Aliases for LETM2 Gene

Aliases for LETM2 Gene

  • Leucine Zipper And EF-Hand Containing Transmembrane Protein 2 2 3 5
  • LETM1 Domain-Containing Protein LETM2, Mitochondrial 3 4
  • LETM1 And EF-Hand Domain-Containing Protein 2 3 4
  • Leucine Zipper-EF-Hand Containing Transmembrane Protein 1-Like Protein 3
  • Leucine Zipper-EF-Hand-Containing Transmembrane Protein 1-Like 4
  • Leucine Zipper-EF-Hand Containing Transmembrane Protein 2 3
  • SLC55A2 3

External Ids for LETM2 Gene

Previous GeneCards Identifiers for LETM2 Gene

  • GC08P038363
  • GC08P038244
  • GC08P036778

Summaries for LETM2 Gene

GeneCards Summary for LETM2 Gene

LETM2 (Leucine Zipper And EF-Hand Containing Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with LETM2 include Cone-Rod Dystrophy 9 and Acute Hemorrhagic Leukoencephalitis. An important paralog of this gene is LETM1.

Additional gene information for LETM2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LETM2 Gene

Genomics for LETM2 Gene

GeneHancer (GH) Regulatory Elements for LETM2 Gene

Promoters and enhancers for LETM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LETM2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LETM2

Top Transcription factor binding sites by QIAGEN in the LETM2 gene promoter:
  • Egr-1
  • FOXD3
  • FOXI1
  • GATA-1
  • HFH-3
  • LUN-1
  • Nkx2-5
  • Pax-4a
  • PPAR-gamma1
  • XBP-1

Genomic Locations for LETM2 Gene

Genomic Locations for LETM2 Gene
23,321 bases
Plus strand
23,321 bases
Plus strand

Genomic View for LETM2 Gene

Genes around LETM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LETM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LETM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LETM2 Gene

Proteins for LETM2 Gene

  • Protein details for LETM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LETM1 domain-containing protein LETM2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NMG3
    • Q8NCR2
    • Q96LL1

    Protein attributes for LETM2 Gene

    491 amino acids
    Molecular mass:
    55921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LETM2 Gene


neXtProt entry for LETM2 Gene

Post-translational modifications for LETM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LETM2 Gene

Domains & Families for LETM2 Gene

Gene Families for LETM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LETM2 Gene


Suggested Antigen Peptide Sequences for LETM2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76602 (A8K1M9_HUMAN)
  • Leucine zipper-EF-hand-containing transmembrane protein 1-like (LETM2_HUMAN)
genes like me logo Genes that share domains with LETM2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LETM2 Gene

Function for LETM2 Gene

Phenotypes From GWAS Catalog for LETM2 Gene

Gene Ontology (GO) - Molecular Function for LETM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with LETM2: view
genes like me logo Genes that share phenotypes with LETM2: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for LETM2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LETM2 Gene

Localization for LETM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LETM2 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LETM2 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LETM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LETM2: view

Pathways & Interactions for LETM2 Gene

PathCards logo

SuperPathways for LETM2 Gene

No Data Available

Interacting Proteins for LETM2 Gene


Gene Ontology (GO) - Biological Process for LETM2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LETM2 Gene

Drugs & Compounds for LETM2 Gene

No Compound Related Data Available

Transcripts for LETM2 Gene

mRNA/cDNA for LETM2 Gene

14 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for LETM2

Alternative Splicing Database (ASD) splice patterns (SP) for LETM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - - -
SP8: - -
SP10: -

Relevant External Links for LETM2 Gene

GeneLoc Exon Structure for

Expression for LETM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LETM2 Gene

mRNA differential expression in normal tissues according to GTEx for LETM2 Gene

This gene is overexpressed in Brain - Cerebellum (x6.5), Brain - Cerebellar Hemisphere (x6.4), and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for LETM2 Gene

This gene is overexpressed in Retina (48.3) and Testis (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LETM2 Gene

Protein tissue co-expression partners for LETM2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LETM2

SOURCE GeneReport for Unigene cluster for LETM2 Gene:


Evidence on tissue expression from TISSUES for LETM2 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with LETM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LETM2 Gene

Orthologs for LETM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LETM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LETM2 31 30
  • 99.39 (n)
(Canis familiaris)
Mammalia LETM2 31 30
  • 88.5 (n)
(Bos Taurus)
Mammalia LETM2 31 30
  • 86.47 (n)
(Mus musculus)
Mammalia Letm2 17 31 30
  • 80.17 (n)
(Rattus norvegicus)
Mammalia Letm2 30
  • 79.63 (n)
(Monodelphis domestica)
Mammalia LETM2 31
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 65 (a)
-- 31
  • 45 (a)
-- 31
  • 25 (a)
(Gallus gallus)
Aves LETM2 31 30
  • 66.3 (n)
(Anolis carolinensis)
Reptilia LETM2 31
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia letm2 30
  • 63.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30798 30
(Danio rerio)
Actinopterygii letm2 31 30
  • 57.89 (n)
Dr.26418 30
fruit fly
(Drosophila melanogaster)
Insecta Letm1 31
  • 15 (a)
(Caenorhabditis elegans)
Secernentea letm-1 31
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLH47 31
  • 24 (a)
MDM38 31
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
Species where no ortholog for LETM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LETM2 Gene

Gene Tree for LETM2 (if available)
Gene Tree for LETM2 (if available)
Evolutionary constrained regions (ECRs) for LETM2: view image

Paralogs for LETM2 Gene

Paralogs for LETM2 Gene

(2) SIMAP similar genes for LETM2 Gene using alignment to 8 proteins:

  • A8K1M9_HUMAN
  • E5RK40_HUMAN
  • E9PN52_HUMAN
genes like me logo Genes that share paralogs with LETM2: view

Variants for LETM2 Gene

Additional dbSNP identifiers (rs#s) for LETM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LETM2 Gene

Variant ID Type Subtype PubMed ID
esv3616924 CNV loss 21293372
esv3616925 CNV loss 21293372

Variation tolerance for LETM2 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LETM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LETM2 Gene

Disorders for LETM2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LETM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cone-rod dystrophy 9
  • retinitis pigmentosa 9
acute hemorrhagic leukoencephalitis
  • ahl
wolf-hirschhorn syndrome
  • whs
- elite association - COSMIC cancer census association via MalaCards
Search LETM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LETM2

genes like me logo Genes that share disorders with LETM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LETM2 Gene

Publications for LETM2 Gene

  1. WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. (PMID: 11549311) Stec I … den Dunnen JT (Genomics 2001) 2 3 54
  2. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 54
  5. Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. (PMID: 18628306) Tamai S … Oka T (Journal of cell science 2008) 3 54

Products for LETM2 Gene

Sources for LETM2 Gene