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Aliases for LCN10 Gene

Aliases for LCN10 Gene

  • Lipocalin 10 2 3 5

External Ids for LCN10 Gene

Previous GeneCards Identifiers for LCN10 Gene

  • GC00U915587
  • GC09M136899
  • GC09M138753
  • GC09M139632
  • GC09M109091
  • GC09M136739
  • GC09M136740
  • GC09M136745
  • GC09M136747
  • GC09M136749

Summaries for LCN10 Gene

Entrez Gene Summary for LCN10 Gene

  • Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]

GeneCards Summary for LCN10 Gene

LCN10 (Lipocalin 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LCN10 Gene

  • May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.

Additional gene information for LCN10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCN10 Gene

Genomics for LCN10 Gene

GeneHancer (GH) Regulatory Elements for LCN10 Gene

Promoters and enhancers for LCN10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I136739 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +1.3 1325 4.8 ELF3 ATF1 MLX ARID4B KLF17 RAD21 DNMT3B ZNF48 ZSCAN9 RARA LCN10 LCN8 ENSG00000204003 LCN6 ENSG00000274356
GH09I136787 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.9 -51.4 -51357 14.2 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC TMEM141 CCDC183 DPH7 LCN8 ANAPC2 ABCA2 SNHG7 LCN10 EXD3 LCN12
GH09I135967 Enhancer 1.3 Ensembl ENCODE 11.7 +775.7 775724 1.1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B IRF4 ZNF302 E2F8 SDCCAG3 SNHG7 INPP5E SEC16A OLFM1 LCN6 LCN10 QSOX2 ENSG00000238058 AJM1
GH09I136784 Enhancer 0.9 ENCODE 11.9 -42.2 -42211 1.8 PKNOX1 ATF1 ARNT DMAP1 TCF12 ZNF766 FOS ATF7 NCOA1 REST LCN8 ABCA2 NDOR1 LCN10 CCDC183-AS1 RABL6 LCN12 PRR31 C8G FBXW5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LCN10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LCN10 gene promoter:

Genomic Locations for LCN10 Gene

Genomic Locations for LCN10 Gene
5,190 bases
Minus strand

Genomic View for LCN10 Gene

Genes around LCN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCN10 Gene

Proteins for LCN10 Gene

  • Protein details for LCN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epididymal-specific lipocalin-10
    Protein Accession:
    Secondary Accessions:
    • A2RUU3
    • B0QZ79

    Protein attributes for LCN10 Gene

    187 amino acids
    Molecular mass:
    20759 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LCN10 Gene


neXtProt entry for LCN10 Gene

Post-translational modifications for LCN10 Gene

Other Protein References for LCN10 Gene

No data available for DME Specific Peptides for LCN10 Gene

Domains & Families for LCN10 Gene

Gene Families for LCN10 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for LCN10 Gene


Suggested Antigen Peptide Sequences for LCN10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calycin superfamily. Lipocalin family.
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with LCN10: view

Function for LCN10 Gene

Molecular function for LCN10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.

Gene Ontology (GO) - Molecular Function for LCN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036094 small molecule binding IEA --
genes like me logo Genes that share ontologies with LCN10: view
genes like me logo Genes that share phenotypes with LCN10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LCN10

miRNA for LCN10 Gene

miRTarBase miRNAs that target LCN10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LCN10 Gene

Localization for LCN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCN10 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCN10 gene
Compartment Confidence
extracellular 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LCN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LCN10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LCN10 Gene

Pathways & Interactions for LCN10 Gene

SuperPathways for LCN10 Gene

No Data Available

Interacting Proteins for LCN10 Gene

Gene Ontology (GO) - Biological Process for LCN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with LCN10: view

No data available for Pathways by source and SIGNOR curated interactions for LCN10 Gene

Drugs & Compounds for LCN10 Gene

No Compound Related Data Available

Transcripts for LCN10 Gene

Unigene Clusters for LCN10 Gene

Lipocalin 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCN10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c · 12d ·
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9: - -
SP10: -
SP11: - - -
SP13: - - -

ExUns: 12e

Relevant External Links for LCN10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LCN10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCN10 Gene

mRNA differential expression in normal tissues according to GTEx for LCN10 Gene

This gene is overexpressed in Cervix - Endocervix (x5.2), Fallopian Tube (x4.7), Heart - Left Ventricle (x4.6), and Uterus (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of LCN10 Gene:


SOURCE GeneReport for Unigene cluster for LCN10 Gene:

genes like me logo Genes that share expression patterns with LCN10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCN10 Gene

Orthologs for LCN10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LCN10 Gene

Organism Taxonomy Gene Similarity Type Details
(Rattus norvegicus)
Mammalia Lcn10 33
  • 78.04 (n)
(Mus musculus)
Mammalia Lcn10 33 16 34
  • 77.11 (n)
(Canis familiaris)
Mammalia LCN10 33 34
  • 74.69 (n)
(Bos Taurus)
Mammalia LCN10 34
  • 59 (a)
(Monodelphis domestica)
Mammalia LCN10 34
  • 40 (a)
Species where no ortholog for LCN10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCN10 Gene

Gene Tree for LCN10 (if available)
Gene Tree for LCN10 (if available)

Paralogs for LCN10 Gene

No data available for Paralogs for LCN10 Gene

Variants for LCN10 Gene

Sequence variations from dbSNP and Humsavar for LCN10 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000588224 -- 136,742,586(-) C/T intron_variant
rs1000683069 -- 136,742,798(-) T/C coding_sequence_variant, missense_variant
rs1000796457 -- 136,738,479(-) C/G 3_prime_UTR_variant
rs1000959194 -- 136,741,653(-) T/C intron_variant
rs1002191303 -- 136,737,804(-) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LCN10 Gene

Variant ID Type Subtype PubMed ID
esv2422220 CNV deletion 17116639
esv2657925 CNV deletion 23128226
esv2759720 CNV loss 17122850
esv3622013 CNV loss 21293372
esv3891732 CNV loss 25118596
nsv469918 CNV loss 18288195
nsv6769 CNV insertion 18451855
nsv818738 CNV gain 17921354
nsv8579 CNV gain 18304495
nsv951203 CNV deletion 24416366

Variation tolerance for LCN10 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCN10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCN10 Gene

Disorders for LCN10 Gene

Additional Disease Information for LCN10

No disorders were found for LCN10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCN10 Gene

Publications for LCN10 Gene

  1. Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2. (PMID: 15363845) Suzuki K … Orgebin-Crist MC (Gene 2004) 2 3 4 22 58
  2. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for LCN10 Gene

Sources for LCN10 Gene

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