LGALS1 Gene (Protein Coding)

Galectin 1

GC22P037675
GIFtS:
45
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008] See more...

Aliases for LGALS1 Gene

Aliases for LGALS1 Gene

  • Galectin 1 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 1 2 3
  • Beta-Galactoside-Binding Lectin L-14-I 3 4
  • Putative MAPK-Activating Protein PM12 3 4
  • 14 KDa Laminin-Binding Protein 3 4
  • Lactose-Binding Lectin 1 3 4
  • S-Lac Lectin 1 3 4
  • 14 KDa Lectin 3 4
  • Galectin-1 3 4
  • Galaptin 3 4
  • HLBP14 3 4
  • Gal-1 3 4
  • HBL 3 4
  • HPL 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Beta-Galactoside-Binding Protein 14kDa 3
  • Lectin Galactoside-Binding Soluble 1 4
  • GAL1 3
  • GBP 3

External Ids for LGALS1 Gene

Previous GeneCards Identifiers for LGALS1 Gene

  • GC22P034686
  • GC22P036314
  • GC22P036396
  • GC22P038071
  • GC22P021039

Summaries for LGALS1 Gene

Entrez Gene Summary for LGALS1 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS1 Gene

LGALS1 (Galectin 1) is a Protein Coding gene. Diseases associated with LGALS1 include Benign Metastasizing Leiomyoma and Placenta Disease. Among its related pathways are Validated targets of C-MYC transcriptional repression and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is LGALS2.

UniProtKB/Swiss-Prot Summary for LGALS1 Gene

  • Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.

Gene Wiki entry for LGALS1 Gene

Additional gene information for LGALS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALS1 Gene

Genomics for LGALS1 Gene

GeneHancer (GH) Regulatory Elements for LGALS1 Gene

Promoters and enhancers for LGALS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LGALS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LGALS1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1
  • HEN1
  • MyoD
  • p53
  • YY1

Genomic Locations for LGALS1 Gene

Genomic Locations for LGALS1 Gene
chr22:37,675,606-37,679,802
(GRCh38/hg38)
Size:
4,197 bases
Orientation:
Plus strand
chr22:38,071,613-38,075,813
(GRCh37/hg19)
Size:
4,201 bases
Orientation:
Plus strand

Genomic View for LGALS1 Gene

Genes around LGALS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LGALS1 Gene

Proteins for LGALS1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LGALS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09382-LEG1_HUMAN
    Recommended name:
    Galectin-1
    Protein Accession:
    P09382
    Secondary Accessions:
    • B2R5E8
    • Q9UDK5

    Protein attributes for LGALS1 Gene

    Size:
    135 amino acids
    Molecular mass:
    14716 Da
    Quaternary structure:
    • Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.

    Three dimensional structures from OCA and Proteopedia for LGALS1 Gene

neXtProt entry for LGALS1 Gene

Protein Expression for LGALS1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LGALS1 Gene

  • Ubiquitination at Lys29 and Lys108
  • Modification sites at PhosphoSitePlus

Other Protein References for LGALS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LGALS1 Gene

Domains & Families for LGALS1 Gene

Gene Families for LGALS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LGALS1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LGALS1 Gene

GenScript: Design optimal peptide antigens:
  • S-Lac lectin 1 (LEG1_HUMAN)
genes like me logo Genes that share domains with LGALS1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LGALS1 Gene

Function for LGALS1 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for LGALS1 Gene

UniProtKB/Swiss-Prot Function:
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 1,autocrine negative growth factor (L14-I)

Phenotypes From GWAS Catalog for LGALS1 Gene

Gene Ontology (GO) - Molecular Function for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 10369126
GO:0030246 carbohydrate binding IBA 21873635
GO:0030395 lactose binding IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with LGALS1: view
genes like me logo Genes that share phenotypes with LGALS1: view

Animal Models for LGALS1 Gene

MGI Knock Outs for LGALS1:

Animal Model Products

CRISPR Products

miRNA for LGALS1 Gene

miRTarBase miRNAs that target LGALS1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGALS1 Gene

Localization for LGALS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS1 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
cytosol 4
extracellular 3
plasma membrane 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA 27068509
GO:0005615 extracellular space IEA,IBA 21873635
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS,IEA 16130169
genes like me logo Genes that share ontologies with LGALS1: view

Pathways & Interactions for LGALS1 Gene

genes like me logo Genes that share pathways with LGALS1: view

Pathways by source for LGALS1 Gene

1 BioSystems pathway for LGALS1 Gene
3 Cell Signaling Technology pathways for LGALS1 Gene

SIGNOR curated interactions for LGALS1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002317 plasma cell differentiation IEA --
GO:0006915 apoptotic process TAS,IEA --
GO:0010812 negative regulation of cell-substrate adhesion IEA --
GO:0010977 negative regulation of neuron projection development IEA --
GO:0031295 T cell costimulation IEA --
genes like me logo Genes that share ontologies with LGALS1: view

Drugs & Compounds for LGALS1 Gene

Products:

