This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] See more...

Aliases for LCORL Gene

Aliases for LCORL Gene

  • Ligand Dependent Nuclear Receptor Corepressor Like 2 3 5
  • Ligand-Dependent Nuclear Receptor Corepressor-Like Protein 3 4
  • Ligand Dependent Nuclear Receptor Corepressor-Like 2
  • Transcription Factor MLR1 3
  • MBLK1-Related Protein 3
  • LCOR-Like Protein 3
  • LCoR-Like Protein 4
  • MLR1 3

External Ids for LCORL Gene

Previous GeneCards Identifiers for LCORL Gene

  • GC04M017453
  • GC04M017199

Summaries for LCORL Gene

Entrez Gene Summary for LCORL Gene

  • This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for LCORL Gene

LCORL (Ligand Dependent Nuclear Receptor Corepressor Like) is a Protein Coding gene. Diseases associated with LCORL include Ichthyosis, Congenital, Autosomal Recessive 11 and Autosomal Recessive Congenital Ichthyosis.

UniProtKB/Swiss-Prot Summary for LCORL Gene

  • May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).

Additional gene information for LCORL Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LCORL Gene

Genomics for LCORL Gene

GeneHancer (GH) Regulatory Elements for LCORL Gene

Promoters and enhancers for LCORL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J018019 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.5 476 4 ZBTB40 SIX5 FOXA1 SMARCE1 POLR2A USF2 ATF1 CREB1 HCFC1 MIXL1 LCORL MED28 DCAF16 NCAPG FAM184B piR-50444-336
GH04J017807 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 +211.0 210991 8.2 SIN3A ZNF24 SP1 ZBTB40 CTCF MLX SMARCE1 RBPJ POLR2A ATF1 DCAF16 NCAPG lnc-DCAF16-1 LCORL piR-52368-104
GH04J017575 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 9 +443.2 443246 5.3 SP1 MLX RBPJ SMARCE1 POLR2A CREB1 ZNF362 MYC NFYC ELF1 LAP3 lnc-FAM184B-7 MED28 DCAF16 ENSG00000249502 NCAPG QDPR LCORL RF00017-4272
GH04J018075 Enhancer 0.7 Ensembl 10.6 -54.3 -54324 0.4 ZBTB40 CTCF CC2D1A ETV6 ELF1 L3MBTL2 RAD21 GTF2F1 MAFK REST MED28 LCORL piR-32461-120
GH04J017818 Promoter 0.6 Ensembl 10.6 +204.4 204376 0.2 CTCF RAD21 TRIM22 SMARCA5 LCORL NCAPG piR-52368-104
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LCORL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LCORL gene promoter:
  • AREB6
  • FOXO4
  • MRF-2
  • Olf-1
  • p300
  • Pax-2
  • Pax-2b
  • SEF-1 (1)
  • ZID

Genomic Locations for LCORL Gene

Genomic Locations for LCORL Gene
chr4:17,841,199-18,021,876
(GRCh38/hg38)
Size:
180,678 bases
Orientation:
Minus strand
chr4:17,842,822-18,023,499
(GRCh37/hg19)
Size:
180,678 bases
Orientation:
Minus strand

Genomic View for LCORL Gene

Genes around LCORL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCORL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCORL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCORL Gene

Proteins for LCORL Gene

  • Protein details for LCORL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3X6-LCORL_HUMAN
    Recommended name:
    Ligand-dependent nuclear receptor corepressor-like protein
    Protein Accession:
    Q8N3X6
    Secondary Accessions:
    • Q96NK1

    Protein attributes for LCORL Gene

    Size:
    602 amino acids
    Molecular mass:
    66964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LCORL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCORL Gene

Post-translational modifications for LCORL Gene

  • Glycosylation at Asn493
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • LCORL_HUMAN (2054)

No data available for DME Specific Peptides for LCORL Gene

Domains & Families for LCORL Gene

Gene Families for LCORL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LCORL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LCORL Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57583, highly similar to Homo sapiens transcription factor MLR1 (MLR1), mRNA (B4DSW0_HUMAN)
  • Ligand-dependent nuclear receptor corepressor-like protein (LCORL_HUMAN)
genes like me logo Genes that share domains with LCORL: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LCORL Gene

Function for LCORL Gene

Molecular function for LCORL Gene

UniProtKB/Swiss-Prot Function:
May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).

Phenotypes From GWAS Catalog for LCORL Gene

Gene Ontology (GO) - Molecular Function for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LCORL: view
genes like me logo Genes that share phenotypes with LCORL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCORL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LCORL Gene

Localization for LCORL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCORL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCORL gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LCORL: view

Pathways & Interactions for LCORL Gene

PathCards logo

SuperPathways for LCORL Gene

No Data Available

Gene Ontology (GO) - Biological Process for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with LCORL: view

No data available for Pathways by source and SIGNOR curated interactions for LCORL Gene

Drugs & Compounds for LCORL Gene

No Compound Related Data Available

Transcripts for LCORL Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCORL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCORL Gene

No ASD Table

Relevant External Links for LCORL Gene

GeneLoc Exon Structure for
LCORL
ECgene alternative splicing isoforms for
LCORL

Expression for LCORL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCORL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LCORL Gene



NURSA nuclear receptor signaling pathways regulating expression of LCORL Gene:

LCORL

SOURCE GeneReport for Unigene cluster for LCORL Gene:

Hs.446201

Evidence on tissue expression from TISSUES for LCORL Gene

  • Nervous system(4.4)
  • Liver(2)
genes like me logo Genes that share expression patterns with LCORL: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCORL Gene

Orthologs for LCORL Gene

This gene was present in the common ancestor of animals.

Orthologs for LCORL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCORL 33 32
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LCORL 33 32
  • 97.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LCORL 33
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcorl 17 33 32
  • 95.89 (n)
rat
(Rattus norvegicus)
Mammalia Lcorl 32
  • 95.02 (n)
oppossum
(Monodelphis domestica)
Mammalia LCORL 33
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCORL 33
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LCORL 33 32
  • 90.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LCORL 33
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lcorl 32
  • 62.18 (n)
wu:fc17b08 33
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Eip93F 33
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mbr-1 33
  • 8 (a)
OneToMany
Species where no ortholog for LCORL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LCORL Gene

ENSEMBL:
Gene Tree for LCORL (if available)
TreeFam:
Gene Tree for LCORL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LCORL: view image

Paralogs for LCORL Gene

(1) SIMAP similar genes for LCORL Gene using alignment to 4 proteins:

  • LCORL_HUMAN
  • B4DSW0_HUMAN
  • C9JI46_HUMAN
  • D6RA10_HUMAN

Pseudogenes.org Pseudogenes for LCORL Gene

genes like me logo Genes that share paralogs with LCORL: view

No data available for Paralogs for LCORL Gene

Variants for LCORL Gene

Sequence variations from dbSNP and Humsavar for LCORL Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000009453 -- 17,919,561(-) C/T intron_variant
rs1000013702 -- 18,018,826(-) A/G intron_variant
rs1000019836 -- 17,899,016(-) G/C intron_variant
rs1000035267 -- 17,938,708(-) C/T intron_variant
rs1000044597 -- 17,846,096(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LCORL Gene

Variant ID Type Subtype PubMed ID
esv2544363 CNV deletion 19546169
esv991821 CNV deletion 20482838
nsv477969 CNV novel sequence insertion 20440878
nsv478080 CNV novel sequence insertion 20440878
nsv819053 CNV loss 19587683
nsv980185 CNV duplication 23825009

Variation tolerance for LCORL Gene

Gene Damage Index Score: 3.30; 53.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCORL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCORL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCORL Gene

Disorders for LCORL Gene

MalaCards: The human disease database

(2) MalaCards diseases for LCORL Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search LCORL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LCORL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LCORL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LCORL Gene

Publications for LCORL Gene

  1. Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). (PMID: 22021425) Carty CL … Kooperberg C (Human molecular genetics 2012) 3 43 56
  2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 43 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 43 56
  5. Genome-wide association study of height and body mass index in Australian twin families. (PMID: 20397748) Liu JZ … McRae AF (Twin research and human genetics : the official journal of the International Society for Twin Studies 2010) 3 43 56

Products for LCORL Gene

Sources for LCORL Gene