LCN2 Gene (Protein Coding)

Lipocalin 2

GC09P128149
GIFtS:
43
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. T... See more...

Aliases for LCN2 Gene

Aliases for LCN2 Gene

  • Lipocalin 2 2 3 5
  • Neutrophil Gelatinase-Associated Lipocalin 2 3 4
  • Oncogene 24p3 2 3 4
  • NGAL 2 3 4
  • 25 KDa Alpha-2-Microglobulin-Related Subunit Of MMP-9 3 4
  • Siderocalin 2 4
  • 24p3 2 3
  • P25 3 4
  • Migration-Stimulating Factor Inhibitor 3
  • Lipocalin 2 (Oncogene 24p3) 2
  • Siderocalin LCN2 3
  • Lipocalin-2 4
  • MSFI 3
  • LCN2 5
  • HNL 4

External Ids for LCN2 Gene

Previous GeneCards Identifiers for LCN2 Gene

  • GC09P122026
  • GC09P122558
  • GC09P124365
  • GC09P126287
  • GC09P127991
  • GC09P129951
  • GC09P130911
  • GC09P100525

Summaries for LCN2 Gene

Entrez Gene Summary for LCN2 Gene

  • This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]

GeneCards Summary for LCN2 Gene

LCN2 (Lipocalin 2) is a Protein Coding gene. Diseases associated with LCN2 include Klebsiella Infection and Acute Pyelonephritis. Among its related pathways are Interleukin-4 and 13 signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and iron ion binding. An important paralog of this gene is LCN12.

UniProtKB/Swiss-Prot Summary for LCN2 Gene

  • Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368).

Gene Wiki entry for LCN2 Gene

Additional gene information for LCN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LCN2 Gene

Genomics for LCN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LCN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J128148 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.3 293 2.5 CTCF IKZF1 MTA2 ZIC2 MTA1 REST SP1 DPF2 HDAC1 CEBPA LCN2 NONHSAG053520.2 C9orf16 L13304-040 RF00017-7949
GH09J128137 Promoter/Enhancer 1 EPDnew ENCODE 600.4 -11.7 -11740 0.1 JUND PKNOX1 HDAC1 SOX6 MTA3 NFE2 NR2C2 FOS ZNF318 FOSL1 LCN2 PTGES2 piR-38005-063 L13304-040
GH09J128150 Enhancer 1 ENCODE dbSUPER 600.7 +1.7 1716 0.2 CTCF IKZF1 JUND MTA2 MTA1 REST DPF2 HDAC1 CBX3 USF2 LCN2 NONHSAG053520.2 C9orf16 L13304-040 RF00017-7949
GH09J128090 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 -51.1 -51135 14.8 CEBPG HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 REST ZNF629 SLC25A25 SLC25A25-AS1 NAIF1 PTGES2 CIZ1 PTGES2-AS1 ENSG00000230848 LCN2 C9orf16 ENSG00000230536
GH09J128065 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -78.8 -78779 10 ARHGAP35 CEBPG SP1 CREB1 GATAD2A HNRNPL ATF7 PRDM10 ZNF629 REST NAIF1 SLC25A25 NUP188 ZNF79 SNORA65 CIZ1 GOLGA2 CDK9 FPGS LOC102723566
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LCN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LCN2

Top Transcription factor binding sites by QIAGEN in the LCN2 gene promoter:
  • E47
  • FOXO1
  • FOXO1a
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3
  • Tal-1

Genomic Locations for LCN2 Gene

Genomic Locations for LCN2 Gene
chr9:128,149,071-128,153,453
(GRCh38/hg38)
Size:
4,383 bases
Orientation:
Plus strand
chr9:130,911,350-130,915,734
(GRCh37/hg19)
Size:
4,385 bases
Orientation:
Plus strand

Genomic View for LCN2 Gene

Genes around LCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCN2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LCN2 Gene

Proteins for LCN2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80188-NGAL_HUMAN
    Recommended name:
    Neutrophil gelatinase-associated lipocalin
    Protein Accession:
    P80188
    Secondary Accessions:
    • A6NII8
    • B4DWV4
    • B7ZAA2
    • P30150
    • Q5SYV9
    • Q5SYW0
    • Q6FGL5
    • Q92683

    Protein attributes for LCN2 Gene

    Size:
    198 amino acids
    Molecular mass:
    22588 Da
    Quaternary structure:
    • Monomer (PubMed:7683678, PubMed:1281792). Homodimer; disulfide-linked (PubMed:7683678). Heterodimer; disulfide-linked with MMP9 (PubMed:7683678).

    Three dimensional structures from OCA and Proteopedia for LCN2 Gene

    Alternative splice isoforms for LCN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCN2 Gene

Protein Expression for LCN2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LCN2 Gene

  • Glycosylation at Asn85
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for LCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for LCN2 Gene

Domains & Families for LCN2 Gene

Gene Families for LCN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for LCN2 Gene

InterPro:
Blocks:
  • Lipocalin signature
  • Neutrophil gelatinase lipocalin signature
ProtoNet:

Suggested Antigen Peptide Sequences for LCN2 Gene

GenScript: Design optimal peptide antigens:
  • Neutrophil gelatinase-associated lipocalin (B2ZDQ1_HUMAN)
  • p25 (NGAL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P80188

UniProtKB/Swiss-Prot:

NGAL_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with LCN2: view

Function for LCN2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for LCN2 Gene

UniProtKB/Swiss-Prot Function:
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368).
UniProtKB/Swiss-Prot Induction:
Expression is activated by the oncoprotein BCR-ABL; BCR-ABL misregulates expression via the JAK/STAT pathway and binding of STAT5A to the promoter.
GENATLAS Biochemistry:
neutrophil gelatinase-associated lipocalin 2,25kDa,found at moderate levels,only in breast and lung,component of human tear (lipophilic ligand carrier protein superfamily,lipocalin family,Kernel group),modulator of inflammation,involved in the transport of hydrophobic ligands

Phenotypes From GWAS Catalog for LCN2 Gene

Gene Ontology (GO) - Molecular Function for LCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0005506 iron ion binding ISS --
GO:0036094 small molecule binding IEA --
GO:0042802 identical protein binding IEA --
GO:1903981 enterobactin binding IDA 27780864
genes like me logo Genes that share ontologies with LCN2: view
genes like me logo Genes that share phenotypes with LCN2: view

Animal Models for LCN2 Gene

MGI Knock Outs for LCN2:
  • Lcn2 Lcn2<tm1Aade>
  • Lcn2 Lcn2<tm1Mak>
  • Lcn2 Lcn2<tm1Mrgr>
  • Lcn2 Lcn2<tm1b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for LCN2

CRISPR Products

miRNA for LCN2 Gene

miRTarBase miRNAs that target LCN2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LCN2 Gene

Localization for LCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCN2 Gene

Secreted. Cytoplasmic granule lumen. Cytoplasmic vesicle lumen. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821). {ECO:0000250 UniProtKB:P11672, ECO:0000269 PubMed:12453413, ECO:0000269 PubMed:20581821}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCN2 gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 3
nucleus 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005615 extracellular space IDA 25645918
GO:0005623 cell IEA --
GO:0005829 cytosol IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with LCN2: view

Pathways & Interactions for LCN2 Gene

genes like me logo Genes that share pathways with LCN2: view

Pathways by source for LCN2 Gene

1 KEGG pathway for LCN2 Gene
1 Cell Signaling Technology pathway for LCN2 Gene

Gene Ontology (GO) - Biological Process for LCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006811 ion transport IEA --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0006915 apoptotic process IEA --
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with LCN2: view

No data available for SIGNOR curated interactions for LCN2 Gene

Drugs & Compounds for LCN2 Gene

Products:

  1. Drug

(29) Drugs for LCN2 Gene - From: DrugBank, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra 685
2,3,-Dihydroxybenzoylserine Experimental Pharma Target 0
2-Pyrocatechuic acid Experimental Pharma Target 0
Carboxymycobactin S Experimental Pharma Target 0
Carboxymycobactin T Experimental Pharma Target 0

(8) Additional Compounds for LCN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for LCN2 Gene

Compound Action Cas Number
SB-3CT gelatinases inhibitor, potent and selective 292605-14-2
genes like me logo Genes that share compounds with LCN2: view

Transcripts for LCN2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LCN2 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCN2

Alternative Splicing Database (ASD) splice patterns (SP) for LCN2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - - - - - -
SP5:
SP6: -
SP7: - -

Relevant External Links for LCN2 Gene

GeneLoc Exon Structure for
LCN2

Expression for LCN2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LCN2 Gene

mRNA expression in normal human tissues for LCN2 Gene
mRNA expression by GTEx for LCN2 GenemRNA expression by BioGPS for LCN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCN2 Gene

This gene is overexpressed in Whole Blood (x12.3), Minor Salivary Gland (x10.8), Esophagus - Mucosa (x7.7), Vagina (x4.7), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for LCN2 Gene

This gene is overexpressed in Neutrophil (31.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LCN2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LCN2

SOURCE GeneReport for Unigene cluster for LCN2 Gene:

Hs.204238

mRNA Expression by UniProt/SwissProt for LCN2 Gene:

P80188-NGAL_HUMAN
Tissue specificity: Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for LCN2 Gene

  • Blood(4.8)
  • Pancreas(4.8)
  • Bone marrow(4.8)
  • Liver(4.6)
  • Saliva(4.3)
  • Intestine(4.2)
  • Stomach(3.8)
  • Kidney(3.7)
  • Urine(3.5)
  • Gall bladder(3.4)
  • Lung(3.2)
  • Skin(3.1)
  • Heart(3)
  • Spleen(2.9)
  • Nervous system(2.8)
  • Muscle(2.7)
  • Thyroid gland(2.6)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with LCN2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCN2 Gene

Orthologs for LCN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LCN2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LCN2 30 31
  • 99.33 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LCN2 30 31
  • 77.72 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LCN2 30 31
  • 77.33 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Lcn2 30 17 31
  • 72.25 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Lcn2 30
  • 71.32 (n)
Oppossum
(Monodelphis domestica)
 Mammalia LCN2 31
  • 41 (a)
 OneToOne
Species where no ortholog for LCN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LCN2 Gene

ENSEMBL:
Gene Tree for LCN2 (if available)
TreeFam:
Gene Tree for LCN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LCN2: view image

Paralogs for LCN2 Gene

Paralogs for LCN2 Gene

(2) SIMAP similar genes for LCN2 Gene using alignment to 2 proteins:

  • NGAL_HUMAN
  • H9KV70_HUMAN
genes like me logo Genes that share paralogs with LCN2: view

Variants for LCN2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LCN2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
707849 Likely Benign: not provided 128,150,229(+) C/A INTRON_VARIANT
731724 Benign: not provided 128,151,725(+) T/C INTRON_VARIANT
731725 Benign: not provided 128,151,903(+) C/A INTRON_VARIANT
731726 Benign: not provided 128,151,921(+) C/T MISSENSE_VARIANT
753120 Likely Benign: not provided 128,149,618(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for LCN2 Gene

Variation tolerance for LCN2 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LCN2 Gene

Disorders for LCN2 Gene

MalaCards: The human disease database

(57) MalaCards diseases for LCN2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
klebsiella infection
  • klebsiella
acute pyelonephritis
hepatorenal syndrome
  • hepato-renal syndrome
acute kidney failure
  • acute renal failure
inferolateral myocardial infarct
- elite association - COSMIC cancer census association via MalaCards
Search LCN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LCN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LCN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LCN2 Gene

Publications for LCN2 Gene

  1. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. (PMID: 7683678) Kjeldsen L … Borregaard N (The Journal of biological chemistry 1993) 2 3 4 23
  2. Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin. (PMID: 10684642) Goetz DH … Strong RK (Biochemistry 2000) 3 4 23
  3. Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils. (PMID: 8060329) Bundgaard JR … Kjeldsen L (Biochemical and biophysical research communications 1994) 3 4 23
  4. Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine. (PMID: 27780864) Shields-Cutler RR … Henderson JP (The Journal of biological chemistry 2016) 3 4
  5. Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients. (PMID: 20435938) Perry TE … CABG Genomics Investigators (Anesthesia and analgesia 2010) 3 23

ExternalLinks

View latest publications for LCN2 gene in Mastermind

Products for LCN2 Gene

  • Addgene plasmids for LCN2

Sources for LCN2 Gene