LEF1 Gene (Protein Coding)

Lymphoid Enhancer Binding Factor 1

GC04M108047
GIFtS:
48
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may functi... See more...

Aliases for LEF1 Gene

Aliases for LEF1 Gene

  • Lymphoid Enhancer Binding Factor 1 2 3 5
  • Lymphoid Enhancer-Binding Factor 1 2 3 4
  • T Cell-Specific Transcription Factor 1-Alpha 3 4
  • TCF1-Alpha 3 4
  • TCF1ALPHA 2 3
  • TCF7L3 2 3
  • LEF-1 3 4
  • TCF10 2 3
  • LEF1 5

External Ids for LEF1 Gene

Previous GeneCards Identifiers for LEF1 Gene

  • GC04M109394
  • GC04M109289
  • GC04M109427
  • GC04M109326
  • GC04M109188
  • GC04M108968
  • GC04M104700

Summaries for LEF1 Gene

Entrez Gene Summary for LEF1 Gene

  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for LEF1 Gene

LEF1 (Lymphoid Enhancer Binding Factor 1) is a Protein Coding gene. Diseases associated with LEF1 include Pilomatrixoma and Cll/Sll. Among its related pathways are Adherens junction and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot Summary for LEF1 Gene

  • Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity).
  • [Isoform 1]: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
  • [Isoform 3]: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling.
  • [Isoform 5]: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.

Gene Wiki entry for LEF1 Gene

Additional gene information for LEF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LEF1 Gene

Genomics for LEF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LEF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LEF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LEF1

Top Transcription factor binding sites by QIAGEN in the LEF1 gene promoter:
  • AREB6
  • c-Myb
  • C/EBPbeta
  • GATA-2
  • Ik-1
  • Ik-2
  • Nkx2-5
  • SEF-1 (1)
  • Sp1

Genomic Locations for LEF1 Gene

Latest Assembly
chr4:108,047,545-108,168,956
(GRCh38/hg38)
Size:
121,412 bases
Orientation:
Minus strand

Previous Assembly
chr4:108,968,704-109,090,088
(GRCh37/hg19 by Entrez Gene)
Size:
121,385 bases
Orientation:
Minus strand

chr4:108,968,701-109,090,112
(GRCh37/hg19 by Ensembl)
Size:
121,412 bases
Orientation:
Minus strand

Genomic View for LEF1 Gene

Genes around LEF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEF1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LEF1 Gene

Proteins for LEF1 Gene

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  • Protein details for LEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJU2-LEF1_HUMAN
    Recommended name:
    Lymphoid enhancer-binding factor 1
    Protein Accession:
    Q9UJU2
    Secondary Accessions:
    • B4DG38
    • B7Z8E2
    • E9PDK3
    • Q3ZCU4
    • Q9HAZ0

    Protein attributes for LEF1 Gene

    Size:
    399 amino acids
    Molecular mass:
    44201 Da
    Quaternary structure:
    • Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK.
    Miscellaneous:
    • [Isoform 1]: Produced by alternative promoter usage.
    • [Isoform 2]: Produced by alternative splicing of isoform 1. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 3]: Produced by alternative promoter usage. Acts as dominant negative mutant.
    • [Isoform 4]: Produced by alternative splicing of isoform 3.
    • [Isoform 5]: Produced by alternative splicing of isoform 1.
    • [Isoform 6]: Produced by alternative splicing of isoform 1.

    Alternative splice isoforms for LEF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LEF1 Gene

Protein Expression for LEF1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LEF1 Gene

  • Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.
  • Glycosylation at Asn128
  • Ubiquitination at Lys324 and Lys382
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for LEF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LEF1 Gene

Domains & Families for LEF1 Gene

Gene Families for LEF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for LEF1 Gene

InterPro:
Blocks:
  • CTNNB1 binding, N-teminal

Suggested Antigen Peptide Sequences for LEF1 Gene

GenScript: Design optimal peptide antigens:
  • T cell-specific transcription factor 1-alpha (LEF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJU2

UniProtKB/Swiss-Prot:

LEF1_HUMAN :
  • Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.
  • Belongs to the TCF/LEF family.
Domain:
  • Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with LEF1: view

Function for LEF1 Gene

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Molecular function for LEF1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 1]: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling.
UniProtKB/Swiss-Prot Function:
[Isoform 5]: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.
GENATLAS Biochemistry:
lymphoid enhancer-binding factor,complexing with TCF4 and beta catenin for activation of wingless responsive genes

Phenotypes From GWAS Catalog for LEF1 Gene

Gene Ontology (GO) - Molecular Function for LEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 23001182
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000987 proximal promoter sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with LEF1: view
genes like me logo Genes that share phenotypes with LEF1: view

Animal Models for LEF1 Gene

MGI Knock Outs for LEF1:
  • Lef1 Lef1<tm1.1(KOMP)Vlcg>
  • Lef1 Lef1<tm1Rug>
  • Lef1 Lef1<tm2Rug>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEF1

Clone products for research

  • Addgene plasmids for LEF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LEF1 Gene

Localization for LEF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEF1 Gene

Nucleus. Note=Found in nuclear bodies upon PIASG binding. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LEF1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 3
cytosol 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA,IDA 17063141
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 11751639
GO:0005737 cytoplasm IDA 19402906
genes like me logo Genes that share ontologies with LEF1: view

Pathways & Interactions for LEF1 Gene

genes like me logo Genes that share pathways with LEF1: view

Pathways by source for LEF1 Gene

1 Sino Biological pathway for LEF1 Gene
3 GeneGo (Thomson Reuters) pathways for LEF1 Gene
  • Cell adhesion Tight junctions
  • Cytoskeleton remodeling Integrin outside-in signaling
  • Signal transduction PTEN pathway
9 Qiagen pathways for LEF1 Gene
  • Colorectal Cancer Metastasis
  • Epithelial Adherens Junctions
  • Factors Promoting Cardiogenesis in Vertebrates
  • Glioblastoma Multiforme
  • GSK3 Signaling
1 Cell Signaling Technology pathway for LEF1 Gene
1 GeneTex pathway for LEF1 Gene

SIGNOR curated interactions for LEF1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001569 branching involved in blood vessel morphogenesis IEA --
GO:0001649 osteoblast differentiation IEP 20128911
GO:0001756 somitogenesis IEA --
GO:0001837 epithelial to mesenchymal transition ISS --
genes like me logo Genes that share ontologies with LEF1: view

Drugs & Compounds for LEF1 Gene

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(5) Drugs for LEF1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethacrynic acid Approved, Investigational Pharma Target 5

(2) Additional Compounds for LEF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LEF1: view

Transcripts for LEF1 Gene

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mRNA/cDNA for LEF1 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEF1

Clone products for research

  • Addgene plasmids for LEF1

Alternative Splicing Database (ASD) splice patterns (SP) for LEF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - -
SP11:

ExUns: 19b · 19c · 19d · 19e · 19f · 19g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for LEF1 Gene

GeneLoc Exon Structure for
LEF1

Expression for LEF1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LEF1 Gene

mRNA expression in normal human tissues for LEF1 Gene
mRNA expression by GTEx for LEF1 GenemRNA expression by BioGPS for LEF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LEF1 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for LEF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.0), CD4 Tcells (18.0), and CD8 Tcells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LEF1 Gene



Protein tissue co-expression partners for LEF1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LEF1

SOURCE GeneReport for Unigene cluster for LEF1 Gene:

Hs.743478

mRNA Expression by UniProt/SwissProt for LEF1 Gene:

Q9UJU2-LEF1_HUMAN
Tissue specificity: Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.

Evidence on tissue expression from TISSUES for LEF1 Gene

  • Skin(4.7)
  • Nervous system(4.5)
  • Intestine(3)
  • Lymph node(3)
  • Blood(2.7)
  • Bone marrow(2.6)
  • Spleen(2.5)
  • Kidney(2.3)
  • Lung(2.2)
  • Heart(2.2)
  • Adrenal gland(2.2)
  • Bone(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with LEF1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LEF1 Gene

Orthologs for LEF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LEF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LEF1 29 30
  • 99.75 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia LEF1 30
  • 97 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LEF1 29 30
  • 95.57 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LEF1 29 30
  • 95.24 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Lef1 29 16 30
  • 91.52 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Lef1 29
  • 90.18 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia LEF1 30
  • 89 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LEF-1 30
  • 95 (a)
 OneToOne
LEF1 29
  • 85.25 (n)
Lizard
(Anolis carolinensis)
 Reptilia LEF1 30
  • 93 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia lef1 29
  • 80.8 (n)
Str.10421 29
African clawed frog
(Xenopus laevis)
 Amphibia LOC398238 29
Zebrafish
(Danio rerio)
 Actinopterygii lef1 29 30
  • 77.38 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta pan 30 31
  • 12 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea pop-1 30
  • 24 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.11069 30
  • 31 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.1608 29
Species where no ortholog for LEF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LEF1 Gene

ENSEMBL:
Gene Tree for LEF1 (if available)
TreeFam:
Gene Tree for LEF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LEF1: view image
Alliance of Genome Resources:
Additional Orthologs for LEF1

Paralogs for LEF1 Gene

Paralogs for LEF1 Gene

(3) SIMAP similar genes for LEF1 Gene using alignment to 5 proteins:

  • LEF1_HUMAN
  • D6RAB1_HUMAN
  • D6RID7_HUMAN
  • D6RIV1_HUMAN
  • G9G139_HUMAN
genes like me logo Genes that share paralogs with LEF1: view

Variants for LEF1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LEF1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs369151256 Benign: not provided 108,083,452(-) A/C
NM_016269.5(LEF1):c.548-6T>G 		INTRON
rs369649181 A colorectal cancer sample p.Gly113Arg
rs61751709 Benign: not provided 108,163,655(-) C/T
NM_016269.5(LEF1):c.327G>A (p.Ser109=) 		SYNONYMOUS
rs61752607 Benign: not provided 108,165,124(-) C/T
NM_016269.5(LEF1):c.253G>A (p.Asp85Asn) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LEF1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LEF1 Gene

Variant ID Type Subtype PubMed ID
esv275379 CNV loss 21479260
esv3369303 CNV insertion 20981092
esv3564417 CNV deletion 23714750
esv3575767 CNV gain 25503493
nsv4458 CNV deletion 18451855
nsv479048 CNV novel sequence insertion 20440878
nsv830032 CNV gain 17160897

Variation tolerance for LEF1 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LEF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LEF1
Leiden Open Variation Database (LOVD)
LEF1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEF1 Gene

Disorders for LEF1 Gene

MalaCards: The human disease database

(31) MalaCards diseases for LEF1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
pilomatrixoma
  • pilomatricoma; ptr
cll/sll
  • chronic lymphocytic leukemia/small lymphocytic lymphoma
severe congenital neutropenia
  • congenital agranulocytosis
hair follicle neoplasm
  • hair matrix neoplasm
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search LEF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LEF1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LEF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LEF1 Gene

Publications for LEF1 Gene

  1. Lef-1 isoforms regulate different target genes and reduce cellular adhesion. (PMID: 19653274) Jesse S … Menke A (International journal of cancer 2010) 3 4 22
  2. Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. (PMID: 12556497) Ishitani T … Matsumoto K (Molecular and cellular biology 2003) 3 4 22
  3. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. (PMID: 11326276) Hovanes K … Waterman ML (Nature genetics 2001) 3 4 22
  4. The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing. (PMID: 10756202) Hovanes K … Waterman ML (Nucleic acids research 2000) 3 4 22
  5. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. (PMID: 9119228) Bruhn L … Grosschedl R (Genes & development 1997) 3 4 22

ExternalLinks

View latest publications for LEF1 gene in Mastermind

Products for LEF1 Gene

  • Addgene plasmids for LEF1

Sources for LEF1 Gene