Aliases for LCLAT1 Gene

Aliases for LCLAT1 Gene

  • Lysocardiolipin Acyltransferase 1 2 3 4 5
  • AGPAT8 2 3 4
  • ALCAT1 2 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 8 3 4
  • Acyl-CoA:Lysocardiolipin Acyltransferase 1 3 4
  • 1-AGP Acyltransferase 8 3 4
  • 1-AGPAT 8 3 4
  • LYCAT 3 4
  • Lysocardiolipin Acyltransferase 2
  • EC 4
  • EC 2.3.1.- 4
  • HSRG1849 3
  • FLJ37965 2
  • 1AGPAT8 3
  • UNQ1849 3
  • LCLAT1 5

External Ids for LCLAT1 Gene

Previous HGNC Symbols for LCLAT1 Gene


Previous GeneCards Identifiers for LCLAT1 Gene

  • GC02P030523
  • GC02P030670
  • GC02P030408

Summaries for LCLAT1 Gene

GeneCards Summary for LCLAT1 Gene

LCLAT1 (Lysocardiolipin Acyltransferase 1) is a Protein Coding gene. Diseases associated with LCLAT1 include Barth Syndrome and Mitochondrial Trifunctional Protein Deficiency. Among its related pathways are Acyl chain remodelling of PE and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT3.

UniProtKB/Swiss-Prot Summary for LCLAT1 Gene

  • Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LCLAT1 Gene

Genomics for LCLAT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LCLAT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J030446 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 260.6 +0.5 499 2.5 BCLAF1 SP1 ZNF207 MYC SSRP1 ZNF592 POLR2A CEBPA ZNF10 ZBTB10 LCLAT1 piR-61101-373 lnc-CAPN13-1 CAPN13
GH02J030511 Enhancer 1.1 Ensembl ENCODE 13.7 +65.5 65475 5.8 NCOR1 JUND ZNF592 CEBPA NFIC CHD4 BHLHE40 MNT HOMEZ FOXA2 LCLAT1 piR-33905-038 piR-48820-051 lnc-CAPN13-1 CAPN13
GH02J030481 Enhancer 0.9 Ensembl ENCODE 14 +34.8 34775 2.8 IKZF1 NFIC ZNF316 SMARCA4 SPI1 EHMT2 POLR2A NRF1 MAFK HLF LCLAT1 piR-48820-051 piR-33905-038 lnc-CAPN13-1 CAPN13
GH02J030436 Enhancer 1 Ensembl ENCODE 10.7 -9.4 -9425 5.2 NCOR1 MYC ZNF592 BHLHE40 NR2C1 ZNF585B ZNF316 NFE2 BCL6 STAT5A LCLAT1 piR-50437-367 LBH
GH02J030407 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 7.3 -36.3 -36260 7.3 JUND MAFF RXRA TAL1 ZNF316 FOSL2 NFE2 RAD21 MAFK MAFG HSALNG0013970 LBH SNORA10B LCLAT1 LINC01936 YPEL5 ENSG00000280154 RF01061-082
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LCLAT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LCLAT1

Top Transcription factor binding sites by QIAGEN in the LCLAT1 gene promoter:
  • AML1a
  • HNF-1
  • HNF-1A
  • Lmo2
  • Pax-6
  • Sox5

Genomic Locations for LCLAT1 Gene

Latest Assembly
197,000 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
196,980 bases
Plus strand

(GRCh37/hg19 by Ensembl)
197,000 bases
Plus strand

Genomic View for LCLAT1 Gene

Genes around LCLAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCLAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCLAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCLAT1 Gene

Proteins for LCLAT1 Gene

  • Protein details for LCLAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysocardiolipin acyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • A6H8Z7
    • Q8N1Q7

    Protein attributes for LCLAT1 Gene

    414 amino acids
    Molecular mass:
    48920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LCLAT1 Gene


neXtProt entry for LCLAT1 Gene

Post-translational modifications for LCLAT1 Gene

  • Ubiquitination at Lys221 and Lys226
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LCLAT1 Gene

Domains & Families for LCLAT1 Gene

Gene Families for LCLAT1 Gene

Protein Domains for LCLAT1 Gene

  • Phospholipid/glycerol acyltransferase

Suggested Antigen Peptide Sequences for LCLAT1 Gene

GenScript: Design optimal peptide antigens:
  • Acyl-CoA:lysocardiolipin acyltransferase 1 (LCLT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LCLAT1: view

Function for LCLAT1 Gene

Molecular function for LCLAT1 Gene

UniProtKB/Swiss-Prot Function:
Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=; Evidence={ECO:0000269|PubMed:16620771};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:33195, ChEBI:CHEBI:57287, ChEBI:CHEBI:57880, ChEBI:CHEBI:58342, ChEBI:CHEBI:64771; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:33203, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64716, ChEBI:CHEBI:64840; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57518, ChEBI:CHEBI:64839; Evidence={ECO:0000269|PubMed:16620771};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74544, ChEBI:CHEBI:74546; Evidence={ECO:0000269|PubMed:16620771};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37135, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74547, ChEBI:CHEBI:74548; Evidence={ECO:0000269|PubMed:16620771};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37139, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74549, ChEBI:CHEBI:74550; Evidence={ECO:0000269|PubMed:16620771};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74544, ChEBI:CHEBI:74551; Evidence={ECO:0000269|PubMed:16620771};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37147, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:74544, ChEBI:CHEBI:74552; Evidence={ECO:0000269|PubMed:16620771};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37619, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:64840, ChEBI:CHEBI:75173; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:37623, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:64771, ChEBI:CHEBI:75116; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35871, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72833, ChEBI:CHEBI:72835; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35875, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72833, ChEBI:CHEBI:72836; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35879, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72833, ChEBI:CHEBI:72837; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35883, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72833, ChEBI:CHEBI:72838; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA; Xref=Rhea:RHEA:35867, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:72833, ChEBI:CHEBI:72834; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35851, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35887, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72839, ChEBI:CHEBI:75158; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35891, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35895, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72840, ChEBI:CHEBI:75158; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37643, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72826, ChEBI:CHEBI:75161; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37647, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72827, ChEBI:CHEBI:72845; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37651, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72828, ChEBI:CHEBI:75163; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:37639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:72833, ChEBI:CHEBI:75160; Evidence={ECO:0000269|PubMed:19075029};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37615, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75137, ChEBI:CHEBI:75139; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37611, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:64743, ChEBI:CHEBI:75140; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37675, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:64743, ChEBI:CHEBI:75205; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37679, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:64743, ChEBI:CHEBI:75203; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37683, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:75137, ChEBI:CHEBI:75201; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37427, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57970, ChEBI:CHEBI:74917; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37687, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:75137, ChEBI:CHEBI:75209; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37691, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75137, ChEBI:CHEBI:75207; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37695, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:75137, ChEBI:CHEBI:75208; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38623, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:64743, ChEBI:CHEBI:75990; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38627, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:75137, ChEBI:CHEBI:75993; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38631, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64743, ChEBI:CHEBI:75994; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38635, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64743, ChEBI:CHEBI:75995; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:75137, ChEBI:CHEBI:75996; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:43960, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:64771, ChEBI:CHEBI:83939; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:43964, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:64872, ChEBI:CHEBI:83940; Evidence={ECO:0000250|UniProtKB:Q3UN02};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=39 uM for arachidonoyl-CoA (20:4) for LPIAT activity {ECO:0000269|PubMed:19075029}; KM=289 uM for oleoyl-CoA (18:1) for LPIAT activity {ECO:0000269|PubMed:19075029}; KM=134 uM for linoleoyl-CoA (18:2) for LPIAT activity {ECO:0000269|PubMed:19075029}; KM=34 uM for stearoyl-CoA (18:0) for LPIAT activity {ECO:0000269|PubMed:19075029}; KM=53 uM for palmitoyl-CoA (16:0) for LPIAT activity {ECO:0000269|PubMed:19075029}; KM=54 uM for oleoyl-CoA (18:1) for LPGAT activity {ECO:0000269|PubMed:19075029}; KM=36 uM for linoleoyl-CoA (18:2) for LPGAT activity {ECO:0000269|PubMed:19075029}; KM=70 uM for stearoyl-CoA (18:0) for LPGAT activity {ECO:0000269|PubMed:19075029}; KM=34 uM for palmitoyl-CoA (16:0) for LPGAT activity {ECO:0000269|PubMed:19075029}; Vmax=3230 nmol/min/mg enzyme toward arachidonoyl-CoA (20:4) for LPIAT activity {ECO:0000269|PubMed:19075029}; Vmax=7489 nmol/min/mg enzyme toward oleoyl-CoA (18:1) for LPIAT activity {ECO:0000269|PubMed:19075029}; Vmax=4696 nmol/min/mg enzyme toward linoleoyl-CoA (18:2) for LPIAT activity {ECO:0000269|PubMed:19075029}; Vmax=1078 nmol/min/mg enzyme toward stearoyl-CoA (18:0) for LPIAT activity {ECO:0000269|PubMed:19075029}; Vmax=11203 nmol/min/mg enzyme toward palmitoyl-CoA (16:0) for LPIAT activity {ECO:0000269|PubMed:19075029}; Vmax=5514 nmol/min/mg enzyme toward oleoyl-CoA (18:1) for LPGAT activity {ECO:0000269|PubMed:19075029}; Vmax=1358 nmol/min/mg enzyme toward linoleoyl-CoA (18:2) for LPGAT activity {ECO:0000269|PubMed:19075029}; Vmax=3530 nmol/min/mg enzyme toward stearoyl-CoA (18:0) for LPGAT activity {ECO:0000269|PubMed:19075029}; Vmax=1673 nmol/min/mg enzyme toward palmitoyl-CoA (16:0) for LPGAT activity {ECO:0000269|PubMed:19075029};

Enzyme Numbers (IUBMB) for LCLAT1 Gene

Phenotypes From GWAS Catalog for LCLAT1 Gene

Gene Ontology (GO) - Molecular Function for LCLAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA,IDA 16620771
GO:0005515 protein binding IPI 25416956
GO:0008374 O-acyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA,IBA 21873635
genes like me logo Genes that share ontologies with LCLAT1: view
genes like me logo Genes that share phenotypes with LCLAT1: view

Animal Models for LCLAT1 Gene

MGI Knock Outs for LCLAT1:

Animal Models for research

miRNA for LCLAT1 Gene

miRTarBase miRNAs that target LCLAT1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCLAT1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LCLAT1 Gene

Localization for LCLAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCLAT1 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCLAT1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
plasma membrane 3
mitochondrion 2
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LCLAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA,IDA 16620771
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol IDA --
GO:0012505 endomembrane system IBA 21873635
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with LCLAT1: view

Pathways & Interactions for LCLAT1 Gene

genes like me logo Genes that share pathways with LCLAT1: view

UniProtKB/Swiss-Prot Q6UWP7-LCLT1_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Gene Ontology (GO) - Biological Process for LCLAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0007275 multicellular organism development IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
genes like me logo Genes that share ontologies with LCLAT1: view

No data available for SIGNOR curated interactions for LCLAT1 Gene

Drugs & Compounds for LCLAT1 Gene

(3) Drugs for LCLAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0

(148) Additional Compounds for LCLAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
  • Dodecenoyl-CoA
  • Dodecenoyl+2-dodecenoyl, (e)-isomer
  • Dodecenoyl-coenzyme A
  • Dodecenoyl+2-dodecenoyl
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
genes like me logo Genes that share compounds with LCLAT1: view

Transcripts for LCLAT1 Gene

mRNA/cDNA for LCLAT1 Gene

16 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCLAT1

Alternative Splicing Database (ASD) splice patterns (SP) for LCLAT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for LCLAT1 Gene

GeneLoc Exon Structure for

Expression for LCLAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LCLAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Heart (Cardiovascular System)

Protein differential expression in normal tissues from HIPED for LCLAT1 Gene

This gene is overexpressed in Testis (9.0) and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LCLAT1 Gene

Protein tissue co-expression partners for LCLAT1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LCLAT1

SOURCE GeneReport for Unigene cluster for LCLAT1 Gene:


mRNA Expression by UniProt/SwissProt for LCLAT1 Gene:

Tissue specificity: Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta.

Evidence on tissue expression from TISSUES for LCLAT1 Gene

  • Heart(2.6)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with LCLAT1: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCLAT1 Gene

Orthologs for LCLAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LCLAT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LCLAT1 29 30
  • 99.6 (n)
(Canis familiaris)
Mammalia LCLAT1 29 30
  • 91.31 (n)
(Bos Taurus)
Mammalia LCLAT1 29 30
  • 89.54 (n)
(Rattus norvegicus)
Mammalia Lclat1 29
  • 85.15 (n)
(Mus musculus)
Mammalia Lclat1 29 16 30
  • 84.84 (n)
(Monodelphis domestica)
Mammalia LCLAT1 30
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia LCLAT1 30
  • 80 (a)
(Gallus gallus)
Aves LCLAT1 29 30
  • 76.29 (n)
(Anolis carolinensis)
Reptilia LCLAT1 30
  • 75 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lclat1 29
  • 73.3 (n)
(Danio rerio)
Actinopterygii lycat 29
  • 60.5 (n)
(Caenorhabditis elegans)
Secernentea acl-8 29 30
  • 49.25 (n)
bus-18 30
  • 34 (a)
acl-9 30
  • 32 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CST26 30
  • 20 (a)
-- 30
  • 18 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons LPAT5 29
  • 45.58 (n)
(Oryza sativa)
Liliopsida Os05g0502200 29
  • 44.54 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 37 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.12405 29
Species where no ortholog for LCLAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LCLAT1 Gene

Gene Tree for LCLAT1 (if available)
Gene Tree for LCLAT1 (if available)
Evolutionary constrained regions (ECRs) for LCLAT1: view image
Alliance of Genome Resources:
Additional Orthologs for LCLAT1

Paralogs for LCLAT1 Gene

Paralogs for LCLAT1 Gene

genes like me logo Genes that share paralogs with LCLAT1: view

Variants for LCLAT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LCLAT1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs12471868 -- p.Ile290Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LCLAT1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LCLAT1 Gene

Variant ID Type Subtype PubMed ID
dgv689e199 CNV deletion 23128226
esv2657230 CNV deletion 23128226
esv2667252 CNV deletion 23128226
esv2719865 CNV deletion 23290073
esv2719866 CNV deletion 23290073
esv2719867 CNV deletion 23290073
esv2762445 CNV loss 21179565
esv3583706 CNV loss 25503493
esv3590200 CNV loss 21293372
esv3590201 CNV loss 21293372
esv3590202 CNV loss 21293372
esv3590203 CNV loss 21293372
nsv1003432 CNV loss 25217958
nsv215004 CNV deletion 16902084
nsv524988 CNV loss 19592680
nsv581266 CNV loss 21841781
nsv833648 CNV gain 17160897

Variation tolerance for LCLAT1 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCLAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCLAT1 Gene

Disorders for LCLAT1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for LCLAT1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LCLAT1

genes like me logo Genes that share disorders with LCLAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LCLAT1 Gene

Publications for LCLAT1 Gene

  1. Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. (PMID: 16620771) Agarwal AK … Garg A (Archives of biochemistry and biophysics 2006) 2 3 4 22
  2. The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. (PMID: 19075029) Zhao Y … Cao G (Journal of lipid research 2009) 3 4 22
  3. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. (PMID: 17675553) Wang C … Xiong JW (Blood 2007) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. (PMID: 15152008) Cao J … Shi Y (The Journal of biological chemistry 2004) 2 3

Products for LCLAT1 Gene

Sources for LCLAT1 Gene