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Aliases for LFNG Gene

Aliases for LFNG Gene

  • LFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 2 3 5
  • Beta-1,3-N-Acetylglucosaminyltransferase Lunatic Fringe 3
  • O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 4
  • Lunatic Fringe (Drosophila) Homolog 2
  • Lunatic Fringe Homolog (Drosophila) 2
  • EC 2.4.1.222 4
  • SCDO3 3

External Ids for LFNG Gene

Previous GeneCards Identifiers for LFNG Gene

  • GC07P002201
  • GC07P002303
  • GC07P002302
  • GC07P002330
  • GC07P002524
  • GC07P002469
  • GC07P002552

Summaries for LFNG Gene

Entrez Gene Summary for LFNG Gene

  • This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. [provided by RefSeq, May 2018]

GeneCards Summary for LFNG Gene

LFNG (LFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with LFNG include Spondylocostal Dysostosis 3, Autosomal Recessive and Spondylocostal Dysostosis 3. Among its related pathways are Notch signaling pathway (KEGG) and Gene regulatory network modelling somitogenesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is RFNG.

UniProtKB/Swiss-Prot for LFNG Gene

  • Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity).

Gene Wiki entry for LFNG Gene

Additional gene information for LFNG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LFNG Gene

Genomics for LFNG Gene

GeneHancer (GH) Regulatory Elements for LFNG Gene

Promoters and enhancers for LFNG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J002515 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 671.5 +11.8 11832 18.1 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A YBX1 ZBTB7B ZNF143 LFNG EIF3B BRAT1 IQCE MIR4648 GC07P002527
GH07J002507 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 661.6 -1.8 -1812 6 FOXA2 ARID4B ZNF766 GLIS2 RUNX3 RXRA SP5 PPARG NFIL3 RCOR2 LFNG BRAT1 GRIFIN
GH07J002626 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.1 +122.1 122096 16.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 TTYH3 BRAT1 CHST12 EIF3B LFNG AMZ1 MRM2 IQCE SNX8
GH07J002756 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +248.1 248064 8.7 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 NEUROD1 SIN3A ZNF2 IRF4 GNA12 BRAT1 CHST12 EIF3B AMZ1 LFNG TTYH3 SNX8 GC07M002729 PIR32151
GH07J002862 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +351.4 351380 3 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A ZBTB7B IRF4 ZNF766 ZNF143 FOS GNA12 LFNG MRM2 TTYH3 LOC100131264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LFNG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LFNG gene promoter:
  • HEN1
  • Pax-4a
  • c-Ets-1
  • GATA-2
  • GR
  • GR-alpha
  • GR-beta
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for LFNG Gene

Genomic Locations for LFNG Gene
chr7:2,512,529-2,529,177
(GRCh38/hg38)
Size:
16,649 bases
Orientation:
Plus strand
chr7:2,552,163-2,568,811
(GRCh37/hg19)
Size:
16,649 bases
Orientation:
Plus strand

Genomic View for LFNG Gene

Genes around LFNG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LFNG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LFNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LFNG Gene

Proteins for LFNG Gene

  • Protein details for LFNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NES3-LFNG_HUMAN
    Recommended name:
    Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Protein Accession:
    Q8NES3
    Secondary Accessions:
    • B3KTY6
    • B5MCR5
    • O00589
    • Q96C39
    • Q9UJW5

    Protein attributes for LFNG Gene

    Size:
    379 amino acids
    Molecular mass:
    41773 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LFNG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LFNG Gene

Post-translational modifications for LFNG Gene

  • A soluble form may be derived from the membrane form by proteolytic processing.
  • Glycosylation at isoforms=2, 3, 4167
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LFNG Gene

Domains & Families for LFNG Gene

Gene Families for LFNG Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LFNG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LFNG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NES3

UniProtKB/Swiss-Prot:

LFNG_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with LFNG: view

Function for LFNG Gene

Molecular function for LFNG Gene

UniProtKB/Swiss-Prot Function:
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.
GENATLAS Biochemistry:
lunatic fringe,putative regulator of developmental processes through regulation of the sensitivity of NOTCH receptor genes for their specific ligands,essential mediator of somite segmentation and patterning

Enzyme Numbers (IUBMB) for LFNG Gene

Phenotypes From GWAS Catalog for LFNG Gene

Gene Ontology (GO) - Molecular Function for LFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LFNG: view
genes like me logo Genes that share phenotypes with LFNG: view

Human Phenotype Ontology for LFNG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LFNG Gene

MGI Knock Outs for LFNG:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for LFNG (Lunatic Fringe/LFNG)

No data available for Transcription Factor Targets and HOMER Transcription for LFNG Gene

Localization for LFNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for LFNG Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LFNG gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 3
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 10341080
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with LFNG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LFNG Gene

Pathways & Interactions for LFNG Gene

genes like me logo Genes that share pathways with LFNG: view

Pathways by source for LFNG Gene

1 GeneGo (Thomson Reuters) pathway for LFNG Gene
1 Qiagen pathway for LFNG Gene
1 Cell Signaling Technology pathway for LFNG Gene

SIGNOR curated interactions for LFNG Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for LFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001756 somitogenesis ISS --
GO:0002315 marginal zone B cell differentiation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007386 compartment pattern specification IEA --
genes like me logo Genes that share ontologies with LFNG: view

Drugs & Compounds for LFNG Gene

No Compound Related Data Available

Transcripts for LFNG Gene

mRNA/cDNA for LFNG Gene

Unigene Clusters for LFNG Gene

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for LFNG (Lunatic Fringe/LFNG)

Alternative Splicing Database (ASD) splice patterns (SP) for LFNG Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for LFNG Gene

GeneLoc Exon Structure for
LFNG
ECgene alternative splicing isoforms for
LFNG

Expression for LFNG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LFNG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LFNG Gene

This gene is overexpressed in Whole Blood (x6.5) and Pancreas (x5.5).

