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Aliases for LDHB Gene

Aliases for LDHB Gene

  • Lactate Dehydrogenase B 2 3 5
  • Renal Carcinoma Antigen NY-REN-46 3 4
  • LDH Heart Subunit 3 4
  • LDH-B 3 4
  • LDH-H 3 4
  • Epididymis Secretory Protein Li 281 3
  • Testicular Secretory Protein Li 25 3
  • L-Lactate Dehydrogenase B Chain 3
  • Lactate Dehydrogenase H Chain 3
  • EC 4
  • HEL-S-281 3
  • LDHBD 3
  • TRG-5 3

External Ids for LDHB Gene

Previous GeneCards Identifiers for LDHB Gene

  • GC12M022074
  • GC12M021789
  • GC12M021688
  • GC12M021679
  • GC12M021788
  • GC12M021561

Summaries for LDHB Gene

Entrez Gene Summary for LDHB Gene

  • This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]

GeneCards Summary for LDHB Gene

LDHB (Lactate Dehydrogenase B) is a Protein Coding gene. Diseases associated with LDHB include Lactate Dehydrogenase B Deficiency and Dressler's Syndrome. Among its related pathways are Metabolism and Metabolic States and Circadian Oscillators. Gene Ontology (GO) annotations related to this gene include identical protein binding and kinase binding. An important paralog of this gene is LDHA.

Additional gene information for LDHB Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHB Gene

Genomics for LDHB Gene

GeneHancer (GH) Regulatory Elements for LDHB Gene

Promoters and enhancers for LDHB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J021655 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.1 +100.7 100670 3.4 ATF1 SMAD1 SIN3A ZNF2 YY1 POLR2B GLIS2 ZNF213 E2F8 ATF7 LDHB ENSG00000256973 ENSG00000256615 GC12P021652 LOC105369689
GH12J022045 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.7 -289.7 -289700 3.9 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF143 KLF13 SP3 CMAS ST8SIA1 LDHB LOC105369690 GC12M021918
GH12J021638 Enhancer 0.4 ENCODE dbSUPER 11.3 +119.7 119665 0.1 ENSG00000256615 LDHB SPX GYS2 GC12P021652
GH12J021509 Enhancer 0.4 ENCODE 10.2 +248.0 248028 1 SMARCA5 SRF ZFP36 PYROXD1 SPX ENSG00000256615 LDHB RECQL GOLT1B
GH12J021513 Enhancer 0.3 FANTOM5 10.2 +244.6 244601 0.4 GYS2 ENSG00000256615 LDHB SPX GOLT1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LDHB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LDHB gene promoter:
  • POU2F1a
  • POU2F1
  • Pax-4a
  • Sp1
  • Sox9
  • Egr-4
  • Ik-1
  • TGIF
  • GR
  • GR-alpha

Genomic Locations for LDHB Gene

Genomic Locations for LDHB Gene
122,517 bases
Minus strand
122,517 bases
Minus strand

Genomic View for LDHB Gene

Genes around LDHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHB Gene

Proteins for LDHB Gene

  • Protein details for LDHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    L-lactate dehydrogenase B chain
    Protein Accession:

    Protein attributes for LDHB Gene

    334 amino acids
    Molecular mass:
    36638 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for LDHB Gene

neXtProt entry for LDHB Gene

Post-translational modifications for LDHB Gene

  • Ubiquitination at isoforms=332, isoforms=319, posLast=310310, posLast=308308, isoforms=233, isoforms=119, isoforms=91, isoforms=77, and posLast=6060
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LDHB Gene

Domains & Families for LDHB Gene

Gene Families for LDHB Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LDHB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDH/MDH superfamily. LDH family.
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHB: view

Function for LDHB Gene

Molecular function for LDHB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH.
GENATLAS Biochemistry:
lactate dehydrogenase B,glycolysis,energy pathway

Enzyme Numbers (IUBMB) for LDHB Gene

Gene Ontology (GO) - Molecular Function for LDHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004457 lactate dehydrogenase activity IEA --
GO:0004459 L-lactate dehydrogenase activity EXP,IEA 1996957
GO:0005515 protein binding IPI 21044950
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with LDHB: view
genes like me logo Genes that share phenotypes with LDHB: view

Animal Models for LDHB Gene

MGI Knock Outs for LDHB:
  • Ldhb Ldhb<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDHB

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LDHB Gene

Localization for LDHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDHB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDHB gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 4
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LDHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with LDHB: view

Pathways & Interactions for LDHB Gene

genes like me logo Genes that share pathways with LDHB: view

UniProtKB/Swiss-Prot P07195-LDHB_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Gene Ontology (GO) - Biological Process for LDHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006089 lactate metabolic process IEA --
GO:0006090 pyruvate metabolic process TAS --
GO:0019674 NAD metabolic process IEA --
GO:0019752 carboxylic acid metabolic process IEA --
genes like me logo Genes that share ontologies with LDHB: view

No data available for SIGNOR curated interactions for LDHB Gene

Drugs & Compounds for LDHB Gene

(12) Drugs for LDHB Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Stiripentol Approved Pharma Target, inhibitor An LDH inhibitor 9
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
Pyruvic acid Approved, Investigational Nutra 0
4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid Experimental Pharma Target 0

(5) Additional Compounds for LDHB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • 2-Hydroxybutanoic acid
  • alpha-Hydroxybutanoic acid
  • alpha-Hydroxybutyric acid
  • 2-Hydroxybutanoate
  • 2-Hydroxybutyrate
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
3-Mercaptopyruvic acid
  • 3-mercapto-2-Oxopropanoic acid
  • 3-Mercaptopyruvate
  • Mercaptopyruvate
  • 3-mercapto-2-Oxopropanoate
  • Mercaptopyruvic acid
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with LDHB: view

Transcripts for LDHB Gene

Unigene Clusters for LDHB Gene

Lactate dehydrogenase B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDHB

Alternative Splicing Database (ASD) splice patterns (SP) for LDHB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for LDHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LDHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LDHB Gene

mRNA differential expression in normal tissues according to GTEx for LDHB Gene

This gene is overexpressed in Heart - Left Ventricle (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LDHB Gene

Protein tissue co-expression partners for LDHB Gene

NURSA nuclear receptor signaling pathways regulating expression of LDHB Gene:


SOURCE GeneReport for Unigene cluster for LDHB Gene:


Evidence on tissue expression from TISSUES for LDHB Gene

  • Nervous system(5)
  • Liver(4.9)
  • Muscle(4.9)
  • Blood(4.8)
  • Skin(4.8)
  • Eye(4.7)
  • Lung(4.6)
  • Kidney(4.4)
  • Intestine(4.2)
  • Heart(3.8)
  • Pancreas(3.5)
  • Thyroid gland(2.6)
  • Bone(2.5)
  • Stomach(2.5)
  • Adrenal gland(2.4)
  • Lymph node(2.4)
  • Spleen(2.3)
  • Gall bladder(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with LDHB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDHB Gene

Orthologs for LDHB Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LDHB 34 33
  • 99.8 (n)
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
-- 34
  • 97 (a)
-- 34
  • 95 (a)
-- 34
  • 95 (a)
LDHB 34 33
  • 93.51 (n)
(Monodelphis domestica)
Mammalia LDHB 34
  • 98 (a)
(Bos Taurus)
Mammalia LDHB 34 33
  • 92.71 (n)
(Mus musculus)
Mammalia Ldhb 16 34 33
  • 86.33 (n)
(Rattus norvegicus)
Mammalia Ldhb 33
  • 86.13 (n)
(Ornithorhynchus anatinus)
Mammalia LDHB 34
  • 79 (a)
(Gallus gallus)
Aves LDHB 34 33
  • 79.98 (n)
(Anolis carolinensis)
Reptilia LDHB 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ldhb 33
  • 75.65 (n)
MGC75741 33
African clawed frog
(Xenopus laevis)
Amphibia ldha-B 33
(Danio rerio)
Actinopterygii ldhba 34 33
  • 71.56 (n)
ldhbb 34
  • 68 (a)
ldhb 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3984 33
fruit fly
(Drosophila melanogaster)
Insecta ImpL3 34 35
  • 62 (a)
CG13334 34 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea ldh-1 34 35
  • 62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 34
  • 58 (a)
Species where no ortholog for LDHB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LDHB Gene

Gene Tree for LDHB (if available)
Gene Tree for LDHB (if available)
Evolutionary constrained regions (ECRs) for LDHB: view image

Paralogs for LDHB Gene

Paralogs for LDHB Gene

(5) SIMAP similar genes for LDHB Gene using alignment to 5 proteins:

  • A8MW50_HUMAN
  • C9J7H8_HUMAN
  • F5H793_HUMAN
  • Q5U077_HUMAN Pseudogenes for LDHB Gene

genes like me logo Genes that share paralogs with LDHB: view

Variants for LDHB Gene

Sequence variations from dbSNP and Humsavar for LDHB Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs118203895 affects, Lactate dehydrogenase B deficiency, Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128] 21,642,032(-) C/T coding_sequence_variant, missense_variant
rs118203896 affects, Lactate dehydrogenase B deficiency, Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128] 21,643,971(-) T/G coding_sequence_variant, missense_variant
rs118203897 affects, Lactate dehydrogenase B deficiency, Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128] 21,654,653(-) T/C coding_sequence_variant, missense_variant
rs141629567 uncertain-significance, Lactate dehydrogenase B deficiency 21,641,962(-) G/A/T coding_sequence_variant, synonymous_variant
rs141707607 uncertain-significance, Lactate dehydrogenase B deficiency 21,643,981(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for LDHB Gene

Variant ID Type Subtype PubMed ID
nsv557741 CNV gain 21841781
nsv557744 CNV loss 21841781
nsv637 CNV insertion 18451855
nsv832349 CNV gain 17160897

Variation tolerance for LDHB Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LDHB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHB Gene

Disorders for LDHB Gene

MalaCards: The human disease database

(7) MalaCards diseases for LDHB Gene - From: HGMD, OMIM, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lactate dehydrogenase b deficiency
  • ldhbd
dressler's syndrome
  • dressler syndrome
  • coenuriasis
maxillary sinus cancer
  • malignant neoplasm of antrum
paranasal sinus cancer
  • adenoid cystic carcinoma of accessory sinus
- elite association - COSMIC cancer census association via MalaCards
Search LDHB in MalaCards View complete list of genes associated with diseases


  • Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128]: A condition with no deleterious effects on health. LDHBD is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected. {ECO:0000269 PubMed:10211631, ECO:0000269 PubMed:11509017, ECO:0000269 PubMed:1587525, ECO:0000269 PubMed:2334429, ECO:0000269 PubMed:8314553, ECO:0000269 PubMed:8462975, ECO:0000269 PubMed:8611651, ECO:0000269 PubMed:9929983, ECO:0000269 Ref.20}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for LDHB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LDHB: view

No data available for Genatlas for LDHB Gene

Publications for LDHB Gene

  1. Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder. (PMID: 12555229) Philibert RA … Coryell WH (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003) 3 22 44 58
  2. Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant. (PMID: 1587525) Sudo K … Toriumi J (Human genetics 1992) 3 4 22 58
  3. A missense mutation found in human lactate dehydrogenase-B (H) variant gene. (PMID: 2334429) Sudo K … Li SS (Biochemical and biophysical research communications 1990) 3 4 22 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58

Products for LDHB Gene

Sources for LDHB Gene

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