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Aliases for LDHAL6B Gene

Aliases for LDHAL6B Gene

  • Lactate Dehydrogenase A Like 6B 2 3 5
  • Lactate Dehydrogenase A-Like 6 2 3
  • EC 1.1.1.27 4 56
  • LDHAL6 3 4
  • LDHL 3 4
  • L-Lactate Dehydrogenase A-Like 6B 3
  • Testicular Tissue Protein Li 105 3
  • EC 1.1.1 56
  • LDH6B 3

External Ids for LDHAL6B Gene

Previous HGNC Symbols for LDHAL6B Gene

  • LDHAL6

Previous GeneCards Identifiers for LDHAL6B Gene

  • GC15P057286
  • GC15P059499
  • GC15P036322

Summaries for LDHAL6B Gene

GeneCards Summary for LDHAL6B Gene

LDHAL6B (Lactate Dehydrogenase A Like 6B) is a Protein Coding gene. Diseases associated with LDHAL6B include Hodgkin's Lymphoma, Lymphocytic Depletion. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6A.

Additional gene information for LDHAL6B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHAL6B Gene

Genomics for LDHAL6B Gene

GeneHancer (GH) Regulatory Elements for LDHAL6B Gene

Promoters and enhancers for LDHAL6B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I059206 Promoter 0.7 EPDnew 550.8 +0.0 35 0.1 L3MBTL2 NRF1 LDHAL6B PIR59873 GC15M059055 MYO1E
GH15I059173 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 32.5 -30.5 -30494 5.2 MEIS2 CTCF TFAP4 PKNOX1 SIN3A CEBPG RAD21 TEAD3 ZFHX2 POLR2A LDHAL6B FAM81A MYO1E RNF111 ADAM10 MIR2116 GC15M059055
GH15I059199 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 32.1 -6.5 -6549 2.2 JUN INSM2 KLF17 SIN3A ZBTB48 ZNF366 PATZ1 PRDM10 FOSL2 FOS LDHAL6B BNIP2 RNF111 ADAM10 MIR2116 GC15M059055 MYO1E
GH15I059190 Enhancer 1 Ensembl ENCODE dbSUPER 22.1 -15.0 -14967 2.9 NFIB JUN SIN3A SIX5 REST SP1 JUND ATF3 POLR2A ZBTB33 LDHAL6B MIR2116 FAM81A GC15M059055 MYO1E
GH15I059168 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.7 -36.7 -36748 3.8 SAP130 ZNF449 JUN CEBPG NFXL1 ZIC2 TEAD3 POLR2A RCOR1 FOSL2 MIR2116 LDHAL6B RNF111 ADAM10 SLTM ENSG00000259732 GC15M059055 MYO1E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LDHAL6B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LDHAL6B gene promoter:

Genomic Locations for LDHAL6B Gene

Genomic Locations for LDHAL6B Gene
chr15:59,206,816-59,208,588
(GRCh38/hg38)
Size:
1,773 bases
Orientation:
Plus strand
chr15:59,499,042-59,500,714
(GRCh37/hg19)

Genomic View for LDHAL6B Gene

Genes around LDHAL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDHAL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDHAL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHAL6B Gene

Proteins for LDHAL6B Gene

  • Protein details for LDHAL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYZ2-LDH6B_HUMAN
    Recommended name:
    L-lactate dehydrogenase A-like 6B
    Protein Accession:
    Q9BYZ2
    Secondary Accessions:
    • Q6DUY4
    • Q96LI2

    Protein attributes for LDHAL6B Gene

    Size:
    381 amino acids
    Molecular mass:
    41943 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDHAL6B Gene

Selected DME Specific Peptides for LDHAL6B Gene

Q9BYZ2:
  • LDTARFR
  • GEHGDSSV
  • MDLQHGS
  • WAIGLSV
  • EDKLKGE
  • SCHGWILGEHGDS
  • NPVDILT
  • ILGEHGD
  • LVIITAGARQ
  • ACAISIL
  • IGSGCNLD

Post-translational modifications for LDHAL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LDHAL6B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LDHAL6B Gene

Gene Families for LDHAL6B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LDHAL6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYZ2

UniProtKB/Swiss-Prot:

LDH6B_HUMAN :
  • Belongs to the LDH/MDH superfamily. LDH family.
Family:
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHAL6B: view

Function for LDHAL6B Gene

Molecular function for LDHAL6B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH.

Enzyme Numbers (IUBMB) for LDHAL6B Gene

Gene Ontology (GO) - Molecular Function for LDHAL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004459 L-lactate dehydrogenase activity TAS --
GO:0005515 protein binding IPI 12107167
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with LDHAL6B: view
genes like me logo Genes that share phenotypes with LDHAL6B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LDHAL6B Gene

Localization for LDHAL6B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDHAL6B gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
extracellular 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LDHAL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with LDHAL6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LDHAL6B Gene

Pathways & Interactions for LDHAL6B Gene

genes like me logo Genes that share pathways with LDHAL6B: view

UniProtKB/Swiss-Prot Q9BYZ2-LDH6B_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Gene Ontology (GO) - Biological Process for LDHAL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006090 pyruvate metabolic process TAS --
GO:0019752 carboxylic acid metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LDHAL6B: view

No data available for SIGNOR curated interactions for LDHAL6B Gene

Drugs & Compounds for LDHAL6B Gene

(7) Drugs for LDHAL6B Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Pyruvic acid Approved, Investigational Nutra 0
2-Ketobutyric acid Experimental Pharma 0
L-lactic acid Pharma Full agonist, Agonist 0
NAD Pharma Full agonist, Agonist 0

(5) Additional Compounds for LDHAL6B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
  • (RS)-2-Hydroxybutyric acid
  • 2-Hydroxy-Butanoate
  • 2-Hydroxy-Butanoic acid
  • 2-Hydroxy-DL-Butyrate
600-15-7
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
2614-83-7
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with LDHAL6B: view

Transcripts for LDHAL6B Gene

mRNA/cDNA for LDHAL6B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDHAL6B Gene

Lactate dehydrogenase A-like 6B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDHAL6B Gene

No ASD Table

Relevant External Links for LDHAL6B Gene

GeneLoc Exon Structure for
LDHAL6B
ECgene alternative splicing isoforms for
LDHAL6B

Expression for LDHAL6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LDHAL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDHAL6B Gene

This gene is overexpressed in Testis (x42.9).

Protein differential expression in normal tissues from HIPED for LDHAL6B Gene

This gene is overexpressed in Lung (22.7), Testis (17.2), Ovary (13.2), and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LDHAL6B Gene



Protein tissue co-expression partners for LDHAL6B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LDHAL6B Gene:

LDHAL6B

SOURCE GeneReport for Unigene cluster for LDHAL6B Gene:

Hs.307052

mRNA Expression by UniProt/SwissProt for LDHAL6B Gene:

Q9BYZ2-LDH6B_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with LDHAL6B: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDHAL6B Gene

Orthologs for LDHAL6B Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHAL6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDHAL6B 34 33
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LDHAL6B 33
  • 85.39 (n)
dog
(Canis familiaris)
Mammalia LOC484048 33
  • 83.64 (n)
LDHB 34
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ldhal6b 33
  • 77.25 (n)
mouse
(Mus musculus)
Mammalia Ldhal6b 33 16
  • 76.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
ManyToMany
-- 34
  • 61 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LDHA 34
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ldha 34
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ImpL3 34
  • 57 (a)
ManyToMany
CG13334 34
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ldh-1 34
  • 55 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 34
  • 50 (a)
OneToMany
Species where no ortholog for LDHAL6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LDHAL6B Gene

ENSEMBL:
Gene Tree for LDHAL6B (if available)
TreeFam:
Gene Tree for LDHAL6B (if available)

Paralogs for LDHAL6B Gene

Paralogs for LDHAL6B Gene

(5) SIMAP similar genes for LDHAL6B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for LDHAL6B Gene

genes like me logo Genes that share paralogs with LDHAL6B: view

Variants for LDHAL6B Gene

Sequence variations from dbSNP and Humsavar for LDHAL6B Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs140447165 likely-benign, not specified 59,205,423(+) G/A/C upstream_transcript_variant
rs1000166152 -- 59,206,524(+) C/G upstream_transcript_variant
rs1001944579 -- 59,208,577(+) G/T 3_prime_UTR_variant
rs1003743217 -- 59,204,864(+) G/C upstream_transcript_variant
rs1004815756 -- 59,205,469(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LDHAL6B Gene

Variant ID Type Subtype PubMed ID
nsv527307 CNV gain 19592680
nsv7266 OTHER inversion 18451855
nsv833025 CNV gain 17160897
nsv833027 CNV gain+loss 17160897
nsv974584 CNV duplication 23825009

Variation tolerance for LDHAL6B Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.13; 98.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LDHAL6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDHAL6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHAL6B Gene

Disorders for LDHAL6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for LDHAL6B Gene - From: DISEASES

Disorder Aliases PubMed IDs
hodgkin's lymphoma, lymphocytic depletion
  • hodgkin lymphoma, lymphocyte depletion
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LDHAL6B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LDHAL6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LDHAL6B Gene

Publications for LDHAL6B Gene

  1. Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis. (PMID: 15870898) Wang H … Sha J (International journal of molecular medicine 2005) 2 3 22 58
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for LDHAL6B Gene

Sources for LDHAL6B Gene

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