Aliases for LENG8 Gene

Aliases for LENG8 Gene

  • Leukocyte Receptor Cluster Member 8 2 3 4 5
  • Leukocyte Receptor Cluster (LRC) Member 8 2 3
  • KIAA1932 2 4
  • Pp13842 2 3
  • MGC40108 2
  • LENG8 5

External Ids for LENG8 Gene

Previous GeneCards Identifiers for LENG8 Gene

  • GC19U990238
  • GC19P059636
  • GC19P059652
  • GC19P059651
  • GC19P054960
  • GC19P051284
  • GC19P054448
  • GC19P055372
  • GC19P055609

Summaries for LENG8 Gene

GeneCards Summary for LENG8 Gene

LENG8 (Leukocyte Receptor Cluster Member 8) is a Protein Coding gene. An important paralog of this gene is MCM3AP.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LENG8 Gene

Genomics for LENG8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LENG8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054448 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 264.6 +1.7 1686 4.6 BCLAF1 SP1 ZNF207 ZNF600 IKZF1 NCOR1 MYC ZNF580 ZNF592 ATF2 LENG8-AS1 LENG8 HSALNG0127531 PRPF31 CNOT3 ENSG00000267838 LENG9 MYADM KMT5C LENG1
GH19J055215 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 149.7 +769.1 769084 2.9 SP1 MYC NCOR1 IKZF1 ZNF600 JUND ZNF580 ZNF592 ZMYM3 ATF2 ENSG00000267649 ENSG00000286230 LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ENSG00000267523 SSC5D ZNF580 KMT5C
GH19J054199 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 106.5 -242.0 -242032 12.4 BCLAF1 SP1 ZNF207 ZNF600 NCOR1 MYC IKZF1 SSRP1 ZNF580 ZNF592 RPS9 HSALNG0127488 PRPF31 LENG8-AS1 LENG8 CNOT3 ZNF525 ENSG00000235681 ZNF845 ZNF761
GH19J055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 75.2 +806.2 806238 14.5 BCLAF1 SP1 ZNF207 MYC NCOR1 IKZF1 ZNF600 JUND ZNF580 ZNF592 PPP6R1 LENG8 LENG8-AS1 ENSG00000235681 ZNF581 ENSG00000267523 ZNF628 ENSG00000267096 HSPBP1 RPL28
GH19J055337 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 48.3 +892.3 892290 4.2 SP1 ZNF207 IKZF1 JUND ZNF580 ATF2 CEBPA ZNF223 ZNF10 ATF3 KMT5C ENSG00000276831 HSALNG0127644 LENG8-AS1 LENG8 ENSG00000235681 ENSG00000267523 ENSG00000267096 ZNF580 FAM71E2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LENG8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LENG8

Top Transcription factor binding sites by QIAGEN in the LENG8 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • GATA-1
  • GATA-2
  • HNF-3beta
  • NF-Y
  • NRSF form 1
  • NRSF form 2

Genomic Locations for LENG8 Gene

Latest Assembly
chr19:54,447,621-54,462,022
(GRCh38/hg38)
Size:
14,402 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,960,377-54,973,196
(GRCh37/hg19 by Entrez Gene)
Size:
12,820 bases
Orientation:
Plus strand

chr19:54,960,065-54,973,217
(GRCh37/hg19 by Ensembl)
Size:
13,153 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr19(ALT_REF_LOCI_1):355,711-368,530 (+)
  • chr19(ALT_REF_LOCI_7):353,885-366,704 (+)
  • chr19(ALT_REF_LOCI_9):431,491-444,310 (+)

Genomic View for LENG8 Gene

Genes around LENG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG8 Gene

Proteins for LENG8 Gene

  • Protein details for LENG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PV6-LENG8_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 8
    Protein Accession:
    Q96PV6
    Secondary Accessions:
    • A0A087WTE7
    • B0VJY9
    • Q8IZ27
    • Q8NCX6

