Aliases for LEMD1 Gene
Aliases for LEMD1 Gene
External Ids for LEMD1 Gene
- HGNC: 18725
- Entrez Gene: 93273
- Ensembl: ENSG00000186007
- OMIM: 610480
- UniProtKB: Q68G75
Previous GeneCards Identifiers for LEMD1 Gene
- GC00U991227
- GC01M202528
- GC01M202082
- GC01M203617
- GC01M205350
- GC01M176516
Summaries for LEMD1 Gene
GeneCards Summary for LEMD1 Gene
LEMD1 (LEM Domain Containing 1) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEMD1 Gene
Genomics for LEMD1 Gene
GeneHancer (GH) Regulatory Elements for LEMD1 Gene
Promoters and enhancers for LEMD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LEMD1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for LEMD1 Gene
Genomic Locations for LEMD1 Gene
- chr1:205,381,378-205,457,091
- (GRCh38/hg38)
- Size:
- 75,714 bases
- Orientation:
- Minus strand
- chr1:205,350,506-205,425,082
- (GRCh37/hg19)
Genomic View for LEMD1 Gene
Genes around LEMD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by Ensembl
- 1q32.1 by Entrez Gene
- 1q32.1 by HGNC
LEMD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LEMD1 Gene
Proteins for LEMD1 Gene
-
Protein details for LEMD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q68G75-LEMD1_HUMAN
- Recommended name:
- LEM domain-containing protein 1
- Protein Accession:
- Q68G75
- Q6L9T9
- Q6L9U0
- Q6L9U1
- Q6L9U2
- Q6L9U3
- Q6L9U4
Protein attributes for LEMD1 Gene
- Size:
- 181 amino acids
- Molecular mass:
- 20326 Da
- Quaternary structure:
- No Data Available
Protein Expression for LEMD1 Gene
Post-translational modifications for LEMD1 Gene
Other Protein References for LEMD1 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for LEMD1
- Invitrogen Antibodies for LEMD1
- GeneTex LEMD1 antibody for LEMD1
-
Custom Antibody ServicesProSci Antibodies for LEMD1
Protein Products
-
OriGene Purified Proteins for LEMD1
- Search Origene for MassSpec and Protein Over-expression Lysates for LEMD1
- Origene Custom Protein Services for LEMD1
- Search GeneTex for Proteins for LEMD1
Assay Products
No data available for DME Specific Peptides for LEMD1 Gene
Domains & Families for LEMD1 Gene
Gene Families for LEMD1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for LEMD1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LEMD1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for LEMD1 Gene
Function for LEMD1 Gene
Phenotypes for LEMD1 Gene
- GenomeRNAi human phenotypes for LEMD1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LEMD1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for LEMD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LEMD1 gene
- Search ViGene Biosciences for LEMD1
CRISPR Products
-
OriGene CRISPR knockouts for LEMD1
- genomics-online: gRNA clones - Search results for 78 available LEMD1 gene related products
- Overview of 78 available LEMD1 gene related products
- Applied Biological Materials CRISPR for LEMD1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LEMD1
- GenScript: Design CRISPR guide RNA sequences for LEMD1
miRNA Products
- Search ViGene Biosciences for LEMD1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LEMD1
- Browse OriGene Inhibitory RNA Products For LEMD1
- genomics-online: shRNA clones - Search results for 78 available LEMD1 gene related products
- Overview of 78 available LEMD1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LEMD1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for LEMD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LEMD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LEMD1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LEMD1
-
ViGene Biosciences adenoviral particle packaged cDNA for LEMD1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LEMD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LEMD1 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LEMD1 Gene
Localization for LEMD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LEMD1 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| extracellular | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
- Cytosol (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for LEMD1 Gene
No data available for Pathways by source and SIGNOR curated interactions for LEMD1 Gene
Transcripts for LEMD1 Gene
mRNA/cDNA for LEMD1 Gene
- (10) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LEMD1 Gene
- LEM domain containing 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LEMD1
- genomics-online: gRNA clones - Search results for 78 available LEMD1 gene related products
- Overview of 78 available LEMD1 gene related products
- Applied Biological Materials CRISPR for LEMD1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LEMD1
- GenScript: Design CRISPR guide RNA sequences for LEMD1
miRNA Products
- Search ViGene Biosciences for LEMD1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LEMD1
- Browse OriGene Inhibitory RNA Products For LEMD1
- genomics-online: shRNA clones - Search results for 78 available LEMD1 gene related products
- Overview of 78 available LEMD1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LEMD1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for LEMD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LEMD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LEMD1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | ||||||||||
| SP3: | - | ||||||||||
| SP4: | - | - | |||||||||
| SP5: | - | - | - |
Expression for LEMD1 Gene
mRNA differential expression in normal tissues according to GTEx for LEMD1 Gene
This gene is overexpressed in Testis (x41.9).
This gene is overexpressed in Pancreas (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LEMD1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of LEMD1 Gene:
LEMD1SOURCE GeneReport for Unigene cluster for LEMD1 Gene:
Hs.655520mRNA Expression by UniProt/SwissProt for LEMD1 Gene:
Q68G75-LEMD1_HUMAN
Tissue specificity:
Testis-specific. Isoform 6 is detected in 17 of 18 colon cancer tissues examined.
Primer Products
-
OriGene qPCR primer pairs for LEMD1
-
OriGene qPCR primer pairs and template standards for LEMD1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LEMD1 Gene
Orthologs for LEMD1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LEMD1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | LEMD1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LEMD1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC102556277 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Lemd1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LEMD1 34 |
|
OneToOne |
- Species where no ortholog for LEMD1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for LEMD1 Gene
No data available for Paralogs for LEMD1 Gene
Variants for LEMD1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000000971 | -- | 205,444,187(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000095534 | -- | 205,444,426(-) | G/C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000098682 | -- | 205,398,069(-) | G/A | intron_variant | |
| rs1000105702 | -- | 205,444,381(-) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000144175 | -- | 205,386,610(-) | CCCCCC/CCCCCCC | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3439684 | CNV | insertion | 20981092 |
| esv3588635 | CNV | gain | 21293372 |
| nsv1014629 | CNV | gain | 25217958 |
| nsv832381 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.62;
72.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LEMD1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LEMD1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEMD1 Gene
Disorders for LEMD1 Gene
Additional Disease Information for LEMD1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for LEMD1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEMD1 Gene
Publications for LEMD1 Gene
- Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers. (PMID: 15254688) Yuki D … Furukawa Y (Oncology reports 2004) 2 3 4 22 58
- Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells. (PMID: 28219643) Takeda R … Torigoe T (Biochemical and biophysical research communications 2017) 3 58
- LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration. (PMID: 27280633) Sasahira T … Kuniyasu H (British journal of cancer 2016) 3 58
- Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer. (PMID: 20682177) Ghafouri-Fard S … Modarressi MH (Archives of medical research 2010) 3 58
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
Products for LEMD1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for LEMD1
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- OriGene qPCR primer pairs and template standards for LEMD1
- OriGene qPCR primer pairs for LEMD1
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- GenScript: Next-day shipping of latest version cDNA ORF clones for LEMD1 in any vector
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for LEMD1
- VectorBuilder custom plasmid, inducible vectors for LEMD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LEMD1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available LEMD1 related products ranked by validation data
- antibodies-online: Search results for available LEMD1 related products ranked by validation data
- antibodies-online: Search results for available LEMD1 related products ranked by validation data
- GeneTex LEMD1 antibody for LEMD1
- Search GeneTex for Proteins for LEMD1
- ViGene Biosciences adenoviral particle packaged cDNA for LEMD1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for LEMD1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for LEMD1 gene
- Search ViGene Biosciences for LEMD1
- Custom Antibody ServicesProSci Antibodies for LEMD1
- Search for LEMD1 Proteins at ProSci
- Horizon Cell Lines for LEMD1
- genomics-online: cdna clones - Search results for 78 available LEMD1 gene related products
- Overview of 78 available LEMD1 gene related products
- orf clones - Search results for 78 available LEMD1 gene related products
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- genomics-online: gRNA clones - Search results for 78 available LEMD1 gene related products
- Overview of 78 available LEMD1 gene related products
- genomics-online: primer clones - Search results for 78 available LEMD1 gene related products
- Overview of 78 available LEMD1 gene related products
- genomics-online: shRNA clones - Search results for 78 available LEMD1 gene related products
- Overview of 78 available LEMD1 gene related products
Sources for LEMD1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