Protein differential expression in normal tissues from HIPED for LFNG Gene

This gene is overexpressed in Heart (31.8), Stomach (20.5), and Pancreas (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LFNG Gene



Protein tissue co-expression partners for LFNG Gene

NURSA nuclear receptor signaling pathways regulating expression of LFNG Gene:

LFNG

SOURCE GeneReport for Unigene cluster for LFNG Gene:

Hs.159142

Evidence on tissue expression from TISSUES for LFNG Gene

  • Kidney(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LFNG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • skull
  • tooth
Thorax:
  • chest wall
  • lung
  • rib
  • rib cage
  • sternum
Pelvis:
  • pelvis
Limb:
  • digit
  • finger
  • hand
  • upper limb
General:
  • blood vessel
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with LFNG: view

No data available for mRNA Expression by UniProt/SwissProt for LFNG Gene

Orthologs for LFNG Gene

This gene was present in the common ancestor of animals.

Orthologs for LFNG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LFNG 34 33
  • 98.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LFNG 34 33
  • 91.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LFNG 34 33
  • 89.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lfng 33
  • 85.45 (n)
mouse
(Mus musculus)
Mammalia Lfng 16 34 33
  • 84.66 (n)
oppossum
(Monodelphis domestica)
Mammalia LFNG 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LFNG 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LFNG 34 33
  • 78.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LFNG 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lfng 33
  • 69.5 (n)
Str.16143 33
African clawed frog
(Xenopus laevis)
Amphibia LOC397855 33
zebrafish
(Danio rerio)
Actinopterygii lfng 34 33 33
  • 70.81 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fng 34 35
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
Species where no ortholog for LFNG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LFNG Gene

ENSEMBL:
Gene Tree for LFNG (if available)
TreeFam:
Gene Tree for LFNG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LFNG: view image

Paralogs for LFNG Gene

Paralogs for LFNG Gene

(2) SIMAP similar genes for LFNG Gene using alignment to 1 proteins:

  • LFNG_HUMAN
genes like me logo Genes that share paralogs with LFNG: view

Variants for LFNG Gene

Sequence variations from dbSNP and Humsavar for LFNG Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs104894024 pathogenic, Spondylocostal dysostosis 3, Spondylocostal dysostosis 3, autosomal recessive (SCDO3) [MIM:609813] 2,525,301(+) C/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs148460430 uncertain-significance, Spondylocostal dysostosis 3 2,525,485(+) C/T coding_sequence_variant, missense_variant
rs62444250 benign, not specified, Spondylocostal dysostosis 3 2,525,215(+) A/G/T intron_variant
rs141008352 likely-benign, not specified 2,524,746(+) G/A intron_variant
rs147266260 likely-benign, not specified 2,525,444(+) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for LFNG Gene

Variant ID Type Subtype PubMed ID
esv2575091 CNV insertion 19546169
esv2733856 CNV deletion 23290073
esv2733857 CNV deletion 23290073
esv3446190 CNV duplication 20981092
esv5169 OTHER sequence alteration 18987735
nsv471216 CNV loss 18288195
nsv605861 CNV loss 21841781
nsv605862 CNV loss 21841781
nsv823981 CNV gain 20364138
nsv830887 CNV loss 17160897
nsv950792 CNV deletion 24416366

Variation tolerance for LFNG Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LFNG Gene

Human Gene Mutation Database (HGMD)
LFNG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LFNG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LFNG Gene

Disorders for LFNG Gene

MalaCards: The human disease database

(6) MalaCards diseases for LFNG Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spondylocostal dysostosis 3, autosomal recessive
  • spondylothoracic dysostosis
spondylocostal dysostosis 3
  • spondylocostal dysostosis 3, autosomal recessive
spondylocostal dysostosis, autosomal recessive
  • spondylocostal dysplasia
spondylocostal dysostosis 1, autosomal recessive
  • spondylothoracic dysostosis
dysostosis
  • dysostoses
- elite association - COSMIC cancer census association via MalaCards
Search LFNG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LFNG_HUMAN
  • Spondylocostal dysostosis 3, autosomal recessive (SCDO3) [MIM:609813]: A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life. {ECO:0000269 PubMed:16385447}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for LFNG

genes like me logo Genes that share disorders with LFNG: view

No data available for Genatlas for LFNG Gene

Publications for LFNG Gene

  1. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. (PMID: 16385447) Sparrow DB … Dunwoodie SL (American journal of human genetics 2006) 3 4 22 58
  2. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. (PMID: 9187150) Johnston SH … Vogt TF (Development (Cambridge, England) 1997) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis. (PMID: 12110169) Cole SE … Vogt TF (Developmental cell 2002) 3 4 58
  5. Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. (PMID: 11346656) Shimizu K … Hirai H (The Journal of biological chemistry 2001) 3 4 58

Products for LFNG Gene

Sources for LFNG Gene

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