Aliases for LEFTY1 Gene
External Ids for LEFTY1 Gene
Previous HGNC Symbols for LEFTY1 Gene
Previous GeneCards Identifiers for LEFTY1 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]
GeneCards Summary for LEFTY1 Gene
LEFTY1 (Left-Right Determination Factor 1) is a Protein Coding gene. Diseases associated with LEFTY1 include Cardiofaciocutaneous Syndrome 2 and Right Atrial Isomerism. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is LEFTY2.
UniProtKB/Swiss-Prot Summary for LEFTY1 Gene
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.