
- Spleen(4.6)
- Kidney(3.7)
- Eye(3.7)
- Muscle(3.7)
- Heart(3.6)
- Intestine(3.4)
- Lymph node(3.1)
- Bone marrow(3)
- Stomach(2.9)
- Adrenal gland(2.9)
- Pancreas(2.8)
- Thyroid gland(2.7)
- Gall bladder(2.4)
- Bone(2.1)
Primer Products
-
OriGene qPCR primer pairs for LGALS1
-
OriGene qPCR primer pairs and template standards for LGALS1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS1 Gene
Orthologs for LGALS1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LGALS1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LGALS1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lgals1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | LGALS1 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Lgals1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LGALS1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LGALS1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LGALS1 30 31 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485378 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lgals2b 30 31 |
|
OneToMany | |
| lgals2a 31 |
|
OneToMany | |||
| lgals1l1 31 |
|
OneToMany |
- Species where no ortholog for LGALS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for LGALS1 Gene
- ENSEMBL:
- Gene Tree for LGALS1 (if available)
- TreeFam:
- Gene Tree for LGALS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LGALS1: view image
Paralogs for LGALS1 Gene
Paralogs for LGALS1 Gene
(9) SIMAP similar genes for LGALS1 Gene using alignment to 3 proteins:
- LEG1_HUMAN
- F8WCQ5_HUMAN
- F8WEI7_HUMAN
Variants for LGALS1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2662670 | CNV | deletion | 23128226 |
| esv2758838 | CNV | loss | 17122850 |
| nsv1057617 | CNV | gain | 25217958 |
| nsv471197 | CNV | loss | 18288195 |
| nsv528985 | CNV | loss | 19592680 |
| nsv829203 | CNV | loss | 20364138 |
| nsv834191 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.40;
8.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LGALS1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LGALS1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LGALS1 Gene
Disorders for LGALS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| trophoblastic neoplasm |
|
|
| fucosidosis |
|
|
| adult hepatocellular carcinoma |
|
|
| paralytic lagophthalmos |
|
|
| partial trisomy distal 4q |
|
|
Search LGALS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LGALS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS1 Gene
Publications for LGALS1 Gene
- Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose. (PMID: 19128029) Di Lella S … Alvarez RM (Biochemistry 2009) 3 4 23
- Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. (PMID: 18824694) Than NG … Wildman DE (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23
- Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. (PMID: 18796645) Nishi N … Nakamura T (Glycobiology 2008) 3 4 23
- Presentation of galectin-1 by extracellular matrix triggers T cell death. (PMID: 14617626) He J … Baum LG (The Journal of biological chemistry 2004) 3 4 23
- Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PMID: 11146440) Tinari N … Liu FT (International journal of cancer 2001) 3 4 23
ExternalLinks
Products for LGALS1 Gene
- View all 16 R&D Systems LGALS1 (Galectin-1) Products
- View all R&D Systems LGALS1 (Galectin-1) Proteins and Enzymes
- View all 9 R&D Systems LGALS1 (Galectin-1) Primary Antibodies
- View all 3 R&D Systems LGALS1 (Galectin-1) ELISAs
- View all R&D Systems LGALS1 (Galectin-1) Luminex Assays
- View all 2 R&D Systems LGALS1 (Galectin-1) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom LGALS1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for LGALS1
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for LGALS1
- Origene Custom Protein Services for LGALS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LGALS1
- Browse OriGene Inhibitory RNA Products For LGALS1
- OriGene qPCR primer pairs for LGALS1
- OriGene qPCR primer pairs and template standards for LGALS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LGALS1
- Sino Biological Human cDNA Clone for LGALS1
- Sino Biological Recombinant Proteins for LGALS1
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for LGALS1
- Sino Biological Assays for LGALS1
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LGALS1
- Novus Biologicals proteins and lysates for LGALS1
- Novus Biologicals ELISA Kits for LGALS1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for LGALS1
- Abcam proteins for LGALS1
- Abcam assays for LGALS1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for LGALS1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for LGALS1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for LGALS1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for LGALS1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LGALS1
- Addgene plasmids for LGALS1
- antibodies-online: Show 69 available LGALS1 Antibodies ranked by validation data
- Compare Top LGALS1 Antibodies
- Recommended
- 171 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 83 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 98 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (fro) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- antibodies-online: Show 8 available LGALS1 Elisa Kits ranked by validation data
- Compare Top LGALS1 Elisa Kits
- Quality Products:
- antibodies-online: Show 57 available LGALS1 Proteins ranked by validation data
- Compare Top LGALS1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for LGALS1
- Search Santa Cruz Biotechnology (SCBT) for LGALS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LGALS1
- Horizon Cell Lines for LGALS1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LGALS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LGALS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LGALS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LGALS1
Sources for LGALS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB