Aliases for LENG1 Gene

Aliases for LENG1 Gene

  • Leukocyte Receptor Cluster Member 1 2 3 4 5
  • Leukocyte Receptor Cluster (LRC) Member 1 2 3
  • LENG1 5

External Ids for LENG1 Gene

Previous GeneCards Identifiers for LENG1 Gene

  • GC19M055305
  • GC19M055084
  • GC19M059335
  • GC19M059351
  • GC19M054658
  • GC19M050976

Summaries for LENG1 Gene

GeneCards Summary for LENG1 Gene

LENG1 (Leukocyte Receptor Cluster Member 1) is a Protein Coding gene. Diseases associated with LENG1 include Mannosidosis, Beta A, Lysosomal.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LENG1 Gene

Genomics for LENG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LENG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LENG1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LENG1

Top Transcription factor binding sites by QIAGEN in the LENG1 gene promoter:
  • c-Ets-1
  • c-Myb
  • E47
  • Egr-3
  • Evi-1
  • FOXF2
  • Pax-5
  • RFX1
  • Tal-1

Genomic Locations for LENG1 Gene

Latest Assembly
chr19:54,155,161-54,159,721
(GRCh38/hg38)
Size:
4,561 bases
Orientation:
Minus strand

Previous Assembly
chr19:54,658,899-54,663,459
(GRCh37/hg19 by Entrez Gene)
Size:
4,561 bases
Orientation:
Minus strand

chr19:54,658,899-54,663,620
(GRCh37/hg19 by Ensembl)
Size:
4,722 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr19(ALT_REF_LOCI_1):130,011-134,571 (-)
  • chr19(ALT_REF_LOCI_2):130,012-134,572 (-)
  • chr19(ALT_REF_LOCI_3):130,012-134,572 (-)
  • chr19(ALT_REF_LOCI_4):130,012-134,572 (-)
  • chr19(ALT_REF_LOCI_5):130,012-134,572 (-)
  • chr19(ALT_REF_LOCI_6):130,012-134,572 (-)
  • chr19(ALT_REF_LOCI_7):130,012-134,572 (-)
  • chr19(ALT_REF_LOCI_8):130,012-134,572 (-)
  • chr19(ALT_REF_LOCI_9):130,012-134,572 (-)

Genomic View for LENG1 Gene

Genes around LENG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG1 Gene

Proteins for LENG1 Gene

  • Protein details for LENG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BZ8-LENG1_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 1
    Protein Accession:
    Q96BZ8
    Secondary Accessions:
    • Q9HCU7

    Protein attributes for LENG1 Gene

    Size:
    264 amino acids
    Molecular mass:
    30529 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG01393.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

neXtProt entry for LENG1 Gene

Post-translational modifications for LENG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LENG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LENG1 Gene

Domains & Families for LENG1 Gene

Gene Families for LENG1 Gene

Protein Domains for LENG1 Gene

InterPro:

Suggested Antigen Peptide Sequences for LENG1 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte receptor cluster (LRC) member 1 (A9C4B2_HUMAN)
  • Leukocyte receptor cluster member 1 (LENG1_HUMAN)
genes like me logo Genes that share domains with LENG1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LENG1 Gene

Function for LENG1 Gene

Phenotypes From GWAS Catalog for LENG1 Gene

Gene Ontology (GO) - Molecular Function for LENG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LENG1: view
genes like me logo Genes that share phenotypes with LENG1: view

miRNA for LENG1 Gene

miRTarBase miRNAs that target LENG1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LENG1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG1 Gene

Localization for LENG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LENG1 gene
Compartment Confidence
nucleus 2
mitochondrion 1
extracellular 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LENG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with LENG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LENG1 Gene

Pathways & Interactions for LENG1 Gene

PathCards logo

SuperPathways for LENG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LENG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LENG1: view

No data available for Pathways by source and SIGNOR curated interactions for LENG1 Gene

Drugs & Compounds for LENG1 Gene

No Compound Related Data Available

Transcripts for LENG1 Gene

mRNA/cDNA for LENG1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LENG1

Alternative Splicing Database (ASD) splice patterns (SP) for LENG1 Gene

No ASD Table

Relevant External Links for LENG1 Gene

GeneLoc Exon Structure for
LENG1

Expression for LENG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LENG1 Gene

Protein differential expression in normal tissues from HIPED for LENG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8), Testis (12.3), CD8 Tcells (11.5), and Blymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LENG1 Gene



Protein tissue co-expression partners for LENG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LENG1

SOURCE GeneReport for Unigene cluster for LENG1 Gene:

Hs.590974
genes like me logo Genes that share expression patterns with LENG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LENG1 Gene

Orthologs for LENG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LENG1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LENG1 29 30
  • 98.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LENG1 29 30
  • 85.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LENG1 29 30
  • 84.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Leng1 29
  • 82.18 (n)
Mouse
(Mus musculus)
Mammalia Leng1 29 16 30
  • 81.41 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LENG1 30
  • 66 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LENG1 30
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia leng1 29
  • 61.61 (n)
Str.18286 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.22904 29
Zebrafish
(Danio rerio)
Actinopterygii leng1 29 30
  • 54.78 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG12818 29 30
  • 48.27 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 46 (a)
OneToOne
Species where no ortholog for LENG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LENG1 Gene

ENSEMBL:
Gene Tree for LENG1 (if available)
TreeFam:
Gene Tree for LENG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LENG1: view image
Alliance of Genome Resources:
Additional Orthologs for LENG1

Paralogs for LENG1 Gene

No data available for Paralogs for LENG1 Gene

Variants for LENG1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LENG1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs35089861 -- p.Glu97Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LENG1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LENG1 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv3644783 CNV gain 21293372
nsv510774 CNV deletion 20534489
nsv515623 CNV loss 19592680
nsv953613 CNV deletion 24416366
nsv9751 CNV gain 18304495

Variation tolerance for LENG1 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LENG1 Gene

Human Gene Mutation Database (HGMD)
LENG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LENG1
Leiden Open Variation Database (LOVD)
LENG1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG1 Gene

Disorders for LENG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LENG1 Gene - From: COP

Disorder Aliases PubMed IDs
mannosidosis, beta a, lysosomal
  • mansb
- elite association - COSMIC cancer census association via MalaCards
Search LENG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LENG1

genes like me logo Genes that share disorders with LENG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LENG1 Gene

Publications for LENG1 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. Network-based prediction of protein interactions. (PMID: 30886144) Kovács IA … Barabási AL (Nature communications 2019) 3

Products for LENG1 Gene

Sources for LENG1 Gene