Free for academic non-profit institutions. Other users need a Commercial license
LDHAL6A (Lactate Dehydrogenase A Like 6A) is a Protein Coding gene. Diseases associated with LDHAL6A include Dressler's Syndrome and Myxedema. Among its related pathways are Central carbon metabolism in cancer and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6B.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J018455 | Promoter | 0.6 | EPDnew | 250.7 | +0.0 | 13 | 0.1 | NRF1 BACH1 EGR1 | LDHAL6A HSALNG0083007 TSG101 | |
GH11J018382 | Promoter/Enhancer | 1.8 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 5.8 | -71.8 | -71750 | 3 | BCL11A CEBPA DEK IRF2 ELF1 CEBPB ZNF395 GTF2E2 FOXA2 SMAD4 | HSALNG0082999 LDHC LDHA LDHAL6A SPTY2D1 HPS5 TSG101 MIR3159 | |
GH11J018457 | Enhancer | 0.8 | Ensembl ENCODE | 10.5 | +2.1 | 2143 | 0.9 | BHLHE40 CEBPB MAX EP300 RFX5 STAT3 FOSL1 TCF7L2 USF2 JUND | LDHAL6A GTF2H1 HPS5 HSALNG0083007 TSG101 | |
GH11J018448 | Enhancer | 0.3 | Ensembl | 5.6 | -6.3 | -6323 | 1.4 | SPI1 | ENSG00000256734 lnc-TSG101-2 LDHC LDHA GTF2H1 HPS5 YWHABP2 LDHAL6A HSALNG0083005 | |
GH11J018489 | Enhancer | 0.9 | Ensembl ENCODE | 0.3 | +35.8 | 35843 | 4.6 | VEZF1 ZEB2 TAL1 SKIL FOSL1 SMARCA4 HDAC2 STAT5A FOXM1 TCF12 | YWHABP2 lnc-UEVLD-5 TSG101 LDHC GTF2H1 HPS5 LDHA SPTY2D1OS ENSG00000256282 SPTY2D1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004459 | L-lactate dehydrogenase activity | IEA,IBA | 21873635 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
|
|
2 | Pyruvate metabolism and Citric Acid (TCA) cycle | ||
3 | Central carbon metabolism in cancer | ||
4 | Sulfur amino acid metabolism | ||
5 | Glucagon signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0019752 | carboxylic acid metabolic process | IEA | -- |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Hydroxybutyric acid |
|
3347-90-8 |
|
|||
3-Mercaptolactic acid |
|
2614-83-7 |
|
|||
3-Mercaptopyruvic acid |
|
2464-23-5 |
|
|||
Hydrogen Ion |
|
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LDHAL6A 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | LDHA 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | ldha 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | ImpL3 31 |
|
ManyToMany | |
CG13334 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ldh-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11301 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2744170 | CNV | deletion | 23290073 |
esv2744171 | CNV | deletion | 23290073 |
esv2744172 | CNV | deletion | 23290073 |
esv3625502 | CNV | loss | 21293372 |
nsv467719 | CNV | gain | 19166990 |
nsv509392 | CNV | insertion | 20534489 |
nsv510999 | OTHER | complex | 20534489 |
nsv553633 | CNV | gain | 21841781 |
nsv553634 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dressler's syndrome |
|
|
myxedema |
|
|