Aliases for LCE3E Gene
Aliases for LCE3E Gene
External Ids for LCE3E Gene
- HGNC: 29463
- Entrez Gene: 353145
- Ensembl: ENSG00000185966
- OMIM: 612617
- UniProtKB: Q5T5B0
Previous GeneCards Identifiers for LCE3E Gene
- GC01M149351
- GC01M150804
- GC01M123911
Summaries for LCE3E Gene
GeneCards Summary for LCE3E Gene
LCE3E (Late Cornified Envelope 3E) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is LCE3D.
UniProtKB/Swiss-Prot for LCE3E Gene
-
Precursors of the cornified envelope of the stratum corneum.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCE3E Gene
Genomics for LCE3E Gene
GeneHancer (GH) Regulatory Elements for LCE3E Gene
Promoters and enhancers for LCE3E Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I152567 | Promoter | 0.5 | EPDnew | 550.8 | 0.0 | -28 | 0.1 | LCE3E LCE3D | ||
| GH01I152566 | Enhancer | 0.2 | ENCODE | 550.8 | -0.2 | -158 | 0.1 | LCE3E LCE3C LCE3D | ||
| GH01I152827 | Promoter | 0.5 | EPDnew | 4.1 | -260.7 | -260673 | 0.1 | LCE1A LCE3E GC01P152823 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LCE3E on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LCE3E gene promoter:
Regulatory Element Products
Genomic Locations for LCE3E Gene
Genomic Locations for LCE3E Gene
- chr1:152,565,654-152,566,772
- (GRCh38/hg38)
- Size:
- 1,119 bases
- Orientation:
- Minus strand
- chr1:152,538,130-152,539,248
- (GRCh37/hg19)
Genomic View for LCE3E Gene
Genes around LCE3E on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
LCE3E Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LCE3E Gene
Proteins for LCE3E Gene
-
Protein details for LCE3E Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T5B0-LCE3E_HUMAN
- Recommended name:
- Late cornified envelope protein 3E
- Protein Accession:
- Q5T5B0
- A2RRM6
Protein attributes for LCE3E Gene
- Size:
- 92 amino acids
- Molecular mass:
- 9507 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Belongs to the LCE cluster present on 1q21.
Post-translational modifications for LCE3E Gene
No Post-translational modifications
Other Protein References for LCE3E Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for LCE3E
Protein Products
-
OriGene Purified Proteins for LCE3E
- Search Origene for MassSpec and Protein Over-expression Lysates for LCE3E
- Origene Custom Protein Services for LCE3E
- antibodies-online: Search results for 2 available LCE3E Proteins ranked by validation data
- Compare Top LCE3E Proteins
-
Quality Products:
- Search GeneTex for Proteins for LCE3E
Assay Products
No data available for DME Specific Peptides for LCE3E Gene
Domains & Families for LCE3E Gene
Gene Families for LCE3E Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for LCE3E Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5T5B0- Family:
-
- Belongs to the LCE family.
Function for LCE3E Gene
Molecular function for LCE3E Gene
- UniProtKB/Swiss-Prot Function:
- Precursors of the cornified envelope of the stratum corneum.
- UniProtKB/Swiss-Prot Induction:
- By UVB.
Phenotypes From GWAS Catalog for LCE3E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for LCE3E Gene
- GenomeRNAi human phenotypes for LCE3E:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LCE3E
-
-
ViGene Biosciences lentiviral particle packaged cDNA for LCE3E gene
- Search ViGene Biosciences for LCE3E
CRISPR Products
-
OriGene CRISPR knockouts for LCE3E
- genomics-online: gRNA clones - Search results for 35 available LCE3E gene related products
- Overview of 35 available LCE3E gene related products
- Applied Biological Materials CRISPR for LCE3E
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LCE3E
- GenScript: Design CRISPR guide RNA sequences for LCE3E
miRNA Products
- Search ViGene Biosciences for LCE3E
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LCE3E
- Browse OriGene Inhibitory RNA Products For LCE3E
- genomics-online: shRNA clones - Search results for 35 available LCE3E gene related products
- Overview of 35 available LCE3E gene related products
- Search ViGene Biosciences for LCE3E
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for LCE3E
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LCE3E
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LCE3E
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LCE3E
-
ViGene Biosciences adenoviral particle packaged cDNA for LCE3E gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LCE3E gene
- Search ViGene Biosciences for LCE3E
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE3E Gene
Localization for LCE3E Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LCE3E Gene
Pathways & Interactions for LCE3E Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratinization |
.33
|
|
| 2 | Developmental Biology | ||
Pathways by source for LCE3E Gene
3 Reactome pathways for LCE3E Gene
Interacting Proteins for LCE3E Gene
Selected Interacting proteins:
Q5T5B0-LCE3E_HUMAN
ENSP00000357778
for LCE3E Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008544 | epidermis development | IEA | -- |
| GO:0018149 | peptide cross-linking | IBA | -- |
| GO:0030216 | keratinocyte differentiation | IBA | -- |
| GO:0031424 | keratinization | IEA | -- |
No data available for SIGNOR curated interactions for LCE3E Gene
Transcripts for LCE3E Gene
mRNA/cDNA for LCE3E Gene
- (2) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LCE3E Gene
CRISPR Products
-
OriGene CRISPR knockouts for LCE3E
- genomics-online: gRNA clones - Search results for 35 available LCE3E gene related products
- Overview of 35 available LCE3E gene related products
- Applied Biological Materials CRISPR for LCE3E
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LCE3E
- GenScript: Design CRISPR guide RNA sequences for LCE3E
miRNA Products
- Search ViGene Biosciences for LCE3E
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LCE3E
- Browse OriGene Inhibitory RNA Products For LCE3E
- genomics-online: shRNA clones - Search results for 35 available LCE3E gene related products
- Overview of 35 available LCE3E gene related products
- Search ViGene Biosciences for LCE3E
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for LCE3E
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LCE3E
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LCE3E
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LCE3E Gene
mRNA differential expression in normal tissues according to GTEx for LCE3E Gene
This gene is overexpressed in Cervix - Ectocervix (x26.6) and Vagina (x15.9).
NURSA nuclear receptor signaling pathways regulating expression of LCE3E Gene:
LCE3ESOURCE GeneReport for Unigene cluster for LCE3E Gene:
Hs.490208mRNA Expression by UniProt/SwissProt for LCE3E Gene:
Q5T5B0-LCE3E_HUMAN
Tissue specificity:
Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
Primer Products
-
OriGene qPCR primer pairs for LCE3E
- genomics-online: primer clones - Search results for 35 available LCE3E gene related products
- Overview of 35 available LCE3E gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCE3E Gene
Orthologs for LCE3E Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LCE3E 34 |
|
OneToOne |
- Species where no ortholog for LCE3E was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for LCE3E Gene
Variants for LCE3E Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000760942 | -- | 152,567,527(-) | T/G | upstream_transcript_variant | |
| rs1000815293 | -- | 152,567,248(-) | G/C | upstream_transcript_variant | |
| rs1001269955 | -- | 152,565,226(-) | T/C | downstream_transcript_variant | |
| rs1001369010 | -- | 152,567,405(-) | TTTTTTT/TTTTTTTT | upstream_transcript_variant | |
| rs1002310908 | -- | 152,567,068(-) | T/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv547862 | CNV | loss | 21841781 |
| nsv516961 | CNV | loss | 19592680 |
| nsv470739 | CNV | loss | 18288195 |
| nsv437244 | CNV | loss | 16327808 |
| nsv2888 | CNV | deletion | 18451855 |
| nsv1002425 | CNV | loss | 25217958 |
| esv3587562 | CNV | gain | 21293372 |
| esv3587561 | CNV | loss | 21293372 |
| esv3578182 | CNV | loss | 25503493 |
| esv2762965 | CNV | loss | 21179565 |
| esv2758970 | CNV | gain+loss | 17122850 |
| esv2750810 | CNV | gain | 17911159 |
| dgv569n54 | CNV | loss | 21841781 |
| dgv568n54 | CNV | loss | 21841781 |
| dgv567n54 | CNV | loss | 21841781 |
| dgv566n54 | CNV | loss | 21841781 |
| dgv565n54 | CNV | loss | 21841781 |
| dgv416n100 | CNV | loss | 25217958 |
| dgv39n27 | CNV | loss | 19166990 |
| dgv38n27 | CNV | loss | 19166990 |
| dgv37n27 | CNV | loss | 19166990 |
| dgv100e212 | CNV | loss | 25503493 |
Residual Variation Intolerance Score:
77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.28;
25.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LCE3E Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LCE3E
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE3E Gene
Disorders for LCE3E Gene
Additional Disease Information for LCE3E
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for LCE3E Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE3E Gene
Publications for LCE3E Gene
- Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. (PMID: 19721433) McClay JL … van den Oord EJ (Molecular psychiatry 2011) 3 44 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B … Byrne C (The Journal of investigative dermatology 2005) 3 4 58
- Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D … Byrne C (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
Products for LCE3E Gene
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- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
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- OriGene Purified Proteins for LCE3E
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- OriGene qPCR primer pairs for LCE3E
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- Cloud-Clone Corp. primary cells service
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for LCE3E
- VectorBuilder custom plasmid, inducible vectors for LCE3E
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LCE3E
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available LCE3E related products ranked by validation data
- antibodies-online: Search results for available LCE3E related products ranked by validation data
- antibodies-online: Search results for 2 available LCE3E Proteins ranked by validation data
- Compare Top LCE3E Proteins
- Quality Products:
- Search GeneTex for Antibodies for LCE3E
- Search GeneTex for Proteins for LCE3E
- ViGene Biosciences adenoviral particle packaged cDNA for LCE3E gene
- ViGene Biosciences lentiviral particle packaged cDNA for LCE3E gene
- Search ViGene Biosciences for LCE3E
- Horizon Cell Lines for LCE3E
- genomics-online: cdna clones - Search results for 35 available LCE3E gene related products
- Overview of 35 available LCE3E gene related products
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- Overview of 35 available LCE3E gene related products
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- Overview of 35 available LCE3E gene related products
- genomics-online: primer clones - Search results for 35 available LCE3E gene related products
- Overview of 35 available LCE3E gene related products
- genomics-online: shRNA clones - Search results for 35 available LCE3E gene related products
- Overview of 35 available LCE3E gene related products
Sources for LCE3E Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew