Aliases for LEUTX Gene

Aliases for LEUTX Gene

  • Leucine Twenty Homeobox 2 3 5
  • Paired-Like Homeodomain Transcription Factor LEUTX 3 4
  • Paired-Like Homeobox Transcription Factor LEUTX 3 4
  • PRD-LIKE Homeobox Transcription Factor LEUTX 3 4
  • Arginine-Fifty Homeobox-Like Pseudogene 3
  • Putative Leucine-Twenty Homeobox 3
  • Leucine-Twenty Homeobox 4
  • LEUTX 5

External Ids for LEUTX Gene

Previous GeneCards Identifiers for LEUTX Gene

  • GC19P044961
  • GC19P040267
  • GC19P036713

Summaries for LEUTX Gene

GeneCards Summary for LEUTX Gene

LEUTX (Leucine Twenty Homeobox) is a Protein Coding gene. Diseases associated with LEUTX include Facioscapulohumeral Muscular Dystrophy 1 and Distal Muscular Dystrophy With Anterior Tibial Onset. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is DBX1.

UniProtKB/Swiss-Prot Summary for LEUTX Gene

  • [Isoform 1]: Paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). May act as a regulator of embryo genome activation (PubMed:27578796). Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355).
  • [Isoform 2]: Inactive transcriptional activity.

Additional gene information for LEUTX Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LEUTX Gene

Genomics for LEUTX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LEUTX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039676 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.3 -97.9 -97868 3.6 SP1 GATAD2A PRDM10 REST ZNF692 POLR2A BACH1 ZHX2 FOXA1 LARP7 LGALS17A ENSG00000269460 LGALS14 ENSG00000268088 HNRNPL LEUTX FBL CLC EID2B ZNF780A
GH19J039813 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 +37.2 37176 1.1 PRDM10 ZNF692 PRDM1 ZNF501 ZNF600 SCRT2 ZBTB44 ZNF639 ZEB1 ZNF585B ENSG00000276445 SNRPA ZNF780B HNRNPL FBL AKT2 EID2B SUPT5H SPTBN4 SAMD4B
GH19J039677 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.3 -100.3 -100297 0.2 BACH1 JUND IKZF2 EED ARID3A DPF2 RUNX3 GATAD2B NFE2 BCLAF1 LEUTX FBL CLC EID2B PLEKHG2 MED29 ZFP36 PAF1 ENSG00000269460 LGALS17A
GH19J039558 Enhancer 1 FANTOM5 ENCODE 10.3 -217.9 -217909 1.8 CREB1 FOXA1 PRDM1 TCF12 IRF2 IKZF2 SP1 ZNF600 PKNOX1 CEBPA HSALNG0126023 PLEKHG2 EID2B CLC DLL3 LEUTX MED29 LGALS4 RPS16 PAF1
GH19J039672 Enhancer 0.8 Ensembl ENCODE 11 -104.3 -104324 0.7 CTCF ZNF692 REST RAD21 TRIM22 IRF3 ZNF561 BCLAF1 SMC3 ZBTB17 EID2 EID2B LEUTX TTC9B ZNF780A piR-41525-343 ENSG00000269460 LGALS17A LGALS16 LGALS14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LEUTX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LEUTX

Top Transcription factor binding sites by QIAGEN in the LEUTX gene promoter:
  • p53
  • STAT3

Genomic Locations for LEUTX Gene

Genomic Locations for LEUTX Gene
chr19:39,776,453-39,786,291
(GRCh38/hg38)
Size:
9,839 bases
Orientation:
Plus strand
chr19:40,267,234-40,276,775
(GRCh37/hg19)
Size:
9,542 bases
Orientation:
Plus strand

Genomic View for LEUTX Gene

Genes around LEUTX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEUTX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEUTX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEUTX Gene

Proteins for LEUTX Gene

  • Protein details for LEUTX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MZ59-LEUTX_HUMAN
    Recommended name:
    Paired-like homeodomain transcription factor LEUTX
    Protein Accession:
    A8MZ59
    Secondary Accessions:
    • A0A1W2PQ33

    Protein attributes for LEUTX Gene

    Size:
    198 amino acids
    Molecular mass:
    22358 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LEUTX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LEUTX Gene

Post-translational modifications for LEUTX Gene

No Post-translational modifications

Other Protein References for LEUTX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LEUTX Gene

Domains & Families for LEUTX Gene

Gene Families for LEUTX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for LEUTX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LEUTX Gene

GenScript: Design optimal peptide antigens:
  • Leucine-twenty homeobox (LEUTX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MZ59

UniProtKB/Swiss-Prot:

LEUTX_HUMAN :
  • [Isoform 1]: The homeobox contain essential residues (Ile-54, Lys-57, Ala-61) for binding to the 5'-TAATCC-3' motif of the targe gene promoters.
  • Belongs to the paired homeobox family.
Domain:
  • [Isoform 1]: The homeobox contain essential residues (Ile-54, Lys-57, Ala-61) for binding to the 5'-TAATCC-3' motif of the targe gene promoters.
  • [Isoform 2]: The homeobox is incomplete and cannot bind to the 36 bp motif found in the promoters of the target genes.
  • The 9aaTAD motif is a conserved putative nine amino acid transactivation motifs in C-terminus of the LEUTX region.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with LEUTX: view

Function for LEUTX Gene

Molecular function for LEUTX Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). May act as a regulator of embryo genome activation (PubMed:27578796). Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Inactive transcriptional activity.

Phenotypes From GWAS Catalog for LEUTX Gene

Gene Ontology (GO) - Molecular Function for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with LEUTX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEUTX

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LEUTX Gene

Localization for LEUTX Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEUTX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LEUTX gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LEUTX: view

Pathways & Interactions for LEUTX Gene

PathCards logo

SuperPathways for LEUTX Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with LEUTX: view

Pathways by source for LEUTX Gene

1 BioSystems pathway for LEUTX Gene

Gene Ontology (GO) - Biological Process for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with LEUTX: view

No data available for SIGNOR curated interactions for LEUTX Gene

Drugs & Compounds for LEUTX Gene

No Compound Related Data Available

Transcripts for LEUTX Gene

mRNA/cDNA for LEUTX Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEUTX

Alternative Splicing Database (ASD) splice patterns (SP) for LEUTX Gene

No ASD Table

Relevant External Links for LEUTX Gene

GeneLoc Exon Structure for
LEUTX

Expression for LEUTX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LEUTX Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LEUTX

SOURCE GeneReport for Unigene cluster for LEUTX Gene:

Hs.451638
genes like me logo Genes that share expression patterns with LEUTX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LEUTX Gene

Orthologs for LEUTX Gene

This gene was present in the common ancestor of mammals.

Orthologs for LEUTX Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LEUTX 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LEUTX 31
  • 46 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LEUTX 31
  • 37 (a)
OneToOne
Species where no ortholog for LEUTX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LEUTX Gene

ENSEMBL:
Gene Tree for LEUTX (if available)
TreeFam:
Gene Tree for LEUTX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LEUTX: view image

Paralogs for LEUTX Gene

Paralogs for LEUTX Gene

Pseudogenes.org Pseudogenes for LEUTX Gene

genes like me logo Genes that share paralogs with LEUTX: view

Variants for LEUTX Gene

Additional dbSNP identifiers (rs#s) for LEUTX Gene

Structural Variations from Database of Genomic Variants (DGV) for LEUTX Gene

Variant ID Type Subtype PubMed ID
dgv3529n100 CNV loss 25217958
esv2758760 CNV gain 17122850
esv2762040 CNV loss 21179565
nsv579511 CNV loss 21841781

Variation tolerance for LEUTX Gene

Gene Damage Index Score: 0.35; 7.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LEUTX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LEUTX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LEUTX Gene

Disorders for LEUTX Gene

MalaCards: The human disease database

(4) MalaCards diseases for LEUTX Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search LEUTX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LEUTX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LEUTX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LEUTX Gene

Publications for LEUTX Gene

  1. The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation. (PMID: 27578796) Jouhilahti EM … Kere J (Development (Cambridge, England) 2016) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Classification and nomenclature of all human homeobox genes. (PMID: 17963489) Holland PW … Bruford EA (BMC biology 2007) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic and mutational analyses of human LEUTX, a homeobox gene implicated in embryogenesis. (PMID: 30479355) Katayama S … Kere J (Scientific reports 2018) 4

Products for LEUTX Gene

Sources for LEUTX Gene