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Aliases for LETM2 Gene

Aliases for LETM2 Gene

  • Leucine Zipper And EF-Hand Containing Transmembrane Protein 2 2 3 5
  • LETM1 And EF-Hand Domain-Containing Protein 2 3 4
  • Leucine Zipper-EF-Hand Containing Transmembrane Protein 1-Like Protein 3
  • Leucine Zipper-EF-Hand-Containing Transmembrane Protein 1-Like 4
  • Leucine Zipper-EF-Hand Containing Transmembrane Protein 2 3
  • LETM1 Domain-Containing Protein LETM2, Mitochondrial 3
  • SLC55A2 3

External Ids for LETM2 Gene

Previous GeneCards Identifiers for LETM2 Gene

  • GC08P038244
  • GC08P036778

Summaries for LETM2 Gene

GeneCards Summary for LETM2 Gene

LETM2 (Leucine Zipper And EF-Hand Containing Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with LETM2 include Acute Hemorrhagic Leukoencephalitis. An important paralog of this gene is LETM1.

Additional gene information for LETM2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LETM2 Gene

Genomics for LETM2 Gene

GeneHancer (GH) Regulatory Elements for LETM2 Gene

Promoters and enhancers for LETM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I038379 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 567.6 -2.7 -2675 8.1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 NFYC NSD3 LETM2 ENSG00000272092 DDHD2 RPS20P22 ERLIN2 ASH2L TM2D2 ENSG00000255201 LOC102723716
GH08I037889 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.1 -488.3 -488300 17.5 CLOCK ZFP64 FEZF1 DMAP1 IRF4 ZNF213 E2F8 SP3 ZC3H11A MEF2D RAB11FIP1 ENSG00000255201 ADGRA2 DDHD2 NSD3 ERLIN2 LOC728024 FGFR1 RPS20P22 LETM2
GH08I038175 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 13.3 -208.7 -208710 4.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 BAG4 LSM1 DDHD2 LETM2 ADGRA2 LOC102723716 ERLIN2 FGFR1 NSD3 GC08M038027
GH08I038764 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +382.2 382189 7.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A YBX1 ZNF2 IRF4 YY1 DDHD2 NSD3 TACC1 ENSG00000255201 ADGRA2 FGFR1 TM2D2 LETM2 EIF4EBP1 RPS20P22
GH08I038361 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -23.1 -23069 2.8 HDGF PKNOX1 BATF CTBP1 NFATC1 ATF7 IKZF2 SRF ZNF687 ZNF740 LETM2 DDHD2 ENSG00000254898 LOC102723716 RNU6-323P NSD3 GC08M038365 GC08P038348
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LETM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LETM2 gene promoter:

Genomic Locations for LETM2 Gene

Genomic Locations for LETM2 Gene
23,321 bases
Plus strand

Genomic View for LETM2 Gene

Genes around LETM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LETM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LETM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LETM2 Gene

Proteins for LETM2 Gene

  • Protein details for LETM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LETM1 domain-containing protein LETM2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NMG3
    • Q8NCR2
    • Q96LL1

    Protein attributes for LETM2 Gene

    491 amino acids
    Molecular mass:
    55921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LETM2 Gene


neXtProt entry for LETM2 Gene

Post-translational modifications for LETM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LETM2 Gene

Domains & Families for LETM2 Gene

Gene Families for LETM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LETM2 Gene


Suggested Antigen Peptide Sequences for LETM2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LETM2: view

No data available for UniProtKB/Swiss-Prot for LETM2 Gene

Function for LETM2 Gene

Phenotypes From GWAS Catalog for LETM2 Gene

Gene Ontology (GO) - Molecular Function for LETM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with LETM2: view
genes like me logo Genes that share phenotypes with LETM2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LETM2 Gene

Localization for LETM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LETM2 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LETM2 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LETM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LETM2: view

Pathways & Interactions for LETM2 Gene

SuperPathways for LETM2 Gene

No Data Available

Interacting Proteins for LETM2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)
Selected Interacting proteins: Q2VYF4-LETM2_HUMAN ENSP00000428765 for LETM2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for LETM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006875 cellular metal ion homeostasis IBA --
genes like me logo Genes that share ontologies with LETM2: view

No data available for Pathways by source and SIGNOR curated interactions for LETM2 Gene

Drugs & Compounds for LETM2 Gene

No Compound Related Data Available

Transcripts for LETM2 Gene

Unigene Clusters for LETM2 Gene

Leucine zipper-EF-hand containing transmembrane protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LETM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - - -
SP8: - -
SP10: -

Relevant External Links for LETM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LETM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LETM2 Gene

mRNA differential expression in normal tissues according to GTEx for LETM2 Gene

This gene is overexpressed in Brain - Cerebellum (x6.5), Brain - Cerebellar Hemisphere (x6.4), and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for LETM2 Gene

This gene is overexpressed in Retina (48.3) and Testis (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LETM2 Gene

Protein tissue co-expression partners for LETM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LETM2 Gene:


SOURCE GeneReport for Unigene cluster for LETM2 Gene:


Evidence on tissue expression from TISSUES for LETM2 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with LETM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LETM2 Gene

Orthologs for LETM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LETM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LETM2 33 34
  • 99.39 (n)
(Canis familiaris)
Mammalia LETM2 33 34
  • 88.5 (n)
(Bos Taurus)
Mammalia LETM2 33 34
  • 86.47 (n)
(Mus musculus)
Mammalia Letm2 33 16 34
  • 80.17 (n)
(Rattus norvegicus)
Mammalia Letm2 33
  • 79.63 (n)
(Monodelphis domestica)
Mammalia LETM2 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
-- 34
  • 45 (a)
-- 34
  • 25 (a)
(Gallus gallus)
Aves LETM2 33 34
  • 66.3 (n)
(Anolis carolinensis)
Reptilia LETM2 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia letm2 33
  • 63.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30798 33
(Danio rerio)
Actinopterygii letm2 33 34
  • 57.89 (n)
Dr.26418 33
fruit fly
(Drosophila melanogaster)
Insecta Letm1 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea letm-1 34
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLH47 34
  • 24 (a)
MDM38 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for LETM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LETM2 Gene

Gene Tree for LETM2 (if available)
Gene Tree for LETM2 (if available)

Paralogs for LETM2 Gene

Paralogs for LETM2 Gene

(2) SIMAP similar genes for LETM2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LETM2: view

Variants for LETM2 Gene

Sequence variations from dbSNP and Humsavar for LETM2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000202792 -- 38,392,005(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000365460 -- 38,402,697(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000448269 -- 38,387,358(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000497460 -- 38,397,607(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000592143 -- 38,408,799(+) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LETM2 Gene

Variant ID Type Subtype PubMed ID
esv3616924 CNV loss 21293372
esv3616925 CNV loss 21293372

Variation tolerance for LETM2 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LETM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LETM2 Gene

Disorders for LETM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LETM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute hemorrhagic leukoencephalitis
  • ahl
- elite association - COSMIC cancer census association via MalaCards
Search LETM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LETM2

genes like me logo Genes that share disorders with LETM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LETM2 Gene

Publications for LETM2 Gene

  1. WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. (PMID: 11549311) Stec I … den Dunnen JT (Genomics 2001) 2 3 58
  2. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 58
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  4. Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. (PMID: 18628306) Tamai S … Oka T (Journal of cell science 2008) 3 58
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for LETM2 Gene

Sources for LETM2 Gene

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