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Aliases for LENG8 Gene

Aliases for LENG8 Gene

  • Leukocyte Receptor Cluster Member 8 2 3 5
  • Leukocyte Receptor Cluster (LRC) Member 8 2 3
  • KIAA1932 4
  • Pp13842 3

External Ids for LENG8 Gene

Previous GeneCards Identifiers for LENG8 Gene

  • GC19U990238
  • GC19P059636
  • GC19P059652
  • GC19P059651
  • GC19P054960
  • GC19P051284

Summaries for LENG8 Gene

GeneCards Summary for LENG8 Gene

LENG8 (Leukocyte Receptor Cluster Member 8) is a Protein Coding gene.

Additional gene information for LENG8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LENG8 Gene

Genomics for LENG8 Gene

GeneHancer (GH) Regulatory Elements for LENG8 Gene

Promoters and enhancers for LENG8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I054447 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 893 4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LENG8-AS1 GC19M054437 LENG8 LENG1 ENSG00000267838 PRPF31 LENG9 CNOT3 PPP1R12C GC19P054461
GH19I054448 Enhancer 0.5 ENCODE dbSUPER 550.8 -1.3 -1301 0.2 PRDM1 ENSG00000235681 GC19M054437 LENG8 LENG8-AS1
GH19I055215 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 139.1 +768.0 767986 2.9 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ENSG00000267649 LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ENSG00000267523 SSC5D ZNF580 ENSG00000267096 ZNF581
GH19I054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 76.9 -243.0 -243009 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 LENG8-AS1 CNOT3 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
GH19I055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 48.8 +805.1 805140 14.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP6R1 LENG8 U2AF2 ZNF581 LENG8-AS1 ENSG00000235681 ENSG00000267523 BRSK1 HSPBP1 FIZ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LENG8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LENG8 gene promoter:

Genomic Locations for LENG8 Gene

Genomic Locations for LENG8 Gene
chr19:54,448,719-54,462,046
(GRCh38/hg38)
Size:
13,328 bases
Orientation:
Plus strand
chr19:54,960,065-54,973,217
(GRCh37/hg19)

Genomic View for LENG8 Gene

Genes around LENG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG8 Gene

Proteins for LENG8 Gene

  • Protein details for LENG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PV6-LENG8_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 8
    Protein Accession:
    Q96PV6
    Secondary Accessions:
    • B0VJY9
    • Q8IZ27
    • Q8NCX6

    Protein attributes for LENG8 Gene

    Size:
    779 amino acids
    Molecular mass:
    86129 Da
    Quaternary structure:
    • May be part of a SEM1-containing complex.
    SequenceCaution:
    • Sequence=BAB67825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LENG8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LENG8 Gene

Post-translational modifications for LENG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LENG8 Gene

Domains & Families for LENG8 Gene

Gene Families for LENG8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LENG8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LENG8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LENG8: view

No data available for UniProtKB/Swiss-Prot for LENG8 Gene

Function for LENG8 Gene

Phenotypes From GWAS Catalog for LENG8 Gene

Gene Ontology (GO) - Molecular Function for LENG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with LENG8: view
genes like me logo Genes that share phenotypes with LENG8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG8 Gene

Localization for LENG8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LENG8 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LENG8 Gene

Pathways & Interactions for LENG8 Gene

SuperPathways for LENG8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LENG8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LENG8 Gene

Drugs & Compounds for LENG8 Gene

No Compound Related Data Available

Transcripts for LENG8 Gene

Unigene Clusters for LENG8 Gene

Leukocyte receptor cluster (LRC) member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LENG8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:

ExUns: 19b ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LENG8 Gene

GeneLoc Exon Structure for
LENG8
ECgene alternative splicing isoforms for
LENG8

Expression for LENG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LENG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LENG8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Placenta (8.1), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LENG8 Gene



Protein tissue co-expression partners for LENG8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LENG8 Gene:

LENG8

SOURCE GeneReport for Unigene cluster for LENG8 Gene:

Hs.502378

Evidence on tissue expression from TISSUES for LENG8 Gene

  • Nervous system(2.8)
  • Intestine(2.4)
  • Kidney(2.1)
  • Lung(2.1)
  • Eye(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with LENG8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LENG8 Gene

Orthologs for LENG8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LENG8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LENG8 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia LENG8 33 34
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia LENG8 33 34
  • 88.29 (n)
mouse
(Mus musculus)
Mammalia Leng8 33 16 34
  • 86.75 (n)
rat
(Rattus norvegicus)
Mammalia Leng8 33
  • 86.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LENG8 34
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LENG8 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LENG8 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495696 33
  • 63.32 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:158262 33
  • 55.95 (n)
LENG8 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6700 34
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hpo-10 34
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THP3 34
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
Species where no ortholog for LENG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LENG8 Gene

ENSEMBL:
Gene Tree for LENG8 (if available)
TreeFam:
Gene Tree for LENG8 (if available)

Paralogs for LENG8 Gene

No data available for Paralogs for LENG8 Gene

Variants for LENG8 Gene

Sequence variations from dbSNP and Humsavar for LENG8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000128531 -- 54,461,898(+) T/C 3_prime_UTR_variant
rs1000163558 -- 54,450,666(+) A/G intron_variant
rs1000304964 -- 54,452,632(+) T/C intron_variant
rs1000481171 -- 54,462,022(+) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000642370 -- 54,451,374(+) C/G coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for LENG8 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
esv2758771 CNV gain+loss 17122850
nsv1148744 OTHER inversion 26484159
nsv833878 CNV loss 17160897
nsv953617 CNV deletion 24416366
nsv9758 CNV gain 18304495

Variation tolerance for LENG8 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LENG8 Gene

Human Gene Mutation Database (HGMD)
LENG8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LENG8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG8 Gene

Disorders for LENG8 Gene

Additional Disease Information for LENG8

No disorders were found for LENG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LENG8 Gene

Publications for LENG8 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  3. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for LENG8 Gene

Sources for LENG8 Gene

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