Aliases for LCP2 Gene
External Ids for LCP2 Gene
Previous HGNC Symbols for LCP2 Gene
Previous GeneCards Identifiers for LCP2 Gene
This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]
GeneCards Summary for LCP2 Gene
LCP2 (Lymphocyte Cytosolic Protein 2) is a Protein Coding gene. Diseases associated with LCP2 include Wiskott-Aldrich Syndrome and Agammaglobulinemia 4, Autosomal Recessive. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and CTLA4 Signaling. An important paralog of this gene is BLNK.
UniProtKB/Swiss-Prot Summary for LCP2 Gene
Involved in T-cell antigen receptor mediated signaling.