Aliases for LCE1F Gene

Aliases for LCE1F Gene

  • Late Cornified Envelope 1F 2 3 5
  • LEP6 2 3 4
  • Late Cornified Envelope Protein 1F 3 4
  • Late Envelope Protein 6 3 4
  • LCE1F 5

External Ids for LCE1F Gene

Previous GeneCards Identifiers for LCE1F Gene

  • GC01P149561
  • GC01P151015
  • GC01P152749
  • GC01P124122
  • GC01P152750

Summaries for LCE1F Gene

GeneCards Summary for LCE1F Gene

LCE1F (Late Cornified Envelope 1F) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is LCE1E.

UniProtKB/Swiss-Prot Summary for LCE1F Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LCE1F Gene

Genomics for LCE1F Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LCE1F Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J152743 Enhancer 0.8 Ensembl ENCODE 10.7 -31.3 -31307 1.7 ZNF217 HES1 ELF1 CTBP1 SMARCE1 FOXA1 DPF2 TOE1 RFX1 NFIB LCEP1 lnc-KPRP-1 LCE1F C1orf68 LCEP2 KPRP
GH01J152745 Enhancer 0.7 ENCODE 10.7 -29.6 -29570 0 CEBPA CEBPB BHLHE40 RAD51 FOXA2 USF2 CTCF MAX ATF4 TOE1 LCEP1 lnc-KPRP-1 LCE1F C1orf68 piR-50852-011 KPRP
GH01J152746 Enhancer 0.4 Ensembl 10.7 -29.2 -29240 0.2 L3MBTL2 MNT FOS LCEP1 lnc-KPRP-1 LCE1F C1orf68 piR-50852-011 KPRP
GH01J152820 Enhancer 0.2 Ensembl 10.4 +45.8 45761 0.6 LCE6A LCE1F LCE1A LCE1B
GH01J152768 Enhancer 0.4 ENCODE 0.4 -5.8 -5758 0.9 CEBPB EP300 CTCF LCE1F KPRP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LCE1F on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LCE1F

Top Transcription factor binding sites by QIAGEN in the LCE1F gene promoter:
  • c-Myc
  • FOXJ2
  • FOXJ2 (long isoform)
  • Max1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2

Genomic Locations for LCE1F Gene

Latest Assembly
1,885 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,885 bases
Plus strand

(GRCh37/hg19 by Ensembl)
598 bases
Plus strand

Genomic View for LCE1F Gene

Genes around LCE1F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE1F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE1F Gene

Proteins for LCE1F Gene

  • Protein details for LCE1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Late cornified envelope protein 1F
    Protein Accession:

    Protein attributes for LCE1F Gene

    118 amino acids
    Molecular mass:
    11654 Da
    Quaternary structure:
    No Data Available
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE1F Gene

Post-translational modifications for LCE1F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCE1F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE1F Gene

Domains & Families for LCE1F Gene

Gene Families for LCE1F Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LCE1F Gene


Suggested Antigen Peptide Sequences for LCE1F Gene

GenScript: Design optimal peptide antigens:
  • Late envelope protein 6 (LCE1F_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LCE family.
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE1F: view

Function for LCE1F Gene

Molecular function for LCE1F Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.
UniProtKB/Swiss-Prot Induction:

Phenotypes From GWAS Catalog for LCE1F Gene

Gene Ontology (GO) - Molecular Function for LCE1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0042802 identical protein binding IPI 32296183
genes like me logo Genes that share ontologies with LCE1F: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCE1F

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE1F Gene

Localization for LCE1F Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCE1F gene
Compartment Confidence
plasma membrane 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LCE1F Gene

Pathways & Interactions for LCE1F Gene

PathCards logo

SuperPathways for LCE1F Gene

genes like me logo Genes that share pathways with LCE1F: view

Pathways by source for LCE1F Gene

Gene Ontology (GO) - Biological Process for LCE1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with LCE1F: view

No data available for SIGNOR curated interactions for LCE1F Gene

Drugs & Compounds for LCE1F Gene

No Compound Related Data Available

Transcripts for LCE1F Gene

mRNA/cDNA for LCE1F Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LCE1F

Alternative Splicing Database (ASD) splice patterns (SP) for LCE1F Gene

No ASD Table

Relevant External Links for LCE1F Gene

GeneLoc Exon Structure for

Expression for LCE1F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LCE1F Gene

mRNA differential expression in normal tissues according to GTEx for LCE1F Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x34.3) and Skin - Not Sun Exposed (Suprapubic) (x18.1).

Protein differential expression in normal tissues from HIPED for LCE1F Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LCE1F Gene

Protein tissue co-expression partners for LCE1F Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LCE1F

SOURCE GeneReport for Unigene cluster for LCE1F Gene:


mRNA Expression by UniProt/SwissProt for LCE1F Gene:

Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta. Expression is observed in the fibroblasts.
genes like me logo Genes that share expression patterns with LCE1F: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCE1F Gene

Orthologs for LCE1F Gene

Evolution for LCE1F Gene

Gene Tree for LCE1F (if available)
Gene Tree for LCE1F (if available)
Evolutionary constrained regions (ECRs) for LCE1F: view image
Alliance of Genome Resources:
Additional Orthologs for LCE1F

No data available for Orthologs for LCE1F Gene

Paralogs for LCE1F Gene

genes like me logo Genes that share paralogs with LCE1F: view

Variants for LCE1F Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LCE1F Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LCE1F Gene

Variant ID Type Subtype PubMed ID
dgv429n100 CNV gain 25217958
esv2758970 CNV gain+loss 17122850
esv2763813 CNV loss 21179565
esv33483 CNV gain+loss 17666407
esv34854 CNV gain 17911159
nsv1004884 CNV gain 25217958
nsv1005867 CNV loss 25217958
nsv2910 CNV deletion 18451855
nsv508615 CNV deletion 20534489
nsv547891 CNV loss 21841781
nsv547899 CNV gain 21841781
nsv79 CNV deletion 15895083

Variation tolerance for LCE1F Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCE1F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LCE1F Gene

Disorders for LCE1F Gene

Additional Disease Information for LCE1F

No disorders were found for LCE1F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE1F Gene

Publications for LCE1F Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B … Byrne C (The Journal of investigative dermatology 2005) 3 4
  3. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D … Byrne C (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for LCE1F Gene

Sources for LCE1F Gene