Free for academic non-profit institutions. Other users need a Commercial license
LDHAL6B (Lactate Dehydrogenase A Like 6B) is a Protein Coding gene. Diseases associated with LDHAL6B include Dressler's Syndrome and Myxedema. Among its related pathways are Central carbon metabolism in cancer and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004459 | L-lactate dehydrogenase activity | TAS | -- |
GO:0005515 | protein binding | IPI | 12107167 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005759 | mitochondrial matrix | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucose metabolism | ||
2 | Metabolism |
.40
|
|
3 | Pyruvate metabolism and Citric Acid (TCA) cycle | ||
4 | Central carbon metabolism in cancer | ||
5 | Sulfur amino acid metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0006090 | pyruvate metabolic process | TAS | -- |
GO:0019752 | carboxylic acid metabolic process | IEA | -- |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Hydroxybutyric acid |
|
3347-90-8 |
|
|||
3-Mercaptolactic acid |
|
2614-83-7 |
|
|||
3-Mercaptopyruvic acid |
|
2464-23-5 |
|
|||
Hydrogen Ion |
|
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LDHAL6B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LDHAL6B 30 |
|
||
Dog (Canis familiaris) |
Mammalia | LOC484048 30 |
|
||
LDHB 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Ldhal6b 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ldhal6b 30 17 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Chicken (Gallus gallus) |
Aves | LDHA 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | ldha 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | ImpL3 31 |
|
ManyToMany | |
CG13334 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ldh-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11301 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35212259 | - |
p.Pro259Ser |
|||
rs3809529 | - |
p.Pro30Leu |
|||
rs3809530 | - |
p.Val14Met |
|||
rs3825937 | - |
p.Ile326Thr |
Disorder | Aliases | PubMed IDs |
---|---|---|
dressler's syndrome |
|
|
myxedema |
|
|