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Aliases for LCN15 Gene

Aliases for LCN15 Gene

  • Lipocalin 15 2 3 5
  • Lipocalin-15 3
  • MSFL2541 3
  • PRO6093 3
  • UNQ2541 3

External Ids for LCN15 Gene

Previous GeneCards Identifiers for LCN15 Gene

  • GC09M138775
  • GC09M139654
  • GC09M109113

Summaries for LCN15 Gene

GeneCards Summary for LCN15 Gene

LCN15 (Lipocalin 15) is a Protein Coding gene. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and small molecule binding. An important paralog of this gene is ENSG00000284341.

Additional gene information for LCN15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCN15 Gene

Genomics for LCN15 Gene

GeneHancer (GH) Regulatory Elements for LCN15 Gene

Promoters and enhancers for LCN15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I136769 Enhancer 0.9 Ensembl dbSUPER 550.8 +0.2 207 1.6 CTCF KLF1 PKNOX1 RB1 ZIC2 RAD21 ZNF335 GLIS2 PATZ1 VEZF1 LCN15 LCN8 TMEM141
GH09I136764 Promoter 0.9 EPDnew 550.4 +5.6 5576 0.1 ZIC2 ATF2 OSR2 ZFHX2 POLR2A GLIS1 ZNF629 PATZ1 ZNF600 ATF7 LCN15 LCN8
GH09I137233 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.3 -468.2 -468192 9.9 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 TUBB4B EHMT1 SDCCAG3 ANAPC2 NDOR1 DPH7 INPP5E LOC651337 MAN1B1 SNHG7
GH09I136757 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 13 +12.0 11957 1.9 HDAC1 PKNOX1 RB1 ARID4B SIN3A ZNF2 RAD21 GLIS2 ZNF143 KLF7 LCN8 EHMT1 SDCCAG3 LCN15 ANAPC2 SEC16A SNHG7 DPH7 MAN1B1 LCN6
GH09I136765 Enhancer 1.1 Ensembl ENCODE 16.3 +3.5 3549 1.8 HDGF PKNOX1 ATF1 ARID4B ZNF2 ZNF207 ZNF143 FOS ATF7 SP3 LCN8 LCN15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LCN15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LCN15 gene promoter:

Genomic Locations for LCN15 Gene

Genomic Locations for LCN15 Gene
10,481 bases
Minus strand

Genomic View for LCN15 Gene

Genes around LCN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCN15 Gene

Proteins for LCN15 Gene

  • Protein details for LCN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for LCN15 Gene

    184 amino acids
    Molecular mass:
    20454 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LCN15 Gene

neXtProt entry for LCN15 Gene

Post-translational modifications for LCN15 Gene

No Post-translational modifications

Other Protein References for LCN15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCN15 Gene

Domains & Families for LCN15 Gene

Gene Families for LCN15 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LCN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calycin superfamily. Lipocalin family.
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with LCN15: view

Function for LCN15 Gene

Phenotypes From GWAS Catalog for LCN15 Gene

Gene Ontology (GO) - Molecular Function for LCN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036094 small molecule binding IEA --
genes like me logo Genes that share ontologies with LCN15: view
genes like me logo Genes that share phenotypes with LCN15: view

Clone Products

  • Addgene plasmids for LCN15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCN15 Gene

Localization for LCN15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCN15 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCN15 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LCN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LCN15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LCN15 Gene

Pathways & Interactions for LCN15 Gene

genes like me logo Genes that share pathways with LCN15: view

Gene Ontology (GO) - Biological Process for LCN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with LCN15: view

No data available for SIGNOR curated interactions for LCN15 Gene

Drugs & Compounds for LCN15 Gene

No Compound Related Data Available

Transcripts for LCN15 Gene

mRNA/cDNA for LCN15 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCN15 Gene

Lipocalin 15:
Representative Sequences:

Clone Products

  • Addgene plasmids for LCN15

Alternative Splicing Database (ASD) splice patterns (SP) for LCN15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7

Relevant External Links for LCN15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LCN15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCN15 Gene

mRNA differential expression in normal tissues according to GTEx for LCN15 Gene

This gene is overexpressed in Brain - Cortex (x11.7), Brain - Frontal Cortex (BA9) (x10.4), and Brain - Anterior cingulate cortex (BA24) (x5.3).

Protein differential expression in normal tissues from HIPED for LCN15 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LCN15 Gene

Protein tissue co-expression partners for LCN15 Gene

NURSA nuclear receptor signaling pathways regulating expression of LCN15 Gene:


SOURCE GeneReport for Unigene cluster for LCN15 Gene:


Evidence on tissue expression from TISSUES for LCN15 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with LCN15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCN15 Gene

Orthologs for LCN15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LCN15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LCN15 33 34
  • 98.91 (n)
(Bos Taurus)
Mammalia LCN15 33 34
  • 84.6 (n)
(Canis familiaris)
Mammalia LCN15 33 34
  • 83.73 (n)
(Monodelphis domestica)
Mammalia LCN15 34
  • 62 (a)
(Mus musculus)
Mammalia LOC102636769 33
  • 61.74 (n)
Gm33749 16
(Ornithorhynchus anatinus)
Mammalia LCN15 34
  • 33 (a)
(Gallus gallus)
Aves CALII 33
  • 58.38 (n)
-- 34
  • 35 (a)
  • 26 (a)
(Danio rerio)
Actinopterygii ptgdsa 34
  • 23 (a)
lcn15 34
  • 19 (a)
Species where no ortholog for LCN15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LCN15 Gene

Gene Tree for LCN15 (if available)
Gene Tree for LCN15 (if available)

Paralogs for LCN15 Gene

Paralogs for LCN15 Gene

(2) SIMAP similar genes for LCN15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LCN15: view

Variants for LCN15 Gene

Sequence variations from dbSNP and Humsavar for LCN15 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000047995 -- 136,761,923(-) C/T intron_variant
rs1000070715 -- 136,762,149(-) G/A intron_variant
rs1000142633 -- 136,762,363(-) A/G intron_variant
rs1000409757 -- 136,766,370(-) T/A/C upstream_transcript_variant
rs1001080477 -- 136,760,895(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LCN15 Gene

Variant ID Type Subtype PubMed ID
esv2422220 CNV deletion 17116639
esv2759720 CNV loss 17122850
esv3891732 CNV loss 25118596
nsv466681 CNV loss 19166990
nsv469918 CNV loss 18288195
nsv615982 CNV loss 21841781
nsv818738 CNV gain 17921354
nsv818739 CNV gain 17921354
nsv8579 CNV gain 18304495
nsv951203 CNV deletion 24416366

Variation tolerance for LCN15 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCN15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCN15 Gene

Disorders for LCN15 Gene

Additional Disease Information for LCN15

No disorders were found for LCN15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCN15 Gene

Publications for LCN15 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for LCN15 Gene

  • Addgene plasmids for LCN15

Sources for LCN15 Gene

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