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Aliases for LECT2 Gene

Aliases for LECT2 Gene

  • Leukocyte Cell Derived Chemotaxin 2 2 3 5
  • Leukocyte Cell-Derived Chemotaxin-2 3
  • Leukocyte Cell-Derived Chemotaxin 2 2
  • Chondromodulin-II 3
  • Chm-II 3
  • LECT-2 4
  • HLECT2 4
  • Chm2 3

External Ids for LECT2 Gene

Previous GeneCards Identifiers for LECT2 Gene

  • GC05M135158
  • GC05M135313
  • GC05M135358
  • GC05M135310
  • GC05M130471

Summaries for LECT2 Gene

Entrez Gene Summary for LECT2 Gene

  • This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

GeneCards Summary for LECT2 Gene

LECT2 (Leukocyte Cell Derived Chemotaxin 2) is a Protein Coding gene. Among its related pathways are C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for LECT2 Gene

  • Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).

Gene Wiki entry for LECT2 Gene

Additional gene information for LECT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LECT2 Gene

Genomics for LECT2 Gene

GeneHancer (GH) Regulatory Elements for LECT2 Gene

Promoters and enhancers for LECT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J135954 Promoter 0.8 EPDnew 650.7 +0.0 32 0.1 SP1 TAF1 HNF4A REST RAD21 YY1 LECT2 FBXL21
GH05J136079 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 11 -125.8 -125823 1.7 PKNOX1 ATF1 ARNT IRF4 BRCA1 NCOA2 YY1 GTF3C2 POLR2B GATA2 GC05M136082 VTRNA2-1 ENSG00000278815 SMAD5 LECT2 SMAD5-AS1 ENSG00000277859
GH05J136013 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -62.8 -62824 9.2 PKNOX1 FOXA2 SIN3A FEZF1 YY1 FOS RXRA REST MAFF STAT3 LECT2 SMAD5 SMAD5-AS1 SMIM32 GC05P136010 LOC105379189
GH05J136051 Enhancer 1.5 Ensembl ENCODE dbSUPER 11 -100.9 -100927 9 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 FOS SMAD5 LECT2 ENSG00000254239 IL9 SMIM32 GC05M136082 TGFBI
GH05J135992 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -40.1 -40121 5 JUN ATF2 SP1 JUND ATF3 POLR2A FOS FOSL2 ATF7 RCOR1 LECT2 SMAD5 IL9 ENSG00000254239 SMAD5-AS1 TGFBI SLC25A48 GC05P136002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LECT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LECT2 gene promoter:
  • AML1a
  • TBP
  • RP58
  • C/EBPbeta
  • Gfi-1
  • FOXJ2 (long isoform)
  • FOXJ2
  • Pax-6
  • AP-1

Genomic Locations for LECT2 Gene

Genomic Locations for LECT2 Gene
32,756 bases
Minus strand
32,756 bases
Minus strand

Genomic View for LECT2 Gene

Genes around LECT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LECT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LECT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LECT2 Gene

Proteins for LECT2 Gene

  • Protein details for LECT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte cell-derived chemotaxin-2
    Protein Accession:
    Secondary Accessions:
    • B2RA90
    • O14565
    • Q52M49

    Protein attributes for LECT2 Gene

    151 amino acids
    Molecular mass:
    16390 Da
    Quaternary structure:
    • Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for LECT2 Gene

neXtProt entry for LECT2 Gene

Post-translational modifications for LECT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LECT2 Gene

Antibody Products

  • Abcam antibodies for LECT2
  • Boster Bio Antibodies for LECT2

No data available for DME Specific Peptides for LECT2 Gene

Domains & Families for LECT2 Gene

Gene Families for LECT2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LECT2 Gene

Suggested Antigen Peptide Sequences for LECT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LECT2/MIM-1 family.
  • Belongs to the LECT2/MIM-1 family.
genes like me logo Genes that share domains with LECT2: view

Function for LECT2 Gene

Molecular function for LECT2 Gene

UniProtKB/Swiss-Prot Function:
Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA).
GENATLAS Biochemistry:
leukocyte cell-derived chemotaxia 2,16kDa,specifically expressed in liver,identical to chondromodulin II,growth stimulator of bovine chondrocyte

Phenotypes From GWAS Catalog for LECT2 Gene

Gene Ontology (GO) - Molecular Function for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27334921
GO:0042802 identical protein binding IPI 23352894
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LECT2: view
genes like me logo Genes that share phenotypes with LECT2: view

Animal Models for LECT2 Gene

MGI Knock Outs for LECT2:

Animal Model Products

miRNA for LECT2 Gene

miRTarBase miRNAs that target LECT2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LECT2 Gene

Localization for LECT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LECT2 Gene

Cytoplasm. Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LECT2 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 9266841
GO:0005737 cytoplasm IEA,TAS --
genes like me logo Genes that share ontologies with LECT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LECT2 Gene

Pathways & Interactions for LECT2 Gene

genes like me logo Genes that share pathways with LECT2: view

Pathways by source for LECT2 Gene

1 BioSystems pathway for LECT2 Gene

Gene Ontology (GO) - Biological Process for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 9545637
GO:0006935 chemotaxis TAS,IEA --
genes like me logo Genes that share ontologies with LECT2: view

No data available for SIGNOR curated interactions for LECT2 Gene

Drugs & Compounds for LECT2 Gene

(5) Drugs for LECT2 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 7224
Immunoglobulins Pharma 7224
Liver Extracts Pharma 4411

(1) Additional Compounds for LECT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LECT2: view

Transcripts for LECT2 Gene

mRNA/cDNA for LECT2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LECT2 Gene

Leukocyte cell-derived chemotaxin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LECT2 Gene

No ASD Table

Relevant External Links for LECT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LECT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LECT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LECT2 Gene

This gene is overexpressed in Liver (x46.8).

NURSA nuclear receptor signaling pathways regulating expression of LECT2 Gene:


SOURCE GeneReport for Unigene cluster for LECT2 Gene:


mRNA Expression by UniProt/SwissProt for LECT2 Gene:

Tissue specificity: Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.

Evidence on tissue expression from TISSUES for LECT2 Gene

  • Liver(4.7)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with LECT2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LECT2 Gene

Orthologs for LECT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LECT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LECT2 34 33
  • 99.34 (n)
(Canis familiaris)
Mammalia LECT2 34 33
  • 85.87 (n)
(Bos Taurus)
Mammalia LECT2 34 33
  • 85.43 (n)
(Mus musculus)
Mammalia Lect2 16 34 33
  • 83.22 (n)
(Rattus norvegicus)
Mammalia Lect2 33
  • 81.9 (n)
(Monodelphis domestica)
Mammalia LECT2 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia LECT2 34
  • 40 (a)
(Gallus gallus)
Aves LECT2 34 33
  • 59.6 (n)
(Danio rerio)
Actinopterygii lect2l 34 33
  • 58.85 (n)
BX005069.2 34
  • 53 (a)
BX005069.4 34
  • 42 (a)
LECT2 (4 of 4) 34
  • 36 (a)
Species where no ortholog for LECT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LECT2 Gene

Gene Tree for LECT2 (if available)
Gene Tree for LECT2 (if available)
Evolutionary constrained regions (ECRs) for LECT2: view image

Paralogs for LECT2 Gene

No data available for Paralogs for LECT2 Gene

Variants for LECT2 Gene

Sequence variations from dbSNP and Humsavar for LECT2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000208019 -- 135,953,801(-) T/G intron_variant
rs1000845122 -- 135,951,722(-) AAAA/AAAAA intron_variant
rs1001107852 -- 135,948,319(-) A/G intron_variant
rs1001319621 -- 135,951,094(-) A/G intron_variant
rs1001478138 -- 135,956,846(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LECT2 Gene

Variant ID Type Subtype PubMed ID
esv2759380 CNV loss 17122850
esv3606871 CNV loss 21293372
nsv471050 CNV loss 18288195
nsv599796 CNV loss 21841781

Variation tolerance for LECT2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LECT2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LECT2 Gene

Disorders for LECT2 Gene

Additional Disease Information for LECT2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LECT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LECT2 Gene

Publications for LECT2 Gene

  1. Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene. (PMID: 9545637) Yamagoe S … Suzuki K (Genomics 1998) 2 3 4 22 58
  2. Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver. (PMID: 9524238) Yamagoe S … Suzuki K (Biochimica et biophysica acta 1998) 3 4 22 58
  3. Systemic expression of a newly recognized protein, LECT2, in the human body. (PMID: 9832057) Nagai H … Suzuki K (Pathology international 1998) 3 4 22 58
  4. Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2. (PMID: 8877413) Yamagoe S … Suzuki K (Immunology letters 1996) 3 4 22 58
  5. Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold. (PMID: 27334921) Zheng H … Tanokura M (The Journal of biological chemistry 2016) 3 4 58

Products for LECT2 Gene

Sources for LECT2 Gene

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