Aliases for LDLRAD4 Gene
External Ids for LDLRAD4 Gene
Previous HGNC Symbols for LDLRAD4 Gene
GeneCards Summary for LDLRAD4 Gene
LDLRAD4 (Low Density Lipoprotein Receptor Class A Domain Containing 4) is a Protein Coding gene. Diseases associated with LDLRAD4 include Cogan-Reese Syndrome. Gene Ontology (GO) annotations related to this gene include R-SMAD binding. An important paralog of this gene is PMEPA1.
UniProtKB/Swiss-Prot Summary for LDLRAD4 Gene
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.