This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. [provided by RefSeq, Jul 2008] See more...

Aliases for LCE2B Gene

Aliases for LCE2B Gene

  • Late Cornified Envelope 2B 2 3 5
  • LEP10 2 3 4
  • XP5 2 3 4
  • Small Proline-Rich-Like Epidermal Differentiation Complex Protein 1B 3 4
  • Small Proline Rich-Like (Epidermal Differentiation Complex) 1B 2 3
  • Late Cornified Envelope Protein 2B 3 4
  • Skin-Specific Protein Xp5 3 4
  • Late Envelope Protein 10 3 4
  • SPRL1B 3 4
  • LCE2B 5

External Ids for LCE2B Gene

Previous HGNC Symbols for LCE2B Gene

  • SPRL1B

Previous GeneCards Identifiers for LCE2B Gene

  • GC01P149471
  • GC01P150925
  • GC01P152658
  • GC01P124032

Summaries for LCE2B Gene

Entrez Gene Summary for LCE2B Gene

  • This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for LCE2B Gene

LCE2B (Late Cornified Envelope 2B) is a Protein Coding gene. Diseases associated with LCE2B include Irritant Dermatitis. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is LCE2C.

UniProtKB/Swiss-Prot Summary for LCE2B Gene

Additional gene information for LCE2B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LCE2B Gene

Genomics for LCE2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LCE2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J152686 Promoter 0.3 EPDnew 600.7 0.0 -33 0.1 LCE2B C1orf68 LCE2C
GH01J152639 Enhancer 0.2 ENCODE 11.6 -45.6 -45649 1.2 RF00994-056 LCE2D LCE2C LCE2B LCE3D piR-43103-004 LCE3A
GH01J152698 Promoter 0.4 EPDnew 0.4 +12.2 12203 0.1 BHLHE40 LCE2A piR-39341-018 LCE2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LCE2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LCE2B

Top Transcription factor binding sites by QIAGEN in the LCE2B gene promoter:
  • AML1a
  • AP-1
  • ATF6
  • Bach2
  • HOXA5
  • NF-1
  • NF-1/L

Genomic Locations for LCE2B Gene

Genomic Locations for LCE2B Gene
chr1:152,686,123-152,687,397
(GRCh38/hg38)
Size:
1,275 bases
Orientation:
Plus strand
chr1:152,647,771-152,659,877
(GRCh37/hg19)
Size:
12,107 bases
Orientation:
Plus strand

Genomic View for LCE2B Gene

Genes around LCE2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE2B Gene

Proteins for LCE2B Gene

  • Protein details for LCE2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14633-LCE2B_HUMAN
    Recommended name:
    Late cornified envelope protein 2B
    Protein Accession:
    O14633
    Secondary Accessions:
    • Q5TA80

    Protein attributes for LCE2B Gene

    Size:
    110 amino acids
    Molecular mass:
    11219 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE2B Gene

Post-translational modifications for LCE2B Gene

No Post-translational modifications

Other Protein References for LCE2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE2B Gene

Domains & Families for LCE2B Gene

Gene Families for LCE2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LCE2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LCE2B Gene

GenScript: Design optimal peptide antigens:
  • Small proline-rich-like epidermal differentiation complex protein 1B (LCE2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14633

UniProtKB/Swiss-Prot:

LCE2B_HUMAN :
  • Belongs to the LCE family.
Family:
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE2B: view

Function for LCE2B Gene

Molecular function for LCE2B Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.
UniProtKB/Swiss-Prot Induction:
By calcium and UVB.

Phenotypes From GWAS Catalog for LCE2B Gene

Gene Ontology (GO) - Molecular Function for LCE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with LCE2B: view
genes like me logo Genes that share phenotypes with LCE2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCE2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE2B Gene

Localization for LCE2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCE2B gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LCE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with LCE2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LCE2B Gene

Pathways & Interactions for LCE2B Gene

PathCards logo

SuperPathways for LCE2B Gene

genes like me logo Genes that share pathways with LCE2B: view

Pathways by source for LCE2B Gene

Gene Ontology (GO) - Biological Process for LCE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 9344646
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with LCE2B: view

No data available for SIGNOR curated interactions for LCE2B Gene

Drugs & Compounds for LCE2B Gene

(1) Drugs for LCE2B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with LCE2B: view

Transcripts for LCE2B Gene

mRNA/cDNA for LCE2B Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCE2B

Alternative Splicing Database (ASD) splice patterns (SP) for LCE2B Gene

No ASD Table

Relevant External Links for LCE2B Gene

GeneLoc Exon Structure for
LCE2B

Expression for LCE2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LCE2B Gene

mRNA differential expression in normal tissues according to GTEx for LCE2B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x33.0) and Skin - Not Sun Exposed (Suprapubic) (x19.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LCE2B

SOURCE GeneReport for Unigene cluster for LCE2B Gene:

Hs.234766

mRNA Expression by UniProt/SwissProt for LCE2B Gene:

O14633-LCE2B_HUMAN
Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.

Evidence on tissue expression from TISSUES for LCE2B Gene

  • Skin(4.6)
genes like me logo Genes that share expression patterns with LCE2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCE2B Gene

Orthologs for LCE2B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LCE2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC735897 30
  • 96.1 (n)
Species where no ortholog for LCE2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LCE2B Gene

ENSEMBL:
Gene Tree for LCE2B (if available)
TreeFam:
Gene Tree for LCE2B (if available)

Paralogs for LCE2B Gene

genes like me logo Genes that share paralogs with LCE2B: view

Variants for LCE2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LCE2B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs28391399 - p.Arg83Gln
rs3737859 - p.Ile51Ser

Additional dbSNP identifiers (rs#s) for LCE2B Gene

Structural Variations from Database of Genomic Variants (DGV) for LCE2B Gene

Variant ID Type Subtype PubMed ID
dgv215e59 CNV duplication 20981092
esv23526 CNV gain 19812545
esv2718217 CNV deletion 23290073
esv2750810 CNV gain 17911159
esv2758970 CNV gain+loss 17122850
esv2764247 CNV gain 21179565
esv33483 CNV gain+loss 17666407
esv3587566 CNV gain 21293372
nsv1151301 CNV duplication 26484159
nsv469873 CNV loss 16826518
nsv509480 CNV insertion 20534489
nsv547891 CNV loss 21841781
nsv8424 CNV gain 18304495
nsv946393 CNV duplication 23825009

Variation tolerance for LCE2B Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.44; 81.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCE2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCE2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE2B Gene

Disorders for LCE2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for LCE2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
irritant dermatitis
  • irritant contact dermatitis
- elite association - COSMIC cancer census association via MalaCards
Search LCE2B in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with LCE2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LCE2B Gene

Publications for LCE2B Gene

  1. Positional cloning of novel skin-specific genes from the human epidermal differentiation complex. (PMID: 9344646) Zhao XP … Elder JT (Genomics 1997) 2 3 4
  2. Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B … Byrne C (The Journal of investigative dermatology 2005) 3 4
  3. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D … Byrne C (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for LCE2B Gene

Sources for LCE2B Gene