Aliases for LDHAL6B Gene
Aliases for LDHAL6B Gene
External Ids for LDHAL6B Gene
- HGNC: 21481
- Entrez Gene: 92483
- Ensembl: ENSG00000171989
- UniProtKB: Q9BYZ2
Previous HGNC Symbols for LDHAL6B Gene
- LDHAL6
Previous GeneCards Identifiers for LDHAL6B Gene
- GC15P057286
- GC15P059499
- GC15P036322
Summaries for LDHAL6B Gene
GeneCards Summary for LDHAL6B Gene
LDHAL6B (Lactate Dehydrogenase A Like 6B) is a Protein Coding gene. Diseases associated with LDHAL6B include Hodgkin's Lymphoma, Lymphocytic Depletion. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6A.
Additional gene information for LDHAL6B Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHAL6B Gene
Genomics for LDHAL6B Gene
GeneHancer (GH) Regulatory Elements for LDHAL6B Gene
Promoters and enhancers for LDHAL6B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LDHAL6B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for LDHAL6B Gene
Genomic Locations for LDHAL6B Gene
- chr15:59,206,816-59,208,588
- (GRCh38/hg38)
- Size:
- 1,773 bases
- Orientation:
- Plus strand
- chr15:59,499,042-59,500,714
- (GRCh37/hg19)
Genomic View for LDHAL6B Gene
Genes around LDHAL6B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.2 by Ensembl
- 15q22.2 by Entrez Gene
- 15q22.2 by HGNC
LDHAL6B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LDHAL6B Gene
Proteins for LDHAL6B Gene
-
Protein details for LDHAL6B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BYZ2-LDH6B_HUMAN
- Recommended name:
- L-lactate dehydrogenase A-like 6B
- Protein Accession:
- Q9BYZ2
- Q6DUY4
- Q96LI2
Protein attributes for LDHAL6B Gene
- Size:
- 381 amino acids
- Molecular mass:
- 41943 Da
- Quaternary structure:
- No Data Available
Protein Expression for LDHAL6B Gene
Selected DME Specific Peptides for LDHAL6B Gene
- Q9BYZ2:
-
- LDTARFR
- GEHGDSSV
- MDLQHGS
- WAIGLSV
- EDKLKGE
- SCHGWILGEHGDS
- NPVDILT
- ILGEHGD
- LVIITAGARQ
- ACAISIL
- IGSGCNLD
Post-translational modifications for LDHAL6B Gene
Other Protein References for LDHAL6B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for LDHAL6B
- Novus Biologicals Antibodies for LDHAL6B
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Protein Products
-
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-
Abcam proteins for LDHAL6B
Assay Products
Domains & Families for LDHAL6B Gene
Gene Families for LDHAL6B Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for LDHAL6B Gene
Suggested Antigen Peptide Sequences for LDHAL6B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BYZ2- Family:
-
- Belongs to the LDH/MDH superfamily. LDH family.
Function for LDHAL6B Gene
Molecular function for LDHAL6B Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- (S)-lactate + NAD(+) = pyruvate + NADH.
Enzyme Numbers (IUBMB) for LDHAL6B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004459 | L-lactate dehydrogenase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 12107167 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | -- |
Phenotypes for LDHAL6B Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for LDHAL6B gene
-
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-
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Vectors and viruses for KO, Activation, Repression, and more
-
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available LDHAL6B gene related products
- orf clones - Search results for available LDHAL6B gene related products
- Applied Biological Materials Clones for LDHAL6B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LDHAL6B
-
ViGene Biosciences adenoviral particle packaged cDNA for LDHAL6B gene
-
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-
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LDHAL6B Gene
Localization for LDHAL6B Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,HDA | 21630459 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005759 | mitochondrial matrix | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LDHAL6B Gene
Pathways & Interactions for LDHAL6B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose metabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Pyruvate metabolism and Citric Acid (TCA) cycle | ||
| 4 | Sulfur amino acid metabolism | ||
| 5 | Glucagon signaling pathway | ||
Pathways by source for LDHAL6B Gene
1 BioSystems pathway for LDHAL6B Gene
4 Reactome pathways for LDHAL6B Gene
6 KEGG pathways for LDHAL6B Gene
UniProtKB/Swiss-Prot Q9BYZ2-LDH6B_HUMAN
- Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Interacting Proteins for LDHAL6B Gene
Selected Interacting proteins:
Q9BYZ2-LDH6B_HUMAN
ENSP00000302393
for LDHAL6B Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006090 | pyruvate metabolic process | TAS | -- |
| GO:0019752 | carboxylic acid metabolic process | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for LDHAL6B Gene
Drugs & Compounds for LDHAL6B Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Hydroxybutyric acid |
|
600-15-7 |
|
|||
| 3-Mercaptolactic acid |
|
2614-83-7 |
|
|||
| 3-Mercaptopyruvic acid |
|
2464-23-5 |
|
|||
| Hydrogen Ion |
|
|
Transcripts for LDHAL6B Gene
mRNA/cDNA for LDHAL6B Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (26) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LDHAL6B Gene
CRISPR Products
-
OriGene CRISPR knockouts for LDHAL6B
- genomics-online: gRNA clones - Search results for available LDHAL6B gene related products
- Applied Biological Materials CRISPR for LDHAL6B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LDHAL6B
- GenScript: Design CRISPR guide RNA sequences for LDHAL6B
miRNA Products
- Search ViGene Biosciences for LDHAL6B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LDHAL6B
- Browse OriGene Inhibitory RNA Products For LDHAL6B
- genomics-online: shRNA clones - Search results for available LDHAL6B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LDHAL6B gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for LDHAL6B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LDHAL6B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available LDHAL6B gene related products
- orf clones - Search results for available LDHAL6B gene related products
- Applied Biological Materials Clones for LDHAL6B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LDHAL6B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Gonad
- Primordial Germ Cell Precursors Epiblast
-
Testis (Reproductive System)
- Mature Sertoli Cells Seminiferous Tubules
mRNA differential expression in normal tissues according to GTEx for LDHAL6B Gene
This gene is overexpressed in Testis (x42.9).
This gene is overexpressed in Lung (22.7), Testis (17.2), Ovary (13.2), and Heart (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LDHAL6B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of LDHAL6B Gene:
LDHAL6BSOURCE GeneReport for Unigene cluster for LDHAL6B Gene:
Hs.307052mRNA Expression by UniProt/SwissProt for LDHAL6B Gene:
Q9BYZ2-LDH6B_HUMAN
Tissue specificity:
Testis specific.
Primer Products
-
OriGene qPCR primer pairs for LDHAL6B
-
OriGene qPCR primer pairs and template standards for LDHAL6B
- genomics-online: primer clones - Search results for available LDHAL6B gene related products
Gene Expression Assay Products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDHAL6B Gene
Orthologs for LDHAL6B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LDHAL6B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LDHAL6B 33 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC484048 33 |
|
||
| LDHB 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Ldhal6b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ldhal6b 33 16 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | LDHA 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | ldha 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | ImpL3 34 |
|
ManyToMany | |
| CG13334 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ldh-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11301 34 |
|
OneToMany |
- Species where no ortholog for LDHAL6B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for LDHAL6B Gene
(5) SIMAP similar genes for LDHAL6B Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for LDHAL6B Gene
Variants for LDHAL6B Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140447165 | likely-benign, not specified | 59,205,423(+) | G/A/C | upstream_transcript_variant | |
| rs1000166152 | -- | 59,206,524(+) | C/G | upstream_transcript_variant | |
| rs1001944579 | -- | 59,208,577(+) | G/T | 3_prime_UTR_variant | |
| rs1003743217 | -- | 59,204,864(+) | G/C | upstream_transcript_variant | |
| rs1004815756 | -- | 59,205,469(+) | T/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
17.13;
98.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LDHAL6B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LDHAL6B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHAL6B Gene
Disorders for LDHAL6B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hodgkin's lymphoma, lymphocytic depletion |
|
|
Search LDHAL6B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LDHAL6B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for LDHAL6B Gene
Publications for LDHAL6B Gene
- Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis. (PMID: 15870898) Wang H … Sha J (International journal of molecular medicine 2005) 2 3 22 58
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for LDHAL6B Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for LDHAL6B
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- ViGene Biosciences adenoviral particle packaged cDNA for LDHAL6B gene
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Sources for LDHAL6B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
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