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This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
LCN2 (Lipocalin 2) is a Protein Coding gene. Diseases associated with LCN2 include Klebsiella Infection and Acute Pyelonephritis. Among its related pathways are Interleukin-4 and 13 signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and iron ion binding. An important paralog of this gene is LCN12.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002020 | protease binding | IEA | -- |
GO:0005506 | iron ion binding | ISS | -- |
GO:0036094 | small molecule binding | IEA | -- |
GO:0042802 | identical protein binding | IEA | -- |
GO:1903981 | enterobactin binding | IDA | 27780864 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005615 | extracellular space | IDA | 25645918 |
GO:0005623 | cell | IEA | -- |
GO:0005829 | cytosol | IEA | -- |
GO:0031410 | cytoplasmic vesicle | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
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2 | Defensins | ||
3 | Cytokine Signaling in Immune system | ||
4 | Glucose / Energy Metabolism | ||
5 | IL-17 Family Signaling Pathways |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0006879 | cellular iron ion homeostasis | TAS | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0006979 | response to oxidative stress | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Vitamin A | Approved, Vet_approved | Nutra | 685 | |||
2,3,-Dihydroxybenzoylserine | Experimental | Pharma | Target | 0 | ||
2-Pyrocatechuic acid | Experimental | Pharma | Target | 0 | ||
Carboxymycobactin S | Experimental | Pharma | Target | 0 | ||
Carboxymycobactin T | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
SB-3CT | gelatinases inhibitor, potent and selective | 292605-14-2 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||
SP7: | - | - |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LCN2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LCN2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LCN2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lcn2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lcn2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | LCN2 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
707849 | Likely Benign: not provided | 128,150,229(+) | C/A | INTRON_VARIANT | |
731724 | Benign: not provided | 128,151,725(+) | T/C | INTRON_VARIANT | |
731725 | Benign: not provided | 128,151,903(+) | C/A | INTRON_VARIANT | |
731726 | Benign: not provided | 128,151,921(+) | C/T | MISSENSE_VARIANT | |
753120 | Likely Benign: not provided | 128,149,618(+) | A/G | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
klebsiella infection |
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|
acute pyelonephritis |
|
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hepatorenal syndrome |
|
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acute kidney failure |
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inferolateral myocardial infarct |
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