    Protein attributes for LENG8 Gene

    Size:
    800 amino acids
    Molecular mass:
    88157 Da
    Quaternary structure:
    • May be part of a SEM1-containing complex.
    SequenceCaution:
    • Sequence=BAB67825.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for LENG8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LENG8 Gene

Post-translational modifications for LENG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LENG8 Gene

Domains & Families for LENG8 Gene

Gene Families for LENG8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LENG8 Gene

InterPro:
Blocks:
  • SAC3/GANP family

Suggested Antigen Peptide Sequences for LENG8 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte receptor cluster (LRC) member 8 (B0VJZ0_HUMAN)
  • Leukocyte receptor cluster member 8 (LENG8_HUMAN)
genes like me logo Genes that share domains with LENG8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LENG8 Gene

Function for LENG8 Gene

Phenotypes From GWAS Catalog for LENG8 Gene

Gene Ontology (GO) - Molecular Function for LENG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with LENG8: view
genes like me logo Genes that share phenotypes with LENG8: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LENG8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG8 Gene

Localization for LENG8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LENG8 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LENG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with LENG8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LENG8 Gene

Pathways & Interactions for LENG8 Gene

PathCards logo

SuperPathways for LENG8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LENG8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LENG8 Gene

Drugs & Compounds for LENG8 Gene

No Compound Related Data Available

Transcripts for LENG8 Gene

mRNA/cDNA for LENG8 Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LENG8

Alternative Splicing Database (ASD) splice patterns (SP) for LENG8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:

ExUns: 19b ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LENG8 Gene

GeneLoc Exon Structure for
LENG8

Expression for LENG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LENG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LENG8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Placenta (8.1), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LENG8 Gene



Protein tissue co-expression partners for LENG8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LENG8

SOURCE GeneReport for Unigene cluster for LENG8 Gene:

Hs.502378

Evidence on tissue expression from TISSUES for LENG8 Gene

  • Nervous system(4.6)
  • Intestine(2.4)
  • Skin(2.2)
  • Lung(2.1)
  • Kidney(2.1)
  • Spleen(2)
  • Eye(2)
genes like me logo Genes that share expression patterns with LENG8: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LENG8 Gene

Orthologs for LENG8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LENG8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LENG8 29 30
  • 99.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LENG8 29 30
  • 90.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LENG8 29 30
  • 88.29 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Leng8 29 16 30
  • 86.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Leng8 29
  • 86.21 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia LENG8 30
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LENG8 30
  • 69 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LENG8 30
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100495696 29
  • 63.32 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:158262 29
  • 55.95 (n)
LENG8 30
  • 49 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6700 30
  • 31 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea hpo-10 30
  • 33 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THP3 30
  • 28 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 59 (a)
OneToMany
-- 30
  • 28 (a)
OneToMany
Species where no ortholog for LENG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LENG8 Gene

ENSEMBL:
Gene Tree for LENG8 (if available)
TreeFam:
Gene Tree for LENG8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LENG8: view image
Alliance of Genome Resources:
Additional Orthologs for LENG8

Paralogs for LENG8 Gene

Paralogs for LENG8 Gene

genes like me logo Genes that share paralogs with LENG8: view

Variants for LENG8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LENG8 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs35061854 -- p.Arg279Pro
rs35336528 -- p.Ile557Val
VAR_082146 -- p.Glu661Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LENG8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LENG8 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
esv2758771 CNV gain+loss 17122850
nsv1148744 OTHER inversion 26484159
nsv833878 CNV loss 17160897
nsv953617 CNV deletion 24416366
nsv9758 CNV gain 18304495

Variation tolerance for LENG8 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LENG8 Gene

Human Gene Mutation Database (HGMD)
LENG8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LENG8
Leiden Open Variation Database (LOVD)
LENG8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG8 Gene

Disorders for LENG8 Gene

Additional Disease Information for LENG8

No disorders were found for LENG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LENG8 Gene

Publications for LENG8 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4
  3. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3
  4. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3

Products for LENG8 Gene

Sources for LENG8 Gene