  1. Drug

(32) Drugs for LGALS1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiodigalactoside Experimental Pharma Target 0
1,4-Dithiothreitol Experimental Pharma Target 0
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 108
Mercaptoethanol Experimental Pharma Target 0
mannose Investigational Pharma 0

(30) Additional Compounds for LGALS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS1: view

Transcripts for LGALS1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LGALS1 Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(1106) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for LGALS1 Gene

GeneLoc Exon Structure for
LGALS1
ECgene alternative splicing isoforms for
LGALS1

Expression for LGALS1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS1 Gene

mRNA expression in normal human tissues for LGALS1 Gene
mRNA expression by BioGPS for LGALS1 GenemRNA expression by GTEx for LGALS1 Gene

Protein differential expression in normal tissues from HIPED for LGALS1 Gene

This gene is overexpressed in Amniocyte (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LGALS1 Gene



NURSA nuclear receptor signaling pathways regulating expression of LGALS1 Gene:

LGALS1

SOURCE GeneReport for Unigene cluster for LGALS1 Gene:

Hs.445351

mRNA Expression by UniProt/SwissProt for LGALS1 Gene:

P09382-LEG1_HUMAN
Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

Evidence on tissue expression from TISSUES for LGALS1 Gene

  • Lung(4.9)
  • Skin(4.9)
  • Nervous system(4.9)
  • Blood(4.6)
  • Liver(4.6)
  • Spleen(4.5)
  • Muscle(3.4)
  • Heart(3.2)
  • Eye(3.1)
  • Kidney(2.9)
  • Intestine(2.8)
  • Adrenal gland(2.5)
  • Gall bladder(2.4)
  • Stomach(2.4)
  • Thyroid gland(2.3)
  • Lymph node(2.2)
  • Pancreas(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with LGALS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS1 Gene

Orthologs for LGALS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LGALS1 33 32
  • 99.51 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia LGALS1 33 32
  • 88.64 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia LGALS1 33 32
  • 86.17 (n)
 OneToMany
-- 33
  • 81 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Lgals1 32
  • 86.17 (n)
mouse
(Mus musculus)
 Mammalia Lgals1 17 33 32
  • 85.93 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia LGALS1 33
  • 75 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia LGALS1 33
  • 62 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LGALS1 33 33 32
  • 60.65 (n)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 52 (a)
 OneToMany
-- 33
  • 50 (a)
 OneToMany
-- 33
  • 49 (a)
 OneToMany
-- 33
  • 47 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100485378 32
  • 57.6 (n)
zebrafish
(Danio rerio)
 Actinopterygii lgals2b 33 32
  • 59.06 (n)
 OneToMany
lgals2a 33
  • 40 (a)
 OneToMany
lgals1l1 33
  • 36 (a)
 OneToMany
Species where no ortholog for LGALS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGALS1 Gene

ENSEMBL:
Gene Tree for LGALS1 (if available)
TreeFam:
Gene Tree for LGALS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LGALS1: view image

Paralogs for LGALS1 Gene

Paralogs for LGALS1 Gene

(9) SIMAP similar genes for LGALS1 Gene using alignment to 3 proteins:

  • LEG1_HUMAN
  • F8WCQ5_HUMAN
  • F8WEI7_HUMAN
genes like me logo Genes that share paralogs with LGALS1: view

Variants for LGALS1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for LGALS1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000146429 -- 37,678,740(+) C/T intron_variant
rs1000530168 -- 37,674,210(+) G/A upstream_transcript_variant
rs1000598049 -- 37,674,997(+) G/A upstream_transcript_variant
rs1000983739 -- 37,674,703(+) G/A/C upstream_transcript_variant
rs1000985750 -- 37,673,852(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS1 Gene

Variant ID Type Subtype PubMed ID
esv2662670 CNV deletion 23128226
esv2758838 CNV loss 17122850
nsv1057617 CNV gain 25217958
nsv471197 CNV loss 18288195
nsv528985 CNV loss 19592680
nsv829203 CNV loss 20364138
nsv834191 CNV loss 17160897

Variation tolerance for LGALS1 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS1 Gene

Disorders for LGALS1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for LGALS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
benign metastasizing leiomyoma
  • benign metastasizing leiomyoma of uterus
placenta disease
  • placenta disorder
gestational trophoblastic neoplasm
  • hydatidiform mole, recurrent, 1
chronic monocytic leukemia
  • leukemia, myeloid
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LGALS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LGALS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS1 Gene

Publications for LGALS1 Gene

  1. Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. (PMID: 18796645) Nishi N … Nakamura T (Glycobiology 2008) 3 4 23 56
  2. Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. (PMID: 18824694) Than NG … Wildman DE (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23 56
  3. Presentation of galectin-1 by extracellular matrix triggers T cell death. (PMID: 14617626) He J … Baum LG (The Journal of biological chemistry 2004) 3 4 23 56
  4. Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PMID: 11146440) Tinari N … Liu FT (International journal of cancer 2001) 3 4 23 56
  5. Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. (PMID: 10764829) Fouillit M … Caron M (Glycobiology 2000) 3 4 23 56

ExternalLinks

View latest publications for LGALS1 gene in Mastermind

Products for LGALS1 Gene

Sources for LGALS1 Gene