Aliases for LDHAL6A Gene
Aliases for LDHAL6A Gene
External Ids for LDHAL6A Gene
- HGNC: 28335
- Entrez Gene: 160287
- Ensembl: ENSG00000166800
- UniProtKB: Q6ZMR3
Previous GeneCards Identifiers for LDHAL6A Gene
- GC11P018163
Summaries for LDHAL6A Gene
GeneCards Summary for LDHAL6A Gene
LDHAL6A (Lactate Dehydrogenase A Like 6A) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6B.
UniProtKB/Swiss-Prot for LDHAL6A Gene
-
Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.
Additional gene information for LDHAL6A Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHAL6A Gene
Genomics for LDHAL6A Gene
GeneHancer (GH) Regulatory Elements for LDHAL6A Gene
Promoters and enhancers for LDHAL6A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J018457 | Enhancer | 0.7 | ENCODE | 659.7 | +1.8 | 1805 | 0.2 | SOX13 MXI1 JUN MAX RFX5 FOSL1 GATA3 RCOR1 FOS TCF7L2 | LDHAL6A YWHABP2 | |
| GH11J018455 | Promoter | 0.7 | EPDnew | 650.7 | +0.0 | 13 | 0.1 | EGR1 NRF1 BACH1 | LDHAL6A YWHABP2 | |
| GH11J019344 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 12 | +890.0 | 890004 | 1.8 | PKNOX1 NFIB SIN3A ZNF2 RAD21 ZEB1 ZNF335 GLIS2 EGR1 FOS | NAV2 LOC100420121 LOC390101 LOC645397 ENSG00000256734 LDHAL6A LDHC GC11P019352 GC11P019350 | |
| GH11J018382 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 5.8 | -71.7 | -71740 | 3 | FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZFP91 ATF7 FOS | LDHC SPTY2D1 SAAL1 ENSG00000256361 ENSG00000256588 TSG101 LDHA LDHAL6A HPS5 MIR3159 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LDHAL6A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for LDHAL6A Gene
Genomic Locations for LDHAL6A Gene
- chr11:18,455,824-18,479,600
- (GRCh38/hg38)
- Size:
- 23,777 bases
- Orientation:
- Plus strand
- chr11:18,477,371-18,501,147
- (GRCh37/hg19)
Genomic View for LDHAL6A Gene
Genes around LDHAL6A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.1 by Entrez Gene
- 11p15.1 by HGNC
- 11p15.1 by Ensembl
LDHAL6A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LDHAL6A Gene
Proteins for LDHAL6A Gene
-
Protein details for LDHAL6A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZMR3-LDH6A_HUMAN
- Recommended name:
- L-lactate dehydrogenase A-like 6A
- Protein Accession:
- Q6ZMR3
- D3DQY5
Protein attributes for LDHAL6A Gene
- Size:
- 332 amino acids
- Molecular mass:
- 36507 Da
- Quaternary structure:
- No Data Available
Protein Expression for LDHAL6A Gene
Post-translational modifications for LDHAL6A Gene
Other Protein References for LDHAL6A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for LDHAL6A
- Novus Biologicals Antibodies for LDHAL6A
- Invitrogen Antibodies for LDHAL6A
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-
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for LDHAL6A Gene
Domains & Families for LDHAL6A Gene
Gene Families for LDHAL6A Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for LDHAL6A Gene
Suggested Antigen Peptide Sequences for LDHAL6A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6ZMR3- Family:
-
- Belongs to the LDH/MDH superfamily. LDH family.
Function for LDHAL6A Gene
Molecular function for LDHAL6A Gene
- UniProtKB/Swiss-Prot Function:
- Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.
- UniProtKB/Swiss-Prot CatalyticActivity:
- (S)-lactate + NAD(+) = pyruvate + NADH.
Enzyme Numbers (IUBMB) for LDHAL6A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004459 | L-lactate dehydrogenase activity | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | -- |
Phenotypes for LDHAL6A Gene
- GenomeRNAi human phenotypes for LDHAL6A:
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for LDHAL6A
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- Applied Biological Materials CRISPR for LDHAL6A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LDHAL6A
miRNA for LDHAL6A Gene
- miRTarBase miRNAs that target LDHAL6A
miRNA Products
Inhibitory RNA Products
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- Overview of 39 available LDHAL6A gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for LDHAL6A
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LDHAL6A
- Applied Biological Materials Clones for LDHAL6A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LDHAL6A
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDHAL6A Gene
Localization for LDHAL6A Gene
Subcellular locations from UniProtKB/Swiss-Prot for LDHAL6A Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LDHAL6A Gene
Pathways & Interactions for LDHAL6A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Pyruvate metabolism and Citric Acid (TCA) cycle | ||
| 3 | Sulfur amino acid metabolism | ||
| 4 | Glucagon signaling pathway | ||
| 5 | Glucose metabolism | ||
Pathways by source for LDHAL6A Gene
4 Reactome pathways for LDHAL6A Gene
6 KEGG pathways for LDHAL6A Gene
UniProtKB/Swiss-Prot Q6ZMR3-LDH6A_HUMAN
- Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Interacting Proteins for LDHAL6A Gene
GPS-Prot Interaction Network for LDHAL6A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0019752 | carboxylic acid metabolic process | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for LDHAL6A Gene
Drugs & Compounds for LDHAL6A Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Hydroxybutyric acid |
|
600-15-7 |
|
|||
| 3-Mercaptolactic acid |
|
2614-83-7 |
|
|||
| 3-Mercaptopyruvic acid |
|
2464-23-5 |
|
|||
| Hydrogen Ion |
|
|
Transcripts for LDHAL6A Gene
mRNA/cDNA for LDHAL6A Gene
- (10) Selected AceView cDNA sequences:
- (7) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000280706 2526 bps (uc001moq.3)
- ENST00000396213 1716 bps (uc001mop.2)
- ENST00000615355 1042 bps (uc057zrv.1)
Unigene Clusters for LDHAL6A Gene
- Lactate dehydrogenase A-like 6A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LDHAL6A
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- genomics-online: gRNA clones - Search results for 39 available LDHAL6A gene related products
- Overview of 39 available LDHAL6A gene related products
- Applied Biological Materials CRISPR for LDHAL6A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LDHAL6A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LDHAL6A
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- genomics-online: shRNA clones - Search results for 39 available LDHAL6A gene related products
- Overview of 39 available LDHAL6A gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for LDHAL6A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LDHAL6A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LDHAL6A
- Applied Biological Materials Clones for LDHAL6A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LDHAL6A Gene
mRNA differential expression in normal tissues according to GTEx for LDHAL6A Gene
This gene is overexpressed in Testis (x22.2).
This gene is overexpressed in Liver (50.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LDHAL6A Gene
NURSA nuclear receptor signaling pathways regulating expression of LDHAL6A Gene:
LDHAL6ASOURCE GeneReport for Unigene cluster for LDHAL6A Gene:
Hs.668877mRNA Expression by UniProt/SwissProt for LDHAL6A Gene:
Q6ZMR3-LDH6A_HUMAN
Tissue specificity:
Testis-specific.
Evidence on tissue expression from TISSUES for LDHAL6A Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for LDHAL6A
-
OriGene qPCR primer pairs for LDHAL6A
- genomics-online: primer clones - Search results for 39 available LDHAL6A gene related products
- Overview of 39 available LDHAL6A gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDHAL6A Gene
Orthologs for LDHAL6A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LDHAL6A 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | LDHA 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | ldha 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | ImpL3 34 |
|
ManyToMany | |
| CG13334 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ldh-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11301 34 |
|
OneToMany |
- Species where no ortholog for LDHAL6A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for LDHAL6A Gene
- ENSEMBL:
- Gene Tree for LDHAL6A (if available)
- TreeFam:
- Gene Tree for LDHAL6A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LDHAL6A: view image
Paralogs for LDHAL6A Gene
Variants for LDHAL6A Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006352 | -- | 18,462,834(+) | C/A | intron_variant | |
| rs1000080729 | -- | 18,462,044(+) | C/T | intron_variant | |
| rs1000438738 | -- | 18,458,713(+) | A/G | intron_variant | |
| rs1000447925 | -- | 18,468,357(+) | G/C/T | intron_variant | |
| rs1000555024 | -- | 18,470,981(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2744170 | CNV | deletion | 23290073 |
| esv2744171 | CNV | deletion | 23290073 |
| esv2744172 | CNV | deletion | 23290073 |
| esv3625502 | CNV | loss | 21293372 |
| nsv467719 | CNV | gain | 19166990 |
| nsv509392 | CNV | insertion | 20534489 |
| nsv510999 | OTHER | complex | 20534489 |
| nsv553633 | CNV | gain | 21841781 |
| nsv553634 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.96;
36.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LDHAL6A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LDHAL6A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHAL6A Gene
Disorders for LDHAL6A Gene
Additional Disease Information for LDHAL6A
No disorders were found for LDHAL6A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDHAL6A Gene
Publications for LDHAL6A Gene
- Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA). (PMID: 18351441) Chen X … Yu L (Molecular biology reports 2009) 2 3 4 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3 58
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
- In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
Products for LDHAL6A Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 34 available LDHAL6A Antibodies ranked by validation data
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Sources for LDHAL6A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
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