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Aliases for LCE3E Gene

Aliases for LCE3E Gene

  • Late Cornified Envelope 3E 2 3 5
  • Late Envelope Protein 17 3 4
  • LEP17 3 4
  • Late Cornified Envelope Protein 3E 3

External Ids for LCE3E Gene

Previous GeneCards Identifiers for LCE3E Gene

  • GC01M149351
  • GC01M150804
  • GC01M123911

Summaries for LCE3E Gene

GeneCards Summary for LCE3E Gene

LCE3E (Late Cornified Envelope 3E) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is LCE3D.

UniProtKB/Swiss-Prot for LCE3E Gene

  • Precursors of the cornified envelope of the stratum corneum.

Additional gene information for LCE3E Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCE3E Gene

Genomics for LCE3E Gene

GeneHancer (GH) Regulatory Elements for LCE3E Gene

Promoters and enhancers for LCE3E Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I152567 Promoter 0.5 EPDnew 550.8 0.0 -28 0.1 LCE3E LCE3D
GH01I152566 Enhancer 0.2 ENCODE 550.8 -0.2 -158 0.1 LCE3E LCE3C LCE3D
GH01I152827 Promoter 0.5 EPDnew 4.1 -260.7 -260673 0.1 LCE1A LCE3E GC01P152823
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LCE3E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LCE3E gene promoter:

Genomic Locations for LCE3E Gene

Genomic Locations for LCE3E Gene
1,119 bases
Minus strand

Genomic View for LCE3E Gene

Genes around LCE3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE3E Gene

Proteins for LCE3E Gene

  • Protein details for LCE3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Late cornified envelope protein 3E
    Protein Accession:
    Secondary Accessions:
    • A2RRM6

    Protein attributes for LCE3E Gene

    92 amino acids
    Molecular mass:
    9507 Da
    Quaternary structure:
    No Data Available
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE3E Gene

Post-translational modifications for LCE3E Gene

No Post-translational modifications

Other Protein References for LCE3E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE3E Gene

Domains & Families for LCE3E Gene

Gene Families for LCE3E Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LCE3E Gene


Suggested Antigen Peptide Sequences for LCE3E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LCE family.
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE3E: view

Function for LCE3E Gene

Molecular function for LCE3E Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.
UniProtKB/Swiss-Prot Induction:

Phenotypes From GWAS Catalog for LCE3E Gene

Gene Ontology (GO) - Molecular Function for LCE3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LCE3E: view

Phenotypes for LCE3E Gene

genes like me logo Genes that share phenotypes with LCE3E: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE3E Gene

Localization for LCE3E Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCE3E gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for LCE3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with LCE3E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LCE3E Gene

Pathways & Interactions for LCE3E Gene

genes like me logo Genes that share pathways with LCE3E: view

Pathways by source for LCE3E Gene

Gene Ontology (GO) - Biological Process for LCE3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0018149 peptide cross-linking IBA --
GO:0030216 keratinocyte differentiation IBA --
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with LCE3E: view

No data available for SIGNOR curated interactions for LCE3E Gene

Drugs & Compounds for LCE3E Gene

No Compound Related Data Available

Transcripts for LCE3E Gene

mRNA/cDNA for LCE3E Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCE3E Gene

Late cornified envelope 3E:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCE3E Gene

No ASD Table

Relevant External Links for LCE3E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LCE3E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCE3E Gene

mRNA differential expression in normal tissues according to GTEx for LCE3E Gene

This gene is overexpressed in Cervix - Ectocervix (x26.6) and Vagina (x15.9).

NURSA nuclear receptor signaling pathways regulating expression of LCE3E Gene:


SOURCE GeneReport for Unigene cluster for LCE3E Gene:


mRNA Expression by UniProt/SwissProt for LCE3E Gene:

Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
genes like me logo Genes that share expression patterns with LCE3E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCE3E Gene

Orthologs for LCE3E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LCE3E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LCE3E 34
  • 97 (a)
Species where no ortholog for LCE3E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCE3E Gene

Gene Tree for LCE3E (if available)
Gene Tree for LCE3E (if available)

Paralogs for LCE3E Gene

Paralogs for LCE3E Gene

genes like me logo Genes that share paralogs with LCE3E: view

Variants for LCE3E Gene

Sequence variations from dbSNP and Humsavar for LCE3E Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000760942 -- 152,567,527(-) T/G upstream_transcript_variant
rs1000815293 -- 152,567,248(-) G/C upstream_transcript_variant
rs1001269955 -- 152,565,226(-) T/C downstream_transcript_variant
rs1001369010 -- 152,567,405(-) TTTTTTT/TTTTTTTT upstream_transcript_variant
rs1002310908 -- 152,567,068(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LCE3E Gene

Variant ID Type Subtype PubMed ID
nsv547862 CNV loss 21841781
nsv516961 CNV loss 19592680
nsv470739 CNV loss 18288195
nsv437244 CNV loss 16327808
nsv2888 CNV deletion 18451855
nsv1002425 CNV loss 25217958
esv3587562 CNV gain 21293372
esv3587561 CNV loss 21293372
esv3578182 CNV loss 25503493
esv2762965 CNV loss 21179565
esv2758970 CNV gain+loss 17122850
esv2750810 CNV gain 17911159
dgv569n54 CNV loss 21841781
dgv568n54 CNV loss 21841781
dgv567n54 CNV loss 21841781
dgv566n54 CNV loss 21841781
dgv565n54 CNV loss 21841781
dgv416n100 CNV loss 25217958
dgv39n27 CNV loss 19166990
dgv38n27 CNV loss 19166990
dgv37n27 CNV loss 19166990
dgv100e212 CNV loss 25503493

Variation tolerance for LCE3E Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCE3E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE3E Gene

Disorders for LCE3E Gene

Additional Disease Information for LCE3E

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LCE3E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE3E Gene

Publications for LCE3E Gene

  1. Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. (PMID: 19721433) McClay JL … van den Oord EJ (Molecular psychiatry 2011) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B … Byrne C (The Journal of investigative dermatology 2005) 3 4 58
  4. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D … Byrne C (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for LCE3E Gene

Sources for LCE3E Gene

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