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Aliases for LDLRAD3 Gene

Aliases for LDLRAD3 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 3 2 3 5
  • Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3 3
  • LRAD3 3

External Ids for LDLRAD3 Gene

Previous GeneCards Identifiers for LDLRAD3 Gene

  • GC11P035664

Summaries for LDLRAD3 Gene

GeneCards Summary for LDLRAD3 Gene

LDLRAD3 (Low Density Lipoprotein Receptor Class A Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include amyloid-beta binding. An important paralog of this gene is LRP10.

UniProtKB/Swiss-Prot for LDLRAD3 Gene

  • May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

Additional gene information for LDLRAD3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDLRAD3 Gene

Genomics for LDLRAD3 Gene

GeneHancer (GH) Regulatory Elements for LDLRAD3 Gene

Promoters and enhancers for LDLRAD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I035943 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.6 562 2.4 ZNF473 KLF17 SIN3A ZNF76 ZBTB40 ZNF2 ZNF335 GLIS2 EGR1 SCRT2 LDLRAD3 ENSG00000254919 LOC100420018
GH11I036008 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 +65.2 65196 3.3 JUN RAD21 RFX5 CTBP1 GATA3 POLR2A FOSL2 FOS SMARCE1 CEBPB MIR3973 LDLRAD3 CD44 RPL12P31
GH11I036072 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.4 +130.3 130282 3.9 MEIS2 PKNOX1 JUN ETV1 TAL1 ZMYM3 ZIC2 ZBTB40 ZNF316 POLR2A LDLRAD3 LOC101928510 GC11M036020
GH11I036108 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.1 +166.5 166527 4.2 BACH1 SIN3A FEZF1 BATF ZNF316 POLR2A ZBTB48 TRIM24 ETV6 NFE2 LDLRAD3 TRIM44 PRR5L PIR54286 LOC101928510
GH11I036090 Enhancer 1.1 ENCODE dbSUPER 10.1 +148.0 148015 2.5 ATF1 FEZF1 TCF12 ZNF766 ATF7 RUNX3 ATF4 SMARCA4 NR2C1 HMBOX1 TRAF6 LDLRAD3 LOC101928510 PIR54286
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LDLRAD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LDLRAD3 gene promoter:

Genomic Locations for LDLRAD3 Gene

Genomic Locations for LDLRAD3 Gene
288,156 bases
Plus strand

Genomic View for LDLRAD3 Gene

Genes around LDLRAD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDLRAD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDLRAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD3 Gene

Proteins for LDLRAD3 Gene

  • Protein details for LDLRAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B7Z1U3
    • B9EG81
    • Q8NBJ0

    Protein attributes for LDLRAD3 Gene

    345 amino acids
    Molecular mass:
    37419 Da
    Quaternary structure:
    • Interacts with APP precursor C-terminus.

    Alternative splice isoforms for LDLRAD3 Gene


neXtProt entry for LDLRAD3 Gene

Post-translational modifications for LDLRAD3 Gene

Other Protein References for LDLRAD3 Gene

No data available for DME Specific Peptides for LDLRAD3 Gene

Domains & Families for LDLRAD3 Gene

Gene Families for LDLRAD3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for LDLRAD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDLR family.
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD3: view

Function for LDLRAD3 Gene

Molecular function for LDLRAD3 Gene

UniProtKB/Swiss-Prot Function:
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

Phenotypes From GWAS Catalog for LDLRAD3 Gene

Gene Ontology (GO) - Molecular Function for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view
genes like me logo Genes that share phenotypes with LDLRAD3: view

Animal Model Products

miRNA for LDLRAD3 Gene

miRTarBase miRNAs that target LDLRAD3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDLRAD3 Gene

Localization for LDLRAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDLRAD3 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view

Pathways & Interactions for LDLRAD3 Gene

SuperPathways for LDLRAD3 Gene

No Data Available

Interacting Proteins for LDLRAD3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q86YD5-LRAD3_HUMAN ENSP00000318607 for LDLRAD3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0070613 regulation of protein processing IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD3 Gene

Drugs & Compounds for LDLRAD3 Gene

No Compound Related Data Available

Transcripts for LDLRAD3 Gene

Unigene Clusters for LDLRAD3 Gene

Low density lipoprotein receptor class A domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD3 Gene

No ASD Table

Relevant External Links for LDLRAD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LDLRAD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LDLRAD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LDLRAD3 Gene:


SOURCE GeneReport for Unigene cluster for LDLRAD3 Gene:


mRNA Expression by UniProt/SwissProt for LDLRAD3 Gene:

Tissue specificity: Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver.

Evidence on tissue expression from TISSUES for LDLRAD3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with LDLRAD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDLRAD3 Gene

Orthologs for LDLRAD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LDLRAD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LDLRAD3 33 34
  • 99.32 (n)
(Bos Taurus)
Mammalia LDLRAD3 33 34
  • 92.37 (n)
(Mus musculus)
Mammalia Ldlrad3 33 16 34
  • 89.57 (n)
(Canis familiaris)
Mammalia LDLRAD3 33 34
  • 89.06 (n)
(Rattus norvegicus)
Mammalia Ldlrad3 33
  • 88.5 (n)
(Monodelphis domestica)
Mammalia LDLRAD3 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia LDLRAD3 34
  • 72 (a)
(Gallus gallus)
Aves LDLRAD3 33 34
  • 80.71 (n)
(Anolis carolinensis)
Reptilia LDLRAD3 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ldlrad3 33
  • 73.25 (n)
Str.3049 33
(Danio rerio)
Actinopterygii ldlrad3 33 34
  • 65.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta modSP 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea M03E7.4 34
  • 12 (a)
Species where no ortholog for LDLRAD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LDLRAD3 Gene

Gene Tree for LDLRAD3 (if available)
Gene Tree for LDLRAD3 (if available)

Paralogs for LDLRAD3 Gene

Variants for LDLRAD3 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000004421 -- 36,050,820(+) C/T intron_variant
rs1000033728 -- 36,210,068(+) A/G intron_variant
rs1000035018 -- 36,176,151(+) T/A intron_variant
rs1000041395 -- 36,201,966(+) T/C intron_variant
rs1000047372 -- 36,127,145(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD3 Gene

Variant ID Type Subtype PubMed ID
nsv983002 CNV duplication 23825009
nsv832122 CNV gain 17160897
nsv7735 CNV insertion 18451855
nsv554003 CNV gain 21841781
nsv554002 CNV loss 21841781
nsv516850 CNV loss 19592680
nsv513311 CNV insertion 21212237
nsv467791 CNV gain 19166990
nsv1070950 CNV deletion 25765185
nsv1042014 CNV loss 25217958
esv3891964 CNV loss 25118596
esv3625950 CNV loss 21293372
esv3625948 CNV loss 21293372
esv3625947 CNV loss 21293372
esv3625942 CNV loss 21293372
esv3579475 CNV loss 25503493
esv3406327 CNV insertion 20981092
esv3373596 CNV insertion 20981092
esv3307600 CNV mobile element insertion 20981092
esv3305351 CNV mobile element insertion 20981092
esv2744345 CNV deletion 23290073
esv2670859 CNV deletion 23128226
esv2548850 CNV insertion 19546169
esv2422305 CNV duplication 17116639
esv1443244 CNV deletion 17803354
esv1294533 CNV insertion 17803354
dgv190e214 CNV loss 21293372

Variation tolerance for LDLRAD3 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LDLRAD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDLRAD3 Gene

Disorders for LDLRAD3 Gene

Additional Disease Information for LDLRAD3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LDLRAD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD3 Gene

Publications for LDLRAD3 Gene

  1. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. (PMID: 21795536) Ranganathan S … Strickland DK (The Journal of neuroscience : the official journal of the Society for Neuroscience 2011) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. (PMID: 20410850) Kantojärvi K … Järvelä I (Psychiatric genetics 2010) 3 44 58
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  5. Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. (PMID: 26854353) Noyes NC … Strickland DK (Biochemistry 2016) 3 58

Products for LDLRAD3 Gene

Sources for LDLRAD3 Gene

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