Aliases for LEFTY2 Gene
External Ids for LEFTY2 Gene
Previous HGNC Symbols for LEFTY2 Gene
Previous GeneCards Identifiers for LEFTY2 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
GeneCards Summary for LEFTY2 Gene
LEFTY2 (Left-Right Determination Factor 2) is a Protein Coding gene. Diseases associated with LEFTY2 include Visceral Heterotaxy and Complete Atrioventricular Canal. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Cyclins and Cell Cycle Regulation. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is LEFTY1.
UniProtKB/Swiss-Prot Summary for LEFTY2 Gene
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.