This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014] See more...

Aliases for LEAP2 Gene

Aliases for LEAP2 Gene

  • Liver Enriched Antimicrobial Peptide 2 2 3 5
  • LEAP-2 2 3 4
  • Liver-Expressed Antimicrobial Peptide 2 3 4
  • Liver Expressed Antimicrobial Peptide 2 2
  • LEAP2 5

External Ids for LEAP2 Gene

Previous GeneCards Identifiers for LEAP2 Gene

  • GC05P132236
  • GC05P127401
  • GC05P132208

Summaries for LEAP2 Gene

Entrez Gene Summary for LEAP2 Gene

  • This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]

GeneCards Summary for LEAP2 Gene

LEAP2 (Liver Enriched Antimicrobial Peptide 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Defensins.

UniProtKB/Swiss-Prot Summary for LEAP2 Gene

Additional gene information for LEAP2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LEAP2 Gene

Genomics for LEAP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LEAP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LEAP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LEAP2

Top Transcription factor binding sites by QIAGEN in the LEAP2 gene promoter:
  • ARP-1
  • Brachyury
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx2-5
  • YY1

Genomic Locations for LEAP2 Gene

Genomic Locations for LEAP2 Gene
chr5:132,873,444-132,875,046
(GRCh38/hg38)
Size:
1,603 bases
Orientation:
Plus strand
chr5:132,208,014-132,210,738
(GRCh37/hg19)
Size:
2,725 bases
Orientation:
Plus strand

Genomic View for LEAP2 Gene

Genes around LEAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEAP2 Gene

Proteins for LEAP2 Gene

  • Protein details for LEAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969E1-LEAP2_HUMAN
    Recommended name:
    Liver-expressed antimicrobial peptide 2
    Protein Accession:
    Q969E1
    Secondary Accessions:
    • D3DQ91

    Protein attributes for LEAP2 Gene

    Size:
    77 amino acids
    Molecular mass:
    8814 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LEAP2 Gene

neXtProt entry for LEAP2 Gene

Post-translational modifications for LEAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LEAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LEAP2 Gene

Domains & Families for LEAP2 Gene

Gene Families for LEAP2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for LEAP2 Gene

InterPro:
Blocks:
  • Liver-expressed antimicrobial peptide 2
ProtoNet:

Suggested Antigen Peptide Sequences for LEAP2 Gene

GenScript: Design optimal peptide antigens:
  • Liver-expressed antimicrobial peptide 2 (LEAP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969E1

UniProtKB/Swiss-Prot:

LEAP2_HUMAN :
  • Belongs to the LEAP2 family.
Family:
  • Belongs to the LEAP2 family.
genes like me logo Genes that share domains with LEAP2: view

Function for LEAP2 Gene

Molecular function for LEAP2 Gene

UniProtKB/Swiss-Prot Function:
Has an antimicrobial activity.

Phenotypes From GWAS Catalog for LEAP2 Gene

genes like me logo Genes that share phenotypes with LEAP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LEAP2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEAP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LEAP2 Gene

Localization for LEAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEAP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LEAP2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with LEAP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LEAP2 Gene

Pathways & Interactions for LEAP2 Gene

PathCards logo

SuperPathways for LEAP2 Gene

genes like me logo Genes that share pathways with LEAP2: view

Pathways by source for LEAP2 Gene

3 Reactome pathways for LEAP2 Gene

Interacting Proteins for LEAP2 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000296877 Q969E1-LEAP2_HUMAN for LEAP2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for LEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019730 antimicrobial humoral response TAS --
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with LEAP2: view

No data available for SIGNOR curated interactions for LEAP2 Gene

Drugs & Compounds for LEAP2 Gene

No Compound Related Data Available

Transcripts for LEAP2 Gene

mRNA/cDNA for LEAP2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LEAP2

Alternative Splicing Database (ASD) splice patterns (SP) for LEAP2 Gene

No ASD Table

Relevant External Links for LEAP2 Gene

GeneLoc Exon Structure for
LEAP2

Expression for LEAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LEAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LEAP2 Gene

This gene is overexpressed in Liver (x30.0).

Protein differential expression in normal tissues from HIPED for LEAP2 Gene

This gene is overexpressed in Urine (45.0), Plasma (15.8), and Serum (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LEAP2 Gene



Protein tissue co-expression partners for LEAP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LEAP2

SOURCE GeneReport for Unigene cluster for LEAP2 Gene:

Hs.337588

Evidence on tissue expression from TISSUES for LEAP2 Gene

  • Liver(4.6)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with LEAP2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LEAP2 Gene

Orthologs for LEAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LEAP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LEAP2 30 31
  • 99.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LEAP2 30 31
  • 91.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LEAP2 30 31
  • 89.61 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Leap2 30 17 31
  • 86.4 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LEAP2 31
  • 58 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LEAP2 31
  • 32 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LEAP2 31
  • 51 (a)
OneToOne
Species where no ortholog for LEAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LEAP2 Gene

ENSEMBL:
Gene Tree for LEAP2 (if available)
TreeFam:
Gene Tree for LEAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LEAP2: view image

Paralogs for LEAP2 Gene

No data available for Paralogs for LEAP2 Gene

Variants for LEAP2 Gene

Additional dbSNP identifiers (rs#s) for LEAP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LEAP2 Gene

Variant ID Type Subtype PubMed ID
esv2730794 CNV deletion 23290073
esv3606811 CNV gain 21293372
nsv5003 CNV deletion 18451855
nsv830489 CNV loss 17160897

Variation tolerance for LEAP2 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LEAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LEAP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LEAP2 Gene

Disorders for LEAP2 Gene

Additional Disease Information for LEAP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for LEAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEAP2 Gene

Publications for LEAP2 Gene

  1. Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. (PMID: 12493837) Krause A … Adermann K (Protein science : a publication of the Protein Society 2003) 2 3 4 23
  2. Structural and functional analysis of human liver-expressed antimicrobial peptide 2. (PMID: 20845358) Henriques ST … Clark RJ (Chembiochem : a European journal of chemical biology 2010) 3 4
  3. Structure-activity relationship of human liver-expressed antimicrobial peptide 2. (PMID: 19852990) Hocquellet A … Costaglioli P (Peptides 2010) 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for LEAP2 Gene

  • Signalway Proteins for LEAP2

Sources for LEAP2 Gene