Aliases for LDB2 Gene
External Ids for LDB2 Gene
Previous GeneCards Identifiers for LDB2 Gene
The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for LDB2 Gene
LDB2 (LIM Domain Binding 2) is a Protein Coding gene. Diseases associated with LDB2 include Retinal Detachment and Hypotrichosis 2. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include enzyme binding and obsolete transcription factor activity, transcription factor binding. An important paralog of this gene is LDB1.
UniProtKB/Swiss-Prot Summary for LDB2 Gene
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.