Aliases for LDHA Gene
Aliases for LDHA Gene
External Ids for LDHA Gene
- HGNC: 6535
- Entrez Gene: 3939
- Ensembl: ENSG00000134333
- OMIM: 150000
- UniProtKB: P00338
Previous GeneCards Identifiers for LDHA Gene
- GC11P019537
- GC11P019358
- GC11P018455
- GC11P018380
- GC11P018372
- GC11P018101
Summaries for LDHA Gene
-
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for LDHA Gene
LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. Diseases associated with LDHA include Fanconi-Bickel Syndrome and Myoglobinuria. Among its related pathways are Cori Cycle and Central carbon metabolism in cancer. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHC.
-
Lactate Dehydrogenase A (LDHA; LDH5), EC 1.1.1.27, is one of five isoforms of the lactate dehydrogenase family. It catalyzes the conversion of pyruvate to lactate under anaerobic conditions and is key in the altered glycolytic metabolism that is a feature of cancer cells.
Additional gene information for LDHA Gene
- Monarch Initiative
- Search for LDHA at DataMed
- Search for LDHA at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHA Gene
Genomics for LDHA Gene
GeneHancer (GH) Regulatory Elements for LDHA Gene
Promoters and enhancers for LDHA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LDHA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LDHA gene promoter:
-
- deltaCREB
- CREB
- POU2F1a
- POU2F1
Regulatory Element Products
Genomic Locations for LDHA Gene
Genomic Locations for LDHA Gene
- chr11:18,394,388-18,408,425
- (GRCh38/hg38)
- Size:
- 14,038 bases
- Orientation:
- Plus strand
- chr11:18,415,935-18,429,972
- (GRCh37/hg19)
- Size:
- 14,038 bases
- Orientation:
- Plus strand
Genomic View for LDHA Gene
Genes around LDHA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.1 by Entrez Gene
- 11p15.1 by HGNC
- 11p15.1 by Ensembl
LDHA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LDHA Gene
Proteins for LDHA Gene
-
Protein details for LDHA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P00338-LDHA_HUMAN
- Recommended name:
- L-lactate dehydrogenase A chain
- Protein Accession:
- P00338
- B4DKQ2
- B7Z5E3
- D3DQY3
- F8W819
- Q53G53
- Q6IBM7
- Q6ZNV1
- Q9UDE8
- Q9UDE9
Protein attributes for LDHA Gene
- Size:
- 332 amino acids
- Molecular mass:
- 36689 Da
- Quaternary structure:
-
- Homotetramer.
Three dimensional structures from OCA and Proteopedia for LDHA Gene
Protein Expression for LDHA Gene
Post-translational modifications for LDHA Gene
- ISGylated.
- Ubiquitination at posLast=2727, isoforms=3, 4328, isoforms=3, 4318, isoforms=3, 4278, posLast=132132, isoforms=2, 3, 5126, isoforms=2, 3, 5118, isoforms=2, 3, 4, 576, posLast=5959, posLast=1414, and posLast=55
- Modification sites at PhosphoSitePlus
Other Protein References for LDHA Gene
- ENSEMBL proteins:
-
- ENSP00000445175
- ENSP00000441241
- ENSP00000395337
- ENSP00000379524
- ENSP00000445331
- ENSP00000441058
- ENSP00000442637
- ENSP00000443545
- ENSP00000368722
- ENSP00000441699
- ENSP00000446415
- ENSP00000486249
- ENSP00000227157
- ENSP00000442979
- ENSP00000440368
- ENSP00000440161
- ENSP00000406172
- ENSP00000444292
- ENSP00000443362
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for LDHA (Lactate Dehydrogenase A/LDHA)
- Novus Biologicals Antibodies for LDHA
-
Abcam antibodies for LDHA
- Invitrogen Antibodies for LDHA
- GeneTex LDHA Antibody for LDHA
-
Santa Cruz Biotechnology (SCBT) Antibodies for LDHA
- Sino Biological Antibodies for LDHA
Protein Products
- R&D Systems Proteins and Enzymes for LDHA (Lactate Dehydrogenase A/LDHA)
-
OriGene Purified Proteins for LDHA
- Search Origene for MassSpec and Protein Over-expression Lysates for LDHA
- Origene Custom Protein Services for LDHA
- Sino Biological Recombinant Proteins for LDHA
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for LDHA
- Search GeneTex for Proteins for LDHA
-
ProSci Proteins for LDHA
-
Abcam proteins for LDHA
Assay Products
No data available for DME Specific Peptides for LDHA Gene
Domains & Families for LDHA Gene
Gene Families for LDHA Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for LDHA Gene
Suggested Antigen Peptide Sequences for LDHA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P00338- Family:
-
- Belongs to the LDH/MDH superfamily. LDH family.
Function for LDHA Gene
Molecular function for LDHA Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- (S)-lactate + NAD(+) = pyruvate + NADH.
- GENATLAS Biochemistry:
- lactate dehydrogenase A,glycolysis,energy pathway,putative up-regulated c-Myc target gene,
Enzyme Numbers (IUBMB) for LDHA Gene
Phenotypes From GWAS Catalog for LDHA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004457 | lactate dehydrogenase activity | IEA | -- |
| GO:0004459 | L-lactate dehydrogenase activity | TAS,NAS | 1953713 |
| GO:0005515 | protein binding | IPI | 23523103 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for LDHA Gene
- MGI mutant phenotypes for LDHA:
- inferred from 13 alleles
- GenomeRNAi human phenotypes for LDHA:
Animal Models for LDHA Gene
- MGI Knock Outs for LDHA:
-
- Ldha Ldha<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LDHA
-
CRISPR Products
-
OriGene CRISPR knockouts for LDHA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LDHA
- Applied Biological Materials CRISPR for LDHA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LDHA
- GenScript: Design CRISPR guide RNA sequences for LDHA
miRNA for LDHA Gene
- miRTarBase miRNAs that target LDHA
-
- hsa-mir-34a-5p (MIRT025431)
- hsa-mir-33a-5p (MIRT028212)
- hsa-mir-320c (MIRT036157)
- hsa-mir-935 (MIRT036678)
- hsa-mir-324-5p (MIRT043068)
- hsa-mir-331-3p (MIRT043554)
- hsa-mir-378a-3p (MIRT043959)
- hsa-mir-23a-3p (MIRT050430)
- hsa-let-7c-5p (MIRT051827)
- hsa-mir-24-3p (MIRT054320)
- hsa-mir-210-3p (MIRT054321)
- hsa-mir-203a-3p (MIRT265630)
- hsa-mir-4305 (MIRT265632)
- hsa-mir-4524b-3p (MIRT265634)
- hsa-mir-425-5p (MIRT332416)
- hsa-mir-489-3p (MIRT332417)
- hsa-mir-3913-3p (MIRT332419)
- hsa-mir-505-5p (MIRT367768)
- hsa-mir-4670-3p (MIRT367770)
- hsa-mir-190b (MIRT474210)
- hsa-mir-190a-5p (MIRT474211)
- hsa-mir-4276 (MIRT504904)
- hsa-mir-190a-3p (MIRT504905)
- hsa-mir-1252-5p (MIRT504906)
- hsa-mir-5190 (MIRT504907)
- hsa-mir-410-3p (MIRT504908)
- hsa-mir-769-3p (MIRT656746)
- hsa-mir-450b-3p (MIRT656747)
- hsa-mir-8057 (MIRT656748)
- hsa-mir-4769-5p (MIRT656749)
- hsa-mir-4654 (MIRT656750)
- hsa-mir-638 (MIRT656751)
- hsa-mir-4713-3p (MIRT656752)
- hsa-mir-4284 (MIRT656753)
- hsa-mir-4772-3p (MIRT656754)
- hsa-mir-6890-3p (MIRT656755)
- hsa-mir-1304-3p (MIRT656756)
- hsa-mir-302a-5p (MIRT702290)
- hsa-mir-1288-5p (MIRT702291)
- hsa-mir-383-5p (MIRT702292)
- hsa-mir-577 (MIRT702293)
- hsa-mir-34b-3p (MIRT702294)
- hsa-mir-8080 (MIRT702295)
- hsa-mir-34a-3p (MIRT732042)
- hsa-mir-374a-5p (MIRT733180)
- hsa-mir-200b-3p (MIRT734229)
- hsa-mir-34c-5p (MIRT741478)
- hsa-mir-4257 (MIRT743412)
- hsa-mir-4466 (MIRT744892)
- hsa-mir-449a (MIRT745402)
- hsa-mir-449b-5p (MIRT745434)
- hsa-mir-548au-3p (MIRT750608)
- hsa-mir-6134 (MIRT752434)
- hsa-mir-675-5p (MIRT754766)
- hsa-mir-6815-5p (MIRT756778)
- hsa-mir-6847-5p (MIRT757475)
- hsa-mir-6865-5p (MIRT757927)
- hsa-mir-7150 (MIRT759166)
- hsa-mir-135a-5p (MIRT783759)
- hsa-mir-135b-5p (MIRT783761)
- hsa-mir-186-5p (MIRT783993)
- hsa-mir-3119 (MIRT784565)
- hsa-mir-3133 (MIRT784601)
- hsa-mir-3616-5p (MIRT784968)
- hsa-mir-4282 (MIRT785579)
- hsa-mir-548ao-5p (MIRT787449)
- hsa-mir-548ax (MIRT787482)
- hsa-mir-5585-5p (MIRT787679)
- hsa-mir-573 (MIRT787844)
- hsa-mir-942-3p (MIRT790008)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LDHA
- Browse OriGene Inhibitory RNA Products For LDHA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDHA
Clone Products
-
OriGene ORF clones in human for LDHA
- RC225375L1V
- RC225375L2V
- RC228293L1V
- RC228293L2V
- RC228206L1V
- RC228206L2V
- RC228175L1V
- RC228175L2V
- RC209378L1V
- RC209378L2V
- RC225375
- RC225375L1
- RC225375L2
- RG225375
- RC228293
- RC228293L1
- RC228293L2
- RG228293
- RC228206
- RC228206L1
- RC228206L2
- RG228206
- RC228175
- RC228175L1
- RC228175L2
- RG228175
- RC209378
- RC209378L1
- RC209378L2
- RG209378
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LDHA
- VectorBuilder custom plasmid, inducible vectors for LDHA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LDHA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LDHA
- genomics-online: cdna clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- orf clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- Applied Biological Materials Clones for LDHA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LDHA
No data available for Transcription Factor Targets and HOMER Transcription for LDHA Gene
Localization for LDHA Gene
Subcellular locations from UniProtKB/Swiss-Prot for LDHA Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | HDA,IEA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for LDHA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose metabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Metabolic States and Circadian Oscillators | ||
| 4 | Pyruvate metabolism and Citric Acid (TCA) cycle | ||
| 5 | Central carbon metabolism in cancer | ||
Pathways by source for LDHA Gene
7 BioSystems pathways for LDHA Gene
4 Reactome pathways for LDHA Gene
1 GeneGo (Thomson Reuters) pathway for LDHA Gene
2 Qiagen pathways for LDHA Gene
1 Cell Signaling Technology pathway for LDHA Gene
UniProtKB/Swiss-Prot P00338-LDHA_HUMAN
- Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Interacting Proteins for LDHA Gene
Selected Interacting proteins:
P00338-LDHA_HUMAN
ENSP00000445175
for LDHA Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for LDHA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006089 | lactate metabolic process | IEA | -- |
| GO:0006090 | pyruvate metabolic process | TAS | -- |
| GO:0006096 | glycolytic process | NAS | 1953713 |
Drugs & Compounds for LDHA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| NADH | Approved | Nutra | Target | 0 | ||
| Nicotinamide | Approved, Investigational | Nutra | Target | 942,946 | ||
| Stiripentol | Approved | Pharma | Target, inhibitor | An LDH inhibitor | 9 | |
| Copper | Approved, Investigational | Pharma | Target | 202 | ||
| Dihydroartemisinin | Approved, Investigational | Pharma | Target, ligand | 100 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Hydroxybutyric acid |
|
600-15-7 |
|
|||
| 3-Mercaptolactic acid |
|
2614-83-7 |
|
|||
| 3-Mercaptopyruvic acid |
|
2464-23-5 |
|
|||
| Hydrogen Ion |
|
|
(4) ApexBio Compounds for LDHA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Galloflavin | ||
| GSK 2837808A | 1445879-21-9 | |
| Isosafrole | A stiripentol analog, a potent LDH inhibitor. | 120-58-1 |
| Stiripentol | An LDH inhibitor | 49763-96-4 |
Transcripts for LDHA Gene
mRNA/cDNA for LDHA Gene
- (5) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (3372) Selected AceView cDNA sequences:
- (25) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000422447 2416 bps (uc001mok.4)
- ENST00000543445 576 bps (uc057zqs.1)
- ENST00000469976 656 bps (uc057zqt.1)
- ENST00000545467 570 bps (uc057zqu.1)
- ENST00000430553 1310 bps (uc010rdc.2)
Unigene Clusters for LDHA Gene
- Lactate dehydrogenase A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LDHA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LDHA
- Applied Biological Materials CRISPR for LDHA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LDHA
- GenScript: Design CRISPR guide RNA sequences for LDHA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LDHA
- Browse OriGene Inhibitory RNA Products For LDHA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDHA
Clone Products
-
OriGene ORF clones in human for LDHA
- RC225375L1V
- RC225375L2V
- RC228293L1V
- RC228293L2V
- RC228206L1V
- RC228206L2V
- RC228175L1V
- RC228175L2V
- RC209378L1V
- RC209378L2V
- RC225375
- RC225375L1
- RC225375L2
- RG225375
- RC228293
- RC228293L1
- RC228293L2
- RG228293
- RC228206
- RC228206L1
- RC228206L2
- RG228206
- RC228175
- RC228175L1
- RC228175L2
- RG228175
- RC209378
- RC209378L1
- RC209378L2
- RG209378
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LDHA
- VectorBuilder custom plasmid, inducible vectors for LDHA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LDHA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LDHA
- genomics-online: cdna clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- orf clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- Applied Biological Materials Clones for LDHA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||
| SP7: |
Expression for LDHA Gene
This gene is overexpressed in Tonsil (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LDHA Gene
NURSA nuclear receptor signaling pathways regulating expression of LDHA Gene:
LDHASOURCE GeneReport for Unigene cluster for LDHA Gene:
Hs.2795Evidence on tissue expression from TISSUES for LDHA Gene
- Liver(5)
- Nervous system(5)
- Heart(4.9)
- Intestine(4.9)
- Muscle(4.9)
- Eye(4.8)
- Kidney(4.8)
- Lung(4.8)
- Skin(4.8)
- Blood(4.7)
- Stomach(4.7)
- Bone marrow(4.5)
- Pancreas(3.9)
- Bone(3.6)
- Spleen(2.7)
- Adrenal gland(2.3)
- Thyroid gland(2.3)
- Gall bladder(2.1)
- Lymph node(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LDHA Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- urinary
Regions:
Head and neck:
- brain
- head
Abdomen:
- kidney
Pelvis:
- ureter
- urinary bladder
General:
- spinal cord
Primer Products
-
OriGene qPCR primer pairs and template standards for LDHA
-
OriGene qPCR primer pairs for LDHA
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LDHA Gene
Orthologs for LDHA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LDHA 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| LDHA 33 |
|
||||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | LDHA 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LDHA 34 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Ldha 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LDHA 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LDHA 34 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ldha 33 |
|
||
| MGC76171 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | ldha-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ldha 34 33 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | ImpL3 34 35 33 |
|
ManyToMany | |
| CG13334 34 35 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004880 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ldh-1 34 35 33 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G17260 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0105400 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.10337 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11301 34 |
|
OneToMany | |
| Cin.3533 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3533 33 |
|
- Species where no ortholog for LDHA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for LDHA Gene
- ENSEMBL:
- Gene Tree for LDHA (if available)
- TreeFam:
- Gene Tree for LDHA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LDHA: view image
Paralogs for LDHA Gene
(5) SIMAP similar genes for LDHA Gene using alignment to 11 proteins:
- LDHA_HUMAN
- F5GWW2_HUMAN
- F5GXC7_HUMAN
- F5GXH2_HUMAN
- F5GXU1_HUMAN
- F5GXY2_HUMAN
- F5GYU2_HUMAN
- F5GZQ4_HUMAN
- F5H5J4_HUMAN
- F5H6W8_HUMAN
- F5H8H6_HUMAN
Pseudogenes.org Pseudogenes for LDHA Gene
Variants for LDHA Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11553870 | uncertain-significance, Glycogen storage disease XI | 18,396,899(+) | C/A/T | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs121912479 | uncertain-significance, Glycogen storage disease XI | 18,407,267(+) | G/T | 3_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant, stop_gained | |
| rs137996815 | uncertain-significance, likely-benign, Glycogen storage disease XI, not specified | 18,405,515(+) | G/A | coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant | |
| rs141158742 | likely-benign, Lactate dehydrogenase deficiency type A | 18,403,797(+) | G/C | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs144317385 | likely-benign, Glycogen storage disease XI | 18,407,863(+) | C/T | 3_prime_UTR_variant, non_coding_transcript_variant |
Residual Variation Intolerance Score:
55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.20;
24.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LDHA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHA Gene
Disorders for LDHA Gene
(15) MalaCards diseases for LDHA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fanconi-bickel syndrome |
|
|
| myoglobinuria |
|
|
| lactate dehydrogenase deficiency |
|
|
| malignant germ cell tumor |
|
|
| subendocardial myocardial infarction |
|
|
Search LDHA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LDHA_HUMAN- Glycogen storage disease 11 (GSD11) [MIM:612933]: A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue. {ECO:0000269 PubMed:2334430}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Genatlas disease for LDHA Gene
myoglobinuria,exertional and/or excessive fatigability
Additional Disease Information for LDHA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for LDHA Gene
- Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder. (PMID: 12555229) Philibert RA … Coryell WH (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003) 3 22 44 58
- Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit. (PMID: 1445373) Sudo K … Toriumi J (Biochemistry international 1992) 3 4 22 58
- Genotypic analysis of families with lactate dehydrogenase A (M) deficiency by selective DNA amplification. (PMID: 1959923) Maekawa M … Kanno T (Human genetics 1991) 3 4 22 58
- Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining. (PMID: 1953713) Maekawa M … Kanno T (Biochemical and biophysical research communications 1991) 3 4 22 58
- Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency. (PMID: 2334430) Maekawa M … Li SS (Biochemical and biophysical research communications 1990) 3 4 22 58
Products for LDHA Gene
- R&D Systems Antibodies for LDHA (Lactate Dehydrogenase A/LDHA)
- R&D Systems Proteins and Enzymes for LDHA (Lactate Dehydrogenase A/LDHA)
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for LDHA
- Browse OriGene ELISA Kits
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- OriGene qPCR primer pairs and template standards for LDHA
- OriGene qPCR primer pairs for LDHA
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- OriGene ORF clones in human for LDHA
- RC225375L1V
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- RC228175
- RC228175L1
- RC228175L2
- RG228175
- RC209378
- RC209378L1
- RC209378L2
- RG209378
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LDHA
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- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for LDHA
- Sino Biological Human cDNA Clone for LDHA
- Sino Biological Recombinant Proteins for LDHA
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- Sino Biological Antibodies for LDHA
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Novus Biologicals proteins and lysates for LDHA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for LDHA
- Abcam proteins for LDHA
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for LDHA
- Cyagen custom Knockout/knockin (KOKI) mouse models for LDHA
- VectorBuilder custom plasmid, inducible vectors for LDHA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LDHA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 250 available Lactate Dehydrogenase A Antibodies ranked by validation data
- Compare Top Lactate Dehydrogenase A Antibodies
- antibodies-online: Search results for 31 available Lactate Dehydrogenase A Elisa Kits ranked by validation data
- Compare Top Lactate Dehydrogenase A Elisa Kits
- antibodies-online: Search results for 64 available Lactate Dehydrogenase A Proteins ranked by validation data
- Compare Top Lactate Dehydrogenase A Proteins
- GeneTex LDHA Antibody for LDHA
- Search GeneTex for Proteins for LDHA
- Santa Cruz Biotechnology (SCBT) Antibodies for LDHA
- Search Santa Cruz Biotechnology (SCBT) for LDHA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LDHA
- Horizon Cell Lines for LDHA
- genomics-online: cdna clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- orf clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- genomics-online: gRNA clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- genomics-online: primer clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- genomics-online: shRNA clones - Search results for 185 available Lactate Dehydrogenase A gene related products
- Overview of 185 available Lactate Dehydrogenase A gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LDHA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LDHA
- GeneCopoeia miRNA 3'UTR Target clone products for LDHA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LDHA
Sources for LDHA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO