This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008... See more...

Aliases for LECT2 Gene

Aliases for LECT2 Gene

  • Leukocyte Cell Derived Chemotaxin 2 2 3 5
  • Leukocyte Cell-Derived Chemotaxin-2 3 4
  • Leukocyte Cell-Derived Chemotaxin 2 2
  • Chondromodulin-II 3
  • Chm-II 3
  • LECT-2 4
  • HLECT2 4
  • Chm2 3

External Ids for LECT2 Gene

Previous GeneCards Identifiers for LECT2 Gene

  • GC05M135158
  • GC05M135945
  • GC05M135313
  • GC05M135358
  • GC05M135310
  • GC05M130471

Summaries for LECT2 Gene

Entrez Gene Summary for LECT2 Gene

  • This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

GeneCards Summary for LECT2 Gene

LECT2 (Leukocyte Cell Derived Chemotaxin 2) is a Protein Coding gene. Diseases associated with LECT2 include Amyloidosis, Familial Visceral and Colon Small Cell Carcinoma. Among its related pathways are C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot Summary for LECT2 Gene

  • Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).

Gene Wiki entry for LECT2 Gene

Additional gene information for LECT2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LECT2 Gene

Genomics for LECT2 Gene

GeneHancer (GH) Regulatory Elements for LECT2 Gene

Promoters and enhancers for LECT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J135954 Promoter 0.6 EPDnew 500.7 +0.0 32 0.1 RAD21 REST HNF4A YY1 TAF1 SP1 LECT2 piR-39904-019
GH05J136079 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11 -125.4 -125426 2.5 NRF1 FOS ZBTB5 TARDBP MYC RUNX1 EP300 CTBP1 JUN POLR2A ENSG00000278815 VTRNA2-1 SMAD5 LECT2 SMAD5-AS1 HSALNG0045075
GH05J136004 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -59.6 -59632 21.1 ZSCAN5C TCF12 JUND FOS CTCF ZIC2 REST ZNF623 NR3C1 EP300 TGFBI LECT2 SMAD5 SMAD5-AS1 SMIM32 FBXL21P lnc-LECT2-2 HSALNG0045073 LOC105379189 HSALNG0045068
GH05J135977 Enhancer 1.1 Ensembl ENCODE dbSUPER 16.7 -24.3 -24266 4.2 CTCF TCF12 REST RAD21 EP300 TRIM22 ATF2 SMC3 FOXA2 ZNF266 LECT2 C5orf66 FBXL21P HSALNG0045068 lnc-LECT2-2
GH05J136051 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -100.9 -100927 9 EP300 FOXK2 ZNF217 CTCF ZSCAN5C TCF12 POLR2G NCOR1 RBAK JUND LECT2 ENSG00000254239 IL9 SMAD5 SMIM32 HSALNG0045075 TGFBI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LECT2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LECT2

Top Transcription factor binding sites by QIAGEN in the LECT2 gene promoter:
  • AML1a
  • AP-1
  • C/EBPbeta
  • FOXJ2
  • FOXJ2 (long isoform)
  • Gfi-1
  • Pax-6
  • RP58
  • TBP

Genomic Locations for LECT2 Gene

Genomic Locations for LECT2 Gene
chr5:135,922,279-135,955,034
(GRCh38/hg38)
Size:
32,756 bases
Orientation:
Minus strand
chr5:135,257,968-135,290,723
(GRCh37/hg19)
Size:
32,756 bases
Orientation:
Minus strand

Genomic View for LECT2 Gene

Genes around LECT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LECT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LECT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LECT2 Gene

Proteins for LECT2 Gene

  • Protein details for LECT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14960-LECT2_HUMAN
    Recommended name:
    Leukocyte cell-derived chemotaxin-2
    Protein Accession:
    O14960
    Secondary Accessions:
    • B2RA90
    • O14565
    • Q52M49

    Protein attributes for LECT2 Gene

    Size:
    151 amino acids
    Molecular mass:
    16390 Da
    Quaternary structure:
    • Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for LECT2 Gene

neXtProt entry for LECT2 Gene

Post-translational modifications for LECT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LECT2 Gene

No data available for DME Specific Peptides for LECT2 Gene

Domains & Families for LECT2 Gene

Gene Families for LECT2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LECT2 Gene

Blocks:
  • Peptidase M23/M37
  • Leukocyte cell-derived chemotaxin 2
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LECT2 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte cell-derived chemotaxin-2 (LECT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14960

UniProtKB/Swiss-Prot:

LECT2_HUMAN :
  • Belongs to the LECT2/MIM-1 family.
Family:
  • Belongs to the LECT2/MIM-1 family.
genes like me logo Genes that share domains with LECT2: view

Function for LECT2 Gene

Molecular function for LECT2 Gene

UniProtKB/Swiss-Prot Function:
Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA).
GENATLAS Biochemistry:
leukocyte cell-derived chemotaxia 2,16kDa,specifically expressed in liver,identical to chondromodulin II,growth stimulator of bovine chondrocyte

Phenotypes From GWAS Catalog for LECT2 Gene

Gene Ontology (GO) - Molecular Function for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27334921
GO:0042802 identical protein binding IPI 23352894
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LECT2: view
genes like me logo Genes that share phenotypes with LECT2: view

Animal Models for LECT2 Gene

MGI Knock Outs for LECT2:

Animal Model Products

CRISPR Products

miRNA for LECT2 Gene

miRTarBase miRNAs that target LECT2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LECT2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LECT2 Gene

Localization for LECT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LECT2 Gene

Cytoplasm. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LECT2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 9266841
GO:0005737 cytoplasm IEA,TAS --
genes like me logo Genes that share ontologies with LECT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LECT2 Gene

Pathways & Interactions for LECT2 Gene

PathCards logo

SuperPathways for LECT2 Gene

genes like me logo Genes that share pathways with LECT2: view

Pathways by source for LECT2 Gene

1 BioSystems pathway for LECT2 Gene

Interacting Proteins for LECT2 Gene

;

Gene Ontology (GO) - Biological Process for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 9545637
GO:0006935 chemotaxis TAS,IEA --
genes like me logo Genes that share ontologies with LECT2: view

No data available for SIGNOR curated interactions for LECT2 Gene

Drugs & Compounds for LECT2 Gene

(6) Drugs for LECT2 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 8750
Immunoglobulins Pharma 8750
Immunologic Factors Pharma 30591
Liver Extracts Pharma 5430

(1) Additional Compounds for LECT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LECT2: view

Transcripts for LECT2 Gene

mRNA/cDNA for LECT2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LECT2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LECT2 Gene

No ASD Table

Relevant External Links for LECT2 Gene

GeneLoc Exon Structure for
LECT2

Expression for LECT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LECT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LECT2 Gene

This gene is overexpressed in Liver (x46.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LECT2

SOURCE GeneReport for Unigene cluster for LECT2 Gene:

Hs.512580

mRNA Expression by UniProt/SwissProt for LECT2 Gene:

O14960-LECT2_HUMAN
Tissue specificity: Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.

Evidence on tissue expression from TISSUES for LECT2 Gene

  • Liver(4.7)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with LECT2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LECT2 Gene

Orthologs for LECT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LECT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LECT2 31 30
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LECT2 31 30
  • 85.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LECT2 31 30
  • 85.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lect2 17 31 30
  • 83.22 (n)
rat
(Rattus norvegicus)
Mammalia Lect2 30
  • 81.9 (n)
oppossum
(Monodelphis domestica)
Mammalia LECT2 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LECT2 31
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves LECT2 31 30
  • 59.6 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lect2l 31 30
  • 58.85 (n)
OneToMany
BX005069.2 31
  • 53 (a)
OneToMany
BX005069.4 31
  • 42 (a)
OneToMany
LECT2 (4 of 4) 31
  • 36 (a)
OneToMany
Species where no ortholog for LECT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LECT2 Gene

ENSEMBL:
Gene Tree for LECT2 (if available)
TreeFam:
Gene Tree for LECT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LECT2: view image

Paralogs for LECT2 Gene

No data available for Paralogs for LECT2 Gene

Variants for LECT2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LECT2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs31517 - p.Ile58Val

Additional dbSNP identifiers (rs#s) for LECT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LECT2 Gene

Variant ID Type Subtype PubMed ID
esv2759380 CNV loss 17122850
esv3606871 CNV loss 21293372
nsv471050 CNV loss 18288195
nsv599796 CNV loss 21841781

Variation tolerance for LECT2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LECT2 Gene

Human Gene Mutation Database (HGMD)
LECT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LECT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LECT2 Gene

Disorders for LECT2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for LECT2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyloidosis, familial visceral
  • amyloidosis viii
colon small cell carcinoma
  • colonic small cell carcinoma
amyloidosis
  • amyloid disease
rheumatoid arthritis
  • ra
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search LECT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LECT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LECT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LECT2 Gene

Publications for LECT2 Gene

  1. Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene. (PMID: 9545637) Yamagoe S … Suzuki K (Genomics 1998) 2 3 4 23 54
  2. Systemic expression of a newly recognized protein, LECT2, in the human body. (PMID: 9832057) Nagai H … Suzuki K (Pathology international 1998) 3 4 23 54
  3. Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver. (PMID: 9524238) Yamagoe S … Suzuki K (Biochimica et biophysica acta 1998) 3 4 23 54
  4. Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2. (PMID: 8877413) Yamagoe S … Suzuki K (Immunology letters 1996) 3 4 23 54
  5. Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold. (PMID: 27334921) Zheng H … Tanokura M (The Journal of biological chemistry 2016) 3 4 54

Products for LECT2 Gene

Sources for LECT2 Gene