Aliases for LENG9 Gene

Aliases for LENG9 Gene

  • Leukocyte Receptor Cluster Member 9 2 3 4 5
  • Leukocyte Receptor Cluster (LRC) Member 9 2 3
  • LENG9 5

External Ids for LENG9 Gene

Previous GeneCards Identifiers for LENG9 Gene

  • GC19M055835
  • GC19M055397
  • GC19M059649
  • GC19U900046
  • GC19M059664
  • GC19M054972
  • GC19M051297

Summaries for LENG9 Gene

GeneCards Summary for LENG9 Gene

LENG9 (Leukocyte Receptor Cluster Member 9) is a Protein Coding gene. Diseases associated with LENG9 include Shipyard Eye. An important paralog of this gene is NUP42.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LENG9 Gene

Genomics for LENG9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LENG9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054459 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.7 -3.2 -3245 14.7 EZH2 SP1 ZNF207 ZNF600 MYC ZNF592 POLR2A ZNF223 NFIC ZIC2 CDC42EP5 LENG8-AS1 ENSG00000267838 PRPF31 LENG9 MYADM LENG8 TTYH1 CNOT3 KMT5C
GH19J054448 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14 +14.5 14471 4.6 BCLAF1 SP1 ZNF207 ZNF600 IKZF1 NCOR1 MYC ZNF580 ZNF592 ATF2 LENG8-AS1 LENG8 HSALNG0127531 PRPF31 CNOT3 ENSG00000267838 LENG9 MYADM KMT5C LENG1
GH19J054451 Enhancer 0.9 ENCODE dbSUPER 0.4 +11.9 11939 0.2 ZIC2 FEZF1 MAFF ZNF316 ZNF843 PRDM6 MAFK ZNF24 MAFG ZNF362 lnc-LENG9-4 PRPF31 LENG1 LENG8-AS1 PPP1R12C LENG8 LENG9
GH19J054452 Enhancer 0.7 ENCODE dbSUPER 0.4 +11.7 11699 0.2 ZNF362 ZNF518A SP7 ZBTB12 ZNF324 ZXDB ZNF660 CBFA2T3 ZNF184 lnc-LENG9-4 LENG8 LENG8-AS1 LENG9
GH19J054457 Enhancer 0.5 dbSUPER 0.4 +5.1 5060 1.5 ZIC2 RARA GLIS1 POLR2A CREB1 GLIS2 RBFOX2 EP300 LENG8-AS1 NONHSAG026526.2 LENG9 lnc-LENG9-4 LENG8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LENG9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LENG9

Top Transcription factor binding sites by QIAGEN in the LENG9 gene promoter:
  • AP-4
  • LyF-1
  • NF-E2
  • NF-E2 p45
  • NRSF form 1
  • NRSF form 2
  • p300
  • Pax-5
  • PPAR-alpha
  • Spz1

Genomic Locations for LENG9 Gene

Latest Assembly
chr19:54,461,732-54,463,778
(GRCh38/hg38)
Size:
2,047 bases
Orientation:
Minus strand

Previous Assembly
chr19:54,972,912-54,974,961
(GRCh37/hg19 by Entrez Gene)
Size:
2,050 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr19(ALT_REF_LOCI_1):368,246-370,292 (-)
  • chr19(ALT_REF_LOCI_7):366,420-368,469 (-)
  • chr19(ALT_REF_LOCI_9):444,026-446,075 (-)

Genomic View for LENG9 Gene

Genes around LENG9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG9 Gene

Proteins for LENG9 Gene

  • Protein details for LENG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B70-LENG9_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 9
    Protein Accession:
    Q96B70
    Secondary Accessions:
    • B2VAM3

    Protein attributes for LENG9 Gene

    Size:
    501 amino acids
    Molecular mass:
    53167 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15921.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for LENG9 Gene

Post-translational modifications for LENG9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LENG9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LENG9 Gene

Domains & Families for LENG9 Gene

Gene Families for LENG9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LENG9 Gene

InterPro:
Blocks:
  • Zn-finger, C-x8-C-x5-C-x3-H type

Suggested Antigen Peptide Sequences for LENG9 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte receptor cluster (LRC) member 9 (B0VJZ1_HUMAN)
  • Leukocyte receptor cluster member 9 (LENG9_HUMAN)
genes like me logo Genes that share domains with LENG9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LENG9 Gene

Function for LENG9 Gene

Phenotypes From GWAS Catalog for LENG9 Gene

Gene Ontology (GO) - Molecular Function for LENG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LENG9: view
genes like me logo Genes that share phenotypes with LENG9: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LENG9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG9 Gene

Localization for LENG9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LENG9 gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LENG9 Gene

Pathways & Interactions for LENG9 Gene

PathCards logo

SuperPathways for LENG9 Gene

No Data Available

Interacting Proteins for LENG9 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q96B70-LENG9_HUMAN ENSP00000479355 for LENG9 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for LENG9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LENG9 Gene

Drugs & Compounds for LENG9 Gene

No Compound Related Data Available

Transcripts for LENG9 Gene

mRNA/cDNA for LENG9 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LENG9

Alternative Splicing Database (ASD) splice patterns (SP) for LENG9 Gene

No ASD Table

Relevant External Links for LENG9 Gene

GeneLoc Exon Structure for
LENG9

Expression for LENG9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LENG9 Gene

mRNA expression in normal human tissues for LENG9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LENG9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.3), Islet of Langerhans (12.2), Heart (9.9), Pancreas (6.9), and Saliva (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LENG9 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LENG9

SOURCE GeneReport for Unigene cluster for LENG9 Gene:

Hs.590976

Evidence on tissue expression from TISSUES for LENG9 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with LENG9: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LENG9 Gene

Orthologs for LENG9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LENG9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LENG9 29
  • 99.23 (n)
Cow
(Bos Taurus)
Mammalia LENG9 29
  • 76.25 (n)
Mouse
(Mus musculus)
Mammalia Leng9 29 16
  • 69.73 (n)
Rat
(Rattus norvegicus)
Mammalia LOC100912286 29
  • 69.51 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100495860 29
  • 49.42 (n)
Zebrafish
(Danio rerio)
Actinopterygii leng9 29
  • 55.98 (n)
Species where no ortholog for LENG9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LENG9 Gene

ENSEMBL:
Gene Tree for LENG9 (if available)
TreeFam:
Gene Tree for LENG9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LENG9: view image
Alliance of Genome Resources:
Additional Orthologs for LENG9

Paralogs for LENG9 Gene

Paralogs for LENG9 Gene

genes like me logo Genes that share paralogs with LENG9: view

Variants for LENG9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LENG9 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10406453 -- p.His153Arg
rs10423424 -- p.Arg499Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LENG9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LENG9 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
esv2758771 CNV gain+loss 17122850
nsv1148744 OTHER inversion 26484159
nsv833878 CNV loss 17160897
nsv953617 CNV deletion 24416366

Variation tolerance for LENG9 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.75; 95.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LENG9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LENG9
Leiden Open Variation Database (LOVD)
LENG9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG9 Gene

Disorders for LENG9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LENG9 Gene - From: COP

Disorder Aliases PubMed IDs
shipyard eye
  • ekc
- elite association - COSMIC cancer census association via MalaCards
Search LENG9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LENG9

genes like me logo Genes that share disorders with LENG9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LENG9 Gene

Publications for LENG9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for LENG9 Gene

Sources for LENG9 Gene