This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in... See more...
Aliases for LDHB Gene
Aliases for LDHB Gene
External Ids for LDHB Gene
- HGNC: 6541
- Entrez Gene: 3945
- Ensembl: ENSG00000111716
- OMIM: 150100
- UniProtKB: P07195
Previous GeneCards Identifiers for LDHB Gene
- GC12M022074
- GC12M021789
- GC12M021688
- GC12M021679
- GC12M021788
- GC12M021561
Summaries for LDHB Gene
-
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]
GeneCards Summary for LDHB Gene
LDHB (Lactate Dehydrogenase B) is a Protein Coding gene. Diseases associated with LDHB include Lactate Dehydrogenase B Deficiency and Dressler's Syndrome. Among its related pathways are Pyruvate metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include identical protein binding and kinase binding. An important paralog of this gene is ENSG00000285854.
Additional gene information for LDHB Gene
- Monarch Initiative
- Search for LDHB at DataMed
- Search for LDHB at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LDHB Gene
Genomics for LDHB Gene
GeneHancer (GH) Regulatory Elements for LDHB Gene
Promoters and enhancers for LDHB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LDHB on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LDHB gene promoter:
-
- Egr-4
- GR
- GR-alpha
- Ik-1
- Pax-4a
- POU2F1
- POU2F1a
- Sox9
- Sp1
- TGIF
Genomic Locations for LDHB Gene
Genomic Locations for LDHB Gene
- chr12:21,635,341-21,757,857
- (GRCh38/hg38)
- Size:
- 122,517 bases
- Orientation:
- Minus strand
- chr12:21,788,275-21,910,791
- (GRCh37/hg19)
- Size:
- 122,517 bases
- Orientation:
- Minus strand
Genomic View for LDHB Gene
Genes around LDHB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.1 by HGNC
- 12p12.1 by Entrez Gene
- 12p12.1 by Ensembl
LDHB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LDHB Gene
Proteins for LDHB Gene
-
Protein details for LDHB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07195-LDHB_HUMAN
- Recommended name:
- L-lactate dehydrogenase B chain
- Protein Accession:
- P07195
Protein attributes for LDHB Gene
- Size:
- 334 amino acids
- Molecular mass:
- 36638 Da
- Quaternary structure:
-
- Homotetramer.
Protein Expression for LDHB Gene
Selected DME Specific Peptides for LDHB Gene
- P07195:
-
- IKLKGYT
- GEHGDSSV
- DELALVDV
- WSGVNVAGV
- MDLQHGS
- WAIGLSV
- EKLGIHPS
- ARFRYLM
- LTYVTWKLSGLP
- KDYSVTA
- IIPQIVKYSP
- PKHRVIG
- NLDSARFR
- DSENWKE
- EDKLKGE
- SCHGWILGEHGDS
- NPVDILT
- WKLSGLP
- KSADTLW
- VTAGVRQ
- LKGYTNWAIG
- DLQHGSLFL
- VVESAYE
- SKIVVVT
- GVNVAGV
- STMVKGM
- ILGEHGD
- VGVGQVGMA
- LDSARFR
- GMYGIENEVFLSLPC
- VVSNPVD
- NKITVVGVG
- ACAISIL
- IGSGCNLD
- QKLKDDEV
- GLTSVINQKLKD
- VVSNPVDI
Post-translational modifications for LDHB Gene
Other Protein References for LDHB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ LDHB Antibody
- NSJ Bioreagents LDHB Antibody / Lactate dehydrogenase B
- Atlas Antibodies Anti-LDHB Antibody
-
Custom Antibody ServicesOriGene Antibodies for LDHB
- Novus Biologicals Antibodies for LDHB
- Invitrogen Antibodies for LDHB (AFLGC-LDHB)
-
Boster Bio Antibodies for LDHB
-
Santa Cruz Biotechnology (SCBT) Antibodies for LDHB
Protein Products
- G Biosciences Human LDH-B, Liquid
- Atlas Antibodies PrEST Antigen LDHB
-
OriGene Purified Proteins for LDHB
- Search Origene for MassSpec and Protein Over-expression Lysates for LDHB
- Origene Custom Protein Services for LDHB
- ProSpec Recombinant Proteins for LDHB
-
ProSci Proteins for LDHB
-
Abcam proteins for LDHB
Assay Products
- Aviva Systems Biology LDHB ELISA Kit (Human) (OKEH03476) and LDHB ELISA Kit (Human) (OKCD07606)
- Novus Biologicals ELISA Kits for LDHB
- antibodies-online: Show 48 available LDHB Elisa Kits ranked by validation data
- Compare Top LDHB Elisa Kits
-
Quality Products:
-
Abcam assays for LDHB
Domains & Families for LDHB Gene
Gene Families for LDHB Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for LDHB Gene
Suggested Antigen Peptide Sequences for LDHB Gene
- GenScript: Design optimal peptide antigens:
-
- L-lactate dehydrogenase (A8MW50_HUMAN)
- Renal carcinoma antigen NY-REN-46 (LDHB_HUMAN)
- L-lactate dehydrogenase (Q5U077_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P07195- Family:
-
- Belongs to the LDH/MDH superfamily. LDH family.
Function for LDHB Gene
Molecular function for LDHB Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate; Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27;.
- GENATLAS Biochemistry:
- lactate dehydrogenase B,glycolysis,energy pathway
Enzyme Numbers (IUBMB) for LDHB Gene
Phenotypes From GWAS Catalog for LDHB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004457 | lactate dehydrogenase activity | IEA | -- |
| GO:0004459 | L-lactate dehydrogenase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | -- |
Phenotypes for LDHB Gene
- MGI mutant phenotypes for LDHB:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LDHB:
-
- Increased shRNA abundance (Z-score > 2)
- Increased HDAC inhibitor resistance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for LDHB Gene
- MGI Knock Outs for LDHB:
-
- Ldhb Ldhb<tm1b(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LDHB - Select products 50% OFF >
- * LDHB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * LDHB CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for LDHB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LDHB
- genomics-online: gRNA clones - Search results for available LDHB gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for LDHB
miRNA for LDHB Gene
- miRTarBase miRNAs that target LDHB
-
- hsa-mir-375 (MIRT019875)
- hsa-mir-186-3p (MIRT038609)
- hsa-mir-766-3p (MIRT039024)
- hsa-mir-615-3p (MIRT040197)
- hsa-mir-324-5p (MIRT043198)
- hsa-mir-185-5p (MIRT045350)
- hsa-mir-221-3p (MIRT046914)
- hsa-mir-197-3p (MIRT048133)
- hsa-mir-100-5p (MIRT048552)
- hsa-mir-20a-5p (MIRT050573)
- hsa-mir-23a-3p (MIRT054322)
- hsa-mir-24-3p (MIRT054323)
- hsa-mir-210-3p (MIRT054324)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LDHB
- Browse OriGene Inhibitory RNA Products For LDHB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDHB
- genomics-online: shRNA clones - Search results for available LDHB gene related products
Clone Products
- Applied Biological Materials (abm): Clones for LDHB - Select products 50% OFF >
- * LDHB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * LDHB tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG204957
- MR204957
- MR204957L3
- MR204957L3V
- MR204957L4
- MR204957L4V
- MR228846
- RC205074
- RC205074L1
- RC205074L1V
- RC205074L2
- RC205074L2V
- RC205074L3
- RC205074L3V
- RC205074L4
- RC205074L4V
- RC229903
- RC229903L3
- RC229903L3V
- RC229903L4
- RC229903L4V
- RG205074
- RG229903
- RR202177
- RR202177L3
- RR202177L3V
- RR202177L4
- RR202177L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LDHB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LDHB
- genomics-online: cdna clones - Search results for available LDHB gene related products
- orf clones - Search results for available LDHB gene related products
Cell Line Products
-
Horizon Cell Lines for LDHB
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LDHB Gene
Localization for LDHB Gene
Subcellular locations from UniProtKB/Swiss-Prot for LDHB Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 3 |
| peroxisome | 1 |
| nucleus | 1 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 0 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 16130169 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | HDA | 19946888 |
| GO:0045121 | membrane raft | IDA | 25204797 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for LDHB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose metabolism | ||
| 2 | Metabolism |
.40
|
|
| 3 | Metabolic States and Circadian Oscillators |
Metabolic States and Circadian Oscillators
-
|
|
| 4 | Pyruvate metabolism and Citric Acid (TCA) cycle | ||
| 5 | Central carbon metabolism in cancer | ||
Pathways by source for LDHB Gene
2 BioSystems pathways for LDHB Gene
4 Reactome pathways for LDHB Gene
8 KEGG pathways for LDHB Gene
1 Qiagen pathway for LDHB Gene
- Metabolic States and Circadian Oscillators
UniProtKB/Swiss-Prot P07195-LDHB_HUMAN
- Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Interacting Proteins for LDHB Gene
Selected Interacting proteins:
P07195-LDHB_HUMAN
ENSP00000379386
for LDHB Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LDHB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006089 | lactate metabolic process | IEA | -- |
| GO:0006090 | pyruvate metabolic process | TAS | -- |
| GO:0019674 | NAD metabolic process | IEA | -- |
| GO:0019752 | carboxylic acid metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for LDHB Gene
Drugs & Compounds for LDHB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| NADH | Approved | Nutra | Target | 0 | ||
| Stiripentol | Approved | Pharma | Target, inhibitor | An LDH inhibitor | 11 | |
| Pyruvic acid | Approved, Investigational | Nutra | 0 | |||
| 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid | Experimental | Pharma | Target | 0 | ||
| Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 108 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Hydroxybutyric acid |
|
600-15-7 |
|
|||
| 3-Mercaptolactic acid |
|
2614-83-7 |
|
|||
| 3-Mercaptopyruvic acid |
|
2464-23-5 |
|
|||
| Hydrogen Ion |
|
|
(2) ApexBio Compounds for LDHB Gene
| Compound | Action | Cas Number |
|---|---|---|
| Isosafrole | A stiripentol analog, a potent LDH inhibitor. | 120-58-1 |
| Stiripentol | An LDH inhibitor | 49763-96-4 |
Drug Products
- G Biosciences Human LDH-B, Liquid
- Atlas Antibodies PrEST Antigen LDHB
- ApexBio compounds for LDHB
Transcripts for LDHB Gene
mRNA/cDNA for LDHB Gene
- (3) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (3067) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000542765 672 bps (ENST00000542765.4)
- ENST00000470985 678 bps (ENST00000470985.3)
- ENST00000396076 1538 bps (ENST00000396076.5)
- ENST00000350669 1303 bps (ENST00000350669.5)
- ENST00000396075 744 bps (ENST00000396075.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LDHB - Select products 50% OFF >
- * LDHB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * LDHB CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for LDHB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LDHB
- genomics-online: gRNA clones - Search results for available LDHB gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for LDHB
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LDHB
- Browse OriGene Inhibitory RNA Products For LDHB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDHB
- genomics-online: shRNA clones - Search results for available LDHB gene related products
Clone Products
- Applied Biological Materials (abm): Clones for LDHB - Select products 50% OFF >
- * LDHB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * LDHB tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG204957
- MR204957
- MR204957L3
- MR204957L3V
- MR204957L4
- MR204957L4V
- MR228846
- RC205074
- RC205074L1
- RC205074L1V
- RC205074L2
- RC205074L2V
- RC205074L3
- RC205074L3V
- RC205074L4
- RC205074L4V
- RC229903
- RC229903L3
- RC229903L3V
- RC229903L4
- RC229903L4V
- RG205074
- RG229903
- RR202177
- RR202177L3
- RR202177L3V
- RR202177L4
- RR202177L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LDHB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LDHB
- genomics-online: cdna clones - Search results for available LDHB gene related products
- orf clones - Search results for available LDHB gene related products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | - | - |
Expression for LDHB Gene
mRNA differential expression in normal tissues according to GTEx for LDHB Gene
This gene is overexpressed in Heart - Left Ventricle (x5.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LDHB Gene
NURSA nuclear receptor signaling pathways regulating expression of LDHB Gene:
LDHBSOURCE GeneReport for Unigene cluster for LDHB Gene:
Hs.446149Evidence on tissue expression from TISSUES for LDHB Gene
- Nervous system(5)
- Liver(4.9)
- Muscle(4.9)
- Blood(4.8)
- Skin(4.8)
- Eye(4.7)
- Lung(4.6)
- Kidney(4.4)
- Intestine(4.2)
- Heart(3.8)
- Pancreas(3.5)
- Thyroid gland(2.6)
- Bone(2.5)
- Stomach(2.5)
- Adrenal gland(2.4)
- Lymph node(2.4)
- Spleen(2.3)
- Gall bladder(2.2)
- Bone marrow(2.1)
Primer Products
-
OriGene qPCR primer pairs for LDHB
-
OriGene qPCR primer pairs and template standards for LDHB
- genomics-online: primer clones - Search results for available LDHB gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDHB Gene
Orthologs for LDHB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LDHB 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LDHB 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| LDHB 33 32 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | LDHB 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ldhb 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ldhb 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LDHB 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LDHB 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | LDHB 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ldhb 32 |
|
||
| MGC75741 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | ldha-B 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ldhba 33 32 |
|
OneToMany | |
| ldhbb 33 |
|
OneToMany | |||
| ldhb 32 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3984 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ImpL3 33 34 |
|
ManyToMany | |
| CG13334 33 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ldh-1 33 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11301 33 |
|
OneToMany |
- Species where no ortholog for LDHB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for LDHB Gene
- ENSEMBL:
- Gene Tree for LDHB (if available)
- TreeFam:
- Gene Tree for LDHB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LDHB: view image
Paralogs for LDHB Gene
(5) SIMAP similar genes for LDHB Gene using alignment to 5 proteins:
- LDHB_HUMAN
- A8MW50_HUMAN
- C9J7H8_HUMAN
- F5H793_HUMAN
- Q5U077_HUMAN
Pseudogenes.org Pseudogenes for LDHB Gene
Variants for LDHB Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs118203895 | affects, Lactate dehydrogenase B deficiency, Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128] | 21,642,032(-) | C/T | coding_sequence_variant, missense_variant | |
| rs118203896 | affects, Lactate dehydrogenase B deficiency, Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128] | 21,643,971(-) | T/G | coding_sequence_variant, missense_variant | |
| rs118203897 | affects, Lactate dehydrogenase B deficiency, Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128] | 21,654,653(-) | T/C | coding_sequence_variant, missense_variant | |
| rs141629567 | uncertain-significance, Lactate dehydrogenase B deficiency | 21,641,962(-) | G/A/T | coding_sequence_variant, synonymous_variant | |
| rs141707607 | uncertain-significance, Lactate dehydrogenase B deficiency | 21,643,981(-) | G/A | coding_sequence_variant, synonymous_variant |
Residual Variation Intolerance Score:
23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.52;
29.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LDHB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHB Gene
Disorders for LDHB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lactate dehydrogenase b deficiency |
|
|
| dressler's syndrome |
|
|
| triosephosphate isomerase deficiency |
|
|
| coenurosis |
|
|
| bladder urothelial carcinoma |
|
|
Search LDHB in MalaCards
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UniProtKB/Swiss-Prot
LDHB_HUMAN- Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128]: A condition with no deleterious effects on health. LDHBD is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected. {ECO:0000269 PubMed:10211631, ECO:0000269 PubMed:11509017, ECO:0000269 PubMed:1587525, ECO:0000269 PubMed:2334429, ECO:0000269 PubMed:8314553, ECO:0000269 PubMed:8462975, ECO:0000269 PubMed:8611651, ECO:0000269 PubMed:9929983, ECO:0000269 Ref.20}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LDHB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for LDHB Gene
Publications for LDHB Gene
- Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder. (PMID: 12555229) Philibert RA … Coryell WH (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003) 3 23 43 56
- Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant. (PMID: 1587525) Sudo K … Toriumi J (Human genetics 1992) 3 4 23 56
- A missense mutation found in human lactate dehydrogenase-B (H) variant gene. (PMID: 2334429) Sudo K … Li SS (Biochemical and biophysical research communications 1990) 3 4 23 56
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 43 56
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 56
ExternalLinks
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