Aliases for LCMT2 Gene
- Leucine Carboxyl Methyltransferase 2 2 3 4 5
- TRNA(Phe) (7-(3-Amino-3-(Methoxycarbonyl)Propyl)Wyosine(37)-N)-Methoxycarbonyltransferase 3 4
- TRNA(Phe) (7-(3-Amino-3-Carboxypropyl)Wyosine(37)-O)-Methyltransferase 3 4
- TRNA YW-Synthesizing Protein 4 3 4
- TYW4 3 4
- P21WAF1/CIP1 Promoter-Interacting Protein 3
- TRNA Wybutosine-Synthesizing Protein 4 3
External Ids for LCMT2 Gene
Previous GeneCards Identifiers for LCMT2 Gene
The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]
GeneCards Summary for LCMT2 Gene
LCMT2 (Leucine Carboxyl Methyltransferase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is LCMT1.
UniProtKB/Swiss-Prot for LCMT2 Gene
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.