The ocular lens is a tissue of epithelial origin and devoid of blood vessels and nerves. Cells of the lens epithelium are responsible for the growth and maintenance of the lens through mitosis, protein synthesis, and active transport of ions and metabolites across the lens capsule. Lens epithelial protein is expressed exclusively in lens epithelial cells and may play a role in ... See more...

Aliases for LENEP Gene

Aliases for LENEP Gene

  • Lens Epithelial Protein 2 3 5
  • Lens Epithelial Cell Protein LEP503 3 4
  • LEP503 3 4

External Ids for LENEP Gene

Previous GeneCards Identifiers for LENEP Gene

  • GC01M148113
  • GC01P150698
  • GC01P151741
  • GC01P152182
  • GC01P151779
  • GC01P153232
  • GC01P154966
  • GC01P126327

Summaries for LENEP Gene

Entrez Gene Summary for LENEP Gene

  • The ocular lens is a tissue of epithelial origin and devoid of blood vessels and nerves. Cells of the lens epithelium are responsible for the growth and maintenance of the lens through mitosis, protein synthesis, and active transport of ions and metabolites across the lens capsule. Lens epithelial protein is expressed exclusively in lens epithelial cells and may play a role in cell differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for LENEP Gene

LENEP (Lens Epithelial Protein) is a Protein Coding gene. Diseases associated with LENEP include Retinitis Pigmentosa 26.

UniProtKB/Swiss-Prot Summary for LENEP Gene

Additional gene information for LENEP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LENEP Gene

Genomics for LENEP Gene

GeneHancer (GH) Regulatory Elements for LENEP Gene

Promoters and enhancers for LENEP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J154992 Promoter/Enhancer 1.1 EPDnew ENCODE 500.7 -0.3 -325 0.7 CTCF ZIC2 MYC HINFP POLR2A ZNF282 ZNF316 CREB3L1 MAX YY1 LENEP HSALNG0007455 FLAD1
GH01J154993 Enhancer 0.3 Ensembl 500.7 -0.9 -885 0.2 POLR2A PCBP2 LENEP SHC1 HSALNG0007455 FLAD1
GH01J155061 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +69.7 69728 4.4 RXRA ZNF217 CTCF TCF12 NRF1 USF1 POLR2G SP1 NCOR1 PHF8 EFNA4 DCST1-AS1 ENSG00000251246 DCST2 PYGO2 KHDC4 ENSG00000271267 GON4L ADAM15 UBAP2L
GH01J155015 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 +23.7 23728 3.2 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G USF1 FOS DCST1 GON4L CLK2 KHDC4 ENSG00000271267 UBAP2L THBS3 FLAD1 PYGO2 ADAM15
GH01J155065 Promoter 1 Ensembl 10.7 +72.2 72215 0.4 ZNF639 ZNF354C ZNF623 KLF7 ZNF266 BCL11A ZBTB11 ZNF426 OVOL3 ZNF213 DCST1-AS1 KHDC4 GON4L UBAP2L ENSG00000271267 MSTO1 CLK2 MSTO2P THBS3 RUSC1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LENEP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LENEP

Top Transcription factor binding sites by QIAGEN in the LENEP gene promoter:
  • AML1a
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for LENEP Gene

Genomic Locations for LENEP Gene
chr1:154,993,586-154,994,315
(GRCh38/hg38)
Size:
730 bases
Orientation:
Plus strand
chr1:154,966,062-154,966,791
(GRCh37/hg19)
Size:
730 bases
Orientation:
Plus strand

Genomic View for LENEP Gene

Genes around LENEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENEP Gene

Proteins for LENEP Gene

  • Protein details for LENEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5L5-LENEP_HUMAN
    Recommended name:
    Lens epithelial cell protein LEP503
    Protein Accession:
    Q9Y5L5
    Secondary Accessions:
    • B5BUM1
    • Q5T1A4

    Protein attributes for LENEP Gene

    Size:
    61 amino acids
    Molecular mass:
    6908 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LENEP Gene

Post-translational modifications for LENEP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LENEP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LENEP Gene

Domains & Families for LENEP Gene

Gene Families for LENEP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LENEP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LENEP Gene

GenScript: Design optimal peptide antigens:
  • Lens epithelial cell protein LEP503 (LENEP_HUMAN)
genes like me logo Genes that share domains with LENEP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LENEP Gene

Function for LENEP Gene

Molecular function for LENEP Gene

UniProtKB/Swiss-Prot Function:
May play a role in lens epithelial cell differentiation.

Phenotypes From GWAS Catalog for LENEP Gene

Gene Ontology (GO) - Molecular Function for LENEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 7641850
genes like me logo Genes that share ontologies with LENEP: view
genes like me logo Genes that share phenotypes with LENEP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LENEP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LENEP Gene

Localization for LENEP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LENEP gene
Compartment Confidence
extracellular 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LENEP Gene

Pathways & Interactions for LENEP Gene

PathCards logo

SuperPathways for LENEP Gene

No Data Available

Interacting Proteins for LENEP Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000376278 for LENEP Gene via STRING

Symbol External ID(s) Details
TMEM72
;

Gene Ontology (GO) - Biological Process for LENEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS,IEA --
genes like me logo Genes that share ontologies with LENEP: view

No data available for Pathways by source and SIGNOR curated interactions for LENEP Gene

Drugs & Compounds for LENEP Gene

No Compound Related Data Available

Transcripts for LENEP Gene

mRNA/cDNA for LENEP Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LENEP

Alternative Splicing Database (ASD) splice patterns (SP) for LENEP Gene

No ASD Table

Relevant External Links for LENEP Gene

GeneLoc Exon Structure for
LENEP

Expression for LENEP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LENEP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LENEP

SOURCE GeneReport for Unigene cluster for LENEP Gene:

Hs.272399

mRNA Expression by UniProt/SwissProt for LENEP Gene:

Q9Y5L5-LENEP_HUMAN
Tissue specificity: Restricted to lens epithelial cells.
genes like me logo Genes that share expression patterns with LENEP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LENEP Gene

Orthologs for LENEP Gene

This gene was present in the common ancestor of mammals.

Orthologs for LENEP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LENEP 31 30
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LENEP 31
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LENEP 31 30
  • 84.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lenep 17 31 30
  • 83.06 (n)
rat
(Rattus norvegicus)
Mammalia Lenep 30
  • 83.06 (n)
Species where no ortholog for LENEP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LENEP Gene

ENSEMBL:
Gene Tree for LENEP (if available)
TreeFam:
Gene Tree for LENEP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LENEP: view image

Paralogs for LENEP Gene

No data available for Paralogs for LENEP Gene

Variants for LENEP Gene

Additional dbSNP identifiers (rs#s) for LENEP Gene

Structural Variations from Database of Genomic Variants (DGV) for LENEP Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV insertion 20534489

Variation tolerance for LENEP Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LENEP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LENEP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LENEP Gene

Disorders for LENEP Gene

MalaCards: The human disease database

(1) MalaCards diseases for LENEP Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 26
  • rp26
- elite association - COSMIC cancer census association via MalaCards
Search LENEP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LENEP

genes like me logo Genes that share disorders with LENEP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LENEP Gene

Publications for LENEP Gene

  1. Functional analysis of the promoter and chromosomal localization for human LEP503, a novel lens epithelium gene. (PMID: 11376938) Wen Y … Sachs G (Gene 2001) 2 3 4 54
  2. A novel lens epithelium gene, LEP503, is highly conserved in different vertebrate species and is developmentally regulated in postnatal rat lens. (PMID: 10655141) Wen Y … Athmann C (Experimental eye research 2000) 2 3 4 54
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3 54

Products for LENEP Gene

Sources for LENEP Gene