Aliases for LDLRAD3 Gene

Aliases for LDLRAD3 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 3 2 3 5
  • Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3 3 4
  • LDLR Class A Domain-Containing Protein 3 3 4
  • LRAD3 3 4

External Ids for LDLRAD3 Gene

Previous GeneCards Identifiers for LDLRAD3 Gene

  • GC11P035923
  • GC11P035664

Summaries for LDLRAD3 Gene

GeneCards Summary for LDLRAD3 Gene

LDLRAD3 (Low Density Lipoprotein Receptor Class A Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include amyloid-beta binding.

UniProtKB/Swiss-Prot Summary for LDLRAD3 Gene

  • May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

Additional gene information for LDLRAD3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LDLRAD3 Gene

Genomics for LDLRAD3 Gene

GeneHancer (GH) Regulatory Elements for LDLRAD3 Gene

Promoters and enhancers for LDLRAD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J035943 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.5 489 2.5 NRF1 ZIC2 REST POLR2A ZBTB26 KLF7 MYC ATF2 HDAC2 MXI1 LDLRAD3 ENSG00000254919 LOC100420018 lnc-COMMD9-7
GH11J036069 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +128.3 128324 7.8 CTCF FOS ZIC2 RAD21 MXI1 NR2F2 ZNF316 SMC3 CBFB ZNF384 LDLRAD3 CD44 LOC101928510 RF00017-896
GH11J036108 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 +166.5 166527 4.2 TEAD4 POLR2A ZNF316 CBFB TRIM28 NANOG TCF12 BATF ZBTB48 ZNF843 LDLRAD3 TRIM44 PRR5L piR-33287 LOC101928510
GH11J036048 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +106.3 106319 4.6 RBM25 TCF7L2 PBX2 BCOR IRF1 ADNP PRDM6 ZNF664 FEZF1 SMARCA4 LDLRAD3 FJX1 RF00017-896 lnc-COMMD9-5
GH11J036001 Enhancer 1 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +58.1 58119 3.8 CTBP1 ZFHX2 GATA3 MYC FOXP2 DPF2 SMARCE1 EGR2 EED FOXA1 LDLRAD3 CD44 RPL12P31 MIR3973
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LDLRAD3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LDLRAD3

Top Transcription factor binding sites by QIAGEN in the LDLRAD3 gene promoter:
  • ATF-2
  • CUTL1
  • Evi-1
  • FOXO1
  • FOXO1a
  • GATA-1
  • HNF-1
  • HNF-1A
  • IRF-2
  • Pax-6

Genomic Locations for LDLRAD3 Gene

Genomic Locations for LDLRAD3 Gene
chr11:35,943,981-36,232,136
(GRCh38/hg38)
Size:
288,156 bases
Orientation:
Plus strand
chr11:35,965,531-36,253,686
(GRCh37/hg19)
Size:
288,156 bases
Orientation:
Plus strand

Genomic View for LDLRAD3 Gene

Genes around LDLRAD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDLRAD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDLRAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD3 Gene

Proteins for LDLRAD3 Gene

  • Protein details for LDLRAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YD5-LRAD3_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 3
    Protein Accession:
    Q86YD5
    Secondary Accessions:
    • B7Z1U3
    • B9EG81
    • Q8NBJ0

    Protein attributes for LDLRAD3 Gene

    Size:
    345 amino acids
    Molecular mass:
    37419 Da
    Quaternary structure:
    • Interacts with APP precursor C-terminus.

    Alternative splice isoforms for LDLRAD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LDLRAD3 Gene

Post-translational modifications for LDLRAD3 Gene

  • Glycosylation at Asn24

Other Protein References for LDLRAD3 Gene

No data available for DME Specific Peptides for LDLRAD3 Gene

Domains & Families for LDLRAD3 Gene

Gene Families for LDLRAD3 Gene

Protein Domains for LDLRAD3 Gene

Blocks:
  • Low density lipoprotein-receptor, class A
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LDLRAD3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57961 (B7Z1U3_HUMAN)
  • cDNA FLJ57174 (B7Z5M8_HUMAN)
  • Low-density lipoprotein receptor class A domain-containing protein 3 (LRAD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86YD5

UniProtKB/Swiss-Prot:

LRAD3_HUMAN :
  • Belongs to the LDLR family.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD3: view

Function for LDLRAD3 Gene

Molecular function for LDLRAD3 Gene

UniProtKB/Swiss-Prot Function:
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

Phenotypes From GWAS Catalog for LDLRAD3 Gene

Gene Ontology (GO) - Molecular Function for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view
genes like me logo Genes that share phenotypes with LDLRAD3: view

Animal Model Products

CRISPR Products

miRNA for LDLRAD3 Gene

miRTarBase miRNAs that target LDLRAD3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDLRAD3 Gene

Localization for LDLRAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDLRAD3 gene
Compartment Confidence
plasma membrane 4
extracellular 3
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view

Pathways & Interactions for LDLRAD3 Gene

PathCards logo

SuperPathways for LDLRAD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0070613 regulation of protein processing IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD3 Gene

Drugs & Compounds for LDLRAD3 Gene

No Compound Related Data Available

Transcripts for LDLRAD3 Gene

mRNA/cDNA for LDLRAD3 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD3 Gene

No ASD Table

Relevant External Links for LDLRAD3 Gene

GeneLoc Exon Structure for
LDLRAD3

Expression for LDLRAD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LDLRAD3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LDLRAD3

SOURCE GeneReport for Unigene cluster for LDLRAD3 Gene:

Hs.745134

mRNA Expression by UniProt/SwissProt for LDLRAD3 Gene:

Q86YD5-LRAD3_HUMAN
Tissue specificity: Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver.

Evidence on tissue expression from TISSUES for LDLRAD3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with LDLRAD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDLRAD3 Gene

Orthologs for LDLRAD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LDLRAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD3 31 30
  • 99.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LDLRAD3 31 30
  • 92.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ldlrad3 17 31 30
  • 89.57 (n)
dog
(Canis familiaris)
Mammalia LDLRAD3 31 30
  • 89.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ldlrad3 30
  • 88.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LDLRAD3 31
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LDLRAD3 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LDLRAD3 31 30
  • 80.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LDLRAD3 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ldlrad3 30
  • 73.25 (n)
Str.3049 30
zebrafish
(Danio rerio)
Actinopterygii ldlrad3 31 30
  • 65.08 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta modSP 31
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 31
  • 12 (a)
OneToMany
Species where no ortholog for LDLRAD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LDLRAD3 Gene

ENSEMBL:
Gene Tree for LDLRAD3 (if available)
TreeFam:
Gene Tree for LDLRAD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LDLRAD3: view image

Paralogs for LDLRAD3 Gene

genes like me logo Genes that share paralogs with LDLRAD3: view

No data available for Paralogs for LDLRAD3 Gene

Variants for LDLRAD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LDLRAD3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
710803 Benign: not provided 36,036,192(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
714499 Benign: not provided 36,229,383(+) A/T MISSENSE_VARIANT
726881 Likely Benign: not provided 36,098,452(+) A/C MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
774623 Likely Benign: not provided 36,036,119(+) C/A SYNONYMOUS_VARIANT,INTRON_VARIANT
785887 Benign: not provided 36,229,224(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for LDLRAD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD3 Gene

Variant ID Type Subtype PubMed ID
dgv190e214 CNV loss 21293372
esv1294533 CNV insertion 17803354
esv1443244 CNV deletion 17803354
esv2422305 CNV duplication 17116639
esv2548850 CNV insertion 19546169
esv2670859 CNV deletion 23128226
esv2744345 CNV deletion 23290073
esv3305351 CNV mobile element insertion 20981092
esv3307600 CNV mobile element insertion 20981092
esv3373596 CNV insertion 20981092
esv3406327 CNV insertion 20981092
esv3579475 CNV loss 25503493
esv3625942 CNV loss 21293372
esv3625947 CNV loss 21293372
esv3625948 CNV loss 21293372
esv3625950 CNV loss 21293372
esv3891964 CNV loss 25118596
nsv1042014 CNV loss 25217958
nsv1070950 CNV deletion 25765185
nsv467791 CNV gain 19166990
nsv513311 CNV insertion 21212237
nsv516850 CNV loss 19592680
nsv554002 CNV loss 21841781
nsv554003 CNV gain 21841781
nsv7735 CNV insertion 18451855
nsv832122 CNV gain 17160897
nsv983002 CNV duplication 23825009

Variation tolerance for LDLRAD3 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LDLRAD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDLRAD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDLRAD3 Gene

Disorders for LDLRAD3 Gene

Additional Disease Information for LDLRAD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LDLRAD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD3 Gene

Publications for LDLRAD3 Gene

  1. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. (PMID: 21795536) Ranganathan S … Strickland DK (The Journal of neuroscience : the official journal of the Society for Neuroscience 2011) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. (PMID: 20410850) Kantojärvi K … Järvelä I (Psychiatric genetics 2010) 3 41 54
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54
  5. Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer. (PMID: 29307994) Yang F … Sun SY (World journal of gastroenterology 2017) 3 54

Products for LDLRAD3 Gene

Sources for LDLRAD3 Gene