Aliases for LEKR1 Gene

Aliases for LEKR1 Gene

  • Leucine, Glutamate And Lysine Rich 1 2 3 5
  • Leucine-, Glutamate- And Lysine-Rich Protein 1 3 4

External Ids for LEKR1 Gene

Previous GeneCards Identifiers for LEKR1 Gene

  • GC03P158029
  • GC03P156543
  • GC03P153940

Summaries for LEKR1 Gene

GeneCards Summary for LEKR1 Gene

LEKR1 (Leucine, Glutamate And Lysine Rich 1) is a Protein Coding gene. Diseases associated with LEKR1 include Obsessive-Compulsive Personality Disorder. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for LEKR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LEKR1 Gene

Genomics for LEKR1 Gene

GeneHancer (GH) Regulatory Elements for LEKR1 Gene

Promoters and enhancers for LEKR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LEKR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LEKR1

Top Transcription factor binding sites by QIAGEN in the LEKR1 gene promoter:
  • ATF-2
  • c-Myc
  • CRE-BP1
  • CREB
  • deltaCREB
  • IRF-1
  • IRF-2
  • Max1
  • Pax-4a
  • SEF-1 (1)

Genomic Locations for LEKR1 Gene

Genomic Locations for LEKR1 Gene
chr3:156,825,481-157,047,659
(GRCh38/hg38)
Size:
222,179 bases
Orientation:
Plus strand
chr3:156,543,270-156,763,918
(GRCh37/hg19)
Size:
220,649 bases
Orientation:
Plus strand

Genomic View for LEKR1 Gene

Genes around LEKR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEKR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEKR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEKR1 Gene

Proteins for LEKR1 Gene

  • Protein details for LEKR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMV7-LEKR1_HUMAN
    Recommended name:
    Leucine-, glutamate- and lysine-rich protein 1
    Protein Accession:
    Q6ZMV7

    Protein attributes for LEKR1 Gene

    Size:
    388 amino acids
    Molecular mass:
    45158 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LEKR1 Gene

Post-translational modifications for LEKR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LEKR1 Gene

Domains & Families for LEKR1 Gene

Gene Families for LEKR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LEKR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LEKR1 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-, glutamate- and lysine-rich protein 1 (LEKR1_HUMAN)
genes like me logo Genes that share domains with LEKR1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LEKR1 Gene

Function for LEKR1 Gene

Phenotypes From GWAS Catalog for LEKR1 Gene

genes like me logo Genes that share phenotypes with LEKR1: view

Animal Model Products

CRISPR Products

miRNA for LEKR1 Gene

miRTarBase miRNAs that target LEKR1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEKR1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LEKR1 Gene

Localization for LEKR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LEKR1 gene
Compartment Confidence
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LEKR1 Gene

Pathways & Interactions for LEKR1 Gene

PathCards logo

SuperPathways for LEKR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LEKR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LEKR1 Gene

Drugs & Compounds for LEKR1 Gene

No Compound Related Data Available

Transcripts for LEKR1 Gene

mRNA/cDNA for LEKR1 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEKR1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LEKR1 Gene

No ASD Table

Relevant External Links for LEKR1 Gene

GeneLoc Exon Structure for
LEKR1

Expression for LEKR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LEKR1 Gene

mRNA differential expression in normal tissues according to GTEx for LEKR1 Gene

This gene is overexpressed in Testis (x13.2).

Protein differential expression in normal tissues from HIPED for LEKR1 Gene

This gene is overexpressed in Cerebrospinal fluid (38.5), Heart (17.8), and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LEKR1 Gene



Protein tissue co-expression partners for LEKR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LEKR1

SOURCE GeneReport for Unigene cluster for LEKR1 Gene:

Hs.478048
genes like me logo Genes that share expression patterns with LEKR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LEKR1 Gene

Orthologs for LEKR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LEKR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LEKR1 30
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia LEKR1 30
  • 88.39 (n)
cow
(Bos Taurus)
Mammalia LEKR1 30
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Lekr1 17 31 30
  • 82.29 (n)
rat
(Rattus norvegicus)
Mammalia Lekr1 30
  • 81.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LEKR1 31
  • 37 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LEKR1 31
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves LEKR1 31 30
  • 64.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LEKR1 31
  • 28 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lekr1 30
  • 54.5 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC796963 30
  • 44.28 (n)
Species where no ortholog for LEKR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LEKR1 Gene

ENSEMBL:
Gene Tree for LEKR1 (if available)
TreeFam:
Gene Tree for LEKR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LEKR1: view image

Paralogs for LEKR1 Gene

(1) SIMAP similar genes for LEKR1 Gene using alignment to 4 proteins:

  • LEKR1_HUMAN
  • D6RAK6_HUMAN
  • D6RJ01_HUMAN
  • J3KP02_HUMAN
genes like me logo Genes that share paralogs with LEKR1: view

No data available for Paralogs for LEKR1 Gene

Variants for LEKR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LEKR1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs61469347 - p.Ile356Val

Additional dbSNP identifiers (rs#s) for LEKR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LEKR1 Gene

Variant ID Type Subtype PubMed ID
esv1226628 CNV deletion 17803354
esv2671734 CNV deletion 23128226
esv2726091 CNV deletion 23290073
esv2726092 CNV deletion 23290073
esv2726093 CNV deletion 23290073
esv2726094 CNV deletion 23290073
esv2726096 CNV deletion 23290073
esv3569071 CNV loss 25503493
nsv1109553 CNV deletion 24896259
nsv1147696 CNV deletion 26484159
nsv592120 CNV loss 21841781
nsv829765 CNV loss 17160897

Variation tolerance for LEKR1 Gene

Gene Damage Index Score: 3.15; 51.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LEKR1 Gene

Human Gene Mutation Database (HGMD)
LEKR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LEKR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEKR1 Gene

Disorders for LEKR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LEKR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
obsessive-compulsive personality disorder
  • anankastic personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search LEKR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LEKR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LEKR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LEKR1 Gene

Publications for LEKR1 Gene

  1. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. (PMID: 20372150) Freathy RM … McCarthy MI (Nature genetics 2010) 3 41 54
  2. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini SE … Oksenberg JR (Human molecular genetics 2009) 3 41 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. (PMID: 27634302) Oliviero G … Cagney G (Molecular & cellular proteomics : MCP 2016) 3 54
  5. Association between LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms and diabetic retinopathy of type 2 diabetes mellitus in the Chinese Han population. (PMID: 27607899) Lin X … Ma X (The journal of gene medicine 2016) 3 54

Products for LEKR1 Gene

Sources for LEKR1 Gene