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Aliases for LDHAL6A Gene

Aliases for LDHAL6A Gene

  • Lactate Dehydrogenase A Like 6A 2 3 5
  • L-Lactate Dehydrogenase A-Like 6A 3
  • EC 4
  • LDH6A 3
  • LDHL2 4

External Ids for LDHAL6A Gene

Previous GeneCards Identifiers for LDHAL6A Gene

  • GC11P018163

Summaries for LDHAL6A Gene

GeneCards Summary for LDHAL6A Gene

LDHAL6A (Lactate Dehydrogenase A Like 6A) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6B.

UniProtKB/Swiss-Prot for LDHAL6A Gene

  • Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.

Additional gene information for LDHAL6A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHAL6A Gene

Genomics for LDHAL6A Gene

GeneHancer (GH) Regulatory Elements for LDHAL6A Gene

Promoters and enhancers for LDHAL6A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J018457 Enhancer 0.7 ENCODE 659.7 +1.8 1805 0.2 SOX13 MXI1 JUN MAX RFX5 FOSL1 GATA3 RCOR1 FOS TCF7L2 LDHAL6A YWHABP2
GH11J018455 Promoter 0.7 EPDnew 650.7 +0.0 13 0.1 EGR1 NRF1 BACH1 LDHAL6A YWHABP2
GH11J019344 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 12 +890.0 890004 1.8 PKNOX1 NFIB SIN3A ZNF2 RAD21 ZEB1 ZNF335 GLIS2 EGR1 FOS NAV2 LOC100420121 LOC390101 LOC645397 ENSG00000256734 LDHAL6A LDHC GC11P019352 GC11P019350
GH11J018382 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -71.7 -71740 3 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZFP91 ATF7 FOS LDHC SPTY2D1 SAAL1 ENSG00000256361 ENSG00000256588 TSG101 LDHA LDHAL6A HPS5 MIR3159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LDHAL6A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LDHAL6A gene promoter:

Genomic Locations for LDHAL6A Gene

Genomic Locations for LDHAL6A Gene
23,777 bases
Plus strand

Genomic View for LDHAL6A Gene

Genes around LDHAL6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDHAL6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDHAL6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHAL6A Gene

Proteins for LDHAL6A Gene

  • Protein details for LDHAL6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    L-lactate dehydrogenase A-like 6A
    Protein Accession:
    Secondary Accessions:
    • D3DQY5

    Protein attributes for LDHAL6A Gene

    332 amino acids
    Molecular mass:
    36507 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDHAL6A Gene

Post-translational modifications for LDHAL6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LDHAL6A Gene

Domains & Families for LDHAL6A Gene

Gene Families for LDHAL6A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LDHAL6A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDH/MDH superfamily. LDH family.
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHAL6A: view

Function for LDHAL6A Gene

Molecular function for LDHAL6A Gene

UniProtKB/Swiss-Prot Function:
Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH.

Enzyme Numbers (IUBMB) for LDHAL6A Gene

Gene Ontology (GO) - Molecular Function for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004459 L-lactate dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with LDHAL6A: view
genes like me logo Genes that share phenotypes with LDHAL6A: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDHAL6A Gene

Localization for LDHAL6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDHAL6A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDHAL6A gene
Compartment Confidence
extracellular 5
cytosol 3

Gene Ontology (GO) - Cellular Components for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with LDHAL6A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LDHAL6A Gene

Pathways & Interactions for LDHAL6A Gene

genes like me logo Genes that share pathways with LDHAL6A: view

UniProtKB/Swiss-Prot Q6ZMR3-LDH6A_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Gene Ontology (GO) - Biological Process for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0019752 carboxylic acid metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LDHAL6A: view

No data available for SIGNOR curated interactions for LDHAL6A Gene

Drugs & Compounds for LDHAL6A Gene

(5) Drugs for LDHAL6A Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Pyruvic acid Approved, Investigational Nutra 0
2-Ketobutyric acid Experimental Pharma 0
L-lactic acid Pharma Full agonist, Agonist 0
NAD Pharma Full agonist, Agonist, Activator 0

(4) Additional Compounds for LDHAL6A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • 2-Hydroxybutanoic acid
  • alpha-Hydroxybutanoic acid
  • alpha-Hydroxybutyric acid
  • 2-Hydroxybutanoate
  • 2-Hydroxybutyrate
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
3-Mercaptopyruvic acid
  • 3-mercapto-2-Oxopropanoic acid
  • 3-Mercaptopyruvate
  • Mercaptopyruvate
  • 3-mercapto-2-Oxopropanoate
  • Mercaptopyruvic acid
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with LDHAL6A: view

Transcripts for LDHAL6A Gene

mRNA/cDNA for LDHAL6A Gene

(10) Selected AceView cDNA sequences:
(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDHAL6A Gene

Lactate dehydrogenase A-like 6A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDHAL6A Gene

No ASD Table

Relevant External Links for LDHAL6A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LDHAL6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LDHAL6A Gene

mRNA differential expression in normal tissues according to GTEx for LDHAL6A Gene

This gene is overexpressed in Testis (x22.2).

Protein differential expression in normal tissues from HIPED for LDHAL6A Gene

This gene is overexpressed in Liver (50.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LDHAL6A Gene

NURSA nuclear receptor signaling pathways regulating expression of LDHAL6A Gene:


SOURCE GeneReport for Unigene cluster for LDHAL6A Gene:


mRNA Expression by UniProt/SwissProt for LDHAL6A Gene:

Tissue specificity: Testis-specific.

Evidence on tissue expression from TISSUES for LDHAL6A Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LDHAL6A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDHAL6A Gene

Orthologs for LDHAL6A Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHAL6A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LDHAL6A 34 33
  • 99.9 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
-- 34
  • 56 (a)
(Canis familiaris)
Mammalia -- 34
  • 59 (a)
(Gallus gallus)
Aves LDHA 34
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
(Danio rerio)
Actinopterygii ldha 34
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta ImpL3 34
  • 57 (a)
CG13334 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea ldh-1 34
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 34
  • 49 (a)
Species where no ortholog for LDHAL6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LDHAL6A Gene

Gene Tree for LDHAL6A (if available)
Gene Tree for LDHAL6A (if available)
Evolutionary constrained regions (ECRs) for LDHAL6A: view image

Paralogs for LDHAL6A Gene

Paralogs for LDHAL6A Gene

(5) SIMAP similar genes for LDHAL6A Gene using alignment to 2 proteins:

  • Q96L19_HUMAN
genes like me logo Genes that share paralogs with LDHAL6A: view

Variants for LDHAL6A Gene

Sequence variations from dbSNP and Humsavar for LDHAL6A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000006352 -- 18,462,834(+) C/A intron_variant
rs1000080729 -- 18,462,044(+) C/T intron_variant
rs1000438738 -- 18,458,713(+) A/G intron_variant
rs1000447925 -- 18,468,357(+) G/C/T intron_variant
rs1000555024 -- 18,470,981(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LDHAL6A Gene

Variant ID Type Subtype PubMed ID
esv2744170 CNV deletion 23290073
esv2744171 CNV deletion 23290073
esv2744172 CNV deletion 23290073
esv3625502 CNV loss 21293372
nsv467719 CNV gain 19166990
nsv509392 CNV insertion 20534489
nsv510999 OTHER complex 20534489
nsv553633 CNV gain 21841781
nsv553634 CNV gain 21841781

Variation tolerance for LDHAL6A Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LDHAL6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHAL6A Gene

Disorders for LDHAL6A Gene

Additional Disease Information for LDHAL6A

No disorders were found for LDHAL6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDHAL6A Gene

Publications for LDHAL6A Gene

  1. Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA). (PMID: 18351441) Chen X … Yu L (Molecular biology reports 2009) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58

Products for LDHAL6A Gene

Sources for LDHAL6A Gene

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