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The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
LGALS1 (Galectin 1) is a Protein Coding gene. Diseases associated with LGALS1 include Trophoblastic Neoplasm and Fucosidosis. Among its related pathways are Validated targets of C-MYC transcriptional repression and MAP Kinase Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is LGALS2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 10369126 |
GO:0030246 | carbohydrate binding | IBA | 21873635 |
GO:0030395 | lactose binding | IEA | -- |
GO:0042802 | identical protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA | 27068509 |
GO:0005615 | extracellular space | IEA,IBA | 21873635 |
GO:0005622 | intracellular | IDA | -- |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002317 | plasma cell differentiation | IEA | -- |
GO:0006915 | apoptotic process | TAS,IEA | -- |
GO:0010812 | negative regulation of cell-substrate adhesion | IEA | -- |
GO:0010977 | negative regulation of neuron projection development | IEA | -- |
GO:0031295 | T cell costimulation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Thiodigalactoside | Experimental | Pharma | Target | 0 | ||
1,4-Dithiothreitol | Experimental | Pharma | Target | 0 | ||
Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 115 | ||
Mercaptoethanol | Experimental | Pharma | Target | 0 | ||
mannose | Investigational | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LGALS1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LGALS1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lgals1 30 |
|
||
Dog (Canis familiaris) |
Mammalia | LGALS1 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Lgals1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LGALS1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LGALS1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LGALS1 30 31 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485378 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lgals2b 30 31 |
|
OneToMany | |
lgals2a 31 |
|
OneToMany | |||
lgals1l1 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2662670 | CNV | deletion | 23128226 |
esv2758838 | CNV | loss | 17122850 |
nsv1057617 | CNV | gain | 25217958 |
nsv471197 | CNV | loss | 18288195 |
nsv528985 | CNV | loss | 19592680 |
nsv829203 | CNV | loss | 20364138 |
nsv834191 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
trophoblastic neoplasm |
|
|
fucosidosis |
|
|
adult hepatocellular carcinoma |
|
|
paralytic lagophthalmos |
|
|
partial trisomy distal 4q |
|
|