Aliases for LDLRAD1 Gene

Aliases for LDLRAD1 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 1 2 3 5
  • Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 1 3 4
  • Low Density Lipoprotein Receptor A Domain Containing 1 2

External Ids for LDLRAD1 Gene

Previous GeneCards Identifiers for LDLRAD1 Gene

  • GC01M054187
  • GC01M054247
  • GC01M054474
  • GC01M052590

Summaries for LDLRAD1 Gene

GeneCards Summary for LDLRAD1 Gene

LDLRAD1 (Low Density Lipoprotein Receptor Class A Domain Containing 1) is a Protein Coding gene.

Additional gene information for LDLRAD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LDLRAD1 Gene

Genomics for LDLRAD1 Gene

GeneHancer (GH) Regulatory Elements for LDLRAD1 Gene

Promoters and enhancers for LDLRAD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054015 Enhancer 1.1 Ensembl ENCODE 760.1 +1.9 1886 2.2 RBPJ TCF7L2 NR2F1 NR2F6 CREB1 HLF ZNF121 MNT ELF3 SP1 LDLRAD1 lnc-TCEANC2-4 TCEANC2
GH01J054017 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 761 -0.1 -56 0.7 PRDM1 SOX13 SAP130 TFAP4 THAP11 ARID4B SP3 KLF1 LDLRAD1 piR-41245-005 TCEANC2
GH01J054051 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -34.9 -34915 3.8 FOXK2 ZNF785 SIN3A ZBTB40 SREBF1 SIX5 ZBTB6 FOXA1 RBPJ SMARCE1 TCEANC2 MIR4781 TMEM59 lnc-LDLRAD1-2 MAGOH NDC1 ENSG00000228838 SSBP3-AS1 HSPB11 LRRC42
GH01J054093 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 14.7 -77.4 -77404 3.6 MYC MAX ZNF121 ELF3 SP1 FOXA2 NR2C2 GABPA NR2F2 CEBPB TCEANC2 LDLRAD1 TMEM59 CDCP2 SSBP3-AS1 MRPL37 ENSG00000279049 lnc-CDCP2-6 ENSG00000225183 lnc-MRPL37-6
GH01J053981 Enhancer 1 ENCODE CraniofacialAtlas 11.7 +35.5 35469 1.4 RBPJ CREB1 MIXL1 ELF1 L3MBTL2 ELF3 SP1 MLLT1 TFE3 CEBPG lnc-LRRC42-1 TCEANC2 HSPB11 LRRC42 LDLRAD1 YIPF1 DIO1 TMEM59 lnc-LDLRAD1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LDLRAD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LDLRAD1 gene promoter:
  • C/EBPalpha
  • HEN1
  • LCR-F1
  • Lmo2
  • Msx-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Pax-4a
  • POU3F2

Genomic Locations for LDLRAD1 Gene

Genomic Locations for LDLRAD1 Gene
chr1:54,007,298-54,018,186
(GRCh38/hg38)
Size:
10,889 bases
Orientation:
Minus strand
chr1:54,474,412-54,483,856
(GRCh37/hg19)
Size:
9,445 bases
Orientation:
Minus strand

Genomic View for LDLRAD1 Gene

Genes around LDLRAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDLRAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDLRAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD1 Gene

Proteins for LDLRAD1 Gene

  • Protein details for LDLRAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T700-LRAD1_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 1
    Protein Accession:
    Q5T700
    Secondary Accessions:
    • A0PJY0
    • B7ZME3
    • Q5T6Z9

    Protein attributes for LDLRAD1 Gene

    Size:
    205 amino acids
    Molecular mass:
    21834 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LDLRAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LDLRAD1 Gene

Post-translational modifications for LDLRAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LDLRAD1 Gene

Domains & Families for LDLRAD1 Gene

Gene Families for LDLRAD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LDLRAD1 Gene

Suggested Antigen Peptide Sequences for LDLRAD1 Gene

GenScript: Design optimal peptide antigens:
  • Low-density lipoprotein receptor class A domain-containing protein 1 (LRAD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T700

UniProtKB/Swiss-Prot:

LRAD1_HUMAN :
  • Belongs to the LDLR family.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD1: view

Function for LDLRAD1 Gene

Phenotypes From GWAS Catalog for LDLRAD1 Gene

Gene Ontology (GO) - Molecular Function for LDLRAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24722188
genes like me logo Genes that share ontologies with LDLRAD1: view

Phenotypes for LDLRAD1 Gene

genes like me logo Genes that share phenotypes with LDLRAD1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LDLRAD1 Gene

Localization for LDLRAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDLRAD1 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LDLRAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LDLRAD1: view

Pathways & Interactions for LDLRAD1 Gene

PathCards logo

SuperPathways for LDLRAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDLRAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD1 Gene

Drugs & Compounds for LDLRAD1 Gene

No Compound Related Data Available

Transcripts for LDLRAD1 Gene

mRNA/cDNA for LDLRAD1 Gene

(5) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD1 Gene

No ASD Table

Relevant External Links for LDLRAD1 Gene

GeneLoc Exon Structure for
LDLRAD1
ECgene alternative splicing isoforms for
LDLRAD1

Expression for LDLRAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LDLRAD1 Gene

mRNA differential expression in normal tissues according to GTEx for LDLRAD1 Gene

This gene is overexpressed in Fallopian Tube (x25.5), Cervix - Endocervix (x9.8), and Lung (x8.2).

NURSA nuclear receptor signaling pathways regulating expression of LDLRAD1 Gene:

LDLRAD1

SOURCE GeneReport for Unigene cluster for LDLRAD1 Gene:

Hs.439583

Evidence on tissue expression from TISSUES for LDLRAD1 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with LDLRAD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDLRAD1 Gene

Orthologs for LDLRAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LDLRAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD1 33 32
  • 98.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LDLRAD1 33 32
  • 83.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LDLRAD1 33 32
  • 81.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ldlrad1 17 33 32
  • 77.95 (n)
rat
(Rattus norvegicus)
Mammalia Ldlrad1 32
  • 77.94 (n)
oppossum
(Monodelphis domestica)
Mammalia LDLRAD1 33
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves LDLRAD1 33 32
  • 62.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LDLRAD1 33
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ldlrad1 32
  • 54.07 (n)
Species where no ortholog for LDLRAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LDLRAD1 Gene

ENSEMBL:
Gene Tree for LDLRAD1 (if available)
TreeFam:
Gene Tree for LDLRAD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LDLRAD1: view image

Paralogs for LDLRAD1 Gene

No data available for Paralogs for LDLRAD1 Gene

Variants for LDLRAD1 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000241137 -- 54,013,735(-) T/C intron_variant
rs1000419486 -- 54,008,851(-) C/A 3_prime_UTR_variant, intron_variant
rs1000464144 -- 54,008,021(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000651175 -- 54,014,010(-) A/G intron_variant
rs1000707575 -- 54,019,904(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD1 Gene

Variant ID Type Subtype PubMed ID
nsv1003904 CNV gain 25217958
nsv1011262 CNV gain 25217958

Variation tolerance for LDLRAD1 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LDLRAD1 Gene

Human Gene Mutation Database (HGMD)
LDLRAD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDLRAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDLRAD1 Gene

Disorders for LDLRAD1 Gene

Additional Disease Information for LDLRAD1

No disorders were found for LDLRAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD1 Gene

Publications for LDLRAD1 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for LDLRAD1 Gene

Sources for LDLRAD1 Gene