Aliases for LDLRAD1 Gene

Aliases for LDLRAD1 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 1 2 3 5
  • Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 1 3 4
  • Low Density Lipoprotein Receptor A Domain Containing 1 2
  • LDLRAD1 5

External Ids for LDLRAD1 Gene

Previous GeneCards Identifiers for LDLRAD1 Gene

  • GC01M054187
  • GC01M054247
  • GC01M054474
  • GC01M052590

Summaries for LDLRAD1 Gene

GeneCards Summary for LDLRAD1 Gene

LDLRAD1 (Low Density Lipoprotein Receptor Class A Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LDLRAD1 Gene

Genomics for LDLRAD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LDLRAD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054015 Enhancer 1.1 Ensembl ENCODE 260.1 +1.9 1921 2.1 SSRP1 ZMYM3 CEBPA ATF3 CHD4 CEBPB HOMEZ ZNF217 KMT2B EP300 LDLRAD1 lnc-TCEANC2-4 TCEANC2 HSPB11
GH01J054017 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 261 -0.1 -56 0.7 THAP11 SAP130 HBP1 TFAP4 ARID4B KLF1 SP3 HNRNPL SOX13 PRDM1 LDLRAD1 piR-41245-005 TCEANC2 TMEM59
GH01J054051 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -34.9 -34915 3.8 BCLAF1 IKZF1 NCOR1 MYC SIX5 SSRP1 ZNF580 ATF2 KLF9 POLR2A TCEANC2 TMEM59 MIR4781 lnc-LDLRAD1-2 MAGOH NDC1 SSBP3-AS1 LRRC42 HSPB11 PARS2
GH01J053981 Enhancer 1 ENCODE CraniofacialAtlas 11.7 +35.5 35469 1.4 IKZF1 CEBPA ATF3 POLR2A YY1 KLF11 CHD2 HOMEZ KMT2B THAP11 lnc-LRRC42-1 TCEANC2 LRRC42 HSPB11 LDLRAD1 DIO1 YIPF1 TMEM59 HSALNG0003727
GH01J054856 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.3 -841.5 -841520 7.8 MYC SSRP1 CEBPA ATF3 MXD4 CEBPB ZFP64 HOMEZ MNT MAX DHCR24-DT DHCR24 LEXM ENSG00000242396 TTC22 ENSG00000237453 LDLRAD1 TCEANC2 TMEM59 TMEM61
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LDLRAD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LDLRAD1

Top Transcription factor binding sites by QIAGEN in the LDLRAD1 gene promoter:
  • C/EBPalpha
  • HEN1
  • LCR-F1
  • Lmo2
  • Msx-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Pax-4a
  • POU3F2

Genomic Locations for LDLRAD1 Gene

Latest Assembly
chr1:54,007,298-54,018,186
(GRCh38/hg38)
Size:
10,889 bases
Orientation:
Minus strand

Previous Assembly
chr1:54,472,971-54,483,859
(GRCh37/hg19 by Entrez Gene)
Size:
10,889 bases
Orientation:
Minus strand

chr1:54,474,412-54,483,856
(GRCh37/hg19 by Ensembl)
Size:
9,445 bases
Orientation:
Minus strand

Genomic View for LDLRAD1 Gene

Genes around LDLRAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDLRAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDLRAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD1 Gene

Proteins for LDLRAD1 Gene

  • Protein details for LDLRAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T700-LRAD1_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 1
    Protein Accession:
    Q5T700
    Secondary Accessions:
    • A0PJY0
    • B7ZME3
    • Q5T6Z9

    Protein attributes for LDLRAD1 Gene

    Size:
    205 amino acids
    Molecular mass:
    21834 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LDLRAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LDLRAD1 Gene

Post-translational modifications for LDLRAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LDLRAD1 Gene

Domains & Families for LDLRAD1 Gene

Gene Families for LDLRAD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LDLRAD1 Gene

InterPro:
Blocks:
  • Low density lipoprotein-receptor, class A

Suggested Antigen Peptide Sequences for LDLRAD1 Gene

GenScript: Design optimal peptide antigens:
  • Low-density lipoprotein receptor class A domain-containing protein 1 (LRAD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T700

UniProtKB/Swiss-Prot:

LRAD1_HUMAN :
  • Belongs to the LDLR family.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD1: view

Function for LDLRAD1 Gene

Phenotypes From GWAS Catalog for LDLRAD1 Gene

Gene Ontology (GO) - Molecular Function for LDLRAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24722188
genes like me logo Genes that share ontologies with LDLRAD1: view
genes like me logo Genes that share phenotypes with LDLRAD1: view

Animal Models for LDLRAD1 Gene

MGI Knock Outs for LDLRAD1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDLRAD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LDLRAD1 Gene

Localization for LDLRAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD1 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDLRAD1 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LDLRAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LDLRAD1: view

Pathways & Interactions for LDLRAD1 Gene

PathCards logo

SuperPathways for LDLRAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDLRAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD1 Gene

Drugs & Compounds for LDLRAD1 Gene

No Compound Related Data Available

Transcripts for LDLRAD1 Gene

mRNA/cDNA for LDLRAD1 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDLRAD1

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD1 Gene

No ASD Table

Relevant External Links for LDLRAD1 Gene

GeneLoc Exon Structure for
LDLRAD1

Expression for LDLRAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LDLRAD1 Gene

mRNA differential expression in normal tissues according to GTEx for LDLRAD1 Gene

This gene is overexpressed in Fallopian Tube (x25.5), Cervix - Endocervix (x9.8), and Lung (x8.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LDLRAD1

SOURCE GeneReport for Unigene cluster for LDLRAD1 Gene:

Hs.439583

Evidence on tissue expression from TISSUES for LDLRAD1 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with LDLRAD1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDLRAD1 Gene

Orthologs for LDLRAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LDLRAD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LDLRAD1 29 30
  • 98.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LDLRAD1 29 30
  • 83.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LDLRAD1 29 30
  • 81.46 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ldlrad1 29 16 30
  • 77.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ldlrad1 29
  • 77.94 (n)
Oppossum
(Monodelphis domestica)
Mammalia LDLRAD1 30
  • 25 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LDLRAD1 29 30
  • 62.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LDLRAD1 30
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ldlrad1 29
  • 54.07 (n)
Species where no ortholog for LDLRAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LDLRAD1 Gene

ENSEMBL:
Gene Tree for LDLRAD1 (if available)
TreeFam:
Gene Tree for LDLRAD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LDLRAD1: view image
Alliance of Genome Resources:
Additional Orthologs for LDLRAD1

Paralogs for LDLRAD1 Gene

No data available for Paralogs for LDLRAD1 Gene

Variants for LDLRAD1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LDLRAD1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD1 Gene

Variant ID Type Subtype PubMed ID
nsv1003904 CNV gain 25217958
nsv1011262 CNV gain 25217958

Variation tolerance for LDLRAD1 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LDLRAD1 Gene

Human Gene Mutation Database (HGMD)
LDLRAD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDLRAD1
Leiden Open Variation Database (LOVD)
LDLRAD1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LDLRAD1 Gene

Disorders for LDLRAD1 Gene

Additional Disease Information for LDLRAD1

No disorders were found for LDLRAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD1 Gene

Publications for LDLRAD1 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  3. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. (PMID: 29892012) Chen S … Yu H (Nature genetics 2018) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for LDLRAD1 Gene

Sources for LDLRAD1 Gene