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Aliases for LDOC1 Gene

Aliases for LDOC1 Gene

  • LDOC1, Regulator Of NFKB Signaling 2 3 5
  • Leucine Zipper Protein Down-Regulated In Cancer Cells 3 4
  • Leucine Zipper Down-Regulated In Cancer 1 2 3
  • Sushi-Ichi Retrotransposon Homolog 7 2 3
  • Mammalian Retrotransposon-Derived 7 2 3
  • Retrotransposon Gag Like 7 2 3
  • BCUR1 3 4
  • Leucine Zipper Downregulated In Cancer 3
  • Breast Cancer, Up-Regulated 1 3
  • Protein LDOC1 3
  • Mart7 3
  • SIRH7 3
  • Mar7 3
  • RTL7 3

External Ids for LDOC1 Gene

Previous HGNC Symbols for LDOC1 Gene

  • BCUR1

Previous GeneCards Identifiers for LDOC1 Gene

  • GC0XM134800
  • GC0XM137127
  • GC0XM138202
  • GC0XM138963
  • GC0XM139995
  • GC0XM140097
  • GC0XM140269
  • GC0XM129731

Summaries for LDOC1 Gene

Entrez Gene Summary for LDOC1 Gene

  • The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for LDOC1 Gene

LDOC1 (LDOC1, Regulator Of NFKB Signaling) is a Protein Coding gene. An important paralog of this gene is RTL8B.

UniProtKB/Swiss-Prot for LDOC1 Gene

  • May have an important role in the development and/or progression of some cancers.

Gene Wiki entry for LDOC1 Gene

Additional gene information for LDOC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDOC1 Gene

Genomics for LDOC1 Gene

GeneHancer (GH) Regulatory Elements for LDOC1 Gene

Promoters and enhancers for LDOC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ141176 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 667.9 +0.3 313 1.8 MXI1 MAX SIN3A ZNF335 POLR2A VEZF1 CHD2 SP3 MAZ ZNF687 LDOC1 ENSG00000261212
GH0XJ141219 Enhancer 0.6 ENCODE 0.3 -43.5 -43491 1.7 SMARCE1 JUN DPF2 EP300 SP1 JUND STAT3 CUX1 FOS FOSL2 GC0XP141237 LDOC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LDOC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LDOC1 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Egr-4
  • COMP1
  • FOXL1

Genomic Locations for LDOC1 Gene

Genomic Locations for LDOC1 Gene
1,470 bases
Minus strand
1,381 bases
Minus strand

Genomic View for LDOC1 Gene

Genes around LDOC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDOC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDOC1 Gene

Proteins for LDOC1 Gene

  • Protein details for LDOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein LDOC1
    Protein Accession:
    Secondary Accessions:
    • Q6IAR6

    Protein attributes for LDOC1 Gene

    146 amino acids
    Molecular mass:
    16968 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDOC1 Gene

Post-translational modifications for LDOC1 Gene

No Post-translational modifications

Other Protein References for LDOC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for LDOC1
  • Boster Bio Antibodies for LDOC1

No data available for DME Specific Peptides for LDOC1 Gene

Domains & Families for LDOC1 Gene

Gene Families for LDOC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LDOC1 Gene


Suggested Antigen Peptide Sequences for LDOC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDOC1 family.
  • Belongs to the LDOC1 family.
genes like me logo Genes that share domains with LDOC1: view

Function for LDOC1 Gene

Molecular function for LDOC1 Gene

UniProtKB/Swiss-Prot Function:
May have an important role in the development and/or progression of some cancers.
GENATLAS Biochemistry:
gene down-regulated in some cancer cell lines

Gene Ontology (GO) - Molecular Function for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15670815
genes like me logo Genes that share ontologies with LDOC1: view
genes like me logo Genes that share phenotypes with LDOC1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDOC1 Gene

Localization for LDOC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDOC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDOC1 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with LDOC1: view

Pathways & Interactions for LDOC1 Gene

SuperPathways for LDOC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001893 maternal placenta development IEA --
GO:0008285 negative regulation of cell proliferation TAS 10403563
GO:0060137 maternal process involved in parturition IEA --
GO:1903547 regulation of growth hormone activity IEA --
genes like me logo Genes that share ontologies with LDOC1: view

No data available for Pathways by source and SIGNOR curated interactions for LDOC1 Gene

Drugs & Compounds for LDOC1 Gene

No Compound Related Data Available

Transcripts for LDOC1 Gene

mRNA/cDNA for LDOC1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(113) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDOC1 Gene

Leucine zipper, down-regulated in cancer 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDOC1 Gene

No ASD Table

Relevant External Links for LDOC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LDOC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LDOC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDOC1 Gene

This gene is overexpressed in Artery - Aorta (x5.8).

Protein differential expression in normal tissues from HIPED for LDOC1 Gene

This gene is overexpressed in Bone (37.3) and Lung (31.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LDOC1 Gene

Protein tissue co-expression partners for LDOC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LDOC1 Gene:


SOURCE GeneReport for Unigene cluster for LDOC1 Gene:


mRNA Expression by UniProt/SwissProt for LDOC1 Gene:

Tissue specificity: Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.

Evidence on tissue expression from TISSUES for LDOC1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with LDOC1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LDOC1 Gene

Orthologs for LDOC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LDOC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LDOC1 34
  • 99 (a)
LOC100614906 33
  • 98.86 (n)
(Canis familiaris)
Mammalia LOC100855971 33
  • 97.71 (n)
LDOC1 34
  • 96 (a)
(Bos Taurus)
Mammalia LDOC1 33
  • 95.28 (n)
(Rattus norvegicus)
Mammalia Ldoc1 33
  • 81.93 (n)
(Mus musculus)
Mammalia Ldoc1 16 34 33
  • 80.66 (n)
Species where no ortholog for LDOC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LDOC1 Gene

Gene Tree for LDOC1 (if available)
Gene Tree for LDOC1 (if available)
Evolutionary constrained regions (ECRs) for LDOC1: view image

Paralogs for LDOC1 Gene

Paralogs for LDOC1 Gene

(5) SIMAP similar genes for LDOC1 Gene using alignment to 2 proteins:

  • E5L8F5_HUMAN Pseudogenes for LDOC1 Gene

genes like me logo Genes that share paralogs with LDOC1: view

Variants for LDOC1 Gene

Sequence variations from dbSNP and Humsavar for LDOC1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1005843391 -- 141,177,447(-) G/A upstream_transcript_variant
rs1006133654 -- 141,178,046(-) A/G upstream_transcript_variant
rs1006678838 -- 141,176,845(-) G/T coding_sequence_variant, synonymous_variant
rs1008233792 -- 141,175,356(-) G/A downstream_transcript_variant
rs1012108161 -- 141,179,156(-) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LDOC1 Gene

Variant ID Type Subtype PubMed ID
esv2758896 CNV gain+loss 17122850
esv3577441 CNV gain 25503493
nsv470367 CNV loss 18288195
nsv470368 CNV gain 18288195
nsv516880 CNV gain+loss 19592680
nsv7462 OTHER inversion 18451855

Variation tolerance for LDOC1 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LDOC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDOC1 Gene

Disorders for LDOC1 Gene

Additional Disease Information for LDOC1

No disorders were found for LDOC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDOC1 Gene

Publications for LDOC1 Gene

  1. Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. (PMID: 10403563) Nagasaki K … Yamaguchi K (Cancer letters 1999) 2 3 4 22 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J … Volff JN (Cytogenetic and genome research 2005) 2 3 58
  4. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J … Volff JN (Gene 2005) 2 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for LDOC1 Gene

Sources for LDOC1 Gene

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