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This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in... See more...
Aliases for LEP Gene
Aliases for LEP Gene
External Ids for LEP Gene
- HGNC: 6553
- Entrez Gene: 3952
- Ensembl: ENSG00000174697
- OMIM: 164160
- UniProtKB: P41159
Previous HGNC Symbols for LEP Gene
- OBS
- OB
Previous GeneCards Identifiers for LEP Gene
- GC07P126358
- GC07P127421
- GC07P127435
- GC07P127475
- GC07P127668
- GC07P127881
- GC07P122242
Summaries for LEP Gene
-
This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Aug 2017]
GeneCards Summary for LEP Gene
LEP (Leptin) is a Protein Coding gene. Diseases associated with LEP include Leptin Deficiency Or Dysfunction and Eating Disorder. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and peptide hormone receptor binding.
UniProtKB/Swiss-Prot Summary for LEP Gene
-
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689).
-
Leptin was initially thought to have a role in energy homeostasis and obesity. It acts via leptin receptors (Ob-Rs), which are transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. There are six isoforms of Ob-R.
Additional gene information for LEP Gene
- HGNC(6553)
- Entrez Gene(3952)
- Ensembl(ENSG00000174697)
- OMIM(164160)
- UniProtKB(P41159)
- Open Targets Platform(ENSG00000174697)
- Monarch Initiative
- Search for LEP at DataMed
- Search for LEP at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LEP Gene
Genomics for LEP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LEP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LEP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LEP
- Top Transcription factor binding sites by QIAGEN in the LEP gene promoter:
-
- AP-1
- AP-2gamma
- AREB6
- ATF-2
- c-Jun
- C/EBPbeta
- GR
- GR-alpha
- GR-beta
Genomic Locations for LEP Gene
Genomic Locations for LEP Gene
- chr7:128,241,201-128,257,629
- (GRCh38/hg38)
- Size:
- 16,429 bases
- Orientation:
- Plus strand
- chr7:127,881,331-127,897,682
- (GRCh37/hg19)
- Size:
- 16,352 bases
- Orientation:
- Plus strand
Genomic View for LEP Gene
Genes around LEP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q32.1 by HGNC
- 7q32.1 by Entrez Gene
- 7q32.1 by Ensembl
LEP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LEP Gene
Proteins for LEP Gene
-
Protein details for LEP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41159-LEP_HUMAN
- Recommended name:
- Leptin
- Protein Accession:
- P41159
- O15158
- Q56A88
Protein attributes for LEP Gene
- Size:
- 167 amino acids
- Molecular mass:
- 18641 Da
- Quaternary structure:
-
- Interacts with SIGLEC6.
Protein Expression for LEP Gene
Post-translational modifications for LEP Gene
Other Protein References for LEP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Ob Antibody
- RayBiotech Rabbit anti-Leptin
- BioLegend Leptin Antibody
-
Custom Antibody ServicesOriGene Antibodies for LEP
- 2LE1-3G7
- 2LE1-4F12
- AM01365PU-N
- AP01127BT-N
- AP01127BT-S
- AP01127PU-N
- AP01127PU-S
- AP05456PU-N
- AP07406PU-N
- AP09197PU-N
- AP13112PU-N
- AP20617PU-N
- AP52465PU-N
- DM2007
- DP2000
- DP2001
- DP2013
- PP050B1
- PP050B2
- PP050P1
- PP050P2
- PP1041B1
- PP1041B2
- PP1041P1
- PP1041P2
- TA319080
- TA321088
- TA321089
- TA328366
- TA328367
- TA328528
- TA328529
- TA332832
- TA346170
- TA346171
- TA346994
- TA346995
- TA350133
- Novus Biologicals Antibodies for LEP
-
Abcam antibodies for LEP
- Invitrogen Antibodies for LEP (AFLGC-Lep)
- antibodies-online: Show 212 available Leptin Antibodies ranked by validation data
- Compare Top Leptin Antibodies
-
Recommended
- 114 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 283 WB Antibodies (anti-human)
- 25 IHC Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 MA Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 95 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 9 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 2 RIA Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- 1 FACS Antibody (anti-rat)
- Sino Biological Antibodies for LEP
Protein Products
- G Biosciences Human Leptin, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for LEP
- Origene Custom Protein Services for LEP
- Sino Biological Recombinant Proteins for LEP
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for LEP
-
ProSci Proteins for LEP
-
Abcam proteins for LEP
Assay Products
- RayBiotech Human Leptin ELISA
-
Custom Assay ServicesOriGene ELISA Kits for LEP
- Novus Biologicals ELISA Kits for LEP
- antibodies-online: Show 212 available Leptin Elisa Kits ranked by validation data
- Compare Top Leptin Elisa Kits
-
Quality Products:
- ABIN365165
- ABIN6574137
- ABIN625035
- ABIN411318
- ABIN1115746
- ABIN414890
- ABIN612724
- ABIN1029096
- ABIN1888530
- ABIN2684852
- ABIN625156
- ABIN1115745
- ABIN365180
- ABIN415517
- ABIN612800
- ABIN5520826
- ABIN455676
- ABIN956062
- ABIN2506965
- ABIN491793
- ABIN1115747
- ABIN625206
- ABIN365192
- ABIN416359
- ABIN1571014
- ABIN3032875
- ABIN5520829
- ABIN2684854
- ABIN5670483
- ABIN2801455
- ABIN843184
- ABIN5665014
- ABIN5520830
- ABIN1055553
- ABIN6205137
- ABIN6205138
- ABIN5074483
-
Abcam assays for LEP
- Sino Biological Assays for LEP
No data available for DME Specific Peptides for LEP Gene
Domains & Families for LEP Gene
Gene Families for LEP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for LEP Gene
- InterPro:
- Blocks:
-
- Obesity factor (leptin) signature
- ProtoNet:
Suggested Antigen Peptide Sequences for LEP Gene
- GenScript: Design optimal peptide antigens:
-
- Leptin (Obesity homolog, mouse) (A4D0Y8_HUMAN)
- Leptin (D3HIE0_HUMAN)
- Obesity factor (LEP_HUMAN)
- Leptin (Q6NT58_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P41159- Family:
-
- Belongs to the leptin family.
Function for LEP Gene
Molecular function for LEP Gene
- UniProtKB/Swiss-Prot Function:
- Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689).
- UniProtKB/Swiss-Prot Induction:
- Induced by secretin.
- GENATLAS Biochemistry:
- leptin,adipocyte-specific secreted protein,18.6kDa,controlling the size of adipose depot by a profound effect of appen appetite and energy expenditure,also involved in control of the hypothalamic-pituitary-gonadal (HPG) axis,also putative angiogenic factor,homolog of the murine obese gene (ob)
LifeMap Function Summary for LEP Gene
During embryonic development, LEP as signaling molecule is secreted from the following cells
-
Adipose
- Subcutaneous White Adipocytes (Facial Subcutaneous White Adipose)
- Subcutaneous White Adipocytes (Cranial Subcutaneous White Adipose)
- Subcutaneous White Adipocytes (Subcutaneous White Adipose)
- Subcutaneous White Adipocytes (Body Subcutaneous White Adipose)
- Subcutaneous White Preadipocytes (Subcutaneous White Adipose)
- Visceral White Adipocytes (Visceral White Adipose)
Phenotypes From GWAS Catalog for LEP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005179 | hormone activity | IBA | 21873635 |
| GO:0051428 | peptide hormone receptor binding | IBA | 21873635 |
| GO:1990460 | leptin receptor binding | IDA | 27037668 |
Phenotypes for LEP Gene
- MGI mutant phenotypes for LEP:
-
inferred from 9 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for LEP:
Animal Models for LEP Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LEP - Select products 50% OFF >
- * LEP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LEP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LEP
-
Santa Cruz Biotechnology (SCBT) CRISPR for LEP
miRNA for LEP Gene
- miRTarBase miRNAs that target LEP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LEP
- Browse OriGene Inhibitory RNA Products For LEP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEP
Clone Products
- Applied Biological Materials (abm): Clones for LEP - Select products 50% OFF >
- * LEP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LEP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LEP
Cell Line Products
-
Horizon Cell Lines for LEP
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LEP Gene
Localization for LEP Gene
Subcellular locations from UniProtKB/Swiss-Prot for LEP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| peroxisome | 3 |
| endoplasmic reticulum | 3 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LEP Gene
Pathways & Interactions for LEP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 2 | Incretin synthesis, secretion, and inactivation | ||
| 3 | Peptide hormone metabolism | ||
| 4 | Adipocytokine signaling pathway | ||
| 5 | PEDF Induced Signaling | ||
Pathways by source for LEP Gene
1 Sino Biological pathway for LEP Gene
9 BioSystems pathways for LEP Gene
9 Reactome pathways for LEP Gene
1 PharmGKB pathway for LEP Gene
6 KEGG pathways for LEP Gene
2 GeneGo (Thomson Reuters) pathways for LEP Gene
- Development_Leptin signaling via JAK/STAT and MAPK cascades
- Development_Leptin signaling via PI3K-dependent pathway
2 R&D Systems pathways for LEP Gene
1 Qiagen pathway for LEP Gene
- AMPK Enzyme Complex Pathway
Interacting Proteins for LEP Gene
Selected Interacting proteins:
P41159-LEP_HUMAN
ENSP00000312652
for LEP Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LEP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0001525 | angiogenesis | IDA | 19910644 |
| GO:0001542 | ovulation from ovarian follicle | IEA | -- |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001819 | positive regulation of cytokine production | IEA | -- |
Drugs & Compounds for LEP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Olanzapine | Approved, Investigational | Pharma | Antagonist, Agonist, Full agonist, Inverse agonist | 442 | ||
| Risperidone | Approved, Investigational | Pharma | Antagonist, Inverse agonist | SR-2A inhibitor | 532 | |
| Androstenedione | Experimental, Illicit | Pharma | 0 | |||
| LEP (116-130) (mouse) | Pharma | An antiobesity hormone, Synthetic leptin peptide fragment | 0 | |||
| antipsychotics | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) Tocris Compounds for LEP Gene
| Compound | Action | Cas Number |
|---|---|---|
| LEP (116-130) (mouse) | Synthetic leptin peptide fragment | 258276-95-8 |
(1) ApexBio Compounds for LEP Gene
| Compound | Action | Cas Number |
|---|---|---|
| LEP (116-130) (mouse) | An antiobesity hormone | 258276-95-8 |
Transcripts for LEP Gene
mRNA/cDNA for LEP Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308868 3427 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LEP - Select products 50% OFF >
- * LEP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LEP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LEP
-
Santa Cruz Biotechnology (SCBT) CRISPR for LEP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LEP
- Browse OriGene Inhibitory RNA Products For LEP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEP
Clone Products
- Applied Biological Materials (abm): Clones for LEP - Select products 50% OFF >
- * LEP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LEP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LEP
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: |
Relevant External Links for LEP Gene
- GeneLoc Exon Structure for
- LEP
Expression for LEP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Subcutaneous White Adipocytes Subcutaneous White Adipose
- Subcutaneous White Adipocytes Cranial Subcutaneous White Adipose
- Subcutaneous White Adipocytes Facial Subcutaneous White Adipose
- Visceral White Adipocytes Visceral White Adipose
- Subcutaneous White Adipocytes Body Subcutaneous White Adipose
- Umbilical Cord (Extraembryonic Tissues)
- Brain (Nervous System)
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
-
Placenta (Extraembryonic Tissues)
-
Breast (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for LEP Gene
This gene is overexpressed in Adipose - Subcutaneous (x28.2), Adipose - Visceral (Omentum) (x12.3), and Breast - Mammary Tissue (x7.1).
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LEP Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LEP
SOURCE GeneReport for Unigene cluster for LEP Gene:
Hs.194236mRNA Expression by UniProt/SwissProt for LEP Gene:
P41159-LEP_HUMAN
Tissue specificity:
Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907).
Evidence on tissue expression from TISSUES for LEP Gene
- Blood(3.8)
- Nervous system(3.7)
- Intestine(3.5)
- Liver(3.5)
- Heart(3.5)
- Muscle(3.5)
- Pancreas(3.4)
- Skin(3.2)
- Adrenal gland(3.1)
- Stomach(3)
- Thyroid gland(3)
- Kidney(3)
- Bone(2.9)
- Urine(2.6)
- Bone marrow(2.6)
- Spleen(2.5)
- Lung(2.5)
- Gall bladder(2.4)
- Lymph node(2.3)
- Saliva(2.1)
- Eye(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LEP Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- endocrine
- immune
- integumentary
- nervous
- reproductive
- respiratory
Regions:
Head and neck:
- brain
- head
- larynx
- neck
- pharynx
- pituitary gland
Thorax:
- breast
- lung
- trachea
Pelvis:
- ovary
- penis
- prostate
- testicle
- uterus
- vagina
- vulva
General:
- blood
- hair
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for LEP
-
OriGene qPCR primer pairs and template standards for LEP
Gene Expression Assay Products
Orthologs for LEP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LEP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LEP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LEP 30 |
|
||
| OB 31 |
|
OneToOne | |||
| Rat (Rattus norvegicus) |
Mammalia | Lep 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Lep 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LEP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LEP 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486715 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lepa 31 |
|
OneToOne |
- Species where no ortholog for LEP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for LEP Gene
- ENSEMBL:
- Gene Tree for LEP (if available)
- TreeFam:
- Gene Tree for LEP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LEP: view image
Paralogs for LEP Gene
No data available for Paralogs for LEP Gene
Variants for LEP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LEP Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 724209 | Conflicting Interpretations: Leptin deficiency or dysfunction; not provided | 128,254,424(+) | G/A | SYNONYMOUS_VARIANT | |
| 741430 | Likely Benign: not provided | 128,252,033(+) | C/G | SYNONYMOUS_VARIANT | |
| 778362 | Benign: not provided | 128,252,093(+) | A/G | SYNONYMOUS_VARIANT | |
| 783831 | Benign: not provided | 128,254,568(+) | C/T | SYNONYMOUS_VARIANT | |
| 908787 | Uncertain Significance: Leptin deficiency or dysfunction | 128,256,081(+) | G/C | THREE_PRIME_UTR_VARIANT |
Residual Variation Intolerance Score:
56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.22;
24.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LEP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEP Gene
Disorders for LEP Gene
(160) MalaCards diseases for LEP Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leptin deficiency or dysfunction |
|
|
| eating disorder |
|
|
| glucose intolerance |
|
|
| apnea, obstructive sleep |
|
|
| bulimia nervosa |
|
Search LEP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LEP_HUMAN- Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. {ECO:0000269 PubMed:25551525, ECO:0000269 PubMed:9500540}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LEP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for LEP Gene
Publications for LEP Gene
- Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa. (PMID: 20140086) Okpechi IG … Ramesar R (PloS one 2010) 3 23 41
- G(-2548)A leptin gene polymorphism in obese subjects is associated with serum leptin concentration and bone mass. (PMID: 20502402) Franek E … Wiecek A (Polskie Archiwum Medycyny Wewnetrznej 2010) 3 23 41
- Leptin gene (TTTC)(n) microsatellite polymorphism as well as leptin receptor R223Q and PPARgamma2 P12A substitutions are not associated with hypertensive disorders in pregnancy. (PMID: 20070288) Wiedemann A … Toth B (American journal of reproductive immunology (New York, N.Y. : 1989) 2010) 3 23 41
- Genotype x nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake. (PMID: 19747414) Bienertová-Vasků J … Vasků A (The British journal of nutrition 2010) 3 23 41
- Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. (PMID: 19697123) Cleveland RJ … Santella RM (Breast cancer research and treatment 2010) 3 23 41
ExternalLinks
Products for LEP Gene
- View all 18 R&D Systems LEP (Leptin/OB) Products
- View all R&D Systems LEP (Leptin/OB) Proteins and Enzymes
- View all 7 R&D Systems LEP (Leptin/OB) Primary Antibodies
- View all 3 R&D Systems LEP (Leptin/OB) ELISAs
- View all R&D Systems LEP (Leptin/OB) Simple Plex Assays
- View all 2 R&D Systems LEP (Leptin/OB) Luminex Assays
- View all 4 R&D Systems LEP (Leptin/OB) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom LEP antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for LEP
- 2LE1-3G7
- 2LE1-4F12
- AM01365PU-N
- AP01127BT-N
- AP01127BT-S
- AP01127PU-N
- AP01127PU-S
- AP05456PU-N
- AP07406PU-N
- AP09197PU-N
- AP13112PU-N
- AP20617PU-N
- AP52465PU-N
- DM2007
- DP2000
- DP2001
- DP2013
- PP050B1
- PP050B2
- PP050P1
- PP050P2
- PP1041B1
- PP1041B2
- PP1041P1
- PP1041P2
- TA319080
- TA321088
- TA321089
- TA328366
- TA328367
- TA328528
- TA328529
- TA332832
- TA346170
- TA346171
- TA346994
- TA346995
- TA350133
- Custom Assay ServicesOriGene ELISA Kits for LEP
- Search Origene for MassSpec and Protein Over-expression Lysates for LEP
- Origene Custom Protein Services for LEP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LEP
- Browse OriGene Inhibitory RNA Products For LEP
- OriGene qPCR primer pairs for LEP
- OriGene qPCR primer pairs and template standards for LEP
- OriGene CRISPR knockouts for LEP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LEP
- Sino Biological Human cDNA Clone for LEP
- Sino Biological Recombinant Proteins for LEP
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for LEP
- Sino Biological Assays for LEP
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LEP
- Novus Biologicals proteins and lysates for LEP
- Novus Biologicals ELISA Kits for LEP
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for LEP
- Abcam proteins for LEP
- Abcam assays for LEP
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for LEP
- VectorBuilder Custom and pre-made DNA vectors for LEP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for LEP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for LEP (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for LEP CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LEP
- antibodies-online: Show 212 available Leptin Antibodies ranked by validation data
- Compare Top Leptin Antibodies
- Recommended
- 114 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 283 WB Antibodies (anti-human)
- 25 IHC Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 MA Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 95 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 9 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 2 RIA Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- 1 FACS Antibody (anti-rat)
- antibodies-online: Show 212 available Leptin Elisa Kits ranked by validation data
- Compare Top Leptin Elisa Kits
- Quality Products:
- ABIN365165
- ABIN6574137
- ABIN625035
- ABIN411318
- ABIN1115746
- ABIN414890
- ABIN612724
- ABIN1029096
- ABIN1888530
- ABIN2684852
- ABIN625156
- ABIN1115745
- ABIN365180
- ABIN415517
- ABIN612800
- ABIN5520826
- ABIN455676
- ABIN956062
- ABIN2506965
- ABIN491793
- ABIN1115747
- ABIN625206
- ABIN365192
- ABIN416359
- ABIN1571014
- ABIN3032875
- ABIN5520829
- ABIN2684854
- ABIN5670483
- ABIN2801455
- ABIN843184
- ABIN5665014
- ABIN5520830
- ABIN1055553
- ABIN6205137
- ABIN6205138
- ABIN5074483
- antibodies-online: Show 175 available Leptin Proteins ranked by validation data
- Compare Top Leptin Proteins
- Search Santa Cruz Biotechnology (SCBT) for LEP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LEP
- Horizon Cell Lines for LEP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LEP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LEP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LEP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEP
Sources for LEP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB