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LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010] See more...
Aliases for LEPROT Gene
Aliases for LEPROT Gene
External Ids for LEPROT Gene
- HGNC: 29477
- Entrez Gene: 54741
- Ensembl: ENSG00000213625
- OMIM: 613461
- UniProtKB: O15243
Previous GeneCards Identifiers for LEPROT Gene
- GC01P065600
- GC01P065658
- GC01P065887
- GC01P063996
Summaries for LEPROT Gene
-
LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]
GeneCards Summary for LEPROT Gene
LEPROT (Leptin Receptor Overlapping Transcript) is a Protein Coding gene. Diseases associated with LEPROT include Leptin Receptor Deficiency and Syndromic Obesity. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is LEPROTL1.
UniProtKB/Swiss-Prot Summary for LEPROT Gene
-
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Additional gene information for LEPROT Gene
- HGNC(29477)
- Entrez Gene(54741)
- Ensembl(ENSG00000213625)
- OMIM(613461)
- UniProtKB(O15243)
- Open Targets Platform(ENSG00000213625)
- Search for LEPROT at DataMed
- Search for LEPROT at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LEPROT Gene
Genomics for LEPROT Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LEPROT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LEPROT on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LEPROT
- Top Transcription factor binding sites by QIAGEN in the LEPROT gene promoter:
-
- AP-1
- STAT3
Genomic Locations for LEPROT Gene
Genomic Locations for LEPROT Gene
- chr1:65,420,587-65,436,007
- (GRCh38/hg38)
- Size:
- 15,421 bases
- Orientation:
- Plus strand
- chr1:65,886,131-65,901,690
- (GRCh37/hg19)
- Size:
- 15,560 bases
- Orientation:
- Plus strand
Genomic View for LEPROT Gene
Genes around LEPROT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by HGNC
- 1p31.3 by Entrez Gene
- 1p31.3 by Ensembl
LEPROT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LEPROT Gene
Proteins for LEPROT Gene
-
Protein details for LEPROT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15243-OBRG_HUMAN
- Recommended name:
- Leptin receptor gene-related protein
- Protein Accession:
- O15243
- Q6FHL5
Protein attributes for LEPROT Gene
- Size:
- 131 amino acids
- Molecular mass:
- 14254 Da
- Quaternary structure:
-
- Interacts with LEPR. Interacts with RAB13 (By similarity).
Protein Expression for LEPROT Gene
Post-translational modifications for LEPROT Gene
No Post-translational modifications
Other Protein References for LEPROT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for LEPROT
- Invitrogen Antibodies for LEPROT (AFLGC-LEPROT)
- antibodies-online: Show 56 available LEPROT Antibodies ranked by validation data
- Compare Top LEPROT Antibodies
-
Quality Products:
Protein Products
-
OriGene Purified Proteins for LEPROT
- Search Origene for MassSpec and Protein Over-expression Lysates for LEPROT
- Origene Custom Protein Services for LEPROT
- Novus Biologicals proteins for LEPROT
No data available for DME Specific Peptides for LEPROT Gene
Domains & Families for LEPROT Gene
Gene Families for LEPROT Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for LEPROT Gene
- InterPro:
- Blocks:
-
- Vacuolar protein sorting 55
- ProtoNet:
Suggested Antigen Peptide Sequences for LEPROT Gene
- GenScript: Design optimal peptide antigens:
-
- OB-R gene-related protein (OBRG_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15243- Family:
-
- Belongs to the OB-RGRP/VPS55 family.
Function for LEPROT Gene
Molecular function for LEPROT Gene
- UniProtKB/Swiss-Prot Function:
- Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Phenotypes From GWAS Catalog for LEPROT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IBA,IDA | 18042720 |
| GO:0005515 | protein binding | IPI | 18042720 |
Phenotypes for LEPROT Gene
- MGI mutant phenotypes for LEPROT:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LEPROT:
Animal Models for LEPROT Gene
- MGI Knock Outs for LEPROT:
-
- Leprot Leprot<tm2a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LEPROT - Select products 50% OFF >
- * LEPROT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LEPROT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LEPROT
-
Santa Cruz Biotechnology (SCBT) CRISPR for LEPROT
miRNA for LEPROT Gene
- miRTarBase miRNAs that target LEPROT
-
- hsa-miR-340-5p (MIRT019548)
- hsa-miR-548d-3p (MIRT074954)
- hsa-miR-548m (MIRT074955)
- hsa-miR-548h-3p (MIRT074956)
- hsa-miR-548z (MIRT074958)
- hsa-miR-548ac (MIRT074959)
- hsa-miR-4678 (MIRT074963)
- hsa-miR-5011-5p (MIRT074964)
- hsa-miR-548as-3p (MIRT074965)
- hsa-miR-548bb-3p (MIRT074967)
- hsa-miR-548t-5p (MIRT074978)
- hsa-miR-548az-5p (MIRT074980)
- hsa-miR-142-5p (MIRT195286)
- hsa-miR-126-5p (MIRT195287)
- hsa-miR-559 (MIRT195288)
- hsa-miR-548b-5p (MIRT195289)
- hsa-miR-548a-5p (MIRT195291)
- hsa-miR-548c-5p (MIRT195292)
- hsa-miR-548d-5p (MIRT195293)
- hsa-miR-548j-5p (MIRT195294)
- hsa-miR-548k (MIRT195295)
- hsa-miR-548l (MIRT195296)
- hsa-miR-548h-5p (MIRT195297)
- hsa-miR-548i (MIRT195298)
- hsa-miR-548w (MIRT195299)
- hsa-miR-548y (MIRT195300)
- hsa-miR-548o-5p (MIRT195301)
- hsa-miR-548ab (MIRT195302)
- hsa-miR-548ad-5p (MIRT195303)
- hsa-miR-548ae-5p (MIRT195304)
- hsa-miR-548ak (MIRT195305)
- hsa-miR-4528 (MIRT195306)
- hsa-miR-548am-5p (MIRT195307)
- hsa-miR-548ap-5p (MIRT195308)
- hsa-miR-548aq-5p (MIRT195309)
- hsa-miR-548ar-5p (MIRT195310)
- hsa-miR-548as-5p (MIRT195311)
- hsa-miR-548au-5p (MIRT195312)
- hsa-miR-5590-3p (MIRT195313)
- hsa-miR-548av-5p (MIRT195314)
- hsa-miR-548ay-5p (MIRT195315)
- hsa-miR-8054 (MIRT195317)
- hsa-miR-548bb-5p (MIRT195318)
- hsa-miR-6830-3p (MIRT556588)
- hsa-miR-302a-5p (MIRT556589)
- hsa-miR-410-3p (MIRT556590)
- hsa-miR-4796-3p (MIRT556591)
- hsa-miR-93-5p (MIRT556592)
- hsa-miR-526b-3p (MIRT556593)
- hsa-miR-519d-3p (MIRT556594)
- hsa-miR-20b-5p (MIRT556595)
- hsa-miR-20a-5p (MIRT556596)
- hsa-miR-17-5p (MIRT556597)
- hsa-miR-106b-5p (MIRT556598)
- hsa-miR-106a-5p (MIRT556599)
- hsa-miR-4799-5p (MIRT566945)
- hsa-miR-4477a (MIRT566947)
- hsa-miR-4282 (MIRT566948)
- hsa-miR-548c-3p (MIRT566949)
- hsa-miR-4652-3p (MIRT702278)
- hsa-miR-4743-3p (MIRT702279)
- hsa-miR-6833-5p (MIRT702280)
- hsa-miR-376b-3p (MIRT702281)
- hsa-miR-376a-3p (MIRT702282)
- hsa-miR-3190-3p (MIRT702283)
- hsa-miR-4705 (MIRT702284)
- hsa-miR-4760-3p (MIRT702285)
- hsa-miR-4327 (MIRT768674)
- hsa-miR-455-3p (MIRT770352)
- hsa-miR-6499-3p (MIRT776292)
- hsa-miR-6516-5p (MIRT777149)
- hsa-miR-6807-5p (MIRT779585)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LEPROT
- Browse OriGene Inhibitory RNA Products For LEPROT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEPROT
Clone Products
- Applied Biological Materials (abm): Clones for LEPROT - Select products 50% OFF >
- * LEPROT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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- MG200755
- MR200755
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- MR200755L4
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- RC208878L2
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- RC230913
- RC230913L3
- RC230913L4
- RC230979
- RC230979L3
- RC230979L4
- RG208878
- RG230913
- RG230979
- RR200981
- RR200981L3
- RR200981L4
- MR200755L3V
- MR200755L4V
- RC208878L1V
- RC208878L2V
- RC208878L3V
- RC208878L4V
- RC230913L3V
- RC230913L4V
- RC230979L3V
- RC230979L4V
- RR200981L3V
- RR200981L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LEPROT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LEPROT
Cell Line Products
-
Horizon Cell Lines for LEPROT
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LEPROT Gene
Localization for LEPROT Gene
Subcellular locations from UniProtKB/Swiss-Prot for LEPROT Gene
- Golgi apparatus membrane. Multi-pass membrane protein. Endosome membrane.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| golgi apparatus | 5 |
| plasma membrane | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Centrosome (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005768 | endosome | IBA,IDA | 18042720 |
| GO:0005794 | Golgi apparatus | IEA,IDA | 18042720 |
| GO:0010008 | endosome membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for LEPROT Gene
Interacting Proteins for LEPROT Gene
Selected Interacting proteins:
O15243-OBRG_HUMAN
ENSP00000483521
for LEPROT Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LEPROT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway | IBA | 21873635 |
| GO:0046426 | negative regulation of JAK-STAT cascade | IBA,IDA | 18042720 |
| GO:0060400 | negative regulation of growth hormone receptor signaling pathway | IBA,IDA | 19907080 |
| GO:1903955 | positive regulation of protein targeting to mitochondrion | HMP | 24270810 |
| GO:2000009 | negative regulation of protein localization to cell surface | IBA,IDA | 18042720 |
No data available for Pathways by source and SIGNOR curated interactions for LEPROT Gene
Transcripts for LEPROT Gene
mRNA/cDNA for LEPROT Gene
- 3 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000371065 4541 nts (view in UCSC)
- ENST00000475108 492 nts (view in UCSC)
- ENST00000484243 549 nts (view in UCSC)
- ENST00000488747 345 nts (view in UCSC)
- ENST00000497874 377 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LEPROT - Select products 50% OFF >
- * LEPROT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LEPROT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LEPROT
-
Santa Cruz Biotechnology (SCBT) CRISPR for LEPROT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LEPROT
- Browse OriGene Inhibitory RNA Products For LEPROT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEPROT
Clone Products
- Applied Biological Materials (abm): Clones for LEPROT - Select products 50% OFF >
- * LEPROT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200755
- MR200755
- MR200755L3
- MR200755L4
- RC208878
- RC208878L1
- RC208878L2
- RC208878L3
- RC208878L4
- RC230913
- RC230913L3
- RC230913L4
- RC230979
- RC230979L3
- RC230979L4
- RG208878
- RG230913
- RG230979
- RR200981
- RR200981L3
- RR200981L4
- MR200755L3V
- MR200755L4V
- RC208878L1V
- RC208878L2V
- RC208878L3V
- RC208878L4V
- RC230913L3V
- RC230913L4V
- RC230979L3V
- RC230979L4V
- RR200981L3V
- RR200981L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LEPROT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LEPROT
Relevant External Links for LEPROT Gene
- GeneLoc Exon Structure for
- LEPROT
Expression for LEPROT Gene
This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Pancreas (12.5), and Spinal cord (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LEPROT Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LEPROT
SOURCE GeneReport for Unigene cluster for LEPROT Gene:
Hs.23581mRNA Expression by UniProt/SwissProt for LEPROT Gene:
O15243-OBRG_HUMAN
Tissue specificity:
Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for LEPROT Gene
- Muscle(4.4)
- Nervous system(3.3)
- Pancreas(2.9)
- Lung(2.4)
- Liver(2.2)
- Kidney(2.1)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for LEPROT
-
OriGene qPCR primer pairs and template standards for LEPROT
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LEPROT Gene
Orthologs for LEPROT Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LEPROT 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LEPROT 31 |
|
OneToOne | |
| LOC609115 30 |
|
||||
| Cow (Bos Taurus) |
Mammalia | LEPROT 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Leprot 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Leprot 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LEPROT 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LEPROT 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LEPROT 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | LEPROT 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | leprot 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | leprot 30 |
|
||
| LEPROT 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG30423 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | C30B5.2 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS55 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for LEPROT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for LEPROT Gene
- ENSEMBL:
- Gene Tree for LEPROT (if available)
- TreeFam:
- Gene Tree for LEPROT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LEPROT: view image
Paralogs for LEPROT Gene
Variants for LEPROT Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LEPROT Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 724943 | Likely Benign: not provided | 65,421,440(+) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 873955 | Uncertain Significance: Leptin receptor deficiency | 65,420,675(+) | C/A | FIVE_PRIME_UTR_VARIANT | |
| 874897 | Uncertain Significance: Leptin receptor deficiency | 65,425,348(+) | T/G | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| rs13306523 | Conflicting Interpretations: Leptin receptor deficiency; Monogenic Non-Syndromic Obesity; not provided | 65,425,307(+) | C/T | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| rs189950527 | Uncertain Significance: Leptin receptor deficiency; Monogenic Non-Syndromic Obesity | 65,420,717(+) | C/T | FIVE_PRIME_UTR_VARIANT |
Residual Variation Intolerance Score:
46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.14;
3.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LEPROT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LEPROT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEPROT Gene
Disorders for LEPROT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leptin receptor deficiency |
|
|
| syndromic obesity |
|
|
| leptin deficiency or dysfunction |
|
|
| body mass index quantitative trait locus 11 |
|
Search LEPROT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LEPROT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LEPROT Gene
Publications for LEPROT Gene
- The leptin receptor promoter controls expression of a second distinct protein. (PMID: 9207021) Bailleul B … Strosberg AD (Nucleic acids research 1997) 2 3 4 23
- LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. (PMID: 19907080) Touvier T … Bailleul B (The Journal of clinical investigation 2009) 3 4 23
- Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. (PMID: 18042720) Couturier C … Jockers R (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 23
- Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. (PMID: 21454707) Séron K … Rouillé Y (The Journal of biological chemistry 2011) 2 3
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
ExternalLinks
Products for LEPROT Gene
- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for LEPROT
- Search Origene for MassSpec and Protein Over-expression Lysates for LEPROT
- Origene Custom Protein Services for LEPROT
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LEPROT
- Browse OriGene Inhibitory RNA Products For LEPROT
- OriGene qPCR primer pairs for LEPROT
- OriGene qPCR primer pairs and template standards for LEPROT
- OriGene CRISPR knockouts for LEPROT
- MG200755
- MR200755
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- MR200755L4
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- RC230979L4V
- RR200981L3V
- RR200981L4V
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- antibodies-online: Show 56 available LEPROT Antibodies ranked by validation data
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Sources for LEPROT Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (30) HomoloGene
- (31) PanEnsembl
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- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (52) OriGene
- (53) PubMed
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (86) PaxDb
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- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
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- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (115) NCBI Bookshelf
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB