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Aliases for LEUTX Gene

Aliases for LEUTX Gene

  • Leucine Twenty Homeobox 2 3 5

External Ids for LEUTX Gene

Previous GeneCards Identifiers for LEUTX Gene

  • GC19P044961
  • GC19P040267
  • GC19P036713

Summaries for LEUTX Gene

GeneCards Summary for LEUTX Gene

LEUTX (Leucine Twenty Homeobox) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding.

Additional gene information for LEUTX Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEUTX Gene

Genomics for LEUTX Gene

GeneHancer (GH) Regulatory Elements for LEUTX Gene

Promoters and enhancers for LEUTX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I039677 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.3 -98.0 -98022 3.6 HDGF PKNOX1 FOXA2 SMAD1 IRF4 ETS1 YY1 ZNF121 ZNF207 ATF7 LGALS17A ENSG00000268088 HNRNPL LEUTX FBL CLC EID2B ZNF780A LGALS16
GH19I039676 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.3 -100.4 -100438 0.2 BACH1 EBF1 BATF IRF4 NFATC1 ETV6 NFE2 BCLAF1 IKZF2 RUNX3 LEUTX FBL CLC EID2B PLEKHG2 MED29 ZFP36 PAF1 LGALS17A LGALS16
GH19I039558 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.3 -218.1 -218050 1.8 HDGF PKNOX1 CLOCK FOXA2 ARID4B FEZF1 ZNF366 ZSCAN5C ATF7 BCLAF1 PLEKHG2 EID2B CLC DLL3 LEUTX MED29 LGALS4 RPS16 PAF1 ZFP36
GH19I039813 Enhancer 1 ENCODE dbSUPER 11.1 +37.0 37035 1.1 ZNF493 INSM2 KLF17 MZF1 FEZF1 ZEB1 ZNF213 ZNF138 ZNF366 SCRT2 ENSG00000276445 SNRPA ZNF780B HNRNPL FBL AKT2 EID2B SUPT5H SPTBN4 SAMD4B
GH19I039814 Enhancer 0.9 dbSUPER 11.1 +41.2 41185 6.8 PKNOX1 SMAD1 ZNF493 ZFP64 IRF4 ZNF213 ATF7 RUNX3 ZNF202 JUNB SNRPA HNRNPL FBL AKT2 ZNF780A ZNF780B SUPT5H RN7SL566P PAK4 EID2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LEUTX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LEUTX gene promoter:

Genomic Locations for LEUTX Gene

Genomic Locations for LEUTX Gene
chr19:39,776,594-39,786,167
(GRCh38/hg38)
Size:
9,574 bases
Orientation:
Plus strand
chr19:40,267,234-40,276,775
(GRCh37/hg19)

Genomic View for LEUTX Gene

Genes around LEUTX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEUTX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEUTX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEUTX Gene

Proteins for LEUTX Gene

  • Protein details for LEUTX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MZ59-LEUTX_HUMAN
    Recommended name:
    Leucine-twenty homeobox
    Protein Accession:
    A8MZ59

    Protein attributes for LEUTX Gene

    Size:
    168 amino acids
    Molecular mass:
    18626 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LEUTX Gene

Post-translational modifications for LEUTX Gene

No Post-translational modifications

Other Protein References for LEUTX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LEUTX Gene

Domains & Families for LEUTX Gene

Gene Families for LEUTX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for LEUTX Gene

Suggested Antigen Peptide Sequences for LEUTX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MZ59

UniProtKB/Swiss-Prot:

LEUTX_HUMAN :
  • Belongs to the paired homeobox family.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with LEUTX: view

Function for LEUTX Gene

Phenotypes From GWAS Catalog for LEUTX Gene

Gene Ontology (GO) - Molecular Function for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with LEUTX: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LEUTX Gene

Localization for LEUTX Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEUTX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LEUTX gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LEUTX: view

Pathways & Interactions for LEUTX Gene

SuperPathways for LEUTX Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with LEUTX: view

Pathways by source for LEUTX Gene

1 BioSystems pathway for LEUTX Gene

Gene Ontology (GO) - Biological Process for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with LEUTX: view

No data available for SIGNOR curated interactions for LEUTX Gene

Drugs & Compounds for LEUTX Gene

No Compound Related Data Available

Transcripts for LEUTX Gene

mRNA/cDNA for LEUTX Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LEUTX Gene

Leucine twenty homeobox:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LEUTX Gene

No ASD Table

Relevant External Links for LEUTX Gene

GeneLoc Exon Structure for
LEUTX
ECgene alternative splicing isoforms for
LEUTX

Expression for LEUTX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LEUTX Gene

NURSA nuclear receptor signaling pathways regulating expression of LEUTX Gene:

LEUTX

SOURCE GeneReport for Unigene cluster for LEUTX Gene:

Hs.451638
genes like me logo Genes that share expression patterns with LEUTX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LEUTX Gene

Orthologs for LEUTX Gene

This gene was present in the common ancestor of mammals.

Orthologs for LEUTX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LEUTX 33 34
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia LEUTX 34
  • 46 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LEUTX 34
  • 37 (a)
OneToOne
Species where no ortholog for LEUTX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LEUTX Gene

ENSEMBL:
Gene Tree for LEUTX (if available)
TreeFam:
Gene Tree for LEUTX (if available)

Paralogs for LEUTX Gene

Pseudogenes.org Pseudogenes for LEUTX Gene

genes like me logo Genes that share paralogs with LEUTX: view

No data available for Paralogs for LEUTX Gene

Variants for LEUTX Gene

Sequence variations from dbSNP and Humsavar for LEUTX Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000568731 -- 39,780,811(+) C/T intron_variant
rs1000694517 -- 39,785,911(+) G/A coding_sequence_variant, missense_variant
rs1000704423 -- 39,786,212(+) A/G downstream_transcript_variant
rs1000831814 -- 39,780,734(+) T/C intron_variant
rs1000914101 -- 39,774,716(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LEUTX Gene

Variant ID Type Subtype PubMed ID
dgv3529n100 CNV loss 25217958
esv2758760 CNV gain 17122850
esv2762040 CNV loss 21179565
nsv579511 CNV loss 21841781

Variation tolerance for LEUTX Gene

Gene Damage Index Score: 0.35; 7.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LEUTX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LEUTX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEUTX Gene

Disorders for LEUTX Gene

Additional Disease Information for LEUTX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LEUTX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEUTX Gene

Publications for LEUTX Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Classification and nomenclature of all human homeobox genes. (PMID: 17963489) Holland PW … Bruford EA (BMC biology 2007) 3 4 58
  3. The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation. (PMID: 27578796) Jouhilahti EM … Kere J (Development (Cambridge, England) 2016) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for LEUTX Gene

Sources for LEUTX Gene

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