Aliases for LCN12 Gene
External Ids for LCN12 Gene
Previous GeneCards Identifiers for LCN12 Gene
Members of the lipocalin family, such as LCN12, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
GeneCards Summary for LCN12 Gene
LCN12 (Lipocalin 12) is a Protein Coding gene. Diseases associated with LCN12 include Corneal Ectasia and Irregular Astigmatism. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and retinoic acid binding. An important paralog of this gene is LCN2.
UniProtKB/Swiss-Prot Summary for LCN12 Gene
Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity).