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Aliases for LEFTY1 Gene

Aliases for LEFTY1 Gene

  • Left-Right Determination Factor 1 2 3 3 5
  • Left-Right Determination Factor B 3 4
  • Protein Lefty-1 3 4
  • Protein Lefty-B 3 4
  • LEFTYB 3 4
  • LEFTB 3 4
  • Left-Right Determination, Factor B 2

External Ids for LEFTY1 Gene

Previous HGNC Symbols for LEFTY1 Gene


Previous GeneCards Identifiers for LEFTY1 Gene

  • GC01M222381
  • GC01M224140
  • GC01M226073
  • GC01M196591

Summaries for LEFTY1 Gene

Entrez Gene Summary for LEFTY1 Gene

  • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]

GeneCards Summary for LEFTY1 Gene

LEFTY1 (Left-Right Determination Factor 1) is a Protein Coding gene. Diseases associated with LEFTY1 include Visceral Heterotaxy. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is LEFTY2.

UniProtKB/Swiss-Prot for LEFTY1 Gene

  • Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

Additional gene information for LEFTY1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEFTY1 Gene

Genomics for LEFTY1 Gene

GeneHancer (GH) Regulatory Elements for LEFTY1 Gene

Promoters and enhancers for LEFTY1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J225887 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 678.2 +21.7 21717 4.8 ATF1 FOXA2 MLX KLF17 THRB RARA YY1 ZNF335 ZNF121 FOS LEFTY1 PYCR2 LEFTY2 TMEM63A ENSG00000255835 ENSG00000248322 DNAH14
GH01J225910 Enhancer 1.1 Ensembl ENCODE dbSUPER 650.7 -0.1 -88 1.2 CTCF RB1 BACH1 SIN3A EBF1 ZNF2 ZNF48 RBPJ RAD21 ZNF614 LEFTY1 ACBD3-AS1 ACBD3 PIR53448 ENSG00000255835
GH01J225888 Promoter/Enhancer 1 EPDnew dbSUPER 662.4 +24.3 24253 0.1 TFAP4 RXRA NR2F1 SMAD4 NR2F6 HNF4A EZH2 LEFTY1 ENSG00000255835 PYCR2 LEFTY2 ENSG00000248322 TMEM63A
GH01J225874 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 +32.2 32222 10.1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF213 TMEM63A LEFTY2 ACBD3 PYCR2 LEFTY1 ENSG00000255835 ENSG00000248322 SDE2 H3F3A ENSG00000242861
GH01J225846 Enhancer 1.3 Ensembl ENCODE dbSUPER 22.7 +63.2 63164 5 HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 GLIS2 ARID2 ZNF143 ENSG00000242861 PYCR2 LEFTY1 LEFTY2 TMEM63A ACBD3 ENSG00000255835 ENSG00000248322 ACBD3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LEFTY1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LEFTY1 gene promoter:
  • GATA-6
  • Pax-4a
  • Roaz
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • PPAR-alpha
  • GCNF

Genomic Locations for LEFTY1 Gene

Genomic Locations for LEFTY1 Gene
25,101 bases
Minus strand
25,101 bases
Minus strand

Genomic View for LEFTY1 Gene

Genes around LEFTY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEFTY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEFTY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEFTY1 Gene

Proteins for LEFTY1 Gene

  • Protein details for LEFTY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Left-right determination factor 1
    Protein Accession:
    Secondary Accessions:
    • B2R7U0
    • Q53H67
    • Q5TE94

    Protein attributes for LEFTY1 Gene

    366 amino acids
    Molecular mass:
    40880 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LEFTY1 Gene

Post-translational modifications for LEFTY1 Gene

  • The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
  • Glycosylation at isoforms=158
  • Modification sites at PhosphoSitePlus

Other Protein References for LEFTY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LEFTY1 Gene

Domains & Families for LEFTY1 Gene

Gene Families for LEFTY1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LEFTY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TGF-beta family.
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with LEFTY1: view

Function for LEFTY1 Gene

Molecular function for LEFTY1 Gene

UniProtKB/Swiss-Prot Function:
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

LifeMap Function Summary for LEFTY1 Gene

During embryonic development, LEFTY1 as signaling molecule is secreted from the following cells
It affects the following cells:

Phenotypes From GWAS Catalog for LEFTY1 Gene

Gene Ontology (GO) - Molecular Function for LEFTY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IEA,IBA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with LEFTY1: view
genes like me logo Genes that share phenotypes with LEFTY1: view

Animal Models for LEFTY1 Gene

MGI Knock Outs for LEFTY1:

Animal Model Products

CRISPR Products

miRNA for LEFTY1 Gene

miRTarBase miRNAs that target LEFTY1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEFTY1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LEFTY1 Gene

Localization for LEFTY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEFTY1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LEFTY1 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LEFTY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with LEFTY1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LEFTY1 Gene

Pathways & Interactions for LEFTY1 Gene

genes like me logo Genes that share pathways with LEFTY1: view

Pathways by source for LEFTY1 Gene

Gene Ontology (GO) - Biological Process for LEFTY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0003007 heart morphogenesis ISS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 10053005
GO:0007275 multicellular organism development IEA --
GO:0007368 determination of left/right symmetry ISS --
genes like me logo Genes that share ontologies with LEFTY1: view

No data available for SIGNOR curated interactions for LEFTY1 Gene

Drugs & Compounds for LEFTY1 Gene

No Compound Related Data Available

Transcripts for LEFTY1 Gene

mRNA/cDNA for LEFTY1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LEFTY1 Gene

Left-right determination factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEFTY1

Alternative Splicing Database (ASD) splice patterns (SP) for LEFTY1 Gene

No ASD Table

Relevant External Links for LEFTY1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LEFTY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LEFTY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LEFTY1 Gene

This gene is overexpressed in Colon - Transverse (x28.9) and Pancreas (x14.6).

Protein differential expression in normal tissues from HIPED for LEFTY1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LEFTY1 Gene

Protein tissue co-expression partners for LEFTY1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LEFTY1 Gene:


SOURCE GeneReport for Unigene cluster for LEFTY1 Gene:


Evidence on tissue expression from TISSUES for LEFTY1 Gene

  • Intestine(4.4)
  • Pancreas(4.4)
  • Spleen(4.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with LEFTY1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LEFTY1 Gene

Orthologs for LEFTY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LEFTY1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LEFTY1 33
  • 99.36 (n)
(Mus musculus)
Mammalia Lefty1 16 34 33
  • 83.38 (n)
Lefty2 34
  • 82 (a)
(Bos Taurus)
Mammalia -- 34
  • 83 (a)
-- 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Lefty1 33
  • 82.15 (n)
(Canis familiaris)
Mammalia -- 34
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 41 (a)
(Gallus gallus)
Aves LEFTY2 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
(Danio rerio)
Actinopterygii lft1 34
  • 36 (a)
lft2 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2199 34
  • 28 (a)
Species where no ortholog for LEFTY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LEFTY1 Gene

Gene Tree for LEFTY1 (if available)
Gene Tree for LEFTY1 (if available)
Evolutionary constrained regions (ECRs) for LEFTY1: view image

Paralogs for LEFTY1 Gene

Paralogs for LEFTY1 Gene

(1) SIMAP similar genes for LEFTY1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LEFTY1: view

Variants for LEFTY1 Gene

Sequence variations from dbSNP and Humsavar for LEFTY1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001093835 -- 225,885,958(-) G/A downstream_transcript_variant
rs1001445240 -- 225,886,159(-) C/G downstream_transcript_variant
rs1001832197 -- 225,886,620(-) A/G 3_prime_UTR_variant
rs1003215549 -- 225,888,047(-) A/C intron_variant
rs1004684843 -- 225,891,121(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LEFTY1 Gene

Variant ID Type Subtype PubMed ID
esv2762223 CNV gain 21179565
esv3578457 CNV loss 25503493
nsv520628 CNV loss 19592680
nsv524126 CNV gain 19592680

Variation tolerance for LEFTY1 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.13; 90.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LEFTY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEFTY1 Gene

Disorders for LEFTY1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LEFTY1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
visceral heterotaxy
  • heterotaxia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LEFTY1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LEFTY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LEFTY1 Gene

Publications for LEFTY1 Gene

  1. Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. (PMID: 10053005) Kosaki K … Casey B (American journal of human genetics 1999) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for LEFTY1 Gene

Sources for LEFTY1 Gene

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