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Aliases for LENG9 Gene

Aliases for LENG9 Gene

  • Leukocyte Receptor Cluster Member 9 2 3 3 5
  • Leukocyte Receptor Cluster (LRC) Member 9 2 3

External Ids for LENG9 Gene

Previous GeneCards Identifiers for LENG9 Gene

  • GC19M055835
  • GC19M055397
  • GC19M059649
  • GC19U900046
  • GC19M059664
  • GC19M054972
  • GC19M051297

Summaries for LENG9 Gene

GeneCards Summary for LENG9 Gene

LENG9 (Leukocyte Receptor Cluster Member 9) is a Protein Coding gene.

Additional gene information for LENG9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LENG9 Gene

Genomics for LENG9 Gene

GeneHancer (GH) Regulatory Elements for LENG9 Gene

Promoters and enhancers for LENG9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054459 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.8 -3.3 -3312 14.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 POLR2B ZNF207 CDC42EP5 LENG8-AS1 CNOT3 LENG8 PRPF31 ENSG00000235681 RPS9 ENSG00000267838 LENG9 TPM3P6
GH19J054447 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14 +14.1 14099 4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LENG8-AS1 GC19M054437 LENG8 LENG1 ENSG00000267838 PRPF31 LENG9 CNOT3 PPP1R12C GC19P054462
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LENG9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LENG9 gene promoter:
  • LyF-1
  • PPAR-alpha
  • NRSF form 2
  • NRSF form 1
  • AP-4
  • p300
  • Spz1
  • Pax-5
  • NF-E2
  • NF-E2 p45

Genomic Locations for LENG9 Gene

Genomic Locations for LENG9 Gene
chr19:54,461,796-54,463,711
(GRCh38/hg38)
Size:
1,916 bases
Orientation:
Minus strand
chr19:54,972,976-54,974,894
(GRCh37/hg19)
Size:
1,919 bases
Orientation:
Minus strand

Genomic View for LENG9 Gene

Genes around LENG9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG9 Gene

Proteins for LENG9 Gene

  • Protein details for LENG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B70-LENG9_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 9
    Protein Accession:
    Q96B70
    Secondary Accessions:
    • B2VAM3

    Protein attributes for LENG9 Gene

    Size:
    501 amino acids
    Molecular mass:
    53167 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15921.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for LENG9 Gene

Post-translational modifications for LENG9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LENG9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LENG9 Gene

Domains & Families for LENG9 Gene

Gene Families for LENG9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LENG9 Gene

Suggested Antigen Peptide Sequences for LENG9 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LENG9: view

No data available for UniProtKB/Swiss-Prot for LENG9 Gene

Function for LENG9 Gene

Gene Ontology (GO) - Molecular Function for LENG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LENG9: view
genes like me logo Genes that share phenotypes with LENG9: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG9 Gene

Localization for LENG9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LENG9 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LENG9 Gene

Pathways & Interactions for LENG9 Gene

SuperPathways for LENG9 Gene

No Data Available

Interacting Proteins for LENG9 Gene

Selected Interacting proteins: Q96B70-LENG9_HUMAN for LENG9 Gene via IID MINT

Gene Ontology (GO) - Biological Process for LENG9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LENG9 Gene

Drugs & Compounds for LENG9 Gene

No Compound Related Data Available

Transcripts for LENG9 Gene

mRNA/cDNA for LENG9 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LENG9 Gene

Leukocyte receptor cluster (LRC) member 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LENG9 Gene

No ASD Table

Relevant External Links for LENG9 Gene

GeneLoc Exon Structure for
LENG9
ECgene alternative splicing isoforms for
LENG9

Expression for LENG9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LENG9 Gene

mRNA expression in normal human tissues for LENG9 Gene

Protein differential expression in normal tissues from HIPED for LENG9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.3), Islet of Langerhans (12.2), Heart (9.9), Pancreas (6.9), and Saliva (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LENG9 Gene



NURSA nuclear receptor signaling pathways regulating expression of LENG9 Gene:

LENG9

SOURCE GeneReport for Unigene cluster for LENG9 Gene:

Hs.590976

Evidence on tissue expression from TISSUES for LENG9 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with LENG9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LENG9 Gene

Orthologs for LENG9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LENG9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LENG9 33
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia LENG9 33
  • 76.25 (n)
mouse
(Mus musculus)
Mammalia Leng9 16 33
  • 69.73 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912286 33
  • 69.51 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495860 33
  • 49.42 (n)
zebrafish
(Danio rerio)
Actinopterygii leng9 33
  • 55.98 (n)
Species where no ortholog for LENG9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LENG9 Gene

ENSEMBL:
Gene Tree for LENG9 (if available)
TreeFam:
Gene Tree for LENG9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LENG9: view image

Paralogs for LENG9 Gene

No data available for Paralogs for LENG9 Gene

Variants for LENG9 Gene

Sequence variations from dbSNP and Humsavar for LENG9 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000015318 -- 54,465,694(-) G/A upstream_transcript_variant
rs1000128531 -- 54,461,898(-) T/C 3_prime_UTR_variant
rs1000338246 -- 54,464,182(-) C/T upstream_transcript_variant
rs1000481171 -- 54,462,022(-) A/G 3_prime_UTR_variant
rs1001362910 -- 54,464,228(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LENG9 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
esv2758771 CNV gain+loss 17122850
nsv1148744 OTHER inversion 26484159
nsv833878 CNV loss 17160897
nsv953617 CNV deletion 24416366

Variation tolerance for LENG9 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.75; 95.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LENG9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LENG9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG9 Gene

Disorders for LENG9 Gene

Additional Disease Information for LENG9

No disorders were found for LENG9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LENG9 Gene

Publications for LENG9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for LENG9 Gene

Sources for LENG9 Gene